iRoot BP Plus promotes osteo/odontogenic differentiation of bone marrow mesenchymal stem cells via MAPK pathways and autophagy.

abstract：BACKGROUND:Currently, the overall therapeutic efficiency of mesenchymal stem cells (MSCs) transplantation for the treatment of cardiovascular disease is not satisfactory. The low viability and angiogenic capacity of the implanted cells in the local infarct tissues restrict their further application. Evidence shows that...

journal_title：Stem cell research & therapy

authors： Hou J,Wang L,Wu Q,Zheng G,Long H,Wu H,Zhou C,Guo T,Zhong T,Wang L,Chen X,Wang T

更新日期：2018-04-19 00:00:00

abstract：:Owing to the several advantages that they have over other cells, mesenchymal stem cells are among the most promising tools in stem cell therapy after ischemic stroke. Mesenchymal stem cells can be obtained from various sources. Therefore, a wide range of careful comparative studies of these cells is required, from the...

journal_title：Stem cell research & therapy

authors： Ikegame Y

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:Silicon-modified biomaterials have been extensively studied in bone tissue engineering. In recent years, the toxicity of silicon-doped biomaterials has gradually attracted attention but requires further elucidation. This study was designed to explore whether high-dose silicate can induce a cytotoxicity effec...

journal_title：Stem cell research & therapy

authors： Li Z,Liu S,Fu T,Peng Y,Zhang J

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:The Activin A and bone morphogenetic protein (BMP) pathways are critical regulators of the immune system and of bone formation. Inappropriate activation of these pathways, as in conditions of congenital heterotopic ossification, are thought to activate an osteogenic program in endothelial cells. However, if ...

journal_title：Stem cell research & therapy

authors： Barruet E,Morales BM,Lwin W,White MP,Theodoris CV,Kim H,Urrutia A,Wong SA,Srivastava D,Hsiao EC

更新日期：2016-08-17 00:00:00

abstract：INTRODUCTION:This is the first study evaluating the interactions of human adipose tissue derived stem cells (ADSCs) and human squamous cell carcinoma cells (SCCs), with regard to a prospective cell-based skin regenerative therapy and a thereby unintended co-localization of ADSCs and SCCs. METHODS:ADSCs were co-culture...

journal_title：Stem cell research & therapy

authors： Koellensperger E,Gramley F,Preisner F,Leimer U,Germann G,Dexheimer V

更新日期：2014-05-12 00:00:00

abstract：INTRODUCTION:Stem cell therapy has emerged as potential therapeutic strategy for damaged heart muscles. Umbilical cord blood (UCB) cells are the most prevalent stem cell source available, yet have not been fully tested in cardiac regeneration. Herein, studies were performed to evaluate the cardiovascular safety and ben...

journal_title：Stem cell research & therapy

authors： Oommen S,Yamada S,Cantero Peral S,Campbell KA,Bruinsma ES,Terzic A,Nelson TJ

更新日期：2015-03-26 00:00:00

abstract：BACKGROUND:Severe acute pancreatitis (SAP) is an acute abdominal disease characterized by pancreatic necrosis and systemic disease. In a previous study, we showed that bone marrow-derived mesenchymal stem cells (BMSCs) can reduce SAP by secreting microRNA (miR)-9; however, the underlying mechanism remains unclear. The ...

journal_title：Stem cell research & therapy

authors： Qian D,Song G,Ma Z,Wang G,Jin L,Hu M,Song Z,Wang X

更新日期：2018-10-25 00:00:00

abstract：BACKGROUND:Apelin plays a key beneficial role in energy metabolism by increasing glucose uptake and insulin sensitivity; however, apelin has a short half-life because it is rapidly cleared from the circulation limiting its therapeutic benefit. The aim of this study is to create a new approach to treat type 2 diabetes b...

journal_title：Stem cell research & therapy

authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

更新日期：2018-12-07 00:00:00

abstract：BACKGROUND:Hertwig's epithelial root sheath (HERS) is important in guiding tooth root formation by differentiating into cementoblasts through epithelial-mesenchymal transition (EMT) and inducing odontoblastic differentiation of dental papilla through epithelial-mesenchymal interaction (EMI) during the tooth root develo...

journal_title：Stem cell research & therapy

authors： Li X,Zhang S,Zhang Z,Guo W,Chen G,Tian W

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:Expansion protocols aim at both increasing the number of umbilical cord blood (UCB) hematopoietic stem cells and progenitor cells (HSPCs) and reducing the period of neutropenia in UCB HSPC graft. Because glycosaminoglycans (GAGs) are known to be important components of the hematopoietic niche and to modulate...

journal_title：Stem cell research & therapy

authors： Faivre L,Parietti V,Siñeriz F,Chantepie S,Gilbert-Sirieix M,Albanese P,Larghero J,Vanneaux V

更新日期：2016-01-07 00:00:00

abstract：BACKGROUND:Patients suffering from osteoporosis show an increased number of adipocytes in their bone marrow, concomitant with a reduction in the pool of human mesenchymal stem cells (hMSCs) that are able to differentiate into osteoblasts, thus leading to suppressed osteogenesis. METHODS:In order to be able to interfer...

journal_title：Stem cell research & therapy

authors： van Zoelen EJ,Duarte I,Hendriks JM,van der Woning SP

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Adult full-thickness cutaneous wound repair suffers from an imbalanced immune response, leading to nonfunctional reconstructed tissue and fibrosis. Although various treatments have been reported, the immune-mediated tissue regeneration driven by biomaterial offers an attractive regenerative strategy for dama...

journal_title：Stem cell research & therapy

authors： Yang Z,He C,He J,Chu J,Liu H,Deng X

更新日期：2018-01-31 00:00:00

abstract：:Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers. Current NK therapies using primary NK cells are prone to manufacturing issues related to expansion and storage. Alternative cell sourc...

journal_title：Stem cell research & therapy

authors： Shankar K,Capitini CM,Saha K

更新日期：2020-06-16 00:00:00

abstract：:Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. However, the efficiency of SCNT remains very low due to some poorly characterized key factors. Compared with fertilized embryos, somatic donor cells lack...

journal_title：Stem cell research & therapy

authors： Qu P,Wang Y,Zhang C,Liu E

更新日期：2020-02-18 00:00:00

abstract：OBJECTIVE:Autograft microskin transplantation has been widely used as a skin graft therapy in full-thickness skin defect. However, skin grafting failure can lead to a pathological delay wound healing due to a poor vascularization bed. Considering the active role of adipose-derived stem cell (ADSC) in promoting angiogen...

journal_title：Stem cell research & therapy

authors： Luo Y,Yi X,Liang T,Jiang S,He R,Hu Y,Bai L,Wang C,Wang K,Zhu L

更新日期：2019-08-30 00:00:00

abstract：INTRODUCTION:Topical administration of eye drops is the major route for drug delivery to the cornea. Orbital fat-derived stem cells (OFSCs) possess an in vitro corneal epithelial differentiation capacity. Both the safety and immunomodulatory ability of systemic OFSC transplantation were demonstrated in our previous wor...

journal_title：Stem cell research & therapy

authors： Lin KJ,Loi MX,Lien GS,Cheng CF,Pao HY,Chang YC,Ji AT,Ho JH

更新日期：2013-06-14 00:00:00

abstract：BACKGROUND:The transfection of human mesenchymal stem cells (hMSCs) with the hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) gene has been demonstrated to provide biological pacing in dogs with complete heart block. The mechanism appears to be the generation of the ion current (If) by the HCN2-...

journal_title：Stem cell research & therapy

authors： Bruzauskaite I,Bironaite D,Bagdonas E,Skeberdis VA,Denkovskij J,Tamulevicius T,Uvarovas V,Bernotiene E

更新日期：2016-04-30 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cells (MSCs) are considered to have a modest benefit on left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI). However, the optimal injection timing and dose needed to induce beneficial cardiac effects are unknown. The purpose of this meta-analysis w...

journal_title：Stem cell research & therapy

authors： Wang Z,Wang L,Su X,Pu J,Jiang M,He B

更新日期：2017-01-28 00:00:00

abstract：BACKGROUND:A keloid is a fibroproliferative disorder occurring in wounds characterized by an exaggerated response to injury. To date, no effective cure has been identified. As multipotent stem cells, human adipose-derived stem cells (ADSCs) may show the possibility for curing diseases such as fibrosis. This study sough...

journal_title：Stem cell research & therapy

authors： Wang X,Ma Y,Gao Z,Yang J

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:Vocal fold (VF) scarring, caused by surgery or inflammation, often results in severe voice problems or aphonia. Effective lasting treatment is lacking. Previous in vitro and in vivo animal studies reported positive effects on VF scar resolution with mesenchymal stromal cell (MSC) implantation. The principal ...

journal_title：Stem cell research & therapy

authors： Hertegård S,Nagubothu SR,Malmström E,LeBlanc K

更新日期：2020-03-20 00:00:00

abstract：INTRODUCTION:Huntington's disease (HD) is an autosomal dominant disorder caused by an expanded CAG repeat (greater than 38) on the short arm of chromosome 4, resulting in loss and dysfunction of neurons in the neostriatum and cortex, leading to cognitive decline, motor dysfunction, and death, typically occurring 15 to ...

journal_title：Stem cell research & therapy

authors： Rossignol J,Fink KD,Crane AT,Davis KK,Bombard MC,Clerc S,Bavar AM,Lowrance SA,Song C,Witte S,Lescaudron L,Dunbar GL

更新日期：2015-02-19 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive accumulation of Lewy body inclusions along with selective destruction of dopaminergic (DA) neurons in the nigrostriatal tract of the brain. Genetic studies have revealed much about the pathophysiology of PD, enabling the identifi...

journal_title：Stem cell research & therapy

authors： Gibson SA,Gao GD,McDonagh K,Shen S

更新日期：2012-04-03 00:00:00

abstract：BACKGROUND:Complex immunophenotypic repertoires defining discrete adipose-derived stem cell (ASC) subpopulations may hold a key toward identifying predictors of clinical utility. To this end, we sorted out of the freshly established ASCs four subpopulations (SPs) according to a specific pattern of co-expression of six ...

journal_title：Stem cell research & therapy

authors： Nielsen FM,Riis SE,Andersen JI,Lesage R,Fink T,Pennisi CP,Zachar V

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:Therapeutic potentials of mesenchymal stem cells (MSCs) from different sources have been evaluated in pre-clinical and clinical settings. Although MSCs from different sources share MSC-specific characteristics and functions, inconsistent or controversial results of pre-clinical and clinical applications of...

journal_title：Stem cell research & therapy

authors： Zhu Y,Yang Y,Zhang Y,Hao G,Liu T,Wang L,Yang T,Wang Q,Zhang G,Wei J,Li Y

更新日期：2014-04-10 00:00:00

abstract：BACKGROUND:Autologous grafting, despite some disadvantages, is still considered the gold standard for reconstruction of maxillofacial bone defects. The aim of this study was to evaluate bone regeneration using bone marrow-derived mesenchymal stromal cells (MSCs) in a clinical trial, a less invasive approach than autolo...

journal_title：Stem cell research & therapy

authors： Gjerde C,Mustafa K,Hellem S,Rojewski M,Gjengedal H,Yassin MA,Feng X,Skaale S,Berge T,Rosen A,Shi XQ,Ahmed AB,Gjertsen BT,Schrezenmeier H,Layrolle P

更新日期：2018-08-09 00:00:00

abstract：:Damage of mitochondria in the initial period of tissue injury aggravates the severity of injury. Restoration of mitochondria dysfunction and mitochondrial-based therapeutics represent a potentially effective therapeutic strategy. Recently, mitochondrial transfer from stem cells has been demonstrated to play a signific...

journal_title：Stem cell research & therapy

authors： Wang J,Li H,Yao Y,Zhao T,Chen YY,Shen YL,Wang LL,Zhu Y

更新日期：2018-04-13 00:00:00

abstract：BACKGROUND:For patients with thromboangiitis obliterans (TAO), revascularization with bypass or angioplasty is frequently not feasible due to the poor outflow of the distal small vessels. We evaluated the long-term results of our experience treating patients with TAO with autologous bone marrow-derived mononuclear cell...

journal_title：Stem cell research & therapy

authors： Guo J,Guo L,Cui S,Tong Z,Dardik A,Gu Y

更新日期：2018-02-22 00:00:00

abstract：:Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulatory and regenerative effects of mesenchymal stem/stromal cells (MSCs) are mainly mediated by soluble paracrine f...

journal_title：Stem cell research & therapy

authors： Qiu G,Zheng G,Ge M,Wang J,Huang R,Shu Q,Xu J

更新日期：2019-11-28 00:00:00

abstract：:Tissue engineering has developed many paradigms and techniques on how to best integrate cells and extracellular matrix to create in vitro structures that replicate native tissue. The strategy best suited for building these constructs depends mainly on the target cells, tissues, and organ of interest, and how readily t...

journal_title：Stem cell research & therapy

authors： Thavandiran N,Nunes SS,Xiao Y,Radisic M

更新日期：2013-02-14 00:00:00

abstract：BACKGROUND:This prospective clinical case series aimed to investigate the safety of subretinal adipose tissue-derived mesenchymal stem cell (ADMSC) implantation in advanced stage retinitis pigmentosa (RP). METHODS:This study included 11 patients with end-stage RP who received subretinal implantation of ADMSCs. All pat...

journal_title：Stem cell research & therapy

authors： Oner A,Gonen ZB,Sinim N,Cetin M,Ozkul Y

更新日期：2016-12-01 00:00:00