当前位置： SCI文献检索 > Stem Cell Research & Therapy期刊下所有文献 > Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus.

Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus.

Abstract：

BACKGROUND:This study explored the details of the immune response after autologous hematopoietic stem cell transplantation (AHSCT) treatment in type 1 diabetes mellitus. METHODS:Peripheral blood mononuclear cells (PBMCs) from 18 patients with type 1 diabetes mellitus were taken at baseline and 12 months after AHSCT or insulin-only therapy. The lymphocyte proliferation, mRNA expression and secretion of pro-inflammatory and anti-inflammatory cytokines belonging to T-helper type 1 (Th1), T-helper type 17 (Th17) and regulatory T (Treg) cells in PBMC culture supernatants were assessed. RESULTS:Compared with patients receiving insulin-only treatment, the patients receiving AHSCT treatment showed better residual C-peptide secretion, lower anti-GAD titers and less exogenous insulin dosages after 12 months of follow-up. AHSCT treatment was associated with significantly reduced Th1 and Th17 cell proportions as well as decreased IFN-γ, IL-2, IL-12p40 and IL-17A levels in the PBMC culture supernatants (all P < 0.05). Although there was no significant Treg cell expansion after AHSCT treatment, we observed increased IL-10, TGF-β and Foxp3 mRNA expression and increased TGF-β levels. However, we found no significant changes in the T-cell subpopulations after insulin treatment, except for higher IL-12p40 mRNA expression and a lower proportion of Treg cells. CONCLUSIONS:AHSCT treatment was associated with decreased expansion and function of Th1 and Th17 cells, which may explain the better therapeutic effect of AHSCT compared with the traditional intensive insulin therapy. TRIAL REGISTRATION:Clinicaltrials.gov NCT00807651 . Registered 18 December 2008.

journal_name

Stem Cell Res Ther

journal_title

Stem cell research & therapy

authors

Ye L,Li L,Wan B,Yang M,Hong J,Gu W,Wang W,Ning G

doi

10.1186/s13287-017-0542-1

subject

Has Abstract

pub_date

2017-04-18 00:00:00

pages

90

issue

1

issn

1757-6512

pii

10.1186/s13287-017-0542-1

journal_volume

8

pub_type

杂志文章

相关文献

Stem Cell Research & Therapy文献大全
  • High quality clinical grade human embryonic stem cell lines derived from fresh discarded embryos.

    abstract：BACKGROUND:Human embryonic stem cells (hESCs) hold tremendous promise for cell replacement therapies for a range of degenerative diseases. In order to provide cost-effective treatments affordable by public health systems, HLA-matched allogeneic tissue banks of the highest quality clinical-grade hESCs will be required. ...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-017-0561-y

    authors： Ye J,Bates N,Soteriou D,Grady L,Edmond C,Ross A,Kerby A,Lewis PA,Adeniyi T,Wright R,Poulton KV,Lowe M,Kimber SJ,Brison DR

    更新日期：2017-06-05 00:00:00

  • Human levator veli palatini muscle: a novel source of mesenchymal stromal cells for use in the rehabilitation of patients with congenital craniofacial malformations.

    abstract：BACKGROUND:Bone reconstruction in congenital craniofacial differences, which affect about 2-3% of newborns, has long been the focus of intensive research in the field of bone tissue engineering. The possibility of using mesenchymal stromal cells in regenerative medicine protocols has opened a new field of investigation...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-020-02017-7

    authors： Bueno DF,Kabayashi GS,Pinheiro CCG,Tanikawa DYS,Raposo-Amaral CE,Rocha DL,Ferreira JRM,Shibuya Y,Hokugo A,Jarrahy R,ZuK PA,Passos-Bueno MR

    更新日期：2020-11-25 00:00:00

  • Mesenchymal stem cells, not conditioned medium, contribute to kidney repair after ischemia-reperfusion injury.

    abstract：INTRODUCTION:Studies have shown that stem cells exert their therapeutic effects on acute kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in an endocrine manner, the injection of the factors that these cells secrete could be effective, but the effect of conditioned medium (C...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/scrt489

    authors： Xing L,Cui R,Peng L,Ma J,Chen X,Xie RJ,Li B

    更新日期：2014-08-21 00:00:00

  • The utility of human fallopian tube mucosa as a novel source of multipotent stem cells for the treatment of autologous reproductive tract injury.

    abstract：INTRODUCTION:Fallopian tube, which is normally discarded in surgical procedures, has proven to be a source of mesenchymal stem cells (MSCs) with increasing evidence. However, fallopian tube mucosa, which can be acquired via non-invasive procedures, is a previously unknown source of MSCs. In the present study, we explor...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-015-0094-1

    authors： Wang J,Zhao Y,Wu X,Yin S,Chuai Y,Wang A

    更新日期：2015-05-21 00:00:00

  • Differentiation of nonhuman primate pluripotent stem cells into functional keratinocytes.

    abstract：BACKGROUND:Epidermal grafting using cells derived from pluripotent stem cells will change the face of this side of regenerative cutaneous medicine. To date, the safety of the graft would be the major unmet deal in order to implement long-term skin grafting. In this context, experiments on large animals appear unavoidab...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-017-0741-9

    authors： Domingues S,Masson Y,Marteyn A,Allouche J,Perrier AL,Peschanski M,Martinat C,Baldeschi C,Lemaître G

    更新日期：2017-12-19 00:00:00

  • TUG1 enhances high glucose-impaired endothelial progenitor cell function via miR-29c-3p/PDGF-BB/Wnt signaling.

    abstract：BACKGROUND:Diabetes is associated with the dysfunction of endothelial progenitor cells (EPCs), characterized as impaired angiogenesis, a phenomenon thought to be involved in the development of diabetic foot. lncRNA plays an essential role in microvascular dysfunction and signaling pathways in patients with diabetes. ln...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-020-01958-3

    authors： Li Y,Zhi K,Han S,Li X,Li M,Lian W,Zhang H,Zhang X

    更新日期：2020-10-15 00:00:00

  • Role of Notch1 in the arterial specification and angiogenic potential of mouse embryonic stem cell-derived endothelial cells.

    abstract：BACKGROUND:Endothelial cells have been shown to mediate angiogenesis in ischemic injury sites and contribute to the repair of damaged tissues. However, the treatment of ischemic disease requires a significant number of endothelial cells, which are difficult to isolate from patients. Embryonic stem cells have been consi...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-018-0945-7

    authors： Park JK,Lee TW,Do EK,Moon HJ,Kim JH

    更新日期：2018-07-18 00:00:00

  • Human mesenchymal stem cells improve rat islet functionality under cytokine stress with combined upregulation of heme oxygenase-1 and ferritin.

    abstract：BACKGROUND:Islets of Langerhans transplantation is a promising therapy for type 1 diabetes mellitus, but this technique is compromised by transplantation stresses including inflammation. In other tissues, co-transplantation with mesenchymal stem cells has been shown to reduce damage by improving anti-inflammatory and a...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-019-1190-4

    authors： Laporte C,Tubbs E,Cristante J,Gauchez AS,Pesenti S,Lamarche F,Cottet-Rousselle C,Garrel C,Moisan A,Moulis JM,Fontaine E,Benhamou PY,Lablanche S

    更新日期：2019-03-12 00:00:00

  • Tackling the physiological barriers for successful mesenchymal stem cell transplantation into the central nervous system.

    abstract：:Over the past decade a lot of research has been performed towards the therapeutic use of mesenchymal stem cells (MSCs) in neurodegenerative and neuroinflammatory diseases. MSCs have shown to be beneficial in different preclinical studies of central nervous system (CNS) disorders due to their immunomodulatory propertie...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/scrt312

    authors： De Vocht N,Praet J,Reekmans K,Le Blon D,Hoornaert C,Daans J,Berneman Z,Van der Linden A,Ponsaerts P

    更新日期：2013-08-22 00:00:00

  • Bile acid: a potential inducer of colon cancer stem cells.

    abstract：BACKGROUND:Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they regulate carcinogenesis is poorly understood. We hypothesize that the cytotoxic bile acids may promot...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-016-0439-4

    authors： Farhana L,Nangia-Makker P,Arbit E,Shango K,Sarkar S,Mahmud H,Hadden T,Yu Y,Majumdar AP

    更新日期：2016-12-01 00:00:00

  • Relevance of HCN2-expressing human mesenchymal stem cells for the generation of biological pacemakers.

    abstract：BACKGROUND:The transfection of human mesenchymal stem cells (hMSCs) with the hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) gene has been demonstrated to provide biological pacing in dogs with complete heart block. The mechanism appears to be the generation of the ion current (If) by the HCN2-...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-016-0326-z

    authors： Bruzauskaite I,Bironaite D,Bagdonas E,Skeberdis VA,Denkovskij J,Tamulevicius T,Uvarovas V,Bernotiene E

    更新日期：2016-04-30 00:00:00

  • A novel method for banking stem cells from human exfoliated deciduous teeth: lentiviral TERT immortalization and phenotypical analysis.

    abstract：BACKGROUND:Stem cells from human exfoliated deciduous teeth (SHED) have recently attracted attention as novel multipotential stem cell sources. However, their application is limited due to in vitro replicative senescence. Ectopic expression of telomerase reverse transcriptase (TERT) is a promising strategy for overcomi...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-016-0309-0

    authors： Yin Z,Wang Q,Li Y,Wei H,Shi J,Li A

    更新日期：2016-04-04 00:00:00

  • Human serum enhances the proliferative capacity and immunomodulatory property of MSCs derived from human placenta and umbilical cord.

    abstract：BACKGROUND:Mesenchymal stromal cells (MSCs) are considered potential candidates that hold great promise in the treatment of immune-related diseases. For therapeutic applications, it is necessary to isolate and expand MSCs with procedures complying with good manufacturing practice (GMP). Recent studies reported the use ...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-019-1175-3

    authors： Thaweesapphithak S,Tantrawatpan C,Kheolamai P,Tantikanlayaporn D,Roytrakul S,Manochantr S

    更新日期：2019-03-07 00:00:00

  • Precision regenerative medicine.

    abstract：BACKGROUND:Precision or individualized medicine is increasingly pervasive across medical and surgical disciplines. However, the concept has not been introduced in regenerative medicine. MAIN BODY:Targeted and engineered cellular and acellular therapy, specific to individuals or disease states, could significantly impr...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-020-02092-w

    authors： Lightner AL,Chan T

    更新日期：2021-01-07 00:00:00

  • Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells.

    abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with immunomodulatory properties. The mechanisms involved in the capacity of MSCs to inhibit the proliferation of proinflammatory T lymphocytes, which appear responsible for causing autoimmune disease, have yet to be fully elucidated. One of ...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/scrt216

    authors： Luz-Crawford P,Kurte M,Bravo-Alegría J,Contreras R,Nova-Lamperti E,Tejedor G,Noël D,Jorgensen C,Figueroa F,Djouad F,Carrión F

    更新日期：2013-06-04 00:00:00

  • Protective effect of miRNA-containing extracellular vesicles derived from mesenchymal stromal cells of old rats on renal function in chronic kidney disease.

    abstract：INTRODUCTION:Mesenchymal stromal cells (MSCs) play an important role in the prevention of cell and tissue fibrosis. Senescence may decrease the function of MSCs during recovery from tissue and organ damage. Extracellular vesicles (EVs) released from MSCs contribute to the repair of kidney injury. We explored the influe...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-020-01792-7

    authors： Wang Y,Guo YF,Fu GP,Guan C,Zhang X,Yang DG,Shi YC

    更新日期：2020-07-08 00:00:00

  • Adipose mesenchymal stem cell transplantation alleviates spinal cord injury-induced neuroinflammation partly by suppressing the Jagged1/Notch pathway.

    abstract：BACKGROUND:The therapeutic effects of adipose-derived mesenchymal stem cell (ADSC) transplantation have been demonstrated in several models of central nervous system (CNS) injury and are thought to involve the modulation of the inflammatory response. However, the exact underlying molecular mechanism is poorly understoo...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-020-01724-5

    authors： Zhou Z,Tian X,Mo B,Xu H,Zhang L,Huang L,Yao S,Huang Z,Wang Y,Xie H,Xu L,Zhang H

    更新日期：2020-06-03 00:00:00

  • In vitro and in vivo evaluation of cord blood hematopoietic stem and progenitor cells amplified with glycosaminoglycan mimetic.

    abstract：BACKGROUND:Expansion protocols aim at both increasing the number of umbilical cord blood (UCB) hematopoietic stem cells and progenitor cells (HSPCs) and reducing the period of neutropenia in UCB HSPC graft. Because glycosaminoglycans (GAGs) are known to be important components of the hematopoietic niche and to modulate...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-015-0267-y

    authors： Faivre L,Parietti V,Siñeriz F,Chantepie S,Gilbert-Sirieix M,Albanese P,Larghero J,Vanneaux V

    更新日期：2016-01-07 00:00:00

  • DMPE-PEG scaffold binding with TGF-β1 receptor enhances cardiomyogenic differentiation of adipose-derived stem cells.

    abstract：BACKGROUND:Heart failure has become a global health problem with increasing incidences worldwide. Traditional pharmacological treatments can delay but cannot reverse the underlying disease processes. The clinical application of myocardial tissue engineering represents a promising strategy because it features cell-based...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-018-1090-z

    authors： Zhang F,Xie Y,Bian Y

    更新日期：2018-12-29 00:00:00

  • Insulin-like growth factor-II overexpression accelerates parthenogenetic stem cell differentiation into cardiomyocytes and improves cardiac function after acute myocardial infarction in mice.

    abstract：BACKGROUND:Parthenogenetic stem cells (PSCs) are a promising source of regenerated cardiomyocytes; however, their application may be limited without a paternal genome. Insulin-like growth factor-II (IGF-II), a paternally expressed growth hormone, is critical in embryonic differentiation. This study investigated whether...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-020-1575-4

    authors： Sui Y,Zhang W,Tang T,Gao L,Cao T,Zhu H,You Q,Yu B,Yang T

    更新日期：2020-02-26 00:00:00

  • Translating stem cell research to the clinic: a primer on translational considerations for your first stem cell protocol.

    abstract：:Over the last two decades, a new therapeutic paradigm has emerged which has changed the way debilitating diseases may be treated in the future. Instead of using small-molecule drugs and devices to ameliorate the symptoms of disease, clinicians may harness the therapeutic power of cells to regenerate and cure diseases ...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-015-0145-7

    authors： O'Brien T,Creane M,Windebank AJ,Terzic A,Dietz AB

    更新日期：2015-08-22 00:00:00

  • Long non-coding RNA FER1L4 promotes osteogenic differentiation of human periodontal ligament stromal cells via miR-874-3p and vascular endothelial growth factor A.

    abstract：BACKGROUND:Periodontal ligament stromal cells (PDLSCs) are ideal cell sources for periodontal tissue repair and regeneration, but little is known about what determines their osteogenic capacity. Long non-coding RNAs (lncRNAs) are important regulatory molecules at both transcriptional and post-transcriptional levels. Ho...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-019-1519-z

    authors： Huang Y,Han Y,Guo R,Liu H,Li X,Jia L,Zheng Y,Li W

    更新日期：2020-01-03 00:00:00

  • Epigenetic silencing of KLF2 by long non-coding RNA SNHG1 inhibits periodontal ligament stem cell osteogenesis differentiation.

    abstract：BACKGROUND:Exploring the effects of lncRNA SNHG1 in the process of osteogenic differentiation of periodontal ligament stem cells (PDLSCs) would provide novel therapeutic strategies for tissue regeneration. METHODS:Loss-of-function and gain-of-function assays were induced by lentivirus. The osteogenic differentiation o...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-020-01953-8

    authors： Li Z,Guo X,Wu S

    更新日期：2020-10-07 00:00:00

  • Resolvin E1 accelerates pulp repair by regulating inflammation and stimulating dentin regeneration in dental pulp stem cells.

    abstract：BACKGROUND:Unresolved inflammation and tissue destruction are considered to underlie the failure of dental pulp repair. As key mediators of the injury response, dental pulp stem cells (DPSCs) play a critical role in pulp tissue repair and regeneration. Resolvin E1 (RvE1), a major dietary omega-3 polyunsaturated fatty-a...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-021-02141-y

    authors： Chen J,Xu H,Xia K,Cheng S,Zhang Q

    更新日期：2021-01-22 00:00:00

  • Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.

    abstract：BACKGROUND:The intervertebral disc (IVD) has limited self-healing potential and disc repair strategies require an appropriate cell source such as progenitor cells that could regenerate the damaged cells and tissues. The objective of this study was to identify nucleus pulposus-derived progenitor cells (NPPC) and examine...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-016-0337-9

    authors： Tekari A,Chan SCW,Sakai D,Grad S,Gantenbein B

    更新日期：2016-05-23 00:00:00

  • Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells.

    abstract：BACKGROUND:Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular matrix changes, reduced hydration, and progressive degeneration. Cell-based IVD therapy has emerged as an area of great interest, with studies reportin...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-018-0797-1

    authors： Tang R,Jing L,Willard VP,Wu CL,Guilak F,Chen J,Setton LA

    更新日期：2018-03-09 00:00:00

  • Rational transplant timing and dose of mesenchymal stromal cells in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials.

    abstract：BACKGROUND:Mesenchymal stromal cells (MSCs) are considered to have a modest benefit on left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI). However, the optimal injection timing and dose needed to induce beneficial cardiac effects are unknown. The purpose of this meta-analysis w...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章,meta分析

    doi：10.1186/s13287-016-0450-9

    authors： Wang Z,Wang L,Su X,Pu J,Jiang M,He B

    更新日期：2017-01-28 00:00:00

  • Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue.

    abstract：BACKGROUND:Poor bone quality, increased fracture risks, and impaired bone healing are orthopedic comorbidities of type 1 diabetes (T1DM). Standard osteogenic growth factor treatments are inadequate in fully rescuing retarded healing of traumatic T1DM long bone injuries where both periosteal and bone marrow niches are d...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-017-0521-6

    authors： Filion TM,Skelly JD,Huang H,Greiner DL,Ayers DC,Song J

    更新日期：2017-03-11 00:00:00

  • Novel venom-based peptides (P13 and its derivative-M6) to maintain self-renewal of human embryonic stem cells by activating FGF and TGFβ signaling pathways.

    abstract：BACKGROUND:In our previous study, a venom-based peptide named Gonearrestide (also named P13) was identified and demonstrated with an effective inhibition in the proliferation of colon cancer cells. In this study, we explored if P13 and its potent mutant M6 could promote the proliferation of human embryonic stem cells a...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13287-020-01766-9

    authors： Ma R,Ren Z,Li B,Siu SWI,Chen G,Kwok HF

    更新日期：2020-06-18 00:00:00

  • Plasticity of Paneth cells and their ability to regulate intestinal stem cells.

    abstract：:Paneth cells (PCs) are located at the bottom of small intestinal crypts and play an important role in maintaining the stability of the intestinal tract. Previous studies reported on how PCs shape the intestinal microbiota or the response to the immune system. Recent studies have determined that PCs play an important r...

    journal_title：Stem cell research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/s13287-020-01857-7

    authors： Mei X,Gu M,Li M

    更新日期：2020-08-12 00:00:00