Epigenetic silencing of KLF2 by long non-coding RNA SNHG1 inhibits periodontal ligament stem cell osteogenesis differentiation.

abstract：BACKGROUND:Treatment-induced cardiotoxicity is a leading noncancer-related cause of acute and late onset morbidity and mortality in cancer patients on antineoplastic drugs such as melphalan-increasing clinical case reports have documented that it could induce cardiotoxicity including severe arrhythmias and heart failur...

journal_title：Stem cell research & therapy

authors： Liu R,Li D,Sun F,Rampoldi A,Maxwell JT,Wu R,Fischbach P,Castellino SM,Du Y,Fu H,Mandawat A,Xu C

更新日期：2020-11-05 00:00:00

abstract：INTRODUCTION:Fallopian tube, which is normally discarded in surgical procedures, has proven to be a source of mesenchymal stem cells (MSCs) with increasing evidence. However, fallopian tube mucosa, which can be acquired via non-invasive procedures, is a previously unknown source of MSCs. In the present study, we explor...

journal_title：Stem cell research & therapy

authors： Wang J,Zhao Y,Wu X,Yin S,Chuai Y,Wang A

更新日期：2015-05-21 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cells (MSCs) are an attractive therapeutic agent in regenerative medicine. Recently, there has been a paradigm shift from differentiation of MSCs to their paracrine effects at the injury site. Several reports elucidate the role of trophic factors secreted by MSCs toward the repair of inju...

journal_title：Stem cell research & therapy

authors： Damania A,Jaiman D,Teotia AK,Kumar A

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells, including those derived from human adipose tissue (hASCs), are currently being widely investigated for cell therapy. However, when transplanted at the site of injury, the survival and engraftment rates of hASCs are low, mainly due to the harsh microenvironment they encounter, characte...

journal_title：Stem cell research & therapy

authors： Garrido-Pascual P,Alonso-Varona A,Castro B,Burón M,Palomares T

更新日期：2020-08-03 00:00:00

abstract：INTRODUCTION:Delivered systemically or natively circulating mesenchymal stem cells accumulate in injured tissues. During homing mesenchymal stem cells adhere to endothelial cells and infiltrate underlying tissue. Previously we have shown that adhesiveness of endothelial cells for mesenchymal stem cells correlates with ...

journal_title：Stem cell research & therapy

authors： Potapova IA,Cohen IS,Doronin SV

更新日期：2010-11-17 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated mesenchymal stem cells (MSCs) as effective mitochondrial donors with therapeutic success in multiple experimental models of human disease. MSCs obtained from different tissue sources such as bone marrow (BM), adipose (AD), dental pulp (DP), and Wharton's jelly (WJ) are routin...

journal_title：Stem cell research & therapy

authors： Paliwal S,Chaudhuri R,Agrawal A,Mohanty S

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMMSCs) are suitable cell sources for dental pulp regeneration, but the mechanism of BMMSCs differentiation into odontogenic lineage remains unknown. The aim of the present study was to reveal the role of magnesium transporter protein 1 (MagT1) and MAPK pathways in the odo...

journal_title：Stem cell research & therapy

authors： Zheng JM,Kong YY,Li YY,Zhang W

更新日期：2019-01-31 00:00:00

abstract：BACKGROUND:Cellular replacement strategies using human induced pluripotent stem cells (iPSCs) and their cardiac derivatives are emerging as novel treatments for post-myocardial infarction (MI) heart failure (HF); however, the mechanism of recovery of heart function is not very clear. The purpose of this study was to in...

journal_title：Stem cell research & therapy

authors： Jiang X,Yang Z,Dong M

更新日期：2020-07-17 00:00:00

abstract：INTRODUCTION:Increased levels of angiotensin II (Ang II) and activity of Ang II receptor type 1 (AT1R) elicit detrimental effects in cardiovascular disease. However, the role of Ang II receptor type 2 (AT2R) remains poorly defined. Mesenchymal stem cells (MSCs) replenish and repair endothelial cells in the cardiovascul...

journal_title：Stem cell research & therapy

authors： Ikhapoh IA,Pelham CJ,Agrawal DK

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:Transplantation of endothelial progenitor cells (EPCs)/endothelial cells (ECs) has been used for the treatment of ischemic diseases and hemophilia A, due to their great capacity for producing factor VIII and for repairing vascular damage. We established an effective approach to stimulate the expansion and di...

journal_title：Stem cell research & therapy

authors： Qin M,Guan X,Wang H,Zhang Y,Shen B,Zhang Q,Dai W,Ma Y,Jiang Y

更新日期：2017-02-07 00:00:00

abstract：BACKGROUND:As the population ages, an increasing number of postmenopausal women are donors of adipose stromal cells (ASCs) and may benefit from autologous ASC-related treatments. However, the effect of menopausal status on ASCs has not been investigated. METHODS:RNA sequencing data were downloaded, and differentially ...

journal_title：Stem cell research & therapy

authors： Xie Y,Fang B,Liu W,Li G,Huang RL,Zhang L,He J,Zhou S,Liu K,Li Q

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:The skeletal muscle regeneration relays on the satellite cells which are stem cells located between basal lamina and plasmalemma of muscle fiber. In the injured muscles, the satellite cells become activated, start to proliferate, and then differentiate into myoblasts, which fuse to form myotubes and finally ...

journal_title：Stem cell research & therapy

authors： Mierzejewski B,Grabowska I,Jackowski D,Irhashava A,Michalska Z,Stremińska W,Jańczyk-Ilach K,Ciemerych MA,Brzoska E

更新日期：2020-08-06 00:00:00

abstract：BACKGROUND:Complex immunophenotypic repertoires defining discrete adipose-derived stem cell (ASC) subpopulations may hold a key toward identifying predictors of clinical utility. To this end, we sorted out of the freshly established ASCs four subpopulations (SPs) according to a specific pattern of co-expression of six ...

journal_title：Stem cell research & therapy

authors： Nielsen FM,Riis SE,Andersen JI,Lesage R,Fink T,Pennisi CP,Zachar V

更新日期：2016-12-01 00:00:00

abstract：AIM:Myocardial infarction (MI) is a severe disease with increased mortality and disability rates, posing heavy economic burden for society. Exosomes were uncovered to mediate intercellular communication after MI. This study aims to explore the effect and mechanism of lncRNA KLF3-AS1 in exosomes secreted by human mesenc...

journal_title：Stem cell research & therapy

authors： Mao Q,Liang XL,Zhang CL,Pang YH,Lu YX

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:Senescent cells are undesirable in cell therapy products due to reduced therapeutic activity and risk of aberrant cellular effects, and methods for assessing senescence are needed. Early-passage mesenchymal stromal cells (MSCs) are known to be small and spindle-shaped but become enlarged upon cell aging. Ind...

journal_title：Stem cell research & therapy

authors： Oja S,Komulainen P,Penttilä A,Nystedt J,Korhonen M

更新日期：2018-01-10 00:00:00

abstract：BACKGROUND:Patients suffering from osteoporosis show an increased number of adipocytes in their bone marrow, concomitant with a reduction in the pool of human mesenchymal stem cells (hMSCs) that are able to differentiate into osteoblasts, thus leading to suppressed osteogenesis. METHODS:In order to be able to interfer...

journal_title：Stem cell research & therapy

authors： van Zoelen EJ,Duarte I,Hendriks JM,van der Woning SP

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:The proangiogenic capacity of adipose tissue and its derivatives has been demonstrated in a variety of studies. The paracrine mechanism of the cellular component is considered to play a critical role in the regenerative properties of these tissues. However, cell-based therapy for clinical application has bee...

journal_title：Stem cell research & therapy

authors： Yu Z,Cai Y,Deng M,Li D,Wang X,Zheng H,Xu Y,Li W,Zhang W

更新日期：2018-11-08 00:00:00

abstract：INTRODUCTION:Adipose tissue-derived stromal cells (ADSCs) are abundant and easy to obtain, but the diversity of differentiation potential from different locations may vary with the developmental origin of their mesenchymal compartment. We therefore aim to compare the myogenic differentiation and reparative activity of ...

journal_title：Stem cell research & therapy

authors： Wang X,Zhang H,Nie L,Xu L,Chen M,Ding Z

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Silicon-modified biomaterials have been extensively studied in bone tissue engineering. In recent years, the toxicity of silicon-doped biomaterials has gradually attracted attention but requires further elucidation. This study was designed to explore whether high-dose silicate can induce a cytotoxicity effec...

journal_title：Stem cell research & therapy

authors： Li Z,Liu S,Fu T,Peng Y,Zhang J

更新日期：2019-11-27 00:00:00

abstract：:Cognitive deficit has been identified in one third of patients affected by Duchenne Muscular Dystrophy, primarily attributed to loss of the short Dp71 dystrophin, the major brain dystrophin isoform. In this study, we investigated for the first time the Dp71 and Dp71-associated proteins cellular localization and expres...

journal_title：Stem cell research & therapy

authors： Ruggieri S,Viggiano L,Annese T,Rubolino C,Gerbino A,De Zio R,Corsi P,Tamma R,Ribatti D,Errede M,Operto F,Margari L,Resta N,Di Tommaso S,Rosati J,Trojano M,Nico B

更新日期：2019-01-15 00:00:00

abstract：:The use of secretome may be a new strand of cell therapy, which is equal to or even superior to the injection of live cells, called cell-free therapy. In ovarian transplantation, this approach may be a therapeutic possibility for the ovarian graft in hypoxia. We designed the present study to evaluate whether the cell-...

journal_title：Stem cell research & therapy

authors： Damous LL,de Carvalho AETS,Nakamuta JS,Shiroma ME,Louzada ACS,Soares-Jr JM,Krieger JE,Baracat EC

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:Mesenchymal stromal/stem cells derived from human umbilical cord (UC-MSCs) uniquely combine properties of embryonic and postnatal MSCs and may be the most acceptable, safe, and effective source for allogeneic cell therapy e.g. for therapeutic angiogenesis. In this report we describe pro-angiogenic properties...

journal_title：Stem cell research & therapy

authors： Arutyunyan I,Fatkhudinov T,Kananykhina E,Usman N,Elchaninov A,Makarov A,Bolshakova G,Goldshtein D,Sukhikh G

更新日期：2016-03-22 00:00:00

abstract：:The original article [1] contains an error in Fig. 5 whereby sub-Fig. 5c, d & 5e are mistakenly mixed-up. ...

journal_title：Stem cell research & therapy

authors： Zuo R,Liu M,Wang Y,Li J,Wang W,Wu J,Sun C,Li B,Wang Z,Lan W,Zhang C,Shi C,Zhou Y

更新日期：2020-01-23 00:00:00

abstract：BACKGROUND:Sepsis is a global inflammatory disease that causes death. It has been reported that mesenchymal stem cell (MSC) treatment can attenuate inflammatory and septic symptoms. In this study, we investigated how interactions between neutrophils and human umbilical cord blood (hUCB)-MSCs in the liver of septic mice...

journal_title：Stem cell research & therapy

authors： Ahn SY,Maeng YS,Kim YR,Choe YH,Hwang HS,Hyun YM

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal cells currently tested for multiple therapeutic purposes. Their potential to home into tumors, to secrete trophic/vasculogenic factors, and to suppress immune response raises questions regarding their biosafety. Our aim was to evaluate wheth...

journal_title：Stem cell research & therapy

authors： Bruna F,Plaza A,Arango M,Espinoza I,Conget P

更新日期：2018-05-11 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) are multipotent and have been derived from various tissues. Although MSCs share many basic features, they often display subtle tissue specific differences. We previously demonstrated that bone marrow (BM) MSCs frequently become polyploid in culture. This tendency was mediated ...

journal_title：Stem cell research & therapy

authors： Ravid O,Shoshani O,Sela M,Weinstock A,Sadan TW,Gur E,Zipori D,Shani N

更新日期：2014-12-17 00:00:00

abstract：INTRODUCTION:Short-term neural stem cell (NSC) transplantation improves cognition in Alzheimer's disease (AD) transgenic mice by enhancing endogenous synaptic connectivity. However, this approach has no effect on the underlying beta-amyloid (Aβ) and neurofibrillary tangle pathology. Long term efficacy of cell based app...

journal_title：Stem cell research & therapy

authors： Blurton-Jones M,Spencer B,Michael S,Castello NA,Agazaryan AA,Davis JL,Müller FJ,Loring JF,Masliah E,LaFerla FM

更新日期：2014-04-16 00:00:00

abstract：BACKGROUND:The development of cellular therapies to treat muscle wastage with disease or age is paramount. Resident muscle satellite cells are not currently regarded as a viable cell source due to their limited migration and growth capability ex vivo. This study investigated the potential of muscle-derived PW1+/Pax7- i...

journal_title：Stem cell research & therapy

authors： Cottle BJ,Lewis FC,Shone V,Ellison-Hughes GM

更新日期：2017-07-04 00:00:00

abstract：:Stem cell therapy has been applied in many fields. Basic and clinical studies on stem cell therapy for acute kidney injury (AKI) have been conducted. Stem cells have been found to exert renal protection through a variety of mechanisms, such as regulating the immune system and secreting growth factors, cytokines, and e...

journal_title：Stem cell research & therapy

authors： Wang SY,Hong Q,Zhang CY,Yang YJ,Cai GY,Chen XM

更新日期：2019-09-03 00:00:00

abstract：INTRODUCTION:Chronic wounds are a major health-care issue, but research is limited by the complexity and heterogeneity in terms of wound etiology as well as patient-related factors. A suitable animal model that replicates the situation in humans is not available. Therefore, the aim of the present work is to present a s...

journal_title：Stem cell research & therapy

authors： Wettstein R,Savic M,Pierer G,Scheufler O,Haug M,Halter J,Gratwohl A,Baumberger M,Schaefer DJ,Kalbermatten DF

更新日期：2014-01-29 00:00:00