Enhanced renoprotective effect of GDNF-modified adipose-derived mesenchymal stem cells on renal interstitial fibrosis.

abstract：:Mesenchymal stem cells have been used for cardiovascular regenerative therapy for decades. These cells have been established as one of the potential therapeutic agents, following several tests in animal models and clinical trials. In the process, various sources of mesenchymal stem cells have been identified which hel...

journal_title：Stem cell research & therapy

authors： Singh A,Singh A,Sen D

更新日期：2016-06-04 00:00:00

abstract：INTRODUCTION:Cell-based therapy represents a new frontier in the treatment of a wide variety of human diseases traditionally associated with morbidity outcomes, including those involving inflammation, autoimmunity, tissue damage, and cancer. However, the use of mesenchymal stem cells (MSCs) to treat multiple myeloma (M...

journal_title：Stem cell research & therapy

authors： Atsuta I,Liu S,Miura Y,Akiyama K,Chen C,An Y,Shi S,Chen FM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory ...

journal_title：Stem cell research & therapy

authors： Li Y,Xu J,Shi W,Chen C,Shao Y,Zhu L,Lu W,Han X

更新日期：2016-10-28 00:00:00

abstract：AIM:Myocardial infarction (MI) is a severe disease with increased mortality and disability rates, posing heavy economic burden for society. Exosomes were uncovered to mediate intercellular communication after MI. This study aims to explore the effect and mechanism of lncRNA KLF3-AS1 in exosomes secreted by human mesenc...

journal_title：Stem cell research & therapy

authors： Mao Q,Liang XL,Zhang CL,Pang YH,Lu YX

更新日期：2019-12-17 00:00:00

abstract：INTRODUCTION:Osteopontin (OPN) is a phosphoglycoprotein with important roles in tissue homeostasis, wound healing, immune regulation, and stress responses. It is expressed constitutively in the brain and upregulated during neuroinflammatory responses; for example, after focal cerebral ischemia. To date, its effects on ...

journal_title：Stem cell research & therapy

authors： Rabenstein M,Hucklenbroich J,Willuweit A,Ladwig A,Fink GR,Schroeter M,Langen KJ,Rueger MA

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:The development of cellular therapies to treat muscle wastage with disease or age is paramount. Resident muscle satellite cells are not currently regarded as a viable cell source due to their limited migration and growth capability ex vivo. This study investigated the potential of muscle-derived PW1+/Pax7- i...

journal_title：Stem cell research & therapy

authors： Cottle BJ,Lewis FC,Shone V,Ellison-Hughes GM

更新日期：2017-07-04 00:00:00

abstract：:Temperature is an important microenvironmental factor that functions epigenetically in normal embryonic development. However, the effect of hyperthermia in the stem cells is not fully understood. Oct4 is a tightly regulated master regulator of pluripotency maintenance in stem cells and during early embryonic developme...

journal_title：Stem cell research & therapy

authors： Cheng MB,Wang X,Huang Y,Zhang Y

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem cells into IPCs in vitro, the mechanisms controlling its differentiation and function are not fully ...

journal_title：Stem cell research & therapy

authors： He F,Li N,Huang HB,Wang JB,Yang XF,Wang HD,Huang W,Li FR

更新日期：2020-04-28 00:00:00

abstract：INTRODUCTION:Idiopathic pulmonary fibrosis is a progressive diffuse parenchymal lung disorder of unknown etiology. Mesenchymal stem cell (MSC)-based therapy is a novel approach with great therapeutic potential for the treatment of lung diseases. Despite demonstration of MSC grafting, the populations of engrafted MSCs h...

journal_title：Stem cell research & therapy

authors： Lan YW,Choo KB,Chen CM,Hung TH,Chen YB,Hsieh CH,Kuo HP,Chong KY

更新日期：2015-05-20 00:00:00

abstract：BACKGROUND:Although adult human tissue-derived epidermal stem cells are capable of differentiating into enamel-secreting ameloblasts and forming teeth with regenerated enamel when recombined with mouse dental mesenchyme that possesses odontogenic potential, the induction rate is relatively low. In addition, whether the...

journal_title：Stem cell research & therapy

authors： Hu X,Lee JW,Zheng X,Zhang J,Lin X,Song Y,Wang B,Hu X,Chang HH,Chen Y,Lin CP,Zhang Y

更新日期：2018-05-02 00:00:00

abstract：OBJECTIVE:Autologous bone marrow stem cell (ABMSC) transplantation has been considered a promising option for hepatitis B virus-related cirrhosis (HBV-C). Although an analysis of the published literature has been performed, the exact effects and safety have yet to be systematically investigated. METHODS:We conducted a...

journal_title：Stem cell research & therapy

authors： Sun A,Gao W,Xiao T

更新日期：2020-03-05 00:00:00

abstract：BACKGROUND:Critical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly diminishing oxygen and nutrient supply. CLI patients usually undergo amputation of fingers, feet, or ex...

journal_title：Stem cell research & therapy

authors： Beltran-Camacho L,Jimenez-Palomares M,Rojas-Torres M,Sanchez-Gomar I,Rosal-Vela A,Eslava-Alcon S,Perez-Segura MC,Serrano A,Antequera-González B,Alonso-Piñero JA,González-Rovira A,Extremera-García MJ,Rodriguez-Piñero M,Moreno-Lu

更新日期：2020-03-06 00:00:00

abstract：BACKGROUND:The skeletal muscle regeneration relays on the satellite cells which are stem cells located between basal lamina and plasmalemma of muscle fiber. In the injured muscles, the satellite cells become activated, start to proliferate, and then differentiate into myoblasts, which fuse to form myotubes and finally ...

journal_title：Stem cell research & therapy

authors： Mierzejewski B,Grabowska I,Jackowski D,Irhashava A,Michalska Z,Stremińska W,Jańczyk-Ilach K,Ciemerych MA,Brzoska E

更新日期：2020-08-06 00:00:00

abstract：BACKGROUND:In recent years, adipose-derived stromal cells (ASCs) have been heavily studied for soft tissue regeneration, augmentation, and dermal wound healing. METHODS:In this review, we investigated the trends in injectable scaffolds for ASC delivery in the dermis, and injectable or implantable scaffolds for ASC del...

journal_title：Stem cell research & therapy

authors： Mamsen FP,Munthe-Fog L,Kring MKM,Duscher D,Taudorf M,Katz AJ,Kølle ST

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Skin is an organ that plays an important role as a physical barrier and has many other complex functions. Skin mimetics may be useful for studying the pathophysiology of diseases in vitro and for repairing lesions in vivo. Cord blood mononuclear cells (CBMCs) have emerged as a potential cell source for regen...

journal_title：Stem cell research & therapy

authors： Kim Y,Park N,Rim YA,Nam Y,Jung H,Lee K,Ju JH

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:Urine-derived stem cells (USCs) are a valuable stem cell source for tissue engineering because they can be harvested non-invasively. Small intestine submucosa (SIS) has been used as scaffolds for soft tissue repair in the clinic. However, the feasibility and efficacy of a combination of USCs and SIS for skin...

journal_title：Stem cell research & therapy

authors： Zhang XR,Huang YZ,Gao HW,Jiang YL,Hu JG,Pi JK,Chen AJ,Zhang Y,Zhou L,Xie HQ

更新日期：2020-04-06 00:00:00

abstract：INTRODUCTION:Nervous system injuries comprise a diverse group of disorders that include traumatic brain injury (TBI). The potential of mesenchymal stem cells (MSCs) to differentiate into neural cell types has aroused hope for the possible development of autologous therapies for central nervous system injury. METHODS:I...

journal_title：Stem cell research & therapy

authors： Nichols JE,Niles JA,DeWitt D,Prough D,Parsley M,Vega S,Cantu A,Lee E,Cortiella J

更新日期：2013-01-06 00:00:00

abstract：BACKGROUND:Epidermal grafting using cells derived from pluripotent stem cells will change the face of this side of regenerative cutaneous medicine. To date, the safety of the graft would be the major unmet deal in order to implement long-term skin grafting. In this context, experiments on large animals appear unavoidab...

journal_title：Stem cell research & therapy

authors： Domingues S,Masson Y,Marteyn A,Allouche J,Perrier AL,Peschanski M,Martinat C,Baldeschi C,Lemaître G

更新日期：2017-12-19 00:00:00

abstract：:Tissues characterized by constant turnover contain post-mitotic, terminally differentiated cells originating from highly proliferative progenitors, which in turn derive from a relatively small population of stem cells. At the population level, self-renewal and differentiation are the possible outcomes of stem cell pro...

journal_title：Stem cell research & therapy

authors： Sottocornola R,Lo Celso C

更新日期：2012-03-19 00:00:00

abstract：:Evidence suggests that transdifferentiation of mesenchymal stem cells (MSCs) into various neuronal cells contributes to functional recovery after experimental spinal cord injury. Qiu et al. have recently published an exciting article in Stem Cell Research & Therapy demonstrating the transdifferentiation of already dif...

journal_title：Stem cell research & therapy

authors： Chelluboina B,Dinh DH,Veeravalli KK

更新日期：2015-10-05 00:00:00

abstract：BACKGROUND:Unresolved inflammation and tissue destruction are considered to underlie the failure of dental pulp repair. As key mediators of the injury response, dental pulp stem cells (DPSCs) play a critical role in pulp tissue repair and regeneration. Resolvin E1 (RvE1), a major dietary omega-3 polyunsaturated fatty-a...

journal_title：Stem cell research & therapy

authors： Chen J,Xu H,Xia K,Cheng S,Zhang Q

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:Although endothelial progenitor cells (EPCs) contribute to wound repair by promoting neovascularization, the mechanism of EPC-mediated wound healing remains poorly understood due to the lack of pivotal molecular targets of dermal wound repair. METHODS AND RESULTS:We found that genetic targeting of the Lnk g...

journal_title：Stem cell research & therapy

authors： Lee JH,Ji ST,Kim J,Takaki S,Asahara T,Hong YJ,Kwon SM

更新日期：2016-10-28 00:00:00

abstract：INTRODUCTION:Facing the challenging treatment of neurodegenerative diseases as well as complex craniofacial injuries such as those common after cancer therapy, the field of regenerative medicine increasingly relies on stem cell transplantation strategies. Here, neural crest-derived stem cells (NCSCs) offer many promisi...

journal_title：Stem cell research & therapy

authors： Greiner JF,Grunwald LM,Müller J,Sudhoff H,Widera D,Kaltschmidt C,Kaltschmidt B

更新日期：2014-03-14 00:00:00

abstract：BACKGROUND:C-kit-positive cardiac stem cells (CSCs) have been shown to be a promising candidate treatment for myocardial infarction and heart failure. Insulin-like growth factor (IGF)-1 is an anabolic growth hormone that regulates cellular proliferation, differentiation, senescence, and death in various tissues. Althou...

journal_title：Stem cell research & therapy

authors： Sun Y,Xu R,Huang J,Yao Y,Pan X,Chen Z,Ma G

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:In the brain of adult mammals, neural stem cells persist in the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus, which are specialized niches with proliferative capacity. Most neural stem cells are in a quiescent state, but in response to extrinsic stimuli, they can...

journal_title：Stem cell research & therapy

authors： Li W,Wang S,He H,Qin J,Cheng X,Zhao H,Tian M,Zhang X,Jin G

更新日期：2021-01-09 00:00:00

abstract：:The efficacy of tendon-derived stem cells (TDSCs) for the promotion of tendon and tendon-bone junction repair has been reported in animal studies. Modulation of the tendon stem cell niche in vivo has also been reported to influence tendon structure. There is a need to have specific and reliable markers that can define...

journal_title：Stem cell research & therapy

authors： Lui PP

更新日期：2015-06-02 00:00:00

abstract：BACKGROUND:Emerging evidence suggests that neural crest-derived cells (NCCs) present important functions in peripheral nerve regeneration to correct the insufficiency of autogenous Schwann cells. Postmigratory NCCs have been successfully isolated from adult rat bone marrow in our previous work. In this study, we aim to...

journal_title：Stem cell research & therapy

authors： Shi H,Li X,Yang J,Zhao Y,Xue C,Wang Y,He Q,Shen M,Zhang Q,Yang Y,Ding F

更新日期：2019-12-18 00:00:00

abstract：BACKGROUND:Due to their intrinsic properties, stem cells are promising tools for new developments in tissue engineering and particularly for cartilage tissue regeneration. Although mesenchymal stromal/stem cells from bone marrow (BM-MSC) have long been the most used stem cell source in cartilage tissue engineering, the...

journal_title：Stem cell research & therapy

authors： Reppel L,Schiavi J,Charif N,Leger L,Yu H,Pinzano A,Henrionnet C,Stoltz JF,Bensoussan D,Huselstein C

更新日期：2015-12-30 00:00:00

abstract：BACKGROUND:Autologous cellular immunotherapy or immune enhancement therapy has demonstrated some promising benefits for prostate cancer. T cell-based immunotherapy or sipuleucel-T therapy has yielded certain beneficial responses and a slight improvement on the overall survival of patients with metastatic castration-res...

journal_title：Stem cell research & therapy

authors： Wang Z,Li Y,Wang Y,Wu D,Lau AHY,Zhao P,Zou C,Dai Y,Chan FL

更新日期：2020-03-17 00:00:00

abstract：BACKGROUND:The proangiogenic capacity of adipose tissue and its derivatives has been demonstrated in a variety of studies. The paracrine mechanism of the cellular component is considered to play a critical role in the regenerative properties of these tissues. However, cell-based therapy for clinical application has bee...

journal_title：Stem cell research & therapy

authors： Yu Z,Cai Y,Deng M,Li D,Wang X,Zheng H,Xu Y,Li W,Zhang W

更新日期：2018-11-08 00:00:00