Angiogenic potency evaluation of cell therapy candidates by a novel application of the in vitro aortic ring assay.

abstract：:Over the past decade a lot of research has been performed towards the therapeutic use of mesenchymal stem cells (MSCs) in neurodegenerative and neuroinflammatory diseases. MSCs have shown to be beneficial in different preclinical studies of central nervous system (CNS) disorders due to their immunomodulatory propertie...

journal_title：Stem cell research & therapy

authors： De Vocht N,Praet J,Reekmans K,Le Blon D,Hoornaert C,Daans J,Berneman Z,Van der Linden A,Ponsaerts P

更新日期：2013-08-22 00:00:00

abstract：BACKGROUND:Unresolved inflammation and tissue destruction are considered to underlie the failure of dental pulp repair. As key mediators of the injury response, dental pulp stem cells (DPSCs) play a critical role in pulp tissue repair and regeneration. Resolvin E1 (RvE1), a major dietary omega-3 polyunsaturated fatty-a...

journal_title：Stem cell research & therapy

authors： Chen J,Xu H,Xia K,Cheng S,Zhang Q

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:Ectopic expression of a defined set of transcription factors allows the reprogramming of mammalian somatic cells to pluripotency. Despite continuous progress in primate and rodent reprogramming, limited attention has been paid to cell reprogramming in domestic and companion species. Previous studies attempti...

journal_title：Stem cell research & therapy

authors： Tobias IC,Kao MC,Parmentier T,Hunter H,LaMarre J,Betts DH

更新日期：2020-12-09 00:00:00

abstract：:Temperature is an important microenvironmental factor that functions epigenetically in normal embryonic development. However, the effect of hyperthermia in the stem cells is not fully understood. Oct4 is a tightly regulated master regulator of pluripotency maintenance in stem cells and during early embryonic developme...

journal_title：Stem cell research & therapy

authors： Cheng MB,Wang X,Huang Y,Zhang Y

更新日期：2020-05-24 00:00:00

abstract：:Stem cell behaviors are regulated by multiple microenvironmental cues. As an external signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate determination, but how this biophysical cue is translated into intracellular signaling remains elusive. Here, we elucidate mechanisms by ...

journal_title：Stem cell research & therapy

authors： Lv H,Li L,Sun M,Zhang Y,Chen L,Rong Y,Li Y

更新日期：2015-05-27 00:00:00

abstract：:Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers. Current NK therapies using primary NK cells are prone to manufacturing issues related to expansion and storage. Alternative cell sourc...

journal_title：Stem cell research & therapy

authors： Shankar K,Capitini CM,Saha K

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:Periodontitis is a widespread infectious disease ultimately resulting in tooth loss. The number of mesenchymal stem cells (MSCs) in patients with periodontitis is decreased, and MSC functions are impaired. Rescuing the impaired function of MSCs in periodontitis is the key for treatment, especially in a manne...

journal_title：Stem cell research & therapy

authors： Han N,Zhang F,Li G,Zhang X,Lin X,Yang H,Wang L,Cao Y,Du J,Fan Z

更新日期：2017-09-29 00:00:00

abstract：OBJECTIVE:Autograft microskin transplantation has been widely used as a skin graft therapy in full-thickness skin defect. However, skin grafting failure can lead to a pathological delay wound healing due to a poor vascularization bed. Considering the active role of adipose-derived stem cell (ADSC) in promoting angiogen...

journal_title：Stem cell research & therapy

authors： Luo Y,Yi X,Liang T,Jiang S,He R,Hu Y,Bai L,Wang C,Wang K,Zhu L

更新日期：2019-08-30 00:00:00

abstract：BACKGROUND:Clinical use of mesenchymal stem cells (MSCs) requires a uniform cell population, and their harvesting is invasive and produces a limited number of cells. Human embryonic stem cell-derived MSCs (hESC-MSCs) can differentiate into three germ layers and possess immunosuppressive effects in vitro. Anticancer tre...

journal_title：Stem cell research & therapy

authors： Yoon SY,Yoon JA,Park M,Shin EY,Jung S,Lee JE,Eum JH,Song H,Lee DR,Lee WS,Lyu SW

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is characterized by rapid failure of renal function and has no curative therapies. Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) are known to carry therapeutic factors, which have shown promise in regenerative medicine applications, including AKI. However, ther...

journal_title：Stem cell research & therapy

authors： Ullah M,Liu DD,Rai S,Razavi M,Concepcion W,Thakor AS

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:Bone defects are a common clinical condition that has gained an increasing amount of attention in recent years. Causes of bone defect include tumors, inflammation, and fractures. Bone tissue engineering is a novel treatment of bone defect, and human mesenchymal stem cells (hMSCs) are the ideal seed cells for...

journal_title：Stem cell research & therapy

authors： Zhu Y,Zhang X,Gu R,Liu X,Wang S,Xia D,Li Z,Lian X,Zhang P,Liu Y,Zhou Y

更新日期：2020-03-25 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cells (MSCs) are considered potential candidates that hold great promise in the treatment of immune-related diseases. For therapeutic applications, it is necessary to isolate and expand MSCs with procedures complying with good manufacturing practice (GMP). Recent studies reported the use ...

journal_title：Stem cell research & therapy

authors： Thaweesapphithak S,Tantrawatpan C,Kheolamai P,Tantikanlayaporn D,Roytrakul S,Manochantr S

更新日期：2019-03-07 00:00:00

abstract：BACKGROUND:Spermatogonial stem cell transplantation (SSCT) could become a fertility restoration tool for childhood cancer survivors. However, since in mice, the colonization efficiency of transplanted spermatogonial stem cells (SSCs) is only 12%, the efficiency of the procedure needs to be improved before clinical impl...

journal_title：Stem cell research & therapy

authors： Kadam P,Ntemou E,Baert Y,Van Laere S,Van Saen D,Goossens E

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:MEG3 downregulated the expression in several tumors and inhibits human tumorigenesis. But so far, the mechanism of MEG3 in tumorigenesis is still unclear. METHODS:In gene infection, cellular and molecular technologies and tumorigenesis test in vitro and in vivo were performed, respectively. RESULTS:Our res...

journal_title：Stem cell research & therapy

authors： Jiang X,Wang L,Xie S,Chen Y,Song S,Lu Y,Lu D

更新日期：2020-11-30 00:00:00

abstract：:The original article [1] contained errors in the presentation of Figure 7. ...

journal_title：Stem cell research & therapy

authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Inner ear supporting cells (SCs) in the neonatal mouse cochlea are a potential source for hair cell (HC) regeneration, but several studies have shown that the regeneration ability of SCs decreases dramatically as mice age and that lost HCs cannot be regenerated in adult mice. To better understand how SCs mig...

journal_title：Stem cell research & therapy

authors： Cheng C,Wang Y,Guo L,Lu X,Zhu W,Muhammad W,Zhang L,Lu L,Gao J,Tang M,Chen F,Gao X,Li H,Chai R

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:The skeletal muscle regeneration relays on the satellite cells which are stem cells located between basal lamina and plasmalemma of muscle fiber. In the injured muscles, the satellite cells become activated, start to proliferate, and then differentiate into myoblasts, which fuse to form myotubes and finally ...

journal_title：Stem cell research & therapy

authors： Mierzejewski B,Grabowska I,Jackowski D,Irhashava A,Michalska Z,Stremińska W,Jańczyk-Ilach K,Ciemerych MA,Brzoska E

更新日期：2020-08-06 00:00:00

abstract：INTRODUCTION:Stem cell-based therapies are currently widely explored as a tool to treat neuroimmune diseases. Multipotent adult progenitor cells (MAPC) have been suggested to have strong immunomodulatory and neuroprotective properties in several experimental models. In this study, we investigate whether MAPC are of the...

journal_title：Stem cell research & therapy

authors： Ravanidis S,Bogie JF,Donders R,Craeye D,Mays RW,Deans R,Gijbels K,Bronckaers A,Stinissen P,Pinxteren J,Hellings N

更新日期：2015-09-16 00:00:00

abstract：:The potential use of stem cells for cell-based tissue repair and regeneration offers alternative therapeutic strategies for various diseases. Adipose-derived stem cells (ADSCs) have emerged as a promising source of stem cells suitable for transplantation in regenerative medicine and wound repair. A recent publication ...

journal_title：Stem cell research & therapy

authors： Gupta MK,Ajay AK

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Due to their intrinsic properties, stem cells are promising tools for new developments in tissue engineering and particularly for cartilage tissue regeneration. Although mesenchymal stromal/stem cells from bone marrow (BM-MSC) have long been the most used stem cell source in cartilage tissue engineering, the...

journal_title：Stem cell research & therapy

authors： Reppel L,Schiavi J,Charif N,Leger L,Yu H,Pinzano A,Henrionnet C,Stoltz JF,Bensoussan D,Huselstein C

更新日期：2015-12-30 00:00:00

abstract：:Tissue engineering has developed many paradigms and techniques on how to best integrate cells and extracellular matrix to create in vitro structures that replicate native tissue. The strategy best suited for building these constructs depends mainly on the target cells, tissues, and organ of interest, and how readily t...

journal_title：Stem cell research & therapy

authors： Thavandiran N,Nunes SS,Xiao Y,Radisic M

更新日期：2013-02-14 00:00:00

abstract：:On 23 May 2013, the Italian health minister decided to endorse a law regarding controversial stem cell-based therapies in 32 young terminally ill patients, shocking many scientists. According to the international scientific community, these therapies could be dangerous because they were not rigorously tested in humans...

journal_title：Stem cell research & therapy

authors： Frati P,Frati G,Gulino M,Montanari Vergallo G,Di Luca A,Fineschi V

更新日期：2013-10-11 00:00:00

abstract：:Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cultivated oral mucosal epithelial cells (COMET) in humans in 2004, which represents the first use of a cultured n...

journal_title：Stem cell research & therapy

authors： Cabral JV,Jackson CJ,Utheim TP,Jirsova K

更新日期：2020-07-21 00:00:00

abstract：:Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. However, the efficiency of SCNT remains very low due to some poorly characterized key factors. Compared with fertilized embryos, somatic donor cells lack...

journal_title：Stem cell research & therapy

authors： Qu P,Wang Y,Zhang C,Liu E

更新日期：2020-02-18 00:00:00

abstract：INTRODUCTION:Estrogen plays an important role in the osteogenic differentiation of mesenchymal stem cells, while stem cells from apical papilla (SCAP) can contribute to the formation of dentin/bone-like tissues. To date, the effects of estrogen on the differentiation of SCAP remain unclear. METHODS:SCAP was isolated a...

journal_title：Stem cell research & therapy

authors： Li Y,Yan M,Wang Z,Zheng Y,Li J,Ma S,Liu G,Yu J

更新日期：2014-11-17 00:00:00

abstract：OBJECTIVES:Mesenchymal stem cells (MSCs) have been intensively investigated as to their therapeutic potentials. However, the full chemical-defined medium supporting the isolation and expansion of human MSCs has not been developed yet. MATERIALS AND METHODS:Here, we developed the full chemical-defined medium, NBVbe med...

journal_title：Stem cell research & therapy

authors： Xu J,Lian W,Chen J,Li W,Li L,Huang Z

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:Stem cells from human exfoliated deciduous teeth (SHED) have been reported to show the in vivo and in vitro hepatic differentiation, SHED-Heps; however, the cholangiogenic potency of SHED-Heps remains unclear. Here, we hypothesized that SHED-Heps contribute to the regeneration of intrahepatic bile duct syste...

journal_title：Stem cell research & therapy

authors： Yuniartha R,Yamaza T,Sonoda S,Yoshimaru K,Matsuura T,Yamaza H,Oda Y,Ohga S,Taguchi T

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:One of the most severe complications of the current COVID-19 pandemic is acute respiratory distress syndrome (ARDS). ARDS is caused by increased amounts of pro-inflammatory cytokines, leading to lung damage and loss of lung function. There are currently no effective therapies for combatting ARDS. Mesenchymal...

journal_title：Stem cell research & therapy

authors： Kaspi H,Semo J,Abramov N,Dekel C,Lindborg S,Kern R,Lebovits C,Aricha R

更新日期：2021-01-19 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with immunomodulatory properties. The mechanisms involved in the capacity of MSCs to inhibit the proliferation of proinflammatory T lymphocytes, which appear responsible for causing autoimmune disease, have yet to be fully elucidated. One of ...

journal_title：Stem cell research & therapy

authors： Luz-Crawford P,Kurte M,Bravo-Alegría J,Contreras R,Nova-Lamperti E,Tejedor G,Noël D,Jorgensen C,Figueroa F,Djouad F,Carrión F

更新日期：2013-06-04 00:00:00

abstract：BACKGROUND:A keloid is a fibroproliferative disorder occurring in wounds characterized by an exaggerated response to injury. To date, no effective cure has been identified. As multipotent stem cells, human adipose-derived stem cells (ADSCs) may show the possibility for curing diseases such as fibrosis. This study sough...

journal_title：Stem cell research & therapy

authors： Wang X,Ma Y,Gao Z,Yang J

更新日期：2018-02-21 00:00:00