Therapeutic angiogenesis induced by human umbilical cord tissue-derived mesenchymal stromal cells in a murine model of hindlimb ischemia.

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMMSCs) are suitable cell sources for dental pulp regeneration, but the mechanism of BMMSCs differentiation into odontogenic lineage remains unknown. The aim of the present study was to reveal the role of magnesium transporter protein 1 (MagT1) and MAPK pathways in the odo...

journal_title：Stem cell research & therapy

authors： Zheng JM,Kong YY,Li YY,Zhang W

更新日期：2019-01-31 00:00:00

abstract：BACKGROUND:As a type of high-frequency electrotherapy, a short-wave can promote the fracture healing process; yet, its underlying therapeutic mechanisms remain unclear. PURPOSE:To observe the effect of Short-Wave therapy on mesenchymal stem cell (MSC) homing and relative mechanisms associated with fracture healing. M...

journal_title：Stem cell research & therapy

authors： Ye D,Chen C,Wang Q,Zhang Q,Li S,Liu H

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:Emerging evidence suggests that neural crest-derived cells (NCCs) present important functions in peripheral nerve regeneration to correct the insufficiency of autogenous Schwann cells. Postmigratory NCCs have been successfully isolated from adult rat bone marrow in our previous work. In this study, we aim to...

journal_title：Stem cell research & therapy

authors： Shi H,Li X,Yang J,Zhao Y,Xue C,Wang Y,He Q,Shen M,Zhang Q,Yang Y,Ding F

更新日期：2019-12-18 00:00:00

abstract：BACKGROUND:The proangiogenic capacity of adipose tissue and its derivatives has been demonstrated in a variety of studies. The paracrine mechanism of the cellular component is considered to play a critical role in the regenerative properties of these tissues. However, cell-based therapy for clinical application has bee...

journal_title：Stem cell research & therapy

authors： Yu Z,Cai Y,Deng M,Li D,Wang X,Zheng H,Xu Y,Li W,Zhang W

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:In regenerative medicine the maintenance of stem cell properties is of crucial importance. Ageing is considered a cause of reduced stemness capability. The limbus is a stem niche of easy access and harbors two stem cell populations: epithelial stem cells and fibroblast-like stem cells. Our aim was to investi...

journal_title：Stem cell research & therapy

authors： Tomasello L,Musso R,Cillino G,Pitrone M,Pizzolanti G,Coppola A,Arancio W,Di Cara G,Pucci-Minafra I,Cillino S,Giordano C

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Bone marrow-derived cell therapy has been used to treat acute myocardial infarction. However, the therapeutic efficacy of this approach remains controversial. Here, we performed a systematic review and meta-analysis to evaluate short-term and long-term effectiveness of bone marrow-derived therapy. METHODS:W...

journal_title：Stem cell research & therapy

authors： Lee SH,Hong JH,Cho KH,Noh JW,Cho HJ

更新日期：2016-10-20 00:00:00

abstract：BACKGROUND:A keloid is a fibroproliferative disorder occurring in wounds characterized by an exaggerated response to injury. To date, no effective cure has been identified. As multipotent stem cells, human adipose-derived stem cells (ADSCs) may show the possibility for curing diseases such as fibrosis. This study sough...

journal_title：Stem cell research & therapy

authors： Wang X,Ma Y,Gao Z,Yang J

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:The therapeutic effect of mesenchymal stem cells (MSCs) from human adipose tissue on renal interstitial fibrosis has been demonstrated by several groups. However, the way to enhance the renoprotective effect of adipose-derived mesenchymal stem cells (AMSCs) and the possible mechanisms are still unclear. The ...

journal_title：Stem cell research & therapy

authors： Li S,Wang Y,Wang Z,Chen L,Zuo B,Liu C,Sun D

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they regulate carcinogenesis is poorly understood. We hypothesize that the cytotoxic bile acids may promot...

journal_title：Stem cell research & therapy

authors： Farhana L,Nangia-Makker P,Arbit E,Shango K,Sarkar S,Mahmud H,Hadden T,Yu Y,Majumdar AP

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Autologous grafting, despite some disadvantages, is still considered the gold standard for reconstruction of maxillofacial bone defects. The aim of this study was to evaluate bone regeneration using bone marrow-derived mesenchymal stromal cells (MSCs) in a clinical trial, a less invasive approach than autolo...

journal_title：Stem cell research & therapy

authors： Gjerde C,Mustafa K,Hellem S,Rojewski M,Gjengedal H,Yassin MA,Feng X,Skaale S,Berge T,Rosen A,Shi XQ,Ahmed AB,Gjertsen BT,Schrezenmeier H,Layrolle P

更新日期：2018-08-09 00:00:00

abstract：BACKGROUND:Pulpitis is a common dental disease characterized by sustained inflammation and impaired pulp self-repair. Mesenchymal stem cell-based minimally invasive vital pulp therapy (MSC-miVPT) is a potential treatment method, but its application is limited by the difficulty in acquiring MSCs. We recently revealed th...

journal_title：Stem cell research & therapy

authors： Hong H,Chen X,Li K,Wang N,Li M,Yang B,Yu X,Wei X

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:Acquired aplastic anemia (AA) is characterized by deficiency or dysfunction of the bone marrow (BM) microenvironment. However, little is known about the impairment of BM-derived mesenchymal stem cells (MSCs) in AA patients. METHODS:We used Illumina HiSeqTM 2000 sequencing, quantitative real-time polymerase ...

journal_title：Stem cell research & therapy

authors： Lu S,Ge M,Zheng Y,Li J,Feng X,Feng S,Huang J,Feng Y,Yang D,Shi J,Chen F,Han Z

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Autologous epidermal basal cell suspension therapy has been proven to be one of the most effective treatments for full-thickness wounds. However, we found there remain obvious defects that significantly confined the utilization and function of the epidermal basal cells (EBCs), especially the epidermal stem c...

journal_title：Stem cell research & therapy

authors： Wang P,Hu Z,Cao X,Huang S,Dong Y,Cheng P,Xu H,Shu B,Xie J,Wu J,Tang B,Zhu J

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Critical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly diminishing oxygen and nutrient supply. CLI patients usually undergo amputation of fingers, feet, or ex...

journal_title：Stem cell research & therapy

authors： Beltran-Camacho L,Jimenez-Palomares M,Rojas-Torres M,Sanchez-Gomar I,Rosal-Vela A,Eslava-Alcon S,Perez-Segura MC,Serrano A,Antequera-González B,Alonso-Piñero JA,González-Rovira A,Extremera-García MJ,Rodriguez-Piñero M,Moreno-Lu

更新日期：2020-03-06 00:00:00

abstract：BACKGROUND:Although endothelial progenitor cells (EPCs) contribute to wound repair by promoting neovascularization, the mechanism of EPC-mediated wound healing remains poorly understood due to the lack of pivotal molecular targets of dermal wound repair. METHODS AND RESULTS:We found that genetic targeting of the Lnk g...

journal_title：Stem cell research & therapy

authors： Lee JH,Ji ST,Kim J,Takaki S,Asahara T,Hong YJ,Kwon SM

更新日期：2016-10-28 00:00:00

abstract：INTRODUCTION:Fallopian tube, which is normally discarded in surgical procedures, has proven to be a source of mesenchymal stem cells (MSCs) with increasing evidence. However, fallopian tube mucosa, which can be acquired via non-invasive procedures, is a previously unknown source of MSCs. In the present study, we explor...

journal_title：Stem cell research & therapy

authors： Wang J,Zhao Y,Wu X,Yin S,Chuai Y,Wang A

更新日期：2015-05-21 00:00:00

abstract：BACKGROUND:Mesenchymal stromal/stem cells (MSCs) have demonstrated pro-healing properties due to their anti-inflammatory, angiogenic, and even antibacterial properties. We have shown previously that minocycline enhances the wound healing phenotype of MSCs, and MSCs encapsulated in poly(ethylene glycol) and gelatin-base...

journal_title：Stem cell research & therapy

authors： Guerra AD,Rose WE,Hematti P,Kao WJ

更新日期：2017-07-21 00:00:00

abstract：:The efficacy of tendon-derived stem cells (TDSCs) for the promotion of tendon and tendon-bone junction repair has been reported in animal studies. Modulation of the tendon stem cell niche in vivo has also been reported to influence tendon structure. There is a need to have specific and reliable markers that can define...

journal_title：Stem cell research & therapy

authors： Lui PP

更新日期：2015-06-02 00:00:00

abstract：BACKGROUND:Parthenogenetic stem cells (PSCs) are a promising source of regenerated cardiomyocytes; however, their application may be limited without a paternal genome. Insulin-like growth factor-II (IGF-II), a paternally expressed growth hormone, is critical in embryonic differentiation. This study investigated whether...

journal_title：Stem cell research & therapy

authors： Sui Y,Zhang W,Tang T,Gao L,Cao T,Zhu H,You Q,Yu B,Yang T

更新日期：2020-02-26 00:00:00

abstract：:Stem cell behaviors are regulated by multiple microenvironmental cues. As an external signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate determination, but how this biophysical cue is translated into intracellular signaling remains elusive. Here, we elucidate mechanisms by ...

journal_title：Stem cell research & therapy

authors： Lv H,Li L,Sun M,Zhang Y,Chen L,Rong Y,Li Y

更新日期：2015-05-27 00:00:00

abstract：:Damage of mitochondria in the initial period of tissue injury aggravates the severity of injury. Restoration of mitochondria dysfunction and mitochondrial-based therapeutics represent a potentially effective therapeutic strategy. Recently, mitochondrial transfer from stem cells has been demonstrated to play a signific...

journal_title：Stem cell research & therapy

authors： Wang J,Li H,Yao Y,Zhao T,Chen YY,Shen YL,Wang LL,Zhu Y

更新日期：2018-04-13 00:00:00

abstract：:Adipogenesis is essential in in vitro experimentation to assess differentiation capability of stem cells, and therefore, its accurate measurement is important. Quantitative analysis of adipogenic levels, however, is challenging and often susceptible to errors due to non-specific reading or manual estimation by observe...

journal_title：Stem cell research & therapy

authors： Yuan C,Chakraborty S,Chitta KK,Subramanian S,Lim TE,Han W,Bhanu Prakash KN,Sugii S

更新日期：2019-01-22 00:00:00

abstract：INTRODUCTION:Preterm newborns often require mechanical respiratory support that can result in ventilation-induced lung injury (VILI), despite exogenous surfactant treatment. Human amnion epithelial cells (hAECs) reduce lung inflammation and resultant abnormal lung development in preterm animals; co-administration with ...

journal_title：Stem cell research & therapy

authors： McDonald CA,Melville JM,Polglase GR,Jenkin G,Moss TJ

更新日期：2014-09-04 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated mesenchymal stem cells (MSCs) as effective mitochondrial donors with therapeutic success in multiple experimental models of human disease. MSCs obtained from different tissue sources such as bone marrow (BM), adipose (AD), dental pulp (DP), and Wharton's jelly (WJ) are routin...

journal_title：Stem cell research & therapy

authors： Paliwal S,Chaudhuri R,Agrawal A,Mohanty S

更新日期：2018-11-08 00:00:00

abstract：INTRODUCTION:Silk fibroin (SF) scaffolds have been shown to be a suitable substrate for tissue engineering and to improve tissue regeneration when cellularized with mesenchymal stromal cells (MSCs). We here demonstrate, for the first time, that electrospun nanofibrous SF patches cellularized with human adipose-derived ...

journal_title：Stem cell research & therapy

authors： Navone SE,Pascucci L,Dossena M,Ferri A,Invernici G,Acerbi F,Cristini S,Bedini G,Tosetti V,Ceserani V,Bonomi A,Pessina A,Freddi G,Alessandrino A,Ceccarelli P,Campanella R,Marfia G,Alessandri G,Parati EA

更新日期：2014-01-14 00:00:00

abstract：BACKGROUND:Silicon-modified biomaterials have been extensively studied in bone tissue engineering. In recent years, the toxicity of silicon-doped biomaterials has gradually attracted attention but requires further elucidation. This study was designed to explore whether high-dose silicate can induce a cytotoxicity effec...

journal_title：Stem cell research & therapy

authors： Li Z,Liu S,Fu T,Peng Y,Zhang J

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:Stress urinary incontinence (SUI) is a common and bothersome condition. Invasive surgery will always be considered after conservative treatment fails, but the rates of postoperative complications and long-term recurrence are high. Thus, a new treatment strategy is still needed. In recent years, bone marrow m...

journal_title：Stem cell research & therapy

authors： Zhang H,Huang J,Liu J,Li Y,Gao Y

更新日期：2020-07-16 00:00:00

abstract：BACKGROUND:Diabetes is associated with the dysfunction of endothelial progenitor cells (EPCs), characterized as impaired angiogenesis, a phenomenon thought to be involved in the development of diabetic foot. lncRNA plays an essential role in microvascular dysfunction and signaling pathways in patients with diabetes. ln...

journal_title：Stem cell research & therapy

authors： Li Y,Zhi K,Han S,Li X,Li M,Lian W,Zhang H,Zhang X

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and human induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC...

journal_title：Stem cell research & therapy

authors： Liao S,Zhang Y,Ting S,Zhen Z,Luo F,Zhu Z,Jiang Y,Sun S,Lai WH,Lian Q,Tse HF

更新日期：2019-03-07 00:00:00

abstract：BACKGROUND:Poor bone quality, increased fracture risks, and impaired bone healing are orthopedic comorbidities of type 1 diabetes (T1DM). Standard osteogenic growth factor treatments are inadequate in fully rescuing retarded healing of traumatic T1DM long bone injuries where both periosteal and bone marrow niches are d...

journal_title：Stem cell research & therapy

authors： Filion TM,Skelly JD,Huang H,Greiner DL,Ayers DC,Song J

更新日期：2017-03-11 00:00:00