Precision regenerative medicine.

abstract：BACKGROUND:Hepatocyte transplantation has been proposed as an effective treatment for patients with acute liver failure (ALF), but its application is limited by a severe shortage of donor livers. Human pluripotent stem cells (hPSCs) have emerged as a potential cell source for regenerative medicine. Human amniotic epith...

journal_title：Stem cell research & therapy

authors： Liu QW,Liu QY,Li JY,Wei L,Ren KK,Zhang XC,Ding T,Xiao L,Zhang WJ,Wu HY,Xin HB

更新日期：2018-11-21 00:00:00

abstract：INTRODUCTION:Stem cell therapy has emerged as potential therapeutic strategy for damaged heart muscles. Umbilical cord blood (UCB) cells are the most prevalent stem cell source available, yet have not been fully tested in cardiac regeneration. Herein, studies were performed to evaluate the cardiovascular safety and ben...

journal_title：Stem cell research & therapy

authors： Oommen S,Yamada S,Cantero Peral S,Campbell KA,Bruinsma ES,Terzic A,Nelson TJ

更新日期：2015-03-26 00:00:00

abstract：BACKGROUND:Vascular injury is one of the most common detrimental effects of cancer radiotherapy on healthy tissues. Since the efficacy of current preventive and therapeutic strategies remains limited, the exploration of new approaches to treat radiation-induced vascular injury (RIV) is on high demands. The use of mesen...

journal_title：Stem cell research & therapy

authors： Tao X,Sun M,Chen M,Ying R,Su W,Zhang J,Xie X,Wei W,Meng X

更新日期：2019-03-13 00:00:00

abstract：BACKGROUND:Urine-derived stem cells (USCs) are a valuable stem cell source for tissue engineering because they can be harvested non-invasively. Small intestine submucosa (SIS) has been used as scaffolds for soft tissue repair in the clinic. However, the feasibility and efficacy of a combination of USCs and SIS for skin...

journal_title：Stem cell research & therapy

authors： Zhang XR,Huang YZ,Gao HW,Jiang YL,Hu JG,Pi JK,Chen AJ,Zhang Y,Zhou L,Xie HQ

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Adult full-thickness cutaneous wound repair suffers from an imbalanced immune response, leading to nonfunctional reconstructed tissue and fibrosis. Although various treatments have been reported, the immune-mediated tissue regeneration driven by biomaterial offers an attractive regenerative strategy for dama...

journal_title：Stem cell research & therapy

authors： Yang Z,He C,He J,Chu J,Liu H,Deng X

更新日期：2018-01-31 00:00:00

abstract：:Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. However, the efficiency of SCNT remains very low due to some poorly characterized key factors. Compared with fertilized embryos, somatic donor cells lack...

journal_title：Stem cell research & therapy

authors： Qu P,Wang Y,Zhang C,Liu E

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Silicon-modified biomaterials have been extensively studied in bone tissue engineering. In recent years, the toxicity of silicon-doped biomaterials has gradually attracted attention but requires further elucidation. This study was designed to explore whether high-dose silicate can induce a cytotoxicity effec...

journal_title：Stem cell research & therapy

authors： Li Z,Liu S,Fu T,Peng Y,Zhang J

更新日期：2019-11-27 00:00:00

abstract：INTRODUCTION:Chronic wounds are a major health-care issue, but research is limited by the complexity and heterogeneity in terms of wound etiology as well as patient-related factors. A suitable animal model that replicates the situation in humans is not available. Therefore, the aim of the present work is to present a s...

journal_title：Stem cell research & therapy

authors： Wettstein R,Savic M,Pierer G,Scheufler O,Haug M,Halter J,Gratwohl A,Baumberger M,Schaefer DJ,Kalbermatten DF

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:The transfection of human mesenchymal stem cells (hMSCs) with the hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) gene has been demonstrated to provide biological pacing in dogs with complete heart block. The mechanism appears to be the generation of the ion current (If) by the HCN2-...

journal_title：Stem cell research & therapy

authors： Bruzauskaite I,Bironaite D,Bagdonas E,Skeberdis VA,Denkovskij J,Tamulevicius T,Uvarovas V,Bernotiene E

更新日期：2016-04-30 00:00:00

abstract：BACKGROUND:Emerging evidence suggests that neural crest-derived cells (NCCs) present important functions in peripheral nerve regeneration to correct the insufficiency of autogenous Schwann cells. Postmigratory NCCs have been successfully isolated from adult rat bone marrow in our previous work. In this study, we aim to...

journal_title：Stem cell research & therapy

authors： Shi H,Li X,Yang J,Zhao Y,Xue C,Wang Y,He Q,Shen M,Zhang Q,Yang Y,Ding F

更新日期：2019-12-18 00:00:00

abstract：:Evidence suggests that transdifferentiation of mesenchymal stem cells (MSCs) into various neuronal cells contributes to functional recovery after experimental spinal cord injury. Qiu et al. have recently published an exciting article in Stem Cell Research & Therapy demonstrating the transdifferentiation of already dif...

journal_title：Stem cell research & therapy

authors： Chelluboina B,Dinh DH,Veeravalli KK

更新日期：2015-10-05 00:00:00

abstract：BACKGROUND:Although endothelial progenitor cells (EPCs) contribute to wound repair by promoting neovascularization, the mechanism of EPC-mediated wound healing remains poorly understood due to the lack of pivotal molecular targets of dermal wound repair. METHODS AND RESULTS:We found that genetic targeting of the Lnk g...

journal_title：Stem cell research & therapy

authors： Lee JH,Ji ST,Kim J,Takaki S,Asahara T,Hong YJ,Kwon SM

更新日期：2016-10-28 00:00:00

abstract：:Tissue engineering has developed many paradigms and techniques on how to best integrate cells and extracellular matrix to create in vitro structures that replicate native tissue. The strategy best suited for building these constructs depends mainly on the target cells, tissues, and organ of interest, and how readily t...

journal_title：Stem cell research & therapy

authors： Thavandiran N,Nunes SS,Xiao Y,Radisic M

更新日期：2013-02-14 00:00:00

abstract：INTRODUCTION:Neural stem cells (NSCs) are among the most promising candidates for cell replacement therapy in neuronal injury and neurodegenerative diseases. One of the remaining obstacles for NSC therapy is to overcome the alloimmune response on NSCs by the host. METHODS:To investigate the mechanisms of immune modula...

journal_title：Stem cell research & therapy

authors： Lee EM,Hurh S,Cho B,Oh KH,Kim SU,Surh CD,Sprent J,Yang J,Kim JY,Ahn C

更新日期：2013-05-21 00:00:00

abstract：BACKGROUND:Mesenchymal stromal/stem cells derived from human umbilical cord (UC-MSCs) uniquely combine properties of embryonic and postnatal MSCs and may be the most acceptable, safe, and effective source for allogeneic cell therapy e.g. for therapeutic angiogenesis. In this report we describe pro-angiogenic properties...

journal_title：Stem cell research & therapy

authors： Arutyunyan I,Fatkhudinov T,Kananykhina E,Usman N,Elchaninov A,Makarov A,Bolshakova G,Goldshtein D,Sukhikh G

更新日期：2016-03-22 00:00:00

abstract：BACKGROUND:Type 1 diabetes (T1D) is an autoimmune disease resulting from the destruction of insulin-secreting islet β cells by autoreactive T cells. Non-obese diabetic (NOD) mice are the widely used animal model for human T1D. Autoimmunity in NOD mice is associated with particular major histocompatibility complex (MHC)...

journal_title：Stem cell research & therapy

authors： Su M,Lin Y,He Z,Lai L

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:This prospective clinical case series aimed to investigate the safety of subretinal adipose tissue-derived mesenchymal stem cell (ADMSC) implantation in advanced stage retinitis pigmentosa (RP). METHODS:This study included 11 patients with end-stage RP who received subretinal implantation of ADMSCs. All pat...

journal_title：Stem cell research & therapy

authors： Oner A,Gonen ZB,Sinim N,Cetin M,Ozkul Y

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The dog represents an excellent large animal model for translational cell-based studies. Importantly, the properties of canine multipotent stromal cells (cMSCs) and the ideal tissue source for specific translational studies have yet to be established. The aim of this study was to characterize cMSCs derived f...

journal_title：Stem cell research & therapy

authors： Bearden RN,Huggins SS,Cummings KJ,Smith R,Gregory CA,Saunders WB

更新日期：2017-10-03 00:00:00

abstract：:Stem cell behaviors are regulated by multiple microenvironmental cues. As an external signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate determination, but how this biophysical cue is translated into intracellular signaling remains elusive. Here, we elucidate mechanisms by ...

journal_title：Stem cell research & therapy

authors： Lv H,Li L,Sun M,Zhang Y,Chen L,Rong Y,Li Y

更新日期：2015-05-27 00:00:00

abstract：BACKGROUND:Hertwig's epithelial root sheath (HERS) is important in guiding tooth root formation by differentiating into cementoblasts through epithelial-mesenchymal transition (EMT) and inducing odontoblastic differentiation of dental papilla through epithelial-mesenchymal interaction (EMI) during the tooth root develo...

journal_title：Stem cell research & therapy

authors： Li X,Zhang S,Zhang Z,Guo W,Chen G,Tian W

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:Myocardial infarction (MI) is a major cause of death worldwide. Although percutaneous coronary intervention and coronary artery bypass grafting can prolong life, cardiac damage persists. In particular, cardiomyocytes have no regenerative capacity. Mesenchymal stem cells (MSCs) are attractive candidates for t...

journal_title：Stem cell research & therapy

authors： Cheng H,Chang S,Xu R,Chen L,Song X,Wu J,Qian J,Zou Y,Ma J

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Liver organoid technology holds great promises to be used in large-scale population-based drug screening and in future regenerative medicine strategies. Recently, some studies reported robust protocols for generating isogenic liver organoids using liver parenchymal and non-parenchymal cells derived from indu...

journal_title：Stem cell research & therapy

authors： Goulart E,de Caires-Junior LC,Telles-Silva KA,Araujo BHS,Kobayashi GS,Musso CM,Assoni AF,Oliveira D,Caldini E,Gerstenhaber JA,Raia S,Lelkes PI,Zatz M

更新日期：2019-08-15 00:00:00

abstract：BACKGROUND:The skeletal muscle regeneration relays on the satellite cells which are stem cells located between basal lamina and plasmalemma of muscle fiber. In the injured muscles, the satellite cells become activated, start to proliferate, and then differentiate into myoblasts, which fuse to form myotubes and finally ...

journal_title：Stem cell research & therapy

authors： Mierzejewski B,Grabowska I,Jackowski D,Irhashava A,Michalska Z,Stremińska W,Jańczyk-Ilach K,Ciemerych MA,Brzoska E

更新日期：2020-08-06 00:00:00

abstract：BACKGROUND:To investigate the therapeutic effect of intercellular adhesion molecule (ICAM)-1-modified mesenchymal stem cells (MSCs) in a mouse model of inflammatory bowel disease (IBD) induced by dextran sulfate sodium. METHODS:Primary MSCs and ICAM-1-overexpressing MSCs (C3 cells) were generated in vitro. The IBD mou...

journal_title：Stem cell research & therapy

authors： Li X,Wang Q,Ding L,Wang YX,Zhao ZD,Mao N,Wu CT,Wang H,Zhu H,Ning SB

更新日期：2019-08-23 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) play a central role in mediating endogenous repair of cell and tissue damage. Biologic aging is a universal process that results in changes at the cellular and molecular levels. In the present study, the role of microRNA (miRNA) in age-induced molecular changes in MSCs derived...

journal_title：Stem cell research & therapy

authors： Pandey AC,Semon JA,Kaushal D,O'Sullivan RP,Glowacki J,Gimble JM,Bunnell BA

更新日期：2011-11-14 00:00:00

abstract：BACKGROUND:Alveolar bone loss is a frequent occurrence. Dental pulp stem cells (DPSCs) which have invasive accessibility and high osteogenic potential is a promising source for cell-based bone regeneration. EphrinB2 is involved in bone homeostasis and osteogenesis. The aim of this study was to investigate the effect an...

journal_title：Stem cell research & therapy

authors： Wang W,Yuan C,Geng T,Liu Y,Zhu S,Zhang C,Liu Z,Wang P

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:Mesenchymal stem/stromal cells derived from chorionic villi of human term placentae (pMSCs) protect human endothelial cells from injury induced by hydrogen peroxide (H2O2). In diabetes, elevated levels of glucose (hyperglycaemia) induce H2O2 production, which causes the endothelial dysfunction that underlies...

journal_title：Stem cell research & therapy

authors： Basmaeil YS,Al Subayyil AM,Khatlani T,Bahattab E,Al-Alwan M,Abomaray FM,Kalionis B,Alshabibi MA,AlAskar AS,Abumaree MH

更新日期：2018-09-21 00:00:00

abstract：BACKGROUND:Human adipose-derived stromal cells (hASCs) have been gaining increasing popularity in regenerative medicine thanks to their multipotency, ease of collection, and efficient culture. Similarly to other stromal cells, their function is particularly sensitive to the culture conditions, including the composition...

journal_title：Stem cell research & therapy

authors： Kuterbekov M,Machillot P,Baillet F,Jonas AM,Glinel K,Picart C

更新日期：2019-08-14 00:00:00

abstract：BACKGROUND:Efficient and sustained hematopoietic recovery after hematopoietic stem cell or bone marrow transplantation is supported by paracrine signaling from specific subpopulations of mesenchymal stromal cells (MSCs). Here, we considered whether in vitro mechanopriming of human MSCs could be administered to predicti...

journal_title：Stem cell research & therapy

authors： Liu FD,Tam K,Pishesha N,Poon Z,Van Vliet KJ

更新日期：2018-10-24 00:00:00

abstract：BACKGROUND:Adipose tissue-derived stem cells are considered to be a promising source in the field of cell therapy and regenerative medicine. In addition to direct cell replacement using adipose tissue or purified stem cells, intercellular molecule exchange by the adipose tissue complex, a vast array of bioactive secret...

journal_title：Stem cell research & therapy

authors： Bellei B,Migliano E,Tedesco M,Caputo S,Papaccio F,Lopez G,Picardo M

更新日期：2018-08-09 00:00:00