Establishment of a complex skin structure via layered co-culture of keratinocytes and fibroblasts derived from induced pluripotent stem cells.

abstract：:Over the last two decades, a new therapeutic paradigm has emerged which has changed the way debilitating diseases may be treated in the future. Instead of using small-molecule drugs and devices to ameliorate the symptoms of disease, clinicians may harness the therapeutic power of cells to regenerate and cure diseases ...

journal_title：Stem cell research & therapy

authors： O'Brien T,Creane M,Windebank AJ,Terzic A,Dietz AB

更新日期：2015-08-22 00:00:00

abstract：BACKGROUND:Cellular replacement strategies using human induced pluripotent stem cells (iPSCs) and their cardiac derivatives are emerging as novel treatments for post-myocardial infarction (MI) heart failure (HF); however, the mechanism of recovery of heart function is not very clear. The purpose of this study was to in...

journal_title：Stem cell research & therapy

authors： Jiang X,Yang Z,Dong M

更新日期：2020-07-17 00:00:00

abstract：INTRODUCTION:Nervous system injuries comprise a diverse group of disorders that include traumatic brain injury (TBI). The potential of mesenchymal stem cells (MSCs) to differentiate into neural cell types has aroused hope for the possible development of autologous therapies for central nervous system injury. METHODS:I...

journal_title：Stem cell research & therapy

authors： Nichols JE,Niles JA,DeWitt D,Prough D,Parsley M,Vega S,Cantu A,Lee E,Cortiella J

更新日期：2013-01-06 00:00:00

abstract：BACKGROUND:This prospective clinical case series aimed to investigate the safety of subretinal adipose tissue-derived mesenchymal stem cell (ADMSC) implantation in advanced stage retinitis pigmentosa (RP). METHODS:This study included 11 patients with end-stage RP who received subretinal implantation of ADMSCs. All pat...

journal_title：Stem cell research & therapy

authors： Oner A,Gonen ZB,Sinim N,Cetin M,Ozkul Y

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:No comparative study of adipose-derived stem cells (ADSCs) and bone marrow mesenchymal stem cells (BMSCs) by using superparamagnetic iron oxide nanoparticles (SPIOs)-labeling and magnetic resonance imaging (MRI) has been performed. METHODS:We studied the biological activity and MRI of ADSCs by labeling th...

journal_title：Stem cell research & therapy

authors： Fan J,Tan Y,Jie L,Wu X,Yu R,Zhang M

更新日期：2013-04-23 00:00:00

abstract：INTRODUCTION:Administration of bone marrow-derived cells produces beneficial effects in experimental extrapulmonary acute respiratory distress syndrome (ARDS). However, there are controversies regarding the effects of timing of cell administration and initial insult severity on inflammatory response. We evaluated the e...

journal_title：Stem cell research & therapy

authors： Maron-Gutierrez T,Silva JD,Cruz FF,Alegria S,Xisto DG,Assis EF,Castro-Faria-Neto HC,Dos Santos CC,Morales MM,Rocco PR

更新日期：2013-10-13 00:00:00

abstract：BACKGROUND:Inner ear supporting cells (SCs) in the neonatal mouse cochlea are a potential source for hair cell (HC) regeneration, but several studies have shown that the regeneration ability of SCs decreases dramatically as mice age and that lost HCs cannot be regenerated in adult mice. To better understand how SCs mig...

journal_title：Stem cell research & therapy

authors： Cheng C,Wang Y,Guo L,Lu X,Zhu W,Muhammad W,Zhang L,Lu L,Gao J,Tang M,Chen F,Gao X,Li H,Chai R

更新日期：2019-12-02 00:00:00

abstract：:Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a membrane-enclosed intercellular delivery system with the potential to improve the therapeutic efficacy of the treatment of a variety of disorders. As the i...

journal_title：Stem cell research & therapy

authors： Hegyesi H,Sándor N,Sáfrány G,Lovas V,Kovács Á,Takács A,Kőhidai L,Turiák L,Kittel Á,Pálóczi K,Bertók L,Buzás EI

更新日期：2019-10-29 00:00:00

abstract：BACKGROUND:Using a toxin-induced nonhuman primate model of acute liver failure (ALF), we previously reported that peripheral infusion of human umbilical cord mesenchymal stem cells (hUC-MSCs) strongly suppresses the activation of circulating monocytes and interleukin-6 (IL-6) production, thereby disrupting the developm...

journal_title：Stem cell research & therapy

authors： Shao M,Xu Q,Wu Z,Chen Y,Shu Y,Cao X,Chen M,Zhang B,Zhou Y,Yao R,Shi Y,Bu H

更新日期：2020-01-23 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMSC) transfer has been attempted as a therapeutic strategy in experimental lung injury and fibrosis. Reduction of neutrophilic infiltration is one of the mechanisms involved in this effect. However, the mechanisms by which BMSC modulate neutrophil remains unknown. METHOD...

journal_title：Stem cell research & therapy

authors： Su X,Yang L,Yin Y,Huang J,Qiao F,Fang Y,Yu L,Wang Y,Zhou K,Wang J

更新日期：2018-09-26 00:00:00

abstract：INTRODUCTION:Bone marrow (BM) stroma currently represents the most common and investigated source of mesenchymal progenitor cells (MPCs); however, comparable adult progenitor or stem cells have also been isolated from a wide variety of tissues. This study aims to assess the functional similarities of MPCs from differen...

journal_title：Stem cell research & therapy

authors： Djouad F,Jackson WM,Bobick BE,Janjanin S,Song Y,Huang GT,Tuan RS

更新日期：2010-05-04 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects female fertility. However, with the lack of a corresponding research model, the pathology mechanism of PCOS is poorly understood. Induced pluripotent stem cell (iPSC) technology has been recognized as means to generate...

journal_title：Stem cell research & therapy

authors： Min Z,Gao Q,Zhen X,Fan Y,Tan T,Li R,Zhao Y,Yu Y

更新日期：2018-08-09 00:00:00

abstract：BACKGROUND:Although endothelial progenitor cells (EPCs) contribute to wound repair by promoting neovascularization, the mechanism of EPC-mediated wound healing remains poorly understood due to the lack of pivotal molecular targets of dermal wound repair. METHODS AND RESULTS:We found that genetic targeting of the Lnk g...

journal_title：Stem cell research & therapy

authors： Lee JH,Ji ST,Kim J,Takaki S,Asahara T,Hong YJ,Kwon SM

更新日期：2016-10-28 00:00:00

abstract：:The potential use of stem cells for cell-based tissue repair and regeneration offers alternative therapeutic strategies for various diseases. Adipose-derived stem cells (ADSCs) have emerged as a promising source of stem cells suitable for transplantation in regenerative medicine and wound repair. A recent publication ...

journal_title：Stem cell research & therapy

authors： Gupta MK,Ajay AK

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Bone reconstruction in congenital craniofacial differences, which affect about 2-3% of newborns, has long been the focus of intensive research in the field of bone tissue engineering. The possibility of using mesenchymal stromal cells in regenerative medicine protocols has opened a new field of investigation...

journal_title：Stem cell research & therapy

authors： Bueno DF,Kabayashi GS,Pinheiro CCG,Tanikawa DYS,Raposo-Amaral CE,Rocha DL,Ferreira JRM,Shibuya Y,Hokugo A,Jarrahy R,ZuK PA,Passos-Bueno MR

更新日期：2020-11-25 00:00:00

abstract：:Adipogenesis is essential in in vitro experimentation to assess differentiation capability of stem cells, and therefore, its accurate measurement is important. Quantitative analysis of adipogenic levels, however, is challenging and often susceptible to errors due to non-specific reading or manual estimation by observe...

journal_title：Stem cell research & therapy

authors： Yuan C,Chakraborty S,Chitta KK,Subramanian S,Lim TE,Han W,Bhanu Prakash KN,Sugii S

更新日期：2019-01-22 00:00:00

abstract：BACKGROUND:One of the most severe complications of the current COVID-19 pandemic is acute respiratory distress syndrome (ARDS). ARDS is caused by increased amounts of pro-inflammatory cytokines, leading to lung damage and loss of lung function. There are currently no effective therapies for combatting ARDS. Mesenchymal...

journal_title：Stem cell research & therapy

authors： Kaspi H,Semo J,Abramov N,Dekel C,Lindborg S,Kern R,Lebovits C,Aricha R

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated that intravenous administration of adipose tissue stem cells (ASCs) could significantly reduce allergic symptoms and suppress eosinophilic inflammation. METHODS:To evaluate the secretome of ASCs, we administrated culture supernatant of ASCs (ASC sup, which contains the A...

journal_title：Stem cell research & therapy

authors： Yu HS,Park MK,Kang SA,Cho KS,Mun SJ,Roh HJ

更新日期：2017-01-23 00:00:00

abstract：INTRODUCTION:Impaction allograft with cement is a common technique used in revision hip surgeries for the last 20 years. However, its clinical results are inconsistent. Recent studies have shown that mesenchymal stem cells (MSCs) seeded onto allograft can enhance bone formation. This in vitro study investigates whether...

journal_title：Stem cell research & therapy

authors： Reissis Y,García-Gareta E,Korda M,Blunn GW,Hua J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Spermatogonial stem cell transplantation (SSCT) could become a fertility restoration tool for childhood cancer survivors. However, since in mice, the colonization efficiency of transplanted spermatogonial stem cells (SSCs) is only 12%, the efficiency of the procedure needs to be improved before clinical impl...

journal_title：Stem cell research & therapy

authors： Kadam P,Ntemou E,Baert Y,Van Laere S,Van Saen D,Goossens E

更新日期：2018-11-21 00:00:00

abstract：:Temperature is an important microenvironmental factor that functions epigenetically in normal embryonic development. However, the effect of hyperthermia in the stem cells is not fully understood. Oct4 is a tightly regulated master regulator of pluripotency maintenance in stem cells and during early embryonic developme...

journal_title：Stem cell research & therapy

authors： Cheng MB,Wang X,Huang Y,Zhang Y

更新日期：2020-05-24 00:00:00

abstract：INTRODUCTION:Octamer-binding transcription factor 4 (Oct4) is a master regulator of early mammalian development. Its expression begins from the oocyte stage, becomes restricted to the inner cell mass of the blastocyst and eventually remains only in primordial germ cells. Unearthing the interactions of Oct4 would provid...

journal_title：Stem cell research & therapy

authors： Cheong CY,Lon Ng PM,Ponnampalam R,Tsai HH,Bourque G,Lufkin T

更新日期：2011-05-13 00:00:00

abstract：INTRODUCTION:Therapeutic potentials of mesenchymal stem cells (MSCs) from different sources have been evaluated in pre-clinical and clinical settings. Although MSCs from different sources share MSC-specific characteristics and functions, inconsistent or controversial results of pre-clinical and clinical applications of...

journal_title：Stem cell research & therapy

authors： Zhu Y,Yang Y,Zhang Y,Hao G,Liu T,Wang L,Yang T,Wang Q,Zhang G,Wei J,Li Y

更新日期：2014-04-10 00:00:00

abstract：BACKGROUND:Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular matrix changes, reduced hydration, and progressive degeneration. Cell-based IVD therapy has emerged as an area of great interest, with studies reportin...

journal_title：Stem cell research & therapy

authors： Tang R,Jing L,Willard VP,Wu CL,Guilak F,Chen J,Setton LA

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Mesenchymal stromal/stem cells derived from human umbilical cord (UC-MSCs) uniquely combine properties of embryonic and postnatal MSCs and may be the most acceptable, safe, and effective source for allogeneic cell therapy e.g. for therapeutic angiogenesis. In this report we describe pro-angiogenic properties...

journal_title：Stem cell research & therapy

authors： Arutyunyan I,Fatkhudinov T,Kananykhina E,Usman N,Elchaninov A,Makarov A,Bolshakova G,Goldshtein D,Sukhikh G

更新日期：2016-03-22 00:00:00

abstract：BACKGROUND:Stress urinary incontinence (SUI) is a common and bothersome condition. Invasive surgery will always be considered after conservative treatment fails, but the rates of postoperative complications and long-term recurrence are high. Thus, a new treatment strategy is still needed. In recent years, bone marrow m...

journal_title：Stem cell research & therapy

authors： Zhang H,Huang J,Liu J,Li Y,Gao Y

更新日期：2020-07-16 00:00:00

abstract：INTRODUCTION:Endothelial dysfunction is found in different pathologies such as diabetes and renal and heart diseases, representing one of the major health problems. The reduced vasodilation of impaired endothelium starts a prothrombotic state associated with irregular blood flow. We aimed to explore the potential of am...

journal_title：Stem cell research & therapy

authors： Schiavo AA,Franzin C,Albiero M,Piccoli M,Spiro G,Bertin E,Urbani L,Visentin S,Cosmi E,Fadini GP,De Coppi P,Pozzobon M

更新日期：2015-10-31 00:00:00

abstract：INTRODUCTION:Cell-based therapy represents a new frontier in the treatment of a wide variety of human diseases traditionally associated with morbidity outcomes, including those involving inflammation, autoimmunity, tissue damage, and cancer. However, the use of mesenchymal stem cells (MSCs) to treat multiple myeloma (M...

journal_title：Stem cell research & therapy

authors： Atsuta I,Liu S,Miura Y,Akiyama K,Chen C,An Y,Shi S,Chen FM

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Advances in tendon engineering with mesenchymal stem cells (MSCs) are hindered by a need for cues to direct tenogenesis, and markers to assess tenogenic state. We examined the effects of factors involved in embryonic tendon development on adult MSCs, and compared MSC responses to that of embryonic tendon p...

journal_title：Stem cell research & therapy

authors： Brown JP,Galassi TV,Stoppato M,Schiele NR,Kuo CK

更新日期：2015-05-09 00:00:00

abstract：BACKGROUND:Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they regulate carcinogenesis is poorly understood. We hypothesize that the cytotoxic bile acids may promot...

journal_title：Stem cell research & therapy

authors： Farhana L,Nangia-Makker P,Arbit E,Shango K,Sarkar S,Mahmud H,Hadden T,Yu Y,Majumdar AP

更新日期：2016-12-01 00:00:00