Intramyocardial transplantation of cardiac mesenchymal stem cells reduces myocarditis in a model of chronic Chagas disease cardiomyopathy.

abstract：BACKGROUND:Mesenchymal stem cell (MSC)-based cartilage tissue regeneration is a treatment with great potential. How to enhance the MSC chondrogenic differentiation is a key issue involved in cartilage formation. In the present study, we seek to expound the phenotypes and mechanisms of DLX5 in chondrogenic differentiati...

journal_title：Stem cell research & therapy

authors： Yang H,Cao Y,Zhang J,Liang Y,Su X,Zhang C,Liu H,Han X,Ge L,Fan Z

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:iRoot BP Plus is a novel bioceramic endodontic material. Recently, it has been considered as an alternative to MTA which is the most popular scaffold cover during regenerative endodontic therapy. This study aimed to evaluate the effects of iRoot BP Plus on the osteo/odontogenic capacity of bone marrow mesenc...

journal_title：Stem cell research & therapy

authors： Lu J,Li Z,Wu X,Chen Y,Yan M,Ge X,Yu J

更新日期：2019-07-29 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is the second most prevalent cause of cancer-related fatality. Long non-coding RNAs (lncRNAs) have been observed to exercise functions in NSCLC. Here, the current study aimed to explore the potential mechanism of lncRNA MBNL1-AS1 in NSCLC. METHODS:Microarray analysis was p...

journal_title：Stem cell research & therapy

authors： Li P,Xing W,Xu J,Yuan D,Liang G,Liu B,Ma H

更新日期：2019-05-21 00:00:00

abstract：INTRODUCTION:Short-term neural stem cell (NSC) transplantation improves cognition in Alzheimer's disease (AD) transgenic mice by enhancing endogenous synaptic connectivity. However, this approach has no effect on the underlying beta-amyloid (Aβ) and neurofibrillary tangle pathology. Long term efficacy of cell based app...

journal_title：Stem cell research & therapy

authors： Blurton-Jones M,Spencer B,Michael S,Castello NA,Agazaryan AA,Davis JL,Müller FJ,Loring JF,Masliah E,LaFerla FM

更新日期：2014-04-16 00:00:00

abstract：BACKGROUND:The long-term survival after vascularized composite allotransplantation (VCA) is often limited by systemic rejection as well as the adverse effects of immunosuppressants. The stromal vascular fraction (SVF) can be expanded to produce adipose-derived stem cells (ADSC) which represents a combination of endothe...

journal_title：Stem cell research & therapy

authors： Chen J,Wang Y,Hu H,Xiong Y,Wang S,Yang J

更新日期：2021-01-29 00:00:00

abstract：BACKGROUND:Acute liver failure (ALF) is a complicated condition that is characterized by global hepatocyte death and often requires immediate liver transplantation. However, this therapy is limited by shortage of donor organs. Mesenchymal stem cells (MSCs) and hepatocytes are two attractive sources of cell-based therap...

journal_title：Stem cell research & therapy

authors： Kong D,Xu H,Chen M,Yu Y,Qian Y,Qin T,Tong Y,Xia Q,Hang H

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:Bone reconstruction in congenital craniofacial differences, which affect about 2-3% of newborns, has long been the focus of intensive research in the field of bone tissue engineering. The possibility of using mesenchymal stromal cells in regenerative medicine protocols has opened a new field of investigation...

journal_title：Stem cell research & therapy

authors： Bueno DF,Kabayashi GS,Pinheiro CCG,Tanikawa DYS,Raposo-Amaral CE,Rocha DL,Ferreira JRM,Shibuya Y,Hokugo A,Jarrahy R,ZuK PA,Passos-Bueno MR

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:C-kit-positive cardiac stem cells (CSCs) have been shown to be a promising candidate treatment for myocardial infarction and heart failure. Insulin-like growth factor (IGF)-1 is an anabolic growth hormone that regulates cellular proliferation, differentiation, senescence, and death in various tissues. Althou...

journal_title：Stem cell research & therapy

authors： Sun Y,Xu R,Huang J,Yao Y,Pan X,Chen Z,Ma G

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:Stress urinary incontinence (SUI) is a common and bothersome condition. Invasive surgery will always be considered after conservative treatment fails, but the rates of postoperative complications and long-term recurrence are high. Thus, a new treatment strategy is still needed. In recent years, bone marrow m...

journal_title：Stem cell research & therapy

authors： Zhang H,Huang J,Liu J,Li Y,Gao Y

更新日期：2020-07-16 00:00:00

abstract：BACKGROUND:Mesenchymal stem/stromal cells derived from chorionic villi of human term placentae (pMSCs) protect human endothelial cells from injury induced by hydrogen peroxide (H2O2). In diabetes, elevated levels of glucose (hyperglycaemia) induce H2O2 production, which causes the endothelial dysfunction that underlies...

journal_title：Stem cell research & therapy

authors： Basmaeil YS,Al Subayyil AM,Khatlani T,Bahattab E,Al-Alwan M,Abomaray FM,Kalionis B,Alshabibi MA,AlAskar AS,Abumaree MH

更新日期：2018-09-21 00:00:00

abstract：BACKGROUND:Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and human induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC...

journal_title：Stem cell research & therapy

authors： Liao S,Zhang Y,Ting S,Zhen Z,Luo F,Zhu Z,Jiang Y,Sun S,Lai WH,Lian Q,Tse HF

更新日期：2019-03-07 00:00:00

abstract：BACKGROUND:We aimed to generate a bioengineered multi-lamellar human corneal stroma tissue in vitro by differentiating periodontal ligament stem cells (PDLSCs) towards keratocytes on an aligned silk membrane. METHODS:Human PDLSCs were isolated and identified. The neuropeptide substance P (SP) was added in keratocyte d...

journal_title：Stem cell research & therapy

authors： Chen J,Zhang W,Kelk P,Backman LJ,Danielson P

更新日期：2017-11-13 00:00:00

abstract：:Mesenchymal stem cells have been used for cardiovascular regenerative therapy for decades. These cells have been established as one of the potential therapeutic agents, following several tests in animal models and clinical trials. In the process, various sources of mesenchymal stem cells have been identified which hel...

journal_title：Stem cell research & therapy

authors： Singh A,Singh A,Sen D

更新日期：2016-06-04 00:00:00

abstract：BACKGROUND:Human adipose-derived stromal cells (hASCs) have been gaining increasing popularity in regenerative medicine thanks to their multipotency, ease of collection, and efficient culture. Similarly to other stromal cells, their function is particularly sensitive to the culture conditions, including the composition...

journal_title：Stem cell research & therapy

authors： Kuterbekov M,Machillot P,Baillet F,Jonas AM,Glinel K,Picart C

更新日期：2019-08-14 00:00:00

abstract：:The role of p53 as "a guardian of the genome" has been well established in somatic cells. However, its role in pluripotent stem cells remains much more elusive. Here, we discuss research progress in understanding the role of p53 in pluripotent stem cells and in pluripotent stem cell-like cancer stem cells. The p53 pro...

journal_title：Stem cell research & therapy

authors： Lin T,Lin Y

更新日期：2017-02-28 00:00:00

abstract：:Stem cell behaviors are regulated by multiple microenvironmental cues. As an external signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate determination, but how this biophysical cue is translated into intracellular signaling remains elusive. Here, we elucidate mechanisms by ...

journal_title：Stem cell research & therapy

authors： Lv H,Li L,Sun M,Zhang Y,Chen L,Rong Y,Li Y

更新日期：2015-05-27 00:00:00

abstract：BACKGROUND:Exploring the effects of lncRNA SNHG1 in the process of osteogenic differentiation of periodontal ligament stem cells (PDLSCs) would provide novel therapeutic strategies for tissue regeneration. METHODS:Loss-of-function and gain-of-function assays were induced by lentivirus. The osteogenic differentiation o...

journal_title：Stem cell research & therapy

authors： Li Z,Guo X,Wu S

更新日期：2020-10-07 00:00:00

abstract：BACKGROUND:In the brain of adult mammals, neural stem cells persist in the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus, which are specialized niches with proliferative capacity. Most neural stem cells are in a quiescent state, but in response to extrinsic stimuli, they can...

journal_title：Stem cell research & therapy

authors： Li W,Wang S,He H,Qin J,Cheng X,Zhao H,Tian M,Zhang X,Jin G

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:Human embryonic stem cells (hESCs) hold tremendous promise for cell replacement therapies for a range of degenerative diseases. In order to provide cost-effective treatments affordable by public health systems, HLA-matched allogeneic tissue banks of the highest quality clinical-grade hESCs will be required. ...

journal_title：Stem cell research & therapy

authors： Ye J,Bates N,Soteriou D,Grady L,Edmond C,Ross A,Kerby A,Lewis PA,Adeniyi T,Wright R,Poulton KV,Lowe M,Kimber SJ,Brison DR

更新日期：2017-06-05 00:00:00

abstract：INTRODUCTION:Studies have shown that stem cells exert their therapeutic effects on acute kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in an endocrine manner, the injection of the factors that these cells secrete could be effective, but the effect of conditioned medium (C...

journal_title：Stem cell research & therapy

authors： Xing L,Cui R,Peng L,Ma J,Chen X,Xie RJ,Li B

更新日期：2014-08-21 00:00:00

abstract：BACKGROUND:Induced pluripotent stem cells (iPSCs) exhibit limitless pluripotent plasticity and proliferation capability to provide an abundant cell source for tissue regenerative medicine. Thus, inducing iPSCs toward a specific differentiation direction is an important scientific question. Traditionally, iPSCs have bee...

journal_title：Stem cell research & therapy

authors： Hu Y,Chen L,Gao Y,Cheng P,Yang L,Wu C,Jie Q

更新日期：2020-02-21 00:00:00

abstract：INTRODUCTION:Octamer-binding transcription factor 4 (Oct4) is a master regulator of early mammalian development. Its expression begins from the oocyte stage, becomes restricted to the inner cell mass of the blastocyst and eventually remains only in primordial germ cells. Unearthing the interactions of Oct4 would provid...

journal_title：Stem cell research & therapy

authors： Cheong CY,Lon Ng PM,Ponnampalam R,Tsai HH,Bourque G,Lufkin T

更新日期：2011-05-13 00:00:00

abstract：BACKGROUND:Stem cells from human exfoliated deciduous teeth (SHED) have been reported to show the in vivo and in vitro hepatic differentiation, SHED-Heps; however, the cholangiogenic potency of SHED-Heps remains unclear. Here, we hypothesized that SHED-Heps contribute to the regeneration of intrahepatic bile duct syste...

journal_title：Stem cell research & therapy

authors： Yuniartha R,Yamaza T,Sonoda S,Yoshimaru K,Matsuura T,Yamaza H,Oda Y,Ohga S,Taguchi T

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:Vocal fold (VF) scarring, caused by surgery or inflammation, often results in severe voice problems or aphonia. Effective lasting treatment is lacking. Previous in vitro and in vivo animal studies reported positive effects on VF scar resolution with mesenchymal stromal cell (MSC) implantation. The principal ...

journal_title：Stem cell research & therapy

authors： Hertegård S,Nagubothu SR,Malmström E,LeBlanc K

更新日期：2020-03-20 00:00:00

abstract：:Cognitive deficit has been identified in one third of patients affected by Duchenne Muscular Dystrophy, primarily attributed to loss of the short Dp71 dystrophin, the major brain dystrophin isoform. In this study, we investigated for the first time the Dp71 and Dp71-associated proteins cellular localization and expres...

journal_title：Stem cell research & therapy

authors： Ruggieri S,Viggiano L,Annese T,Rubolino C,Gerbino A,De Zio R,Corsi P,Tamma R,Ribatti D,Errede M,Operto F,Margari L,Resta N,Di Tommaso S,Rosati J,Trojano M,Nico B

更新日期：2019-01-15 00:00:00

abstract：INTRODUCTION:Nervous system injuries comprise a diverse group of disorders that include traumatic brain injury (TBI). The potential of mesenchymal stem cells (MSCs) to differentiate into neural cell types has aroused hope for the possible development of autologous therapies for central nervous system injury. METHODS:I...

journal_title：Stem cell research & therapy

authors： Nichols JE,Niles JA,DeWitt D,Prough D,Parsley M,Vega S,Cantu A,Lee E,Cortiella J

更新日期：2013-01-06 00:00:00

abstract：BACKGROUND:This study explored the details of the immune response after autologous hematopoietic stem cell transplantation (AHSCT) treatment in type 1 diabetes mellitus. METHODS:Peripheral blood mononuclear cells (PBMCs) from 18 patients with type 1 diabetes mellitus were taken at baseline and 12 months after AHSCT or...

journal_title：Stem cell research & therapy

authors： Ye L,Li L,Wan B,Yang M,Hong J,Gu W,Wang W,Ning G

更新日期：2017-04-18 00:00:00

abstract：BACKGROUND:In regenerative medicine the maintenance of stem cell properties is of crucial importance. Ageing is considered a cause of reduced stemness capability. The limbus is a stem niche of easy access and harbors two stem cell populations: epithelial stem cells and fibroblast-like stem cells. Our aim was to investi...

journal_title：Stem cell research & therapy

authors： Tomasello L,Musso R,Cillino G,Pitrone M,Pizzolanti G,Coppola A,Arancio W,Di Cara G,Pucci-Minafra I,Cillino S,Giordano C

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) plays a role in a number of physiological processes including stem cell differentiation and osteogenesis. Endothelial nitric oxide synthase (eNOS), one of three NO-producing enzymes, is located in a close conformation with the caveolin-1 (CAV-1WT) membrane protein which is inhibitory to NO ...

journal_title：Stem cell research & therapy

authors： Bandara N,Gurusinghe S,Lim SY,Chen H,Chen S,Wang D,Hilbert B,Wang LX,Strappe P

更新日期：2016-12-07 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects female fertility. However, with the lack of a corresponding research model, the pathology mechanism of PCOS is poorly understood. Induced pluripotent stem cell (iPSC) technology has been recognized as means to generate...

journal_title：Stem cell research & therapy

authors： Min Z,Gao Q,Zhen X,Fan Y,Tan T,Li R,Zhao Y,Yu Y

更新日期：2018-08-09 00:00:00