The march of pluripotent stem cells in cardiovascular regenerative medicine.

abstract：BACKGROUND:Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular matrix changes, reduced hydration, and progressive degeneration. Cell-based IVD therapy has emerged as an area of great interest, with studies reportin...

journal_title：Stem cell research & therapy

authors： Tang R,Jing L,Willard VP,Wu CL,Guilak F,Chen J,Setton LA

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects female fertility. However, with the lack of a corresponding research model, the pathology mechanism of PCOS is poorly understood. Induced pluripotent stem cell (iPSC) technology has been recognized as means to generate...

journal_title：Stem cell research & therapy

authors： Min Z,Gao Q,Zhen X,Fan Y,Tan T,Li R,Zhao Y,Yu Y

更新日期：2018-08-09 00:00:00

abstract：BACKGROUND:C-kit-positive cardiac stem cells (CSCs) have been shown to be a promising candidate treatment for myocardial infarction and heart failure. Insulin-like growth factor (IGF)-1 is an anabolic growth hormone that regulates cellular proliferation, differentiation, senescence, and death in various tissues. Althou...

journal_title：Stem cell research & therapy

authors： Sun Y,Xu R,Huang J,Yao Y,Pan X,Chen Z,Ma G

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:In regenerative medicine the maintenance of stem cell properties is of crucial importance. Ageing is considered a cause of reduced stemness capability. The limbus is a stem niche of easy access and harbors two stem cell populations: epithelial stem cells and fibroblast-like stem cells. Our aim was to investi...

journal_title：Stem cell research & therapy

authors： Tomasello L,Musso R,Cillino G,Pitrone M,Pizzolanti G,Coppola A,Arancio W,Di Cara G,Pucci-Minafra I,Cillino S,Giordano C

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated that intravenous administration of adipose tissue stem cells (ASCs) could significantly reduce allergic symptoms and suppress eosinophilic inflammation. METHODS:To evaluate the secretome of ASCs, we administrated culture supernatant of ASCs (ASC sup, which contains the A...

journal_title：Stem cell research & therapy

authors： Yu HS,Park MK,Kang SA,Cho KS,Mun SJ,Roh HJ

更新日期：2017-01-23 00:00:00

abstract：OBJECTIVE:Autograft microskin transplantation has been widely used as a skin graft therapy in full-thickness skin defect. However, skin grafting failure can lead to a pathological delay wound healing due to a poor vascularization bed. Considering the active role of adipose-derived stem cell (ADSC) in promoting angiogen...

journal_title：Stem cell research & therapy

authors： Luo Y,Yi X,Liang T,Jiang S,He R,Hu Y,Bai L,Wang C,Wang K,Zhu L

更新日期：2019-08-30 00:00:00

abstract：BACKGROUND:Transplantation of endothelial progenitor cells (EPCs)/endothelial cells (ECs) has been used for the treatment of ischemic diseases and hemophilia A, due to their great capacity for producing factor VIII and for repairing vascular damage. We established an effective approach to stimulate the expansion and di...

journal_title：Stem cell research & therapy

authors： Qin M,Guan X,Wang H,Zhang Y,Shen B,Zhang Q,Dai W,Ma Y,Jiang Y

更新日期：2017-02-07 00:00:00

abstract：BACKGROUND:Unresolved inflammation and tissue destruction are considered to underlie the failure of dental pulp repair. As key mediators of the injury response, dental pulp stem cells (DPSCs) play a critical role in pulp tissue repair and regeneration. Resolvin E1 (RvE1), a major dietary omega-3 polyunsaturated fatty-a...

journal_title：Stem cell research & therapy

authors： Chen J,Xu H,Xia K,Cheng S,Zhang Q

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:Vocal fold (VF) scarring, caused by surgery or inflammation, often results in severe voice problems or aphonia. Effective lasting treatment is lacking. Previous in vitro and in vivo animal studies reported positive effects on VF scar resolution with mesenchymal stromal cell (MSC) implantation. The principal ...

journal_title：Stem cell research & therapy

authors： Hertegård S,Nagubothu SR,Malmström E,LeBlanc K

更新日期：2020-03-20 00:00:00

abstract：:Over the last two decades, a new therapeutic paradigm has emerged which has changed the way debilitating diseases may be treated in the future. Instead of using small-molecule drugs and devices to ameliorate the symptoms of disease, clinicians may harness the therapeutic power of cells to regenerate and cure diseases ...

journal_title：Stem cell research & therapy

authors： O'Brien T,Creane M,Windebank AJ,Terzic A,Dietz AB

更新日期：2015-08-22 00:00:00

abstract：BACKGROUND:Heart failure has become a global health problem with increasing incidences worldwide. Traditional pharmacological treatments can delay but cannot reverse the underlying disease processes. The clinical application of myocardial tissue engineering represents a promising strategy because it features cell-based...

journal_title：Stem cell research & therapy

authors： Zhang F,Xie Y,Bian Y

更新日期：2018-12-29 00:00:00

abstract：INTRODUCTION:Osteopontin (OPN) is a phosphoglycoprotein with important roles in tissue homeostasis, wound healing, immune regulation, and stress responses. It is expressed constitutively in the brain and upregulated during neuroinflammatory responses; for example, after focal cerebral ischemia. To date, its effects on ...

journal_title：Stem cell research & therapy

authors： Rabenstein M,Hucklenbroich J,Willuweit A,Ladwig A,Fink GR,Schroeter M,Langen KJ,Rueger MA

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:The Activin A and bone morphogenetic protein (BMP) pathways are critical regulators of the immune system and of bone formation. Inappropriate activation of these pathways, as in conditions of congenital heterotopic ossification, are thought to activate an osteogenic program in endothelial cells. However, if ...

journal_title：Stem cell research & therapy

authors： Barruet E,Morales BM,Lwin W,White MP,Theodoris CV,Kim H,Urrutia A,Wong SA,Srivastava D,Hsiao EC

更新日期：2016-08-17 00:00:00

abstract：:Periostin is a matricellular protein that is reactivated during tissue damage and repair and has been shown to be a critical regulator of multiple biological pathways involved in the repair of tissue after myocardial infarction, peripheral vascular disease, and skin wounds. The tissue repair properties attributed to p...

journal_title：Stem cell research & therapy

authors： Chow T,Rogers IM

更新日期：2015-11-04 00:00:00

abstract：BACKGROUND:Liver fibrosis resulting from chronic liver injury is one of the major causes of mortality worldwide. Stem cell-secreted secretome has been evaluated for overcoming the limitations of cell-based therapy in hepatic disease, while maintaining its advantages. METHODS:In this study, we investigated the effect o...

journal_title：Stem cell research & therapy

authors： Yao X,Wang J,Zhu J,Rong X

更新日期：2020-09-03 00:00:00

abstract：BACKGROUND:Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of mesenchymal stromal cells (MSCs). First-trimester human umbilical cord-derived perivascular cells (FTM HUCPVCs) have multipotent characteristics and pr...

journal_title：Stem cell research & therapy

authors： Iqbal F,Szaraz P,Librach M,Gauthier-Fisher A,Librach CL

更新日期：2017-08-14 00:00:00

abstract：BACKGROUND:Exosomes are nanovesicles (30-120 nm) of endosomal origin. These exosomes contain various functional proteins and RNAs that could be used for therapeutic purposes. Currently, having a standard method for exosome isolation retaining its biological properties with increased yield and purity is a major challeng...

journal_title：Stem cell research & therapy

authors： Gupta S,Rawat S,Arora V,Kottarath SK,Dinda AK,Vaishnav PK,Nayak B,Mohanty S

更新日期：2018-07-04 00:00:00

abstract：:Mesenchymal stem cells have been used for cardiovascular regenerative therapy for decades. These cells have been established as one of the potential therapeutic agents, following several tests in animal models and clinical trials. In the process, various sources of mesenchymal stem cells have been identified which hel...

journal_title：Stem cell research & therapy

authors： Singh A,Singh A,Sen D

更新日期：2016-06-04 00:00:00

abstract：BACKGROUND:Severe acute pancreatitis (SAP) is an acute abdominal disease characterized by pancreatic necrosis and systemic disease. In a previous study, we showed that bone marrow-derived mesenchymal stem cells (BMSCs) can reduce SAP by secreting microRNA (miR)-9; however, the underlying mechanism remains unclear. The ...

journal_title：Stem cell research & therapy

authors： Qian D,Song G,Ma Z,Wang G,Jin L,Hu M,Song Z,Wang X

更新日期：2018-10-25 00:00:00

abstract：INTRODUCTION:Octamer-binding transcription factor 4 (Oct4) is a master regulator of early mammalian development. Its expression begins from the oocyte stage, becomes restricted to the inner cell mass of the blastocyst and eventually remains only in primordial germ cells. Unearthing the interactions of Oct4 would provid...

journal_title：Stem cell research & therapy

authors： Cheong CY,Lon Ng PM,Ponnampalam R,Tsai HH,Bourque G,Lufkin T

更新日期：2011-05-13 00:00:00

abstract：BACKGROUND:Currently, the overall therapeutic efficiency of mesenchymal stem cells (MSCs) transplantation for the treatment of cardiovascular disease is not satisfactory. The low viability and angiogenic capacity of the implanted cells in the local infarct tissues restrict their further application. Evidence shows that...

journal_title：Stem cell research & therapy

authors： Hou J,Wang L,Wu Q,Zheng G,Long H,Wu H,Zhou C,Guo T,Zhong T,Wang L,Chen X,Wang T

更新日期：2018-04-19 00:00:00

abstract：INTRODUCTION:Estrogen plays an important role in the osteogenic differentiation of mesenchymal stem cells, while stem cells from apical papilla (SCAP) can contribute to the formation of dentin/bone-like tissues. To date, the effects of estrogen on the differentiation of SCAP remain unclear. METHODS:SCAP was isolated a...

journal_title：Stem cell research & therapy

authors： Li Y,Yan M,Wang Z,Zheng Y,Li J,Ma S,Liu G,Yu J

更新日期：2014-11-17 00:00:00

abstract：:The potential use of stem cells for cell-based tissue repair and regeneration offers alternative therapeutic strategies for various diseases. Adipose-derived stem cells (ADSCs) have emerged as a promising source of stem cells suitable for transplantation in regenerative medicine and wound repair. A recent publication ...

journal_title：Stem cell research & therapy

authors： Gupta MK,Ajay AK

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Transplanting mesenchymal stromal cells (MSCs) or their derivatives into a neurodegenerative environment is believed to be beneficial because of the trophic support, migratory guidance, immunosuppression, and neurogenic stimuli they provide. SB623, a cell therapy for the treatment of chronic stroke, curren...

journal_title：Stem cell research & therapy

authors： Aizman I,Tirumalashetty BJ,McGrogan M,Case CC

更新日期：2014-02-26 00:00:00

abstract：:Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cultivated oral mucosal epithelial cells (COMET) in humans in 2004, which represents the first use of a cultured n...

journal_title：Stem cell research & therapy

authors： Cabral JV,Jackson CJ,Utheim TP,Jirsova K

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:Stem cells from human exfoliated deciduous teeth (SHED) have recently attracted attention as novel multipotential stem cell sources. However, their application is limited due to in vitro replicative senescence. Ectopic expression of telomerase reverse transcriptase (TERT) is a promising strategy for overcomi...

journal_title：Stem cell research & therapy

authors： Yin Z,Wang Q,Li Y,Wei H,Shi J,Li A

更新日期：2016-04-04 00:00:00

abstract：BACKGROUND:Neonatal hypoxia-ischemia induces massive brain damage during the perinatal period, resulting in long-term consequences to central nervous system structural and functional maturation. Although neural progenitor cells (NPCs) migrate through the parenchyma and home in to injury sites in the rodent brain, the m...

journal_title：Stem cell research & therapy

authors： Wang F,Baba N,Shen Y,Yamashita T,Tsuru E,Tsuda M,Maeda N,Sagara Y

更新日期：2017-02-07 00:00:00

abstract：OBJECTIVES:Mesenchymal stem cells (MSCs) have been intensively investigated as to their therapeutic potentials. However, the full chemical-defined medium supporting the isolation and expansion of human MSCs has not been developed yet. MATERIALS AND METHODS:Here, we developed the full chemical-defined medium, NBVbe med...

journal_title：Stem cell research & therapy

authors： Xu J,Lian W,Chen J,Li W,Li L,Huang Z

更新日期：2020-03-19 00:00:00

abstract：:Stem cell behaviors are regulated by multiple microenvironmental cues. As an external signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate determination, but how this biophysical cue is translated into intracellular signaling remains elusive. Here, we elucidate mechanisms by ...

journal_title：Stem cell research & therapy

authors： Lv H,Li L,Sun M,Zhang Y,Chen L,Rong Y,Li Y

更新日期：2015-05-27 00:00:00

abstract：INTRODUCTION:Fetal bovine serum (FBS) is an animal product used as a medium supplement. The animal origin of FBS is a concern if cultured stem cells are to be utilized for human cell therapy. Therefore, a substitute for FBS is desirable. In this study, an industrial, xeno-free, pharmaceutical-grade supplement for cell ...

journal_title：Stem cell research & therapy

authors： Díez JM,Bauman E,Gajardo R,Jorquera JI

更新日期：2015-03-13 00:00:00