Fat extract promotes angiogenesis in a murine model of limb ischemia: a novel cell-free therapeutic strategy.

abstract：BACKGROUND:Periodontitis is a widespread infectious disease ultimately resulting in tooth loss. The number of mesenchymal stem cells (MSCs) in patients with periodontitis is decreased, and MSC functions are impaired. Rescuing the impaired function of MSCs in periodontitis is the key for treatment, especially in a manne...

journal_title：Stem cell research & therapy

authors： Han N,Zhang F,Li G,Zhang X,Lin X,Yang H,Wang L,Cao Y,Du J,Fan Z

更新日期：2017-09-29 00:00:00

abstract：INTRODUCTION:Topical administration of eye drops is the major route for drug delivery to the cornea. Orbital fat-derived stem cells (OFSCs) possess an in vitro corneal epithelial differentiation capacity. Both the safety and immunomodulatory ability of systemic OFSC transplantation were demonstrated in our previous wor...

journal_title：Stem cell research & therapy

authors： Lin KJ,Loi MX,Lien GS,Cheng CF,Pao HY,Chang YC,Ji AT,Ho JH

更新日期：2013-06-14 00:00:00

abstract：BACKGROUND:Using a toxin-induced nonhuman primate model of acute liver failure (ALF), we previously reported that peripheral infusion of human umbilical cord mesenchymal stem cells (hUC-MSCs) strongly suppresses the activation of circulating monocytes and interleukin-6 (IL-6) production, thereby disrupting the developm...

journal_title：Stem cell research & therapy

authors： Shao M,Xu Q,Wu Z,Chen Y,Shu Y,Cao X,Chen M,Zhang B,Zhou Y,Yao R,Shi Y,Bu H

更新日期：2020-01-23 00:00:00

abstract：BACKGROUND:Emerging evidence suggests that neural crest-derived cells (NCCs) present important functions in peripheral nerve regeneration to correct the insufficiency of autogenous Schwann cells. Postmigratory NCCs have been successfully isolated from adult rat bone marrow in our previous work. In this study, we aim to...

journal_title：Stem cell research & therapy

authors： Shi H,Li X,Yang J,Zhao Y,Xue C,Wang Y,He Q,Shen M,Zhang Q,Yang Y,Ding F

更新日期：2019-12-18 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a major cause of limb dysfunction, and distraction arthroplasty which generates intermittent hydrostatic pressure (IHP) is an effective approach for OA treatment. However, the result was not always satisfactory and the reasons remained unresolved. Because aging is recognized as an impo...

journal_title：Stem cell research & therapy

authors： Dai H,Chen R,Gui C,Tao T,Ge Y,Zhao X,Qin R,Yao W,Gu S,Jiang Y,Gui J

更新日期：2020-05-25 00:00:00

abstract：BACKGROUND:Senescent cells are undesirable in cell therapy products due to reduced therapeutic activity and risk of aberrant cellular effects, and methods for assessing senescence are needed. Early-passage mesenchymal stromal cells (MSCs) are known to be small and spindle-shaped but become enlarged upon cell aging. Ind...

journal_title：Stem cell research & therapy

authors： Oja S,Komulainen P,Penttilä A,Nystedt J,Korhonen M

更新日期：2018-01-10 00:00:00

abstract：INTRODUCTION:Administration of bone marrow-derived cells produces beneficial effects in experimental extrapulmonary acute respiratory distress syndrome (ARDS). However, there are controversies regarding the effects of timing of cell administration and initial insult severity on inflammatory response. We evaluated the e...

journal_title：Stem cell research & therapy

authors： Maron-Gutierrez T,Silva JD,Cruz FF,Alegria S,Xisto DG,Assis EF,Castro-Faria-Neto HC,Dos Santos CC,Morales MM,Rocco PR

更新日期：2013-10-13 00:00:00

abstract：:The efficacy of tendon-derived stem cells (TDSCs) for the promotion of tendon and tendon-bone junction repair has been reported in animal studies. Modulation of the tendon stem cell niche in vivo has also been reported to influence tendon structure. There is a need to have specific and reliable markers that can define...

journal_title：Stem cell research & therapy

authors： Lui PP

更新日期：2015-06-02 00:00:00

abstract：BACKGROUND:Considerable progress has been made in converting human pluripotent stem cells (hPSCs) into cortical neurons for disease modeling and regenerative medicine. However, these procedures are hard to provide sufficient cells for their applications. Using a combination of small-molecules and growth factors, we pre...

journal_title：Stem cell research & therapy

authors： Zhao S,Duan K,Ai Z,Niu B,Chen Y,Kong R,Li T

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Expansion protocols aim at both increasing the number of umbilical cord blood (UCB) hematopoietic stem cells and progenitor cells (HSPCs) and reducing the period of neutropenia in UCB HSPC graft. Because glycosaminoglycans (GAGs) are known to be important components of the hematopoietic niche and to modulate...

journal_title：Stem cell research & therapy

authors： Faivre L,Parietti V,Siñeriz F,Chantepie S,Gilbert-Sirieix M,Albanese P,Larghero J,Vanneaux V

更新日期：2016-01-07 00:00:00

abstract：:Tendon injuries, as one of the most common orthopedic disorders, are the major cause of early retirement or wastage among sport horses which mainly affect the superficial digital flexor tendon (SDFT). Tendon repair is a slow process, and tendon tissue is often replaced by scar tissue. The current treatment options are...

journal_title：Stem cell research & therapy

authors： Shojaee A,Parham A

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:Endothelial cells have been shown to mediate angiogenesis in ischemic injury sites and contribute to the repair of damaged tissues. However, the treatment of ischemic disease requires a significant number of endothelial cells, which are difficult to isolate from patients. Embryonic stem cells have been consi...

journal_title：Stem cell research & therapy

authors： Park JK,Lee TW,Do EK,Moon HJ,Kim JH

更新日期：2018-07-18 00:00:00

abstract：INTRODUCTION:Mesenchymal stromal cells (MSCs) play an important role in the prevention of cell and tissue fibrosis. Senescence may decrease the function of MSCs during recovery from tissue and organ damage. Extracellular vesicles (EVs) released from MSCs contribute to the repair of kidney injury. We explored the influe...

journal_title：Stem cell research & therapy

authors： Wang Y,Guo YF,Fu GP,Guan C,Zhang X,Yang DG,Shi YC

更新日期：2020-07-08 00:00:00

abstract：BACKGROUND:Bone reconstruction in congenital craniofacial differences, which affect about 2-3% of newborns, has long been the focus of intensive research in the field of bone tissue engineering. The possibility of using mesenchymal stromal cells in regenerative medicine protocols has opened a new field of investigation...

journal_title：Stem cell research & therapy

authors： Bueno DF,Kabayashi GS,Pinheiro CCG,Tanikawa DYS,Raposo-Amaral CE,Rocha DL,Ferreira JRM,Shibuya Y,Hokugo A,Jarrahy R,ZuK PA,Passos-Bueno MR

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:Human adipose-derived stem cells (hASCs) are a subset of mesenchymal stem cells (MSCs); it has been regarded as one of the most promising stem cells. We previously found that fibroblast growth factor-2 (FGF-2) enhanced the proliferation and differentiation of hASC. However, the mechanisms involved in the gro...

journal_title：Stem cell research & therapy

authors： Ma Y,Kakudo N,Morimoto N,Lai F,Taketani S,Kusumoto K

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:Pulpitis is a common dental disease characterized by sustained inflammation and impaired pulp self-repair. Mesenchymal stem cell-based minimally invasive vital pulp therapy (MSC-miVPT) is a potential treatment method, but its application is limited by the difficulty in acquiring MSCs. We recently revealed th...

journal_title：Stem cell research & therapy

authors： Hong H,Chen X,Li K,Wang N,Li M,Yang B,Yu X,Wei X

更新日期：2020-08-03 00:00:00

abstract：:Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past decades, a better understanding of molecular and cellular mechanisms of CVD as well as improved therapeutic str...

journal_title：Stem cell research & therapy

authors： Abou-Saleh H,Zouein FA,El-Yazbi A,Sanoudou D,Raynaud C,Rao C,Pintus G,Dehaini H,Eid AH

更新日期：2018-07-27 00:00:00

abstract：BACKGROUND:The development of cellular therapies to treat muscle wastage with disease or age is paramount. Resident muscle satellite cells are not currently regarded as a viable cell source due to their limited migration and growth capability ex vivo. This study investigated the potential of muscle-derived PW1+/Pax7- i...

journal_title：Stem cell research & therapy

authors： Cottle BJ,Lewis FC,Shone V,Ellison-Hughes GM

更新日期：2017-07-04 00:00:00

abstract：INTRODUCTION:No comparative study of adipose-derived stem cells (ADSCs) and bone marrow mesenchymal stem cells (BMSCs) by using superparamagnetic iron oxide nanoparticles (SPIOs)-labeling and magnetic resonance imaging (MRI) has been performed. METHODS:We studied the biological activity and MRI of ADSCs by labeling th...

journal_title：Stem cell research & therapy

authors： Fan J,Tan Y,Jie L,Wu X,Yu R,Zhang M

更新日期：2013-04-23 00:00:00

abstract：:The discovery of induced pluripotent stem cells (iPSCs) in 2006 was a major breakthrough for regenerative medicine. The establishment of patient-specific iPSCs has created the opportunity to model diseases in culture systems, with the potential to rapidly advance the drug discovery field. Current methods of drug disco...

journal_title：Stem cell research & therapy

authors： Guo Z,Higgins CA,Gillette BM,Itoh M,Umegaki N,Gledhill K,Sia SK,Christiano AM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Heart failure has become a global health problem with increasing incidences worldwide. Traditional pharmacological treatments can delay but cannot reverse the underlying disease processes. The clinical application of myocardial tissue engineering represents a promising strategy because it features cell-based...

journal_title：Stem cell research & therapy

authors： Zhang F,Xie Y,Bian Y

更新日期：2018-12-29 00:00:00

abstract：BACKGROUND:Vocal fold (VF) scarring, caused by surgery or inflammation, often results in severe voice problems or aphonia. Effective lasting treatment is lacking. Previous in vitro and in vivo animal studies reported positive effects on VF scar resolution with mesenchymal stromal cell (MSC) implantation. The principal ...

journal_title：Stem cell research & therapy

authors： Hertegård S,Nagubothu SR,Malmström E,LeBlanc K

更新日期：2020-03-20 00:00:00

abstract：BACKGROUND:WNT and TGFβ signaling pathways play critical regulatory roles in cardiomyocyte fate determination and differentiation. MiRNAs are also known to regulate different biological processes and signaling pathways. Here, we intended to find candidate miRNAs that are involved in cardiac differentiation through regu...

journal_title：Stem cell research & therapy

authors： Kay M,Soltani BM,Aghdaei FH,Ansari H,Baharvand H

更新日期：2019-06-27 00:00:00

abstract：BACKGROUND:Critical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly diminishing oxygen and nutrient supply. CLI patients usually undergo amputation of fingers, feet, or ex...

journal_title：Stem cell research & therapy

authors： Beltran-Camacho L,Jimenez-Palomares M,Rojas-Torres M,Sanchez-Gomar I,Rosal-Vela A,Eslava-Alcon S,Perez-Segura MC,Serrano A,Antequera-González B,Alonso-Piñero JA,González-Rovira A,Extremera-García MJ,Rodriguez-Piñero M,Moreno-Lu

更新日期：2020-03-06 00:00:00

abstract：INTRODUCTION:Impaction allograft with cement is a common technique used in revision hip surgeries for the last 20 years. However, its clinical results are inconsistent. Recent studies have shown that mesenchymal stem cells (MSCs) seeded onto allograft can enhance bone formation. This in vitro study investigates whether...

journal_title：Stem cell research & therapy

authors： Reissis Y,García-Gareta E,Korda M,Blunn GW,Hua J

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:This is the first study evaluating the interactions of human adipose tissue derived stem cells (ADSCs) and human squamous cell carcinoma cells (SCCs), with regard to a prospective cell-based skin regenerative therapy and a thereby unintended co-localization of ADSCs and SCCs. METHODS:ADSCs were co-culture...

journal_title：Stem cell research & therapy

authors： Koellensperger E,Gramley F,Preisner F,Leimer U,Germann G,Dexheimer V

更新日期：2014-05-12 00:00:00

abstract：:The potential use of stem cells for cell-based tissue repair and regeneration offers alternative therapeutic strategies for various diseases. Adipose-derived stem cells (ADSCs) have emerged as a promising source of stem cells suitable for transplantation in regenerative medicine and wound repair. A recent publication ...

journal_title：Stem cell research & therapy

authors： Gupta MK,Ajay AK

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Many factors may influence the efficacy of cell therapy for intrinsic urinary sphincter deficiency (ISD), including the route of administration of the cells and the condition of the sphincter. The goal of this study was to compare local versus intravenous administration of autologous skeletal muscle precurso...

journal_title：Stem cell research & therapy

authors： Williams JK,Badlani G,Dean A,Lankford S,Poppante K,Criswell T,Andersson KE

更新日期：2016-10-07 00:00:00

abstract：BACKGROUND:Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and human induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC...

journal_title：Stem cell research & therapy

authors： Liao S,Zhang Y,Ting S,Zhen Z,Luo F,Zhu Z,Jiang Y,Sun S,Lai WH,Lian Q,Tse HF

更新日期：2019-03-07 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells derived from human umbilical cord tissue, termed UCX®, have the potential to promote a full range of events leading to tissue regeneration and homeostasis. The main goal of this work was to investigate UCX® action in experimentally induced hindlimb ischemia (HLI). METHODS:UCX®, obtain...

journal_title：Stem cell research & therapy

authors： Pereira AR,Mendes TF,Ministro A,Teixeira M,Filipe M,Santos JM,Bárcia RN,Goyri-O'Neill J,Pinto F,Cruz PE,Cruz HJ,Santos SC

更新日期：2016-09-29 00:00:00