Mechanism of regulation of stem cell differentiation by matrix stiffness.

abstract：BACKGROUND:Patients suffering from osteoporosis show an increased number of adipocytes in their bone marrow, concomitant with a reduction in the pool of human mesenchymal stem cells (hMSCs) that are able to differentiate into osteoblasts, thus leading to suppressed osteogenesis. METHODS:In order to be able to interfer...

journal_title：Stem cell research & therapy

authors： van Zoelen EJ,Duarte I,Hendriks JM,van der Woning SP

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Skin is an organ that plays an important role as a physical barrier and has many other complex functions. Skin mimetics may be useful for studying the pathophysiology of diseases in vitro and for repairing lesions in vivo. Cord blood mononuclear cells (CBMCs) have emerged as a potential cell source for regen...

journal_title：Stem cell research & therapy

authors： Kim Y,Park N,Rim YA,Nam Y,Jung H,Lee K,Ju JH

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:WNT and TGFβ signaling pathways play critical regulatory roles in cardiomyocyte fate determination and differentiation. MiRNAs are also known to regulate different biological processes and signaling pathways. Here, we intended to find candidate miRNAs that are involved in cardiac differentiation through regu...

journal_title：Stem cell research & therapy

authors： Kay M,Soltani BM,Aghdaei FH,Ansari H,Baharvand H

更新日期：2019-06-27 00:00:00

abstract：INTRODUCTION:Chronic wounds are a major health-care issue, but research is limited by the complexity and heterogeneity in terms of wound etiology as well as patient-related factors. A suitable animal model that replicates the situation in humans is not available. Therefore, the aim of the present work is to present a s...

journal_title：Stem cell research & therapy

authors： Wettstein R,Savic M,Pierer G,Scheufler O,Haug M,Halter J,Gratwohl A,Baumberger M,Schaefer DJ,Kalbermatten DF

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:Endothelial cells have been shown to mediate angiogenesis in ischemic injury sites and contribute to the repair of damaged tissues. However, the treatment of ischemic disease requires a significant number of endothelial cells, which are difficult to isolate from patients. Embryonic stem cells have been consi...

journal_title：Stem cell research & therapy

authors： Park JK,Lee TW,Do EK,Moon HJ,Kim JH

更新日期：2018-07-18 00:00:00

abstract：:Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers. Current NK therapies using primary NK cells are prone to manufacturing issues related to expansion and storage. Alternative cell sourc...

journal_title：Stem cell research & therapy

authors： Shankar K,Capitini CM,Saha K

更新日期：2020-06-16 00:00:00

abstract：INTRODUCTION:Cell-based therapy represents a new frontier in the treatment of a wide variety of human diseases traditionally associated with morbidity outcomes, including those involving inflammation, autoimmunity, tissue damage, and cancer. However, the use of mesenchymal stem cells (MSCs) to treat multiple myeloma (M...

journal_title：Stem cell research & therapy

authors： Atsuta I,Liu S,Miura Y,Akiyama K,Chen C,An Y,Shi S,Chen FM

更新日期：2013-01-01 00:00:00

abstract：:Paneth cells (PCs) are located at the bottom of small intestinal crypts and play an important role in maintaining the stability of the intestinal tract. Previous studies reported on how PCs shape the intestinal microbiota or the response to the immune system. Recent studies have determined that PCs play an important r...

journal_title：Stem cell research & therapy

authors： Mei X,Gu M,Li M

更新日期：2020-08-12 00:00:00

abstract：BACKGROUND:Sepsis is a global inflammatory disease that causes death. It has been reported that mesenchymal stem cell (MSC) treatment can attenuate inflammatory and septic symptoms. In this study, we investigated how interactions between neutrophils and human umbilical cord blood (hUCB)-MSCs in the liver of septic mice...

journal_title：Stem cell research & therapy

authors： Ahn SY,Maeng YS,Kim YR,Choe YH,Hwang HS,Hyun YM

更新日期：2020-02-03 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) are adult multipotent stem cells that possess regenerative and immunomodulatory properties. They have been widely investigated as therapeutic agents for a variety of disease conditions, including tissue repair, inflammation, autoimmunity, and organ transplantation. Importantly...

journal_title：Stem cell research & therapy

authors： Liu L,Zhang SX,Aeran R,Liao W,Lu M,Polovin G,Pone EJ,Zhao W

更新日期：2015-09-21 00:00:00

abstract：BACKGROUND:We aimed to determine and compare the in vitro effects of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) and mesenchymal stem cell supernatant (MSC-Sp) on the wound healing capacity of equine corneal fibroblasts using a scratch assay. METHODS:Bone marrow aspirates and eyes were collected fr...

journal_title：Stem cell research & therapy

authors： Sherman AB,Gilger BC,Berglund AK,Schnabel LV

更新日期：2017-05-25 00:00:00

abstract：BACKGROUND:Exploring the effects of lncRNA SNHG1 in the process of osteogenic differentiation of periodontal ligament stem cells (PDLSCs) would provide novel therapeutic strategies for tissue regeneration. METHODS:Loss-of-function and gain-of-function assays were induced by lentivirus. The osteogenic differentiation o...

journal_title：Stem cell research & therapy

authors： Li Z,Guo X,Wu S

更新日期：2020-10-07 00:00:00

abstract：:Owing to the aging of the population, our society now faces an impending wave of age-related neurodegenerative pathologies, the most significant of which is Alzheimer's disease. Currently, no effective therapies for Alzheimer's disease have been developed. However, recent advances in the fields of neural stem cells an...

journal_title：Stem cell research & therapy

authors： Byrne JA

更新日期：2014-05-30 00:00:00

abstract：BACKGROUND:In our previous study, a venom-based peptide named Gonearrestide (also named P13) was identified and demonstrated with an effective inhibition in the proliferation of colon cancer cells. In this study, we explored if P13 and its potent mutant M6 could promote the proliferation of human embryonic stem cells a...

journal_title：Stem cell research & therapy

authors： Ma R,Ren Z,Li B,Siu SWI,Chen G,Kwok HF

更新日期：2020-06-18 00:00:00

abstract：BACKGROUND:Efficient and sustained hematopoietic recovery after hematopoietic stem cell or bone marrow transplantation is supported by paracrine signaling from specific subpopulations of mesenchymal stromal cells (MSCs). Here, we considered whether in vitro mechanopriming of human MSCs could be administered to predicti...

journal_title：Stem cell research & therapy

authors： Liu FD,Tam K,Pishesha N,Poon Z,Van Vliet KJ

更新日期：2018-10-24 00:00:00

abstract：INTRODUCTION:Endothelial dysfunction is found in different pathologies such as diabetes and renal and heart diseases, representing one of the major health problems. The reduced vasodilation of impaired endothelium starts a prothrombotic state associated with irregular blood flow. We aimed to explore the potential of am...

journal_title：Stem cell research & therapy

authors： Schiavo AA,Franzin C,Albiero M,Piccoli M,Spiro G,Bertin E,Urbani L,Visentin S,Cosmi E,Fadini GP,De Coppi P,Pozzobon M

更新日期：2015-10-31 00:00:00

abstract：AIM:Myocardial infarction (MI) is a severe disease with increased mortality and disability rates, posing heavy economic burden for society. Exosomes were uncovered to mediate intercellular communication after MI. This study aims to explore the effect and mechanism of lncRNA KLF3-AS1 in exosomes secreted by human mesenc...

journal_title：Stem cell research & therapy

authors： Mao Q,Liang XL,Zhang CL,Pang YH,Lu YX

更新日期：2019-12-17 00:00:00

abstract：OBJECTIVE:Autograft microskin transplantation has been widely used as a skin graft therapy in full-thickness skin defect. However, skin grafting failure can lead to a pathological delay wound healing due to a poor vascularization bed. Considering the active role of adipose-derived stem cell (ADSC) in promoting angiogen...

journal_title：Stem cell research & therapy

authors： Luo Y,Yi X,Liang T,Jiang S,He R,Hu Y,Bai L,Wang C,Wang K,Zhu L

更新日期：2019-08-30 00:00:00

abstract：BACKGROUND:Pulpitis is a common dental disease characterized by sustained inflammation and impaired pulp self-repair. Mesenchymal stem cell-based minimally invasive vital pulp therapy (MSC-miVPT) is a potential treatment method, but its application is limited by the difficulty in acquiring MSCs. We recently revealed th...

journal_title：Stem cell research & therapy

authors： Hong H,Chen X,Li K,Wang N,Li M,Yang B,Yu X,Wei X

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells derived from human umbilical cord tissue, termed UCX®, have the potential to promote a full range of events leading to tissue regeneration and homeostasis. The main goal of this work was to investigate UCX® action in experimentally induced hindlimb ischemia (HLI). METHODS:UCX®, obtain...

journal_title：Stem cell research & therapy

authors： Pereira AR,Mendes TF,Ministro A,Teixeira M,Filipe M,Santos JM,Bárcia RN,Goyri-O'Neill J,Pinto F,Cruz PE,Cruz HJ,Santos SC

更新日期：2016-09-29 00:00:00

abstract：BACKGROUND:Transplantation of endothelial progenitor cells (EPCs)/endothelial cells (ECs) has been used for the treatment of ischemic diseases and hemophilia A, due to their great capacity for producing factor VIII and for repairing vascular damage. We established an effective approach to stimulate the expansion and di...

journal_title：Stem cell research & therapy

authors： Qin M,Guan X,Wang H,Zhang Y,Shen B,Zhang Q,Dai W,Ma Y,Jiang Y

更新日期：2017-02-07 00:00:00

abstract：BACKGROUND:Nanosecond pulsed electric fields (nsPEFs) can produce more significant biological effects than traditional electric fields and have thus attracted rising attention in developing medical applications based on short pulse duration and high field strength, such as effective cancer therapy. However, little is k...

journal_title：Stem cell research & therapy

authors： Ning T,Guo J,Zhang K,Li K,Zhang J,Yang Z,Ge Z

更新日期：2019-01-24 00:00:00

abstract：INTRODUCTION:New therapeutic options are necessary for patients with chronic Chagas disease, a leading cause of heart failure in Latin American countries. Stem cell therapy focused on improving cardiac function is a promising approach for treating heart disease. Here, we evaluated the therapeutic effects of cardiac mes...

journal_title：Stem cell research & therapy

authors： Silva DN,de Freitas Souza BS,Azevedo CM,Vasconcelos JF,Carvalho RH,Soares MB,Dos Santos RR

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:In regenerative medicine the maintenance of stem cell properties is of crucial importance. Ageing is considered a cause of reduced stemness capability. The limbus is a stem niche of easy access and harbors two stem cell populations: epithelial stem cells and fibroblast-like stem cells. Our aim was to investi...

journal_title：Stem cell research & therapy

authors： Tomasello L,Musso R,Cillino G,Pitrone M,Pizzolanti G,Coppola A,Arancio W,Di Cara G,Pucci-Minafra I,Cillino S,Giordano C

更新日期：2016-06-13 00:00:00

abstract：INTRODUCTION:Estrogen plays an important role in the osteogenic differentiation of mesenchymal stem cells, while stem cells from apical papilla (SCAP) can contribute to the formation of dentin/bone-like tissues. To date, the effects of estrogen on the differentiation of SCAP remain unclear. METHODS:SCAP was isolated a...

journal_title：Stem cell research & therapy

authors： Li Y,Yan M,Wang Z,Zheng Y,Li J,Ma S,Liu G,Yu J

更新日期：2014-11-17 00:00:00

abstract：BACKGROUND:Currently, the overall therapeutic efficiency of mesenchymal stem cells (MSCs) transplantation for the treatment of cardiovascular disease is not satisfactory. The low viability and angiogenic capacity of the implanted cells in the local infarct tissues restrict their further application. Evidence shows that...

journal_title：Stem cell research & therapy

authors： Hou J,Wang L,Wu Q,Zheng G,Long H,Wu H,Zhou C,Guo T,Zhong T,Wang L,Chen X,Wang T

更新日期：2018-04-19 00:00:00

abstract：BACKGROUND:Hepatocyte transplantation has been proposed as an effective treatment for patients with acute liver failure (ALF), but its application is limited by a severe shortage of donor livers. Human pluripotent stem cells (hPSCs) have emerged as a potential cell source for regenerative medicine. Human amniotic epith...

journal_title：Stem cell research & therapy

authors： Liu QW,Liu QY,Li JY,Wei L,Ren KK,Zhang XC,Ding T,Xiao L,Zhang WJ,Wu HY,Xin HB

更新日期：2018-11-21 00:00:00

abstract：:The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential...

journal_title：Stem cell research & therapy

authors： Sipp D

更新日期：2010-04-12 00:00:00

abstract：BACKGROUND:For patients with thromboangiitis obliterans (TAO), revascularization with bypass or angioplasty is frequently not feasible due to the poor outflow of the distal small vessels. We evaluated the long-term results of our experience treating patients with TAO with autologous bone marrow-derived mononuclear cell...

journal_title：Stem cell research & therapy

authors： Guo J,Guo L,Cui S,Tong Z,Dardik A,Gu Y

更新日期：2018-02-22 00:00:00

abstract：BACKGROUND:Within the last years, the interest in physical exercise as non-invasive stimulus influencing circulating hematopoietic stem and progenitor cell (CPC) concentrations has constantly grown. Cell estimates are often derived by determining the subgroup of CPC as percent lymphocytes (LYM) or mononuclear cells (MN...

journal_title：Stem cell research & therapy

authors： Kröpfl JM,Schmid M,Di Marzio Y,Schreiber K,Spengler CM

更新日期：2019-10-17 00:00:00