Overexpression of apelin in Wharton' jelly mesenchymal stem cell reverses insulin resistance and promotes pancreatic β cell proliferation in type 2 diabetic rats.

abstract：:Stem cell behaviors are regulated by multiple microenvironmental cues. As an external signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate determination, but how this biophysical cue is translated into intracellular signaling remains elusive. Here, we elucidate mechanisms by ...

journal_title：Stem cell research & therapy

authors： Lv H,Li L,Sun M,Zhang Y,Chen L,Rong Y,Li Y

更新日期：2015-05-27 00:00:00

abstract：BACKGROUND:Bone reconstruction in congenital craniofacial differences, which affect about 2-3% of newborns, has long been the focus of intensive research in the field of bone tissue engineering. The possibility of using mesenchymal stromal cells in regenerative medicine protocols has opened a new field of investigation...

journal_title：Stem cell research & therapy

authors： Bueno DF,Kabayashi GS,Pinheiro CCG,Tanikawa DYS,Raposo-Amaral CE,Rocha DL,Ferreira JRM,Shibuya Y,Hokugo A,Jarrahy R,ZuK PA,Passos-Bueno MR

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:Efficient and sustained hematopoietic recovery after hematopoietic stem cell or bone marrow transplantation is supported by paracrine signaling from specific subpopulations of mesenchymal stromal cells (MSCs). Here, we considered whether in vitro mechanopriming of human MSCs could be administered to predicti...

journal_title：Stem cell research & therapy

authors： Liu FD,Tam K,Pishesha N,Poon Z,Van Vliet KJ

更新日期：2018-10-24 00:00:00

abstract：BACKGROUND:Within the last years, the interest in physical exercise as non-invasive stimulus influencing circulating hematopoietic stem and progenitor cell (CPC) concentrations has constantly grown. Cell estimates are often derived by determining the subgroup of CPC as percent lymphocytes (LYM) or mononuclear cells (MN...

journal_title：Stem cell research & therapy

authors： Kröpfl JM,Schmid M,Di Marzio Y,Schreiber K,Spengler CM

更新日期：2019-10-17 00:00:00

abstract：BACKGROUND:In our previous study, a venom-based peptide named Gonearrestide (also named P13) was identified and demonstrated with an effective inhibition in the proliferation of colon cancer cells. In this study, we explored if P13 and its potent mutant M6 could promote the proliferation of human embryonic stem cells a...

journal_title：Stem cell research & therapy

authors： Ma R,Ren Z,Li B,Siu SWI,Chen G,Kwok HF

更新日期：2020-06-18 00:00:00

abstract：BACKGROUND:The transplantation of human umbilical cord blood (UCB) CD34+ cells has been successfully used to treat hematological disorders but one major limitation has been the low cell numbers available. Mesenchymal stem cells (MSCs) lying within the bone marrow in vivo behave like a scaffold on which CD34+ cells inte...

journal_title：Stem cell research & therapy

authors： Lin HD,Fong CY,Biswas A,Bongso A

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Silicon-modified biomaterials have been extensively studied in bone tissue engineering. In recent years, the toxicity of silicon-doped biomaterials has gradually attracted attention but requires further elucidation. This study was designed to explore whether high-dose silicate can induce a cytotoxicity effec...

journal_title：Stem cell research & therapy

authors： Li Z,Liu S,Fu T,Peng Y,Zhang J

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:Stem cells from human exfoliated deciduous teeth (SHED) have recently attracted attention as novel multipotential stem cell sources. However, their application is limited due to in vitro replicative senescence. Ectopic expression of telomerase reverse transcriptase (TERT) is a promising strategy for overcomi...

journal_title：Stem cell research & therapy

authors： Yin Z,Wang Q,Li Y,Wei H,Shi J,Li A

更新日期：2016-04-04 00:00:00

abstract：BACKGROUND:Although the mononuclear cell (MNC) transplantation could theoretically induce therapeutic angiogenesis in the patients with no-option critical limb ischemia (NO-CLI), the clinical responses to this approach are inconsistent among different clinical trials. The purpose of this study was to identify the progn...

journal_title：Stem cell research & therapy

authors： Pan T,Liu H,Fang Y,Wei Z,Gu S,Fang G,Liu Y,Luo Y,Guo D,Xu X,Chen B,Jiang J,Yang J,Shi Z,Zhu T,Shi Y,Liu P,Dong Z,Fu W

更新日期：2019-01-11 00:00:00

abstract：BACKGROUND:Stem cells from human exfoliated deciduous teeth (SHED) have been reported to show the in vivo and in vitro hepatic differentiation, SHED-Heps; however, the cholangiogenic potency of SHED-Heps remains unclear. Here, we hypothesized that SHED-Heps contribute to the regeneration of intrahepatic bile duct syste...

journal_title：Stem cell research & therapy

authors： Yuniartha R,Yamaza T,Sonoda S,Yoshimaru K,Matsuura T,Yamaza H,Oda Y,Ohga S,Taguchi T

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:For patients with thromboangiitis obliterans (TAO), revascularization with bypass or angioplasty is frequently not feasible due to the poor outflow of the distal small vessels. We evaluated the long-term results of our experience treating patients with TAO with autologous bone marrow-derived mononuclear cell...

journal_title：Stem cell research & therapy

authors： Guo J,Guo L,Cui S,Tong Z,Dardik A,Gu Y

更新日期：2018-02-22 00:00:00

abstract：BACKGROUND:Nanosecond pulsed electric fields (nsPEFs) can produce more significant biological effects than traditional electric fields and have thus attracted rising attention in developing medical applications based on short pulse duration and high field strength, such as effective cancer therapy. However, little is k...

journal_title：Stem cell research & therapy

authors： Ning T,Guo J,Zhang K,Li K,Zhang J,Yang Z,Ge Z

更新日期：2019-01-24 00:00:00

abstract：BACKGROUND:Neonatal hypoxia-ischemia induces massive brain damage during the perinatal period, resulting in long-term consequences to central nervous system structural and functional maturation. Although neural progenitor cells (NPCs) migrate through the parenchyma and home in to injury sites in the rodent brain, the m...

journal_title：Stem cell research & therapy

authors： Wang F,Baba N,Shen Y,Yamashita T,Tsuru E,Tsuda M,Maeda N,Sagara Y

更新日期：2017-02-07 00:00:00

abstract：:The role of p53 as "a guardian of the genome" has been well established in somatic cells. However, its role in pluripotent stem cells remains much more elusive. Here, we discuss research progress in understanding the role of p53 in pluripotent stem cells and in pluripotent stem cell-like cancer stem cells. The p53 pro...

journal_title：Stem cell research & therapy

authors： Lin T,Lin Y

更新日期：2017-02-28 00:00:00

abstract：INTRODUCTION:Idiopathic pulmonary fibrosis is a progressive diffuse parenchymal lung disorder of unknown etiology. Mesenchymal stem cell (MSC)-based therapy is a novel approach with great therapeutic potential for the treatment of lung diseases. Despite demonstration of MSC grafting, the populations of engrafted MSCs h...

journal_title：Stem cell research & therapy

authors： Lan YW,Choo KB,Chen CM,Hung TH,Chen YB,Hsieh CH,Kuo HP,Chong KY

更新日期：2015-05-20 00:00:00

abstract：INTRODUCTION:Osteopontin (OPN) is a phosphoglycoprotein with important roles in tissue homeostasis, wound healing, immune regulation, and stress responses. It is expressed constitutively in the brain and upregulated during neuroinflammatory responses; for example, after focal cerebral ischemia. To date, its effects on ...

journal_title：Stem cell research & therapy

authors： Rabenstein M,Hucklenbroich J,Willuweit A,Ladwig A,Fink GR,Schroeter M,Langen KJ,Rueger MA

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:Although adult human tissue-derived epidermal stem cells are capable of differentiating into enamel-secreting ameloblasts and forming teeth with regenerated enamel when recombined with mouse dental mesenchyme that possesses odontogenic potential, the induction rate is relatively low. In addition, whether the...

journal_title：Stem cell research & therapy

authors： Hu X,Lee JW,Zheng X,Zhang J,Lin X,Song Y,Wang B,Hu X,Chang HH,Chen Y,Lin CP,Zhang Y

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:To reduce young female fertility loss, the in-vitro culture of cryopreserved ovarian cortical tissues (OCTs) is considered an effective approach without delaying treatment and undergoing stimulation medicine. However, ischemic damage and follicular loss during the in-vitro culture of OCTs are major technical...

journal_title：Stem cell research & therapy

authors： Jia Y,Shi X,Xie Y,Xie X,Wang Y,Li S

更新日期：2017-06-24 00:00:00

abstract：BACKGROUND:Acute liver failure (ALF) is a complicated condition that is characterized by global hepatocyte death and often requires immediate liver transplantation. However, this therapy is limited by shortage of donor organs. Mesenchymal stem cells (MSCs) and hepatocytes are two attractive sources of cell-based therap...

journal_title：Stem cell research & therapy

authors： Kong D,Xu H,Chen M,Yu Y,Qian Y,Qin T,Tong Y,Xia Q,Hang H

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:The therapeutic effects of adipose-derived mesenchymal stem cell (ADSC) transplantation have been demonstrated in several models of central nervous system (CNS) injury and are thought to involve the modulation of the inflammatory response. However, the exact underlying molecular mechanism is poorly understoo...

journal_title：Stem cell research & therapy

authors： Zhou Z,Tian X,Mo B,Xu H,Zhang L,Huang L,Yao S,Huang Z,Wang Y,Xie H,Xu L,Zhang H

更新日期：2020-06-03 00:00:00

abstract：INTRODUCTION:Short-term neural stem cell (NSC) transplantation improves cognition in Alzheimer's disease (AD) transgenic mice by enhancing endogenous synaptic connectivity. However, this approach has no effect on the underlying beta-amyloid (Aβ) and neurofibrillary tangle pathology. Long term efficacy of cell based app...

journal_title：Stem cell research & therapy

authors： Blurton-Jones M,Spencer B,Michael S,Castello NA,Agazaryan AA,Davis JL,Müller FJ,Loring JF,Masliah E,LaFerla FM

更新日期：2014-04-16 00:00:00

abstract：:The discovery of induced pluripotent stem cells (iPSCs) in 2006 was a major breakthrough for regenerative medicine. The establishment of patient-specific iPSCs has created the opportunity to model diseases in culture systems, with the potential to rapidly advance the drug discovery field. Current methods of drug disco...

journal_title：Stem cell research & therapy

authors： Guo Z,Higgins CA,Gillette BM,Itoh M,Umegaki N,Gledhill K,Sia SK,Christiano AM

更新日期：2013-01-01 00:00:00

abstract：:Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. However, the efficiency of SCNT remains very low due to some poorly characterized key factors. Compared with fertilized embryos, somatic donor cells lack...

journal_title：Stem cell research & therapy

authors： Qu P,Wang Y,Zhang C,Liu E

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated that intravenous administration of adipose tissue stem cells (ASCs) could significantly reduce allergic symptoms and suppress eosinophilic inflammation. METHODS:To evaluate the secretome of ASCs, we administrated culture supernatant of ASCs (ASC sup, which contains the A...

journal_title：Stem cell research & therapy

authors： Yu HS,Park MK,Kang SA,Cho KS,Mun SJ,Roh HJ

更新日期：2017-01-23 00:00:00

abstract：INTRODUCTION:Stem cells have been evaluated as a potential therapeutic approach for several neurological disorders of the central and peripheral nervous system as well as for traumatic brain and spinal cord injury. Currently, the lack of a reliable and safe method to accurately and non-invasively locate the site of imp...

journal_title：Stem cell research & therapy

authors： Micci MA,Boone DR,Parsley MA,Wei J,Patrikeev I,Motamedi M,Hellmich HL

更新日期：2015-07-21 00:00:00

abstract：:Adipogenesis is essential in in vitro experimentation to assess differentiation capability of stem cells, and therefore, its accurate measurement is important. Quantitative analysis of adipogenic levels, however, is challenging and often susceptible to errors due to non-specific reading or manual estimation by observe...

journal_title：Stem cell research & therapy

authors： Yuan C,Chakraborty S,Chitta KK,Subramanian S,Lim TE,Han W,Bhanu Prakash KN,Sugii S

更新日期：2019-01-22 00:00:00

abstract：BACKGROUND:Alveolar bone loss is a frequent occurrence. Dental pulp stem cells (DPSCs) which have invasive accessibility and high osteogenic potential is a promising source for cell-based bone regeneration. EphrinB2 is involved in bone homeostasis and osteogenesis. The aim of this study was to investigate the effect an...

journal_title：Stem cell research & therapy

authors： Wang W,Yuan C,Geng T,Liu Y,Zhu S,Zhang C,Liu Z,Wang P

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:Type 1 diabetes (T1D) is an autoimmune disease resulting from the destruction of insulin-secreting islet β cells by autoreactive T cells. Non-obese diabetic (NOD) mice are the widely used animal model for human T1D. Autoimmunity in NOD mice is associated with particular major histocompatibility complex (MHC)...

journal_title：Stem cell research & therapy

authors： Su M,Lin Y,He Z,Lai L

更新日期：2019-08-06 00:00:00

abstract：:Mesenchymal stem cells have been used for cardiovascular regenerative therapy for decades. These cells have been established as one of the potential therapeutic agents, following several tests in animal models and clinical trials. In the process, various sources of mesenchymal stem cells have been identified which hel...

journal_title：Stem cell research & therapy

authors： Singh A,Singh A,Sen D

更新日期：2016-06-04 00:00:00

abstract：BACKGROUND:The intervertebral disc (IVD) has limited self-healing potential and disc repair strategies require an appropriate cell source such as progenitor cells that could regenerate the damaged cells and tissues. The objective of this study was to identify nucleus pulposus-derived progenitor cells (NPPC) and examine...

journal_title：Stem cell research & therapy

authors： Tekari A,Chan SCW,Sakai D,Grad S,Gantenbein B

更新日期：2016-05-23 00:00:00