Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies.

abstract：:The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential...

journal_title：Stem cell research & therapy

authors： Sipp D

更新日期：2010-04-12 00:00:00

abstract：INTRODUCTION:Transplanting mesenchymal stromal cells (MSCs) or their derivatives into a neurodegenerative environment is believed to be beneficial because of the trophic support, migratory guidance, immunosuppression, and neurogenic stimuli they provide. SB623, a cell therapy for the treatment of chronic stroke, curren...

journal_title：Stem cell research & therapy

authors： Aizman I,Tirumalashetty BJ,McGrogan M,Case CC

更新日期：2014-02-26 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cells (MSCs) are considered to have a modest benefit on left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI). However, the optimal injection timing and dose needed to induce beneficial cardiac effects are unknown. The purpose of this meta-analysis w...

journal_title：Stem cell research & therapy

authors： Wang Z,Wang L,Su X,Pu J,Jiang M,He B

更新日期：2017-01-28 00:00:00

abstract：BACKGROUND:As the population ages, an increasing number of postmenopausal women are donors of adipose stromal cells (ASCs) and may benefit from autologous ASC-related treatments. However, the effect of menopausal status on ASCs has not been investigated. METHODS:RNA sequencing data were downloaded, and differentially ...

journal_title：Stem cell research & therapy

authors： Xie Y,Fang B,Liu W,Li G,Huang RL,Zhang L,He J,Zhou S,Liu K,Li Q

更新日期：2020-02-28 00:00:00

abstract：:Tendon injuries, as one of the most common orthopedic disorders, are the major cause of early retirement or wastage among sport horses which mainly affect the superficial digital flexor tendon (SDFT). Tendon repair is a slow process, and tendon tissue is often replaced by scar tissue. The current treatment options are...

journal_title：Stem cell research & therapy

authors： Shojaee A,Parham A

更新日期：2019-06-18 00:00:00

abstract：INTRODUCTION:Facing the challenging treatment of neurodegenerative diseases as well as complex craniofacial injuries such as those common after cancer therapy, the field of regenerative medicine increasingly relies on stem cell transplantation strategies. Here, neural crest-derived stem cells (NCSCs) offer many promisi...

journal_title：Stem cell research & therapy

authors： Greiner JF,Grunwald LM,Müller J,Sudhoff H,Widera D,Kaltschmidt C,Kaltschmidt B

更新日期：2014-03-14 00:00:00

abstract：BACKGROUND:The therapeutic effects of adipose-derived mesenchymal stem cell (ADSC) transplantation have been demonstrated in several models of central nervous system (CNS) injury and are thought to involve the modulation of the inflammatory response. However, the exact underlying molecular mechanism is poorly understoo...

journal_title：Stem cell research & therapy

authors： Zhou Z,Tian X,Mo B,Xu H,Zhang L,Huang L,Yao S,Huang Z,Wang Y,Xie H,Xu L,Zhang H

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Although the mononuclear cell (MNC) transplantation could theoretically induce therapeutic angiogenesis in the patients with no-option critical limb ischemia (NO-CLI), the clinical responses to this approach are inconsistent among different clinical trials. The purpose of this study was to identify the progn...

journal_title：Stem cell research & therapy

authors： Pan T,Liu H,Fang Y,Wei Z,Gu S,Fang G,Liu Y,Luo Y,Guo D,Xu X,Chen B,Jiang J,Yang J,Shi Z,Zhu T,Shi Y,Liu P,Dong Z,Fu W

更新日期：2019-01-11 00:00:00

abstract：INTRODUCTION:Delivered systemically or natively circulating mesenchymal stem cells accumulate in injured tissues. During homing mesenchymal stem cells adhere to endothelial cells and infiltrate underlying tissue. Previously we have shown that adhesiveness of endothelial cells for mesenchymal stem cells correlates with ...

journal_title：Stem cell research & therapy

authors： Potapova IA,Cohen IS,Doronin SV

更新日期：2010-11-17 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cells (MSCs) are an attractive therapeutic agent in regenerative medicine. Recently, there has been a paradigm shift from differentiation of MSCs to their paracrine effects at the injury site. Several reports elucidate the role of trophic factors secreted by MSCs toward the repair of inju...

journal_title：Stem cell research & therapy

authors： Damania A,Jaiman D,Teotia AK,Kumar A

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) from the human umbilical cord have been studied extensively due to their immunomodulatory functions. Large-conductance Ca2+-activated K+ (BKCa channels) channels are involved in many inflammatory responses, but their involvement in the anti-inflammator...

journal_title：Stem cell research & therapy

authors： Song A,Wang J,Tong Y,Fang J,Zhang Y,Zhang H,Ruan H,Wang K,Liu Y

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:In recent years, adipose-derived stromal cells (ASCs) have been heavily studied for soft tissue regeneration, augmentation, and dermal wound healing. METHODS:In this review, we investigated the trends in injectable scaffolds for ASC delivery in the dermis, and injectable or implantable scaffolds for ASC del...

journal_title：Stem cell research & therapy

authors： Mamsen FP,Munthe-Fog L,Kring MKM,Duscher D,Taudorf M,Katz AJ,Kølle ST

更新日期：2021-01-19 00:00:00

abstract：INTRODUCTION:Increased levels of angiotensin II (Ang II) and activity of Ang II receptor type 1 (AT1R) elicit detrimental effects in cardiovascular disease. However, the role of Ang II receptor type 2 (AT2R) remains poorly defined. Mesenchymal stem cells (MSCs) replenish and repair endothelial cells in the cardiovascul...

journal_title：Stem cell research & therapy

authors： Ikhapoh IA,Pelham CJ,Agrawal DK

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:Degeneration of smooth muscles in sphincters can cause debilitating diseases such as fecal incontinence. Skeletal muscle-derived cells have been effectively used in clinics for the regeneration of the skeletal muscle sphincters, such as the external anal or urinary sphincter. However, little is known about t...

journal_title：Stem cell research & therapy

authors： Thurner M,Deutsch M,Janke K,Messner F,Kreutzer C,Beyl S,Couillard-Després S,Hering S,Troppmair J,Marksteiner R

更新日期：2020-06-12 00:00:00

abstract：BACKGROUND:C-kit-positive cardiac stem cells (CSCs) have been shown to be a promising candidate treatment for myocardial infarction and heart failure. Insulin-like growth factor (IGF)-1 is an anabolic growth hormone that regulates cellular proliferation, differentiation, senescence, and death in various tissues. Althou...

journal_title：Stem cell research & therapy

authors： Sun Y,Xu R,Huang J,Yao Y,Pan X,Chen Z,Ma G

更新日期：2018-02-21 00:00:00

abstract：INTRODUCTION:This is the first study evaluating the interactions of human adipose tissue derived stem cells (ADSCs) and human squamous cell carcinoma cells (SCCs), with regard to a prospective cell-based skin regenerative therapy and a thereby unintended co-localization of ADSCs and SCCs. METHODS:ADSCs were co-culture...

journal_title：Stem cell research & therapy

authors： Koellensperger E,Gramley F,Preisner F,Leimer U,Germann G,Dexheimer V

更新日期：2014-05-12 00:00:00

abstract：INTRODUCTION:Ischemic stroke is a leading cause of death and disability, but treatment options are severely limited. Cell therapy offers an attractive strategy for regenerating lost tissues and enhancing the endogenous healing process. In this study, we investigated the use of human embryonic stem cell-derived neural p...

journal_title：Stem cell research & therapy

authors： Drury-Stewart D,Song M,Mohamad O,Guo Y,Gu X,Chen D,Wei L

更新日期：2013-08-08 00:00:00

abstract：BACKGROUND:Autologous grafting, despite some disadvantages, is still considered the gold standard for reconstruction of maxillofacial bone defects. The aim of this study was to evaluate bone regeneration using bone marrow-derived mesenchymal stromal cells (MSCs) in a clinical trial, a less invasive approach than autolo...

journal_title：Stem cell research & therapy

authors： Gjerde C,Mustafa K,Hellem S,Rojewski M,Gjengedal H,Yassin MA,Feng X,Skaale S,Berge T,Rosen A,Shi XQ,Ahmed AB,Gjertsen BT,Schrezenmeier H,Layrolle P

更新日期：2018-08-09 00:00:00

abstract：BACKGROUND:Pulpitis is a common dental disease characterized by sustained inflammation and impaired pulp self-repair. Mesenchymal stem cell-based minimally invasive vital pulp therapy (MSC-miVPT) is a potential treatment method, but its application is limited by the difficulty in acquiring MSCs. We recently revealed th...

journal_title：Stem cell research & therapy

authors： Hong H,Chen X,Li K,Wang N,Li M,Yang B,Yu X,Wei X

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:Exosomes are nanovesicles (30-120 nm) of endosomal origin. These exosomes contain various functional proteins and RNAs that could be used for therapeutic purposes. Currently, having a standard method for exosome isolation retaining its biological properties with increased yield and purity is a major challeng...

journal_title：Stem cell research & therapy

authors： Gupta S,Rawat S,Arora V,Kottarath SK,Dinda AK,Vaishnav PK,Nayak B,Mohanty S

更新日期：2018-07-04 00:00:00

abstract：BACKGROUND:Chronic low back pain is a prevalent disability, often caused by intervertebral disc (IVD) degeneration. Mesenchymal stem cell (MSC) therapy could be a safe and feasible option for repairing the degenerated disc. However, for successful translation to the clinic, various challenges need to be overcome includ...

journal_title：Stem cell research & therapy

authors： Muttigi MS,Kim BJ,Kumar H,Park S,Choi UY,Han I,Park H,Lee SH

更新日期：2020-08-24 00:00:00

abstract：INTRODUCTION:New therapeutic options are necessary for patients with chronic Chagas disease, a leading cause of heart failure in Latin American countries. Stem cell therapy focused on improving cardiac function is a promising approach for treating heart disease. Here, we evaluated the therapeutic effects of cardiac mes...

journal_title：Stem cell research & therapy

authors： Silva DN,de Freitas Souza BS,Azevedo CM,Vasconcelos JF,Carvalho RH,Soares MB,Dos Santos RR

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is characterized by rapid failure of renal function and has no curative therapies. Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) are known to carry therapeutic factors, which have shown promise in regenerative medicine applications, including AKI. However, ther...

journal_title：Stem cell research & therapy

authors： Ullah M,Liu DD,Rai S,Razavi M,Concepcion W,Thakor AS

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:Exploring the effects of lncRNA SNHG1 in the process of osteogenic differentiation of periodontal ligament stem cells (PDLSCs) would provide novel therapeutic strategies for tissue regeneration. METHODS:Loss-of-function and gain-of-function assays were induced by lentivirus. The osteogenic differentiation o...

journal_title：Stem cell research & therapy

authors： Li Z,Guo X,Wu S

更新日期：2020-10-07 00:00:00

abstract：:Cognitive deficit has been identified in one third of patients affected by Duchenne Muscular Dystrophy, primarily attributed to loss of the short Dp71 dystrophin, the major brain dystrophin isoform. In this study, we investigated for the first time the Dp71 and Dp71-associated proteins cellular localization and expres...

journal_title：Stem cell research & therapy

authors： Ruggieri S,Viggiano L,Annese T,Rubolino C,Gerbino A,De Zio R,Corsi P,Tamma R,Ribatti D,Errede M,Operto F,Margari L,Resta N,Di Tommaso S,Rosati J,Trojano M,Nico B

更新日期：2019-01-15 00:00:00

abstract：INTRODUCTION:Human multipotent stromal cells (MSCs) isolated from bone marrow or other tissue sources have great potential to treat a wide range of injuries and disorders in the field of regenerative medicine and tissue engineering. In particular, MSCs have inherent characteristics to suppress the immune system and are...

journal_title：Stem cell research & therapy

authors： Bellayr IH,Catalano JG,Lababidi S,Yang AX,Lo Surdo JL,Bauer SR,Puri RK

更新日期：2014-04-28 00:00:00

abstract：INTRODUCTION:Studies have demonstrated that mesenchymal stromal cells (MSCs) could reverse acute and chronic kidney injury by a paracrine or endocrine mechanism, and microvesicles (MVs) have been regarded as a crucial means of intercellular communication. In the current study, we focused on the therapeutic effects of h...

journal_title：Stem cell research & therapy

authors： Zou X,Zhang G,Cheng Z,Yin D,Du T,Ju G,Miao S,Liu G,Lu M,Zhu Y

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:We aimed to generate a bioengineered multi-lamellar human corneal stroma tissue in vitro by differentiating periodontal ligament stem cells (PDLSCs) towards keratocytes on an aligned silk membrane. METHODS:Human PDLSCs were isolated and identified. The neuropeptide substance P (SP) was added in keratocyte d...

journal_title：Stem cell research & therapy

authors： Chen J,Zhang W,Kelk P,Backman LJ,Danielson P

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:The widely recognized anti-cancer potential of aspirin has created a broad interest to explore the clinical benefits of aspirin in cancer therapy. However, the current understanding of the molecular mechanisms involved in the anti-cancer potential of aspirin remains limited. METHODS:Cancer stemness assays w...

journal_title：Stem cell research & therapy

authors： Zhang X,Du R,Luo N,Xiang R,Shen W

更新日期：2020-08-27 00:00:00

abstract：BACKGROUND:Mesenchymal stromal/stem cells derived from human umbilical cord (UC-MSCs) uniquely combine properties of embryonic and postnatal MSCs and may be the most acceptable, safe, and effective source for allogeneic cell therapy e.g. for therapeutic angiogenesis. In this report we describe pro-angiogenic properties...

journal_title：Stem cell research & therapy

authors： Arutyunyan I,Fatkhudinov T,Kananykhina E,Usman N,Elchaninov A,Makarov A,Bolshakova G,Goldshtein D,Sukhikh G

更新日期：2016-03-22 00:00:00