Therapeutic efficiency of human amniotic epithelial stem cell-derived functional hepatocyte-like cells in mice with acute hepatic failure.

abstract：OBJECTIVE:Autologous bone marrow stem cell (ABMSC) transplantation has been considered a promising option for hepatitis B virus-related cirrhosis (HBV-C). Although an analysis of the published literature has been performed, the exact effects and safety have yet to be systematically investigated. METHODS:We conducted a...

journal_title：Stem cell research & therapy

authors： Sun A,Gao W,Xiao T

更新日期：2020-03-05 00:00:00

abstract：BACKGROUND:Myocardial infarction (MI) is a major cause of death worldwide. Although percutaneous coronary intervention and coronary artery bypass grafting can prolong life, cardiac damage persists. In particular, cardiomyocytes have no regenerative capacity. Mesenchymal stem cells (MSCs) are attractive candidates for t...

journal_title：Stem cell research & therapy

authors： Cheng H,Chang S,Xu R,Chen L,Song X,Wu J,Qian J,Zou Y,Ma J

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Dystrophic epidermolysis bullosa (DEB), a rare genodermatosis, is characterized by the formation of intra-epidermal blistering and the development of chronic nonhealing skin wounds. Recently, attempts have been made to develop cell-based therapies for this currently intractable disorder. The molecular mechan...

journal_title：Stem cell research & therapy

authors： Alexeev V,Donahue A,Uitto J,Igoucheva O

更新日期：2016-08-27 00:00:00

abstract：:Injuries of the spinal cord trigger local healing but hardly restore normal function. Spinal cord injury (SCI) has been deeply studied to develop strategies for functional recovery. The study by van Gorp and colleagues uses a rat model of acute SCI to characterize the effects of intraspinal grafting of human fetal spi...

journal_title：Stem cell research & therapy

authors： Tavares I

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:Parthenogenetic stem cells (PSCs) are a promising source of regenerated cardiomyocytes; however, their application may be limited without a paternal genome. Insulin-like growth factor-II (IGF-II), a paternally expressed growth hormone, is critical in embryonic differentiation. This study investigated whether...

journal_title：Stem cell research & therapy

authors： Sui Y,Zhang W,Tang T,Gao L,Cao T,Zhu H,You Q,Yu B,Yang T

更新日期：2020-02-26 00:00:00

abstract：BACKGROUND:Acute liver failure (ALF) is a complicated condition that is characterized by global hepatocyte death and often requires immediate liver transplantation. However, this therapy is limited by shortage of donor organs. Mesenchymal stem cells (MSCs) and hepatocytes are two attractive sources of cell-based therap...

journal_title：Stem cell research & therapy

authors： Kong D,Xu H,Chen M,Yu Y,Qian Y,Qin T,Tong Y,Xia Q,Hang H

更新日期：2020-10-23 00:00:00

abstract：:Temperature is an important microenvironmental factor that functions epigenetically in normal embryonic development. However, the effect of hyperthermia in the stem cells is not fully understood. Oct4 is a tightly regulated master regulator of pluripotency maintenance in stem cells and during early embryonic developme...

journal_title：Stem cell research & therapy

authors： Cheng MB,Wang X,Huang Y,Zhang Y

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:In recent years, adipose-derived stromal cells (ASCs) have been heavily studied for soft tissue regeneration, augmentation, and dermal wound healing. METHODS:In this review, we investigated the trends in injectable scaffolds for ASC delivery in the dermis, and injectable or implantable scaffolds for ASC del...

journal_title：Stem cell research & therapy

authors： Mamsen FP,Munthe-Fog L,Kring MKM,Duscher D,Taudorf M,Katz AJ,Kølle ST

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Treatment-induced cardiotoxicity is a leading noncancer-related cause of acute and late onset morbidity and mortality in cancer patients on antineoplastic drugs such as melphalan-increasing clinical case reports have documented that it could induce cardiotoxicity including severe arrhythmias and heart failur...

journal_title：Stem cell research & therapy

authors： Liu R,Li D,Sun F,Rampoldi A,Maxwell JT,Wu R,Fischbach P,Castellino SM,Du Y,Fu H,Mandawat A,Xu C

更新日期：2020-11-05 00:00:00

abstract：INTRODUCTION:Stem cell-based therapies are currently widely explored as a tool to treat neuroimmune diseases. Multipotent adult progenitor cells (MAPC) have been suggested to have strong immunomodulatory and neuroprotective properties in several experimental models. In this study, we investigate whether MAPC are of the...

journal_title：Stem cell research & therapy

authors： Ravanidis S,Bogie JF,Donders R,Craeye D,Mays RW,Deans R,Gijbels K,Bronckaers A,Stinissen P,Pinxteren J,Hellings N

更新日期：2015-09-16 00:00:00

abstract：BACKGROUND:Application of genetically modified hematopoietic stem cells is increasingly mooted as a clinically relevant approach to protein replacement therapy, immune tolerance induction or conditions where both outcomes may be helpful. Hematopoietic stem and progenitor cell (HSPC)-mediated gene therapy often requires...

journal_title：Stem cell research & therapy

authors： Bhatt KH,Rudraraju R,Brooks JF,Jung JW,Galea R,Wells JW,Steptoe RJ

更新日期：2017-03-09 00:00:00

abstract：BACKGROUND:Although endothelial progenitor cells (EPCs) contribute to wound repair by promoting neovascularization, the mechanism of EPC-mediated wound healing remains poorly understood due to the lack of pivotal molecular targets of dermal wound repair. METHODS AND RESULTS:We found that genetic targeting of the Lnk g...

journal_title：Stem cell research & therapy

authors： Lee JH,Ji ST,Kim J,Takaki S,Asahara T,Hong YJ,Kwon SM

更新日期：2016-10-28 00:00:00

abstract：BACKGROUND:The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory ...

journal_title：Stem cell research & therapy

authors： Li Y,Xu J,Shi W,Chen C,Shao Y,Zhu L,Lu W,Han X

更新日期：2016-10-28 00:00:00

abstract：BACKGROUND:Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular matrix changes, reduced hydration, and progressive degeneration. Cell-based IVD therapy has emerged as an area of great interest, with studies reportin...

journal_title：Stem cell research & therapy

authors： Tang R,Jing L,Willard VP,Wu CL,Guilak F,Chen J,Setton LA

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells derived from human umbilical cord tissue, termed UCX®, have the potential to promote a full range of events leading to tissue regeneration and homeostasis. The main goal of this work was to investigate UCX® action in experimentally induced hindlimb ischemia (HLI). METHODS:UCX®, obtain...

journal_title：Stem cell research & therapy

authors： Pereira AR,Mendes TF,Ministro A,Teixeira M,Filipe M,Santos JM,Bárcia RN,Goyri-O'Neill J,Pinto F,Cruz PE,Cruz HJ,Santos SC

更新日期：2016-09-29 00:00:00

abstract：BACKGROUND:Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and human induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC...

journal_title：Stem cell research & therapy

authors： Liao S,Zhang Y,Ting S,Zhen Z,Luo F,Zhu Z,Jiang Y,Sun S,Lai WH,Lian Q,Tse HF

更新日期：2019-03-07 00:00:00

abstract：:Periostin is a matricellular protein that is reactivated during tissue damage and repair and has been shown to be a critical regulator of multiple biological pathways involved in the repair of tissue after myocardial infarction, peripheral vascular disease, and skin wounds. The tissue repair properties attributed to p...

journal_title：Stem cell research & therapy

authors： Chow T,Rogers IM

更新日期：2015-11-04 00:00:00

abstract：:The outbreak of 2019 novel coronavirus disease (COVID-19) worldwide is becoming rapidly a major concern. The number of severe cases has increased dramatically worldwide, while specific treatment options are scarce. The main pathologic features of severe or critical COVID-19 were consistent with acute lung injure (ALI)...

journal_title：Stem cell research & therapy

authors： Liu S,Peng D,Qiu H,Yang K,Fu Z,Zou L

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:Spinal metastasis is a major challenge in patients with advanced lung cancer, but the mechanisms in the organotropism of metastasis are still unclear. Adipose-derived mesenchymal stem cells (ADSCs) exhibit cancer-promoting properties that influence the tumour microenvironment; however, there is no research o...

journal_title：Stem cell research & therapy

authors： Wang Y,Chu Y,Ren X,Xiang H,Xi Y,Ma X,Zhu K,Guo Z,Zhou C,Zhang G,Chen B

更新日期：2019-06-13 00:00:00

abstract：:Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. However, the efficiency of SCNT remains very low due to some poorly characterized key factors. Compared with fertilized embryos, somatic donor cells lack...

journal_title：Stem cell research & therapy

authors： Qu P,Wang Y,Zhang C,Liu E

更新日期：2020-02-18 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) play a central role in mediating endogenous repair of cell and tissue damage. Biologic aging is a universal process that results in changes at the cellular and molecular levels. In the present study, the role of microRNA (miRNA) in age-induced molecular changes in MSCs derived...

journal_title：Stem cell research & therapy

authors： Pandey AC,Semon JA,Kaushal D,O'Sullivan RP,Glowacki J,Gimble JM,Bunnell BA

更新日期：2011-11-14 00:00:00

abstract：INTRODUCTION:Octamer-binding transcription factor 4 (Oct4) is a master regulator of early mammalian development. Its expression begins from the oocyte stage, becomes restricted to the inner cell mass of the blastocyst and eventually remains only in primordial germ cells. Unearthing the interactions of Oct4 would provid...

journal_title：Stem cell research & therapy

authors： Cheong CY,Lon Ng PM,Ponnampalam R,Tsai HH,Bourque G,Lufkin T

更新日期：2011-05-13 00:00:00

abstract：BACKGROUND:Efficient and sustained hematopoietic recovery after hematopoietic stem cell or bone marrow transplantation is supported by paracrine signaling from specific subpopulations of mesenchymal stromal cells (MSCs). Here, we considered whether in vitro mechanopriming of human MSCs could be administered to predicti...

journal_title：Stem cell research & therapy

authors： Liu FD,Tam K,Pishesha N,Poon Z,Van Vliet KJ

更新日期：2018-10-24 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a major cause of limb dysfunction, and distraction arthroplasty which generates intermittent hydrostatic pressure (IHP) is an effective approach for OA treatment. However, the result was not always satisfactory and the reasons remained unresolved. Because aging is recognized as an impo...

journal_title：Stem cell research & therapy

authors： Dai H,Chen R,Gui C,Tao T,Ge Y,Zhao X,Qin R,Yao W,Gu S,Jiang Y,Gui J

更新日期：2020-05-25 00:00:00

abstract：BACKGROUND:Pulpitis is a common dental disease characterized by sustained inflammation and impaired pulp self-repair. Mesenchymal stem cell-based minimally invasive vital pulp therapy (MSC-miVPT) is a potential treatment method, but its application is limited by the difficulty in acquiring MSCs. We recently revealed th...

journal_title：Stem cell research & therapy

authors： Hong H,Chen X,Li K,Wang N,Li M,Yang B,Yu X,Wei X

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:Urine-derived stem cells (USCs) are a valuable stem cell source for tissue engineering because they can be harvested non-invasively. Small intestine submucosa (SIS) has been used as scaffolds for soft tissue repair in the clinic. However, the feasibility and efficacy of a combination of USCs and SIS for skin...

journal_title：Stem cell research & therapy

authors： Zhang XR,Huang YZ,Gao HW,Jiang YL,Hu JG,Pi JK,Chen AJ,Zhang Y,Zhou L,Xie HQ

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Mesenchymal stromal/stem cells derived from human umbilical cord (UC-MSCs) uniquely combine properties of embryonic and postnatal MSCs and may be the most acceptable, safe, and effective source for allogeneic cell therapy e.g. for therapeutic angiogenesis. In this report we describe pro-angiogenic properties...

journal_title：Stem cell research & therapy

authors： Arutyunyan I,Fatkhudinov T,Kananykhina E,Usman N,Elchaninov A,Makarov A,Bolshakova G,Goldshtein D,Sukhikh G

更新日期：2016-03-22 00:00:00

abstract：BACKGROUND:This study explored the details of the immune response after autologous hematopoietic stem cell transplantation (AHSCT) treatment in type 1 diabetes mellitus. METHODS:Peripheral blood mononuclear cells (PBMCs) from 18 patients with type 1 diabetes mellitus were taken at baseline and 12 months after AHSCT or...

journal_title：Stem cell research & therapy

authors： Ye L,Li L,Wan B,Yang M,Hong J,Gu W,Wang W,Ning G

更新日期：2017-04-18 00:00:00

abstract：BACKGROUND:Human induced pluripotent stem cells (hiPSCs) offer a renewable source of cells for the generation of hematopoietic cells for cell-based therapy, disease modeling, and drug screening. However, current serum/feeder-free differentiation protocols rely on the use of various cytokines, which makes the process ve...

journal_title：Stem cell research & therapy

authors： Netsrithong R,Suwanpitak S,Boonkaew B,Trakarnsanga K,Chang LJ,Tipgomut C,Vatanashevanopakorn C,Pattanapanyasat K,Wattanapanitch M

更新日期：2020-11-11 00:00:00

abstract：:Stem cell behaviors are regulated by multiple microenvironmental cues. As an external signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate determination, but how this biophysical cue is translated into intracellular signaling remains elusive. Here, we elucidate mechanisms by ...

journal_title：Stem cell research & therapy

authors： Lv H,Li L,Sun M,Zhang Y,Chen L,Rong Y,Li Y

更新日期：2015-05-27 00:00:00