Von willebrand factor increases endothelial cell adhesiveness for human mesenchymal stem cells by activating p38 mitogen-activated protein kinase.

abstract：BACKGROUND:A keloid is a fibroproliferative disorder occurring in wounds characterized by an exaggerated response to injury. To date, no effective cure has been identified. As multipotent stem cells, human adipose-derived stem cells (ADSCs) may show the possibility for curing diseases such as fibrosis. This study sough...

journal_title：Stem cell research & therapy

authors： Wang X,Ma Y,Gao Z,Yang J

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:Apelin plays a key beneficial role in energy metabolism by increasing glucose uptake and insulin sensitivity; however, apelin has a short half-life because it is rapidly cleared from the circulation limiting its therapeutic benefit. The aim of this study is to create a new approach to treat type 2 diabetes b...

journal_title：Stem cell research & therapy

authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

更新日期：2018-12-07 00:00:00

abstract：:The original article [1] contained errors in the presentation of Figure 7. ...

journal_title：Stem cell research & therapy

authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

更新日期：2019-01-08 00:00:00

abstract：AIM:Myocardial infarction (MI) is a severe disease with increased mortality and disability rates, posing heavy economic burden for society. Exosomes were uncovered to mediate intercellular communication after MI. This study aims to explore the effect and mechanism of lncRNA KLF3-AS1 in exosomes secreted by human mesenc...

journal_title：Stem cell research & therapy

authors： Mao Q,Liang XL,Zhang CL,Pang YH,Lu YX

更新日期：2019-12-17 00:00:00

abstract：INTRODUCTION:Human hematopoietic stem cells (HSCs) have been clinically used for transplantation and gene and cellular therapy for more than 4 decades. However, this use is limited because of the challenges in the ex vivo culturing of HSCs. The major hurdle is to amplify these cells without losing their self-renewing p...

journal_title：Stem cell research & therapy

authors： Kaur K,Mirlashari MR,Kvalheim G,Kjeldsen-Kragh J

更新日期：2013-05-24 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cell (MSC)-based therapy is a promising strategy for preventing the progression of chronic kidney disease (CKD), with the potential to induce tissue regeneration. In search of the best cellular source we compared, in the rat model of adriamycin (ADR) nephropathy, the regenerative potentia...

journal_title：Stem cell research & therapy

authors： Rota C,Morigi M,Cerullo D,Introna M,Colpani O,Corna D,Capelli C,Rabelink TJ,Leuning DG,Rottoli D,Benigni A,Zoja C,Remuzzi G

更新日期：2018-08-14 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal cells currently tested for multiple therapeutic purposes. Their potential to home into tumors, to secrete trophic/vasculogenic factors, and to suppress immune response raises questions regarding their biosafety. Our aim was to evaluate wheth...

journal_title：Stem cell research & therapy

authors： Bruna F,Plaza A,Arango M,Espinoza I,Conget P

更新日期：2018-05-11 00:00:00

abstract：OBJECTIVES:Mesenchymal stem cells (MSCs) have been intensively investigated as to their therapeutic potentials. However, the full chemical-defined medium supporting the isolation and expansion of human MSCs has not been developed yet. MATERIALS AND METHODS:Here, we developed the full chemical-defined medium, NBVbe med...

journal_title：Stem cell research & therapy

authors： Xu J,Lian W,Chen J,Li W,Li L,Huang Z

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:As a type of high-frequency electrotherapy, a short-wave can promote the fracture healing process; yet, its underlying therapeutic mechanisms remain unclear. PURPOSE:To observe the effect of Short-Wave therapy on mesenchymal stem cell (MSC) homing and relative mechanisms associated with fracture healing. M...

journal_title：Stem cell research & therapy

authors： Ye D,Chen C,Wang Q,Zhang Q,Li S,Liu H

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:Application of genetically modified hematopoietic stem cells is increasingly mooted as a clinically relevant approach to protein replacement therapy, immune tolerance induction or conditions where both outcomes may be helpful. Hematopoietic stem and progenitor cell (HSPC)-mediated gene therapy often requires...

journal_title：Stem cell research & therapy

authors： Bhatt KH,Rudraraju R,Brooks JF,Jung JW,Galea R,Wells JW,Steptoe RJ

更新日期：2017-03-09 00:00:00

abstract：:The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential...

journal_title：Stem cell research & therapy

authors： Sipp D

更新日期：2010-04-12 00:00:00

abstract：BACKGROUND:In our previous study, a venom-based peptide named Gonearrestide (also named P13) was identified and demonstrated with an effective inhibition in the proliferation of colon cancer cells. In this study, we explored if P13 and its potent mutant M6 could promote the proliferation of human embryonic stem cells a...

journal_title：Stem cell research & therapy

authors： Ma R,Ren Z,Li B,Siu SWI,Chen G,Kwok HF

更新日期：2020-06-18 00:00:00

abstract：BACKGROUND:Considerable progress has been made in converting human pluripotent stem cells (hPSCs) into cortical neurons for disease modeling and regenerative medicine. However, these procedures are hard to provide sufficient cells for their applications. Using a combination of small-molecules and growth factors, we pre...

journal_title：Stem cell research & therapy

authors： Zhao S,Duan K,Ai Z,Niu B,Chen Y,Kong R,Li T

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Stem cells from human exfoliated deciduous teeth (SHED) have recently attracted attention as novel multipotential stem cell sources. However, their application is limited due to in vitro replicative senescence. Ectopic expression of telomerase reverse transcriptase (TERT) is a promising strategy for overcomi...

journal_title：Stem cell research & therapy

authors： Yin Z,Wang Q,Li Y,Wei H,Shi J,Li A

更新日期：2016-04-04 00:00:00

abstract：BACKGROUND:Human adipose-derived stromal cells (hASCs) have been gaining increasing popularity in regenerative medicine thanks to their multipotency, ease of collection, and efficient culture. Similarly to other stromal cells, their function is particularly sensitive to the culture conditions, including the composition...

journal_title：Stem cell research & therapy

authors： Kuterbekov M,Machillot P,Baillet F,Jonas AM,Glinel K,Picart C

更新日期：2019-08-14 00:00:00

abstract：BACKGROUND:In regenerative medicine the maintenance of stem cell properties is of crucial importance. Ageing is considered a cause of reduced stemness capability. The limbus is a stem niche of easy access and harbors two stem cell populations: epithelial stem cells and fibroblast-like stem cells. Our aim was to investi...

journal_title：Stem cell research & therapy

authors： Tomasello L,Musso R,Cillino G,Pitrone M,Pizzolanti G,Coppola A,Arancio W,Di Cara G,Pucci-Minafra I,Cillino S,Giordano C

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells, including those derived from human adipose tissue (hASCs), are currently being widely investigated for cell therapy. However, when transplanted at the site of injury, the survival and engraftment rates of hASCs are low, mainly due to the harsh microenvironment they encounter, characte...

journal_title：Stem cell research & therapy

authors： Garrido-Pascual P,Alonso-Varona A,Castro B,Burón M,Palomares T

更新日期：2020-08-03 00:00:00

abstract：:Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cultivated oral mucosal epithelial cells (COMET) in humans in 2004, which represents the first use of a cultured n...

journal_title：Stem cell research & therapy

authors： Cabral JV,Jackson CJ,Utheim TP,Jirsova K

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:Neonatal hypoxia-ischemia induces massive brain damage during the perinatal period, resulting in long-term consequences to central nervous system structural and functional maturation. Although neural progenitor cells (NPCs) migrate through the parenchyma and home in to injury sites in the rodent brain, the m...

journal_title：Stem cell research & therapy

authors： Wang F,Baba N,Shen Y,Yamashita T,Tsuru E,Tsuda M,Maeda N,Sagara Y

更新日期：2017-02-07 00:00:00

abstract：BACKGROUND:Alveolar bone loss is a frequent occurrence. Dental pulp stem cells (DPSCs) which have invasive accessibility and high osteogenic potential is a promising source for cell-based bone regeneration. EphrinB2 is involved in bone homeostasis and osteogenesis. The aim of this study was to investigate the effect an...

journal_title：Stem cell research & therapy

authors： Wang W,Yuan C,Geng T,Liu Y,Zhu S,Zhang C,Liu Z,Wang P

更新日期：2020-01-29 00:00:00

abstract：:Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a membrane-enclosed intercellular delivery system with the potential to improve the therapeutic efficacy of the treatment of a variety of disorders. As the i...

journal_title：Stem cell research & therapy

authors： Hegyesi H,Sándor N,Sáfrány G,Lovas V,Kovács Á,Takács A,Kőhidai L,Turiák L,Kittel Á,Pálóczi K,Bertók L,Buzás EI

更新日期：2019-10-29 00:00:00

abstract：BACKGROUND:For adipose-derived stromal cells (ASCs) to be safe for use in the clinical setting, they need to be prepared using good manufacturing practices (GMPs). Fetal bovine serum (FBS), used to expand ASCs in vitro in some human clinical trials, runs the risk of xenoimmunization and zoonotic disease transmission. T...

journal_title：Stem cell research & therapy

authors： Dessels C,Ambele MA,Pepper MS

更新日期：2019-08-14 00:00:00

abstract：:Stem cell therapy has been applied in many fields. Basic and clinical studies on stem cell therapy for acute kidney injury (AKI) have been conducted. Stem cells have been found to exert renal protection through a variety of mechanisms, such as regulating the immune system and secreting growth factors, cytokines, and e...

journal_title：Stem cell research & therapy

authors： Wang SY,Hong Q,Zhang CY,Yang YJ,Cai GY,Chen XM

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMSCs) exhibit the capacity to self-renew and differentiate into multi-lineage cell types, including osteoblasts, which are crucial regulators of fracture healing. Thus, this study aims to investigate the effect of microRNA (miR)-22-3p from BMSC-derived EVs on osteogenic d...

journal_title：Stem cell research & therapy

authors： Zhang X,Wang Y,Zhao H,Han X,Zhao T,Qu P,Li G,Wang W

更新日期：2020-06-10 00:00:00

abstract：BACKGROUND:Pulpitis is a common dental disease characterized by sustained inflammation and impaired pulp self-repair. Mesenchymal stem cell-based minimally invasive vital pulp therapy (MSC-miVPT) is a potential treatment method, but its application is limited by the difficulty in acquiring MSCs. We recently revealed th...

journal_title：Stem cell research & therapy

authors： Hong H,Chen X,Li K,Wang N,Li M,Yang B,Yu X,Wei X

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a major cause of limb dysfunction, and distraction arthroplasty which generates intermittent hydrostatic pressure (IHP) is an effective approach for OA treatment. However, the result was not always satisfactory and the reasons remained unresolved. Because aging is recognized as an impo...

journal_title：Stem cell research & therapy

authors： Dai H,Chen R,Gui C,Tao T,Ge Y,Zhao X,Qin R,Yao W,Gu S,Jiang Y,Gui J

更新日期：2020-05-25 00:00:00

abstract：:The discovery of induced pluripotent stem cells (iPSCs) in 2006 was a major breakthrough for regenerative medicine. The establishment of patient-specific iPSCs has created the opportunity to model diseases in culture systems, with the potential to rapidly advance the drug discovery field. Current methods of drug disco...

journal_title：Stem cell research & therapy

authors： Guo Z,Higgins CA,Gillette BM,Itoh M,Umegaki N,Gledhill K,Sia SK,Christiano AM

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Stem cell therapy has emerged as potential therapeutic strategy for damaged heart muscles. Umbilical cord blood (UCB) cells are the most prevalent stem cell source available, yet have not been fully tested in cardiac regeneration. Herein, studies were performed to evaluate the cardiovascular safety and ben...

journal_title：Stem cell research & therapy

authors： Oommen S,Yamada S,Cantero Peral S,Campbell KA,Bruinsma ES,Terzic A,Nelson TJ

更新日期：2015-03-26 00:00:00

abstract：:Tissue engineering has developed many paradigms and techniques on how to best integrate cells and extracellular matrix to create in vitro structures that replicate native tissue. The strategy best suited for building these constructs depends mainly on the target cells, tissues, and organ of interest, and how readily t...

journal_title：Stem cell research & therapy

authors： Thavandiran N,Nunes SS,Xiao Y,Radisic M

更新日期：2013-02-14 00:00:00

abstract：BACKGROUND:Epidermal grafting using cells derived from pluripotent stem cells will change the face of this side of regenerative cutaneous medicine. To date, the safety of the graft would be the major unmet deal in order to implement long-term skin grafting. In this context, experiments on large animals appear unavoidab...

journal_title：Stem cell research & therapy

authors： Domingues S,Masson Y,Marteyn A,Allouche J,Perrier AL,Peschanski M,Martinat C,Baldeschi C,Lemaître G

更新日期：2017-12-19 00:00:00