Hyperthermia depletes Oct4 in mouse blastocysts and stem cells.

abstract：BACKGROUND:Nicotinamide adenine dinucleotide (NAD+) is a critical molecule involved in various biological functions. Poly (ADP-ribose) polymerase 1 (PARP1) and sirtuin 1 (SIRT1) affect cellular NAD+ levels and play essential roles in regulating metabolism. However, there has been little research on the effects of PARP1...

journal_title：Stem cell research & therapy

authors： Zha S,Li Z,Cao Q,Wang F,Liu F

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:Considerable progress has been made in converting human pluripotent stem cells (hPSCs) into cortical neurons for disease modeling and regenerative medicine. However, these procedures are hard to provide sufficient cells for their applications. Using a combination of small-molecules and growth factors, we pre...

journal_title：Stem cell research & therapy

authors： Zhao S,Duan K,Ai Z,Niu B,Chen Y,Kong R,Li T

更新日期：2020-10-02 00:00:00

abstract：:Because of their multi/pluripotency and immunosuppressive properties, mesenchymal stem/stromal cells (MSCs) are important tools for treating immune disorders and for tissue repair. The increasing use of MSCs, their definition as advanced-therapy medicinal products in European regulations, and the US Food and Drug Admi...

journal_title：Stem cell research & therapy

authors： Sensebé L,Gadelorge M,Fleury-Cappellesso S

更新日期：2013-06-07 00:00:00

abstract：:Over the past decade a lot of research has been performed towards the therapeutic use of mesenchymal stem cells (MSCs) in neurodegenerative and neuroinflammatory diseases. MSCs have shown to be beneficial in different preclinical studies of central nervous system (CNS) disorders due to their immunomodulatory propertie...

journal_title：Stem cell research & therapy

authors： De Vocht N,Praet J,Reekmans K,Le Blon D,Hoornaert C,Daans J,Berneman Z,Van der Linden A,Ponsaerts P

更新日期：2013-08-22 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) are multipotent and have been derived from various tissues. Although MSCs share many basic features, they often display subtle tissue specific differences. We previously demonstrated that bone marrow (BM) MSCs frequently become polyploid in culture. This tendency was mediated ...

journal_title：Stem cell research & therapy

authors： Ravid O,Shoshani O,Sela M,Weinstock A,Sadan TW,Gur E,Zipori D,Shani N

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Ectopic expression of a defined set of transcription factors allows the reprogramming of mammalian somatic cells to pluripotency. Despite continuous progress in primate and rodent reprogramming, limited attention has been paid to cell reprogramming in domestic and companion species. Previous studies attempti...

journal_title：Stem cell research & therapy

authors： Tobias IC,Kao MC,Parmentier T,Hunter H,LaMarre J,Betts DH

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Mesenchymal stromal/stem cells (MSCs) have demonstrated pro-healing properties due to their anti-inflammatory, angiogenic, and even antibacterial properties. We have shown previously that minocycline enhances the wound healing phenotype of MSCs, and MSCs encapsulated in poly(ethylene glycol) and gelatin-base...

journal_title：Stem cell research & therapy

authors： Guerra AD,Rose WE,Hematti P,Kao WJ

更新日期：2017-07-21 00:00:00

abstract：INTRODUCTION:Ischemic stroke is a leading cause of death and disability, but treatment options are severely limited. Cell therapy offers an attractive strategy for regenerating lost tissues and enhancing the endogenous healing process. In this study, we investigated the use of human embryonic stem cell-derived neural p...

journal_title：Stem cell research & therapy

authors： Drury-Stewart D,Song M,Mohamad O,Guo Y,Gu X,Chen D,Wei L

更新日期：2013-08-08 00:00:00

abstract：BACKGROUND:In regenerative medicine the maintenance of stem cell properties is of crucial importance. Ageing is considered a cause of reduced stemness capability. The limbus is a stem niche of easy access and harbors two stem cell populations: epithelial stem cells and fibroblast-like stem cells. Our aim was to investi...

journal_title：Stem cell research & therapy

authors： Tomasello L,Musso R,Cillino G,Pitrone M,Pizzolanti G,Coppola A,Arancio W,Di Cara G,Pucci-Minafra I,Cillino S,Giordano C

更新日期：2016-06-13 00:00:00

abstract：INTRODUCTION:Adipose tissue-derived stromal cells (ADSCs) are abundant and easy to obtain, but the diversity of differentiation potential from different locations may vary with the developmental origin of their mesenchymal compartment. We therefore aim to compare the myogenic differentiation and reparative activity of ...

journal_title：Stem cell research & therapy

authors： Wang X,Zhang H,Nie L,Xu L,Chen M,Ding Z

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:One of the most severe complications of the current COVID-19 pandemic is acute respiratory distress syndrome (ARDS). ARDS is caused by increased amounts of pro-inflammatory cytokines, leading to lung damage and loss of lung function. There are currently no effective therapies for combatting ARDS. Mesenchymal...

journal_title：Stem cell research & therapy

authors： Kaspi H,Semo J,Abramov N,Dekel C,Lindborg S,Kern R,Lebovits C,Aricha R

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem cells into IPCs in vitro, the mechanisms controlling its differentiation and function are not fully ...

journal_title：Stem cell research & therapy

authors： He F,Li N,Huang HB,Wang JB,Yang XF,Wang HD,Huang W,Li FR

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMMSCs) are suitable cell sources for dental pulp regeneration, but the mechanism of BMMSCs differentiation into odontogenic lineage remains unknown. The aim of the present study was to reveal the role of magnesium transporter protein 1 (MagT1) and MAPK pathways in the odo...

journal_title：Stem cell research & therapy

authors： Zheng JM,Kong YY,Li YY,Zhang W

更新日期：2019-01-31 00:00:00

abstract：:The use of secretome may be a new strand of cell therapy, which is equal to or even superior to the injection of live cells, called cell-free therapy. In ovarian transplantation, this approach may be a therapeutic possibility for the ovarian graft in hypoxia. We designed the present study to evaluate whether the cell-...

journal_title：Stem cell research & therapy

authors： Damous LL,de Carvalho AETS,Nakamuta JS,Shiroma ME,Louzada ACS,Soares-Jr JM,Krieger JE,Baracat EC

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:Treatment-induced cardiotoxicity is a leading noncancer-related cause of acute and late onset morbidity and mortality in cancer patients on antineoplastic drugs such as melphalan-increasing clinical case reports have documented that it could induce cardiotoxicity including severe arrhythmias and heart failur...

journal_title：Stem cell research & therapy

authors： Liu R,Li D,Sun F,Rampoldi A,Maxwell JT,Wu R,Fischbach P,Castellino SM,Du Y,Fu H,Mandawat A,Xu C

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Application of genetically modified hematopoietic stem cells is increasingly mooted as a clinically relevant approach to protein replacement therapy, immune tolerance induction or conditions where both outcomes may be helpful. Hematopoietic stem and progenitor cell (HSPC)-mediated gene therapy often requires...

journal_title：Stem cell research & therapy

authors： Bhatt KH,Rudraraju R,Brooks JF,Jung JW,Galea R,Wells JW,Steptoe RJ

更新日期：2017-03-09 00:00:00

abstract：BACKGROUND:Multiple sclerosis is a demyelinating disease mostly of autoimmune origin that affects and damages the central nervous system, leading to a disabling condition. The aim of the present study was to investigate whether administration of mesenchymal stem cells from human periodontal ligament (hPDLSCs) could ame...

journal_title：Stem cell research & therapy

authors： Trubiani O,Giacoppo S,Ballerini P,Diomede F,Piattelli A,Bramanti P,Mazzon E

更新日期：2016-01-04 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells derived from human umbilical cord tissue, termed UCX®, have the potential to promote a full range of events leading to tissue regeneration and homeostasis. The main goal of this work was to investigate UCX® action in experimentally induced hindlimb ischemia (HLI). METHODS:UCX®, obtain...

journal_title：Stem cell research & therapy

authors： Pereira AR,Mendes TF,Ministro A,Teixeira M,Filipe M,Santos JM,Bárcia RN,Goyri-O'Neill J,Pinto F,Cruz PE,Cruz HJ,Santos SC

更新日期：2016-09-29 00:00:00

abstract：BACKGROUND:Nanosecond pulsed electric fields (nsPEFs) can produce more significant biological effects than traditional electric fields and have thus attracted rising attention in developing medical applications based on short pulse duration and high field strength, such as effective cancer therapy. However, little is k...

journal_title：Stem cell research & therapy

authors： Ning T,Guo J,Zhang K,Li K,Zhang J,Yang Z,Ge Z

更新日期：2019-01-24 00:00:00

abstract：BACKGROUND:Heart failure has become a global health problem with increasing incidences worldwide. Traditional pharmacological treatments can delay but cannot reverse the underlying disease processes. The clinical application of myocardial tissue engineering represents a promising strategy because it features cell-based...

journal_title：Stem cell research & therapy

authors： Zhang F,Xie Y,Bian Y

更新日期：2018-12-29 00:00:00

abstract：:The discovery of induced pluripotent stem cells (iPSCs) in 2006 was a major breakthrough for regenerative medicine. The establishment of patient-specific iPSCs has created the opportunity to model diseases in culture systems, with the potential to rapidly advance the drug discovery field. Current methods of drug disco...

journal_title：Stem cell research & therapy

authors： Guo Z,Higgins CA,Gillette BM,Itoh M,Umegaki N,Gledhill K,Sia SK,Christiano AM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Dystrophic epidermolysis bullosa (DEB), a rare genodermatosis, is characterized by the formation of intra-epidermal blistering and the development of chronic nonhealing skin wounds. Recently, attempts have been made to develop cell-based therapies for this currently intractable disorder. The molecular mechan...

journal_title：Stem cell research & therapy

authors： Alexeev V,Donahue A,Uitto J,Igoucheva O

更新日期：2016-08-27 00:00:00

abstract：INTRODUCTION:Human multipotent stromal cells (MSCs) isolated from bone marrow or other tissue sources have great potential to treat a wide range of injuries and disorders in the field of regenerative medicine and tissue engineering. In particular, MSCs have inherent characteristics to suppress the immune system and are...

journal_title：Stem cell research & therapy

authors： Bellayr IH,Catalano JG,Lababidi S,Yang AX,Lo Surdo JL,Bauer SR,Puri RK

更新日期：2014-04-28 00:00:00

abstract：:The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential...

journal_title：Stem cell research & therapy

authors： Sipp D

更新日期：2010-04-12 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated mesenchymal stem cells (MSCs) as effective mitochondrial donors with therapeutic success in multiple experimental models of human disease. MSCs obtained from different tissue sources such as bone marrow (BM), adipose (AD), dental pulp (DP), and Wharton's jelly (WJ) are routin...

journal_title：Stem cell research & therapy

authors： Paliwal S,Chaudhuri R,Agrawal A,Mohanty S

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:The dog represents an excellent large animal model for translational cell-based studies. Importantly, the properties of canine multipotent stromal cells (cMSCs) and the ideal tissue source for specific translational studies have yet to be established. The aim of this study was to characterize cMSCs derived f...

journal_title：Stem cell research & therapy

authors： Bearden RN,Huggins SS,Cummings KJ,Smith R,Gregory CA,Saunders WB

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:Hepatocyte transplantation has been proposed as an effective treatment for patients with acute liver failure (ALF), but its application is limited by a severe shortage of donor livers. Human pluripotent stem cells (hPSCs) have emerged as a potential cell source for regenerative medicine. Human amniotic epith...

journal_title：Stem cell research & therapy

authors： Liu QW,Liu QY,Li JY,Wei L,Ren KK,Zhang XC,Ding T,Xiao L,Zhang WJ,Wu HY,Xin HB

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:Many factors may influence the efficacy of cell therapy for intrinsic urinary sphincter deficiency (ISD), including the route of administration of the cells and the condition of the sphincter. The goal of this study was to compare local versus intravenous administration of autologous skeletal muscle precurso...

journal_title：Stem cell research & therapy

authors： Williams JK,Badlani G,Dean A,Lankford S,Poppante K,Criswell T,Andersson KE

更新日期：2016-10-07 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with immunomodulatory properties. The mechanisms involved in the capacity of MSCs to inhibit the proliferation of proinflammatory T lymphocytes, which appear responsible for causing autoimmune disease, have yet to be fully elucidated. One of ...

journal_title：Stem cell research & therapy

authors： Luz-Crawford P,Kurte M,Bravo-Alegría J,Contreras R,Nova-Lamperti E,Tejedor G,Noël D,Jorgensen C,Figueroa F,Djouad F,Carrión F

更新日期：2013-06-04 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive accumulation of Lewy body inclusions along with selective destruction of dopaminergic (DA) neurons in the nigrostriatal tract of the brain. Genetic studies have revealed much about the pathophysiology of PD, enabling the identifi...

journal_title：Stem cell research & therapy

authors： Gibson SA,Gao GD,McDonagh K,Shen S

更新日期：2012-04-03 00:00:00