Pre-conditioned mesenchymal stem cells: a better way for cell-based therapy.

abstract：BACKGROUND:Inner ear supporting cells (SCs) in the neonatal mouse cochlea are a potential source for hair cell (HC) regeneration, but several studies have shown that the regeneration ability of SCs decreases dramatically as mice age and that lost HCs cannot be regenerated in adult mice. To better understand how SCs mig...

journal_title：Stem cell research & therapy

authors： Cheng C,Wang Y,Guo L,Lu X,Zhu W,Muhammad W,Zhang L,Lu L,Gao J,Tang M,Chen F,Gao X,Li H,Chai R

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Although adult human tissue-derived epidermal stem cells are capable of differentiating into enamel-secreting ameloblasts and forming teeth with regenerated enamel when recombined with mouse dental mesenchyme that possesses odontogenic potential, the induction rate is relatively low. In addition, whether the...

journal_title：Stem cell research & therapy

authors： Hu X,Lee JW,Zheng X,Zhang J,Lin X,Song Y,Wang B,Hu X,Chang HH,Chen Y,Lin CP,Zhang Y

更新日期：2018-05-02 00:00:00

abstract：INTRODUCTION:The bursa subacromialis (BS) provides the gliding mechanism of the shoulder and regenerates itself after surgical removal. Therefore, we explored the presence of mesenchymal stem cells (MSCs) within the human adult BS tissue and characterized the BS cells compared to MSCs from bone marrow (BMSCs) on a mole...

journal_title：Stem cell research & therapy

authors： Steinert AF,Kunz M,Prager P,Göbel S,Klein-Hitpass L,Ebert R,Nöth U,Jakob F,Gohlke F

更新日期：2015-06-03 00:00:00

abstract：BACKGROUND:Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem cells into IPCs in vitro, the mechanisms controlling its differentiation and function are not fully ...

journal_title：Stem cell research & therapy

authors： He F,Li N,Huang HB,Wang JB,Yang XF,Wang HD,Huang W,Li FR

更新日期：2020-04-28 00:00:00

abstract：:The original article [1] contains an error in Fig. 5 whereby sub-Fig. 5c, d & 5e are mistakenly mixed-up. ...

journal_title：Stem cell research & therapy

authors： Zuo R,Liu M,Wang Y,Li J,Wang W,Wu J,Sun C,Li B,Wang Z,Lan W,Zhang C,Shi C,Zhou Y

更新日期：2020-01-23 00:00:00

abstract：BACKGROUND:Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and human induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC...

journal_title：Stem cell research & therapy

authors： Liao S,Zhang Y,Ting S,Zhen Z,Luo F,Zhu Z,Jiang Y,Sun S,Lai WH,Lian Q,Tse HF

更新日期：2019-03-07 00:00:00

abstract：BACKGROUND:Efficient and sustained hematopoietic recovery after hematopoietic stem cell or bone marrow transplantation is supported by paracrine signaling from specific subpopulations of mesenchymal stromal cells (MSCs). Here, we considered whether in vitro mechanopriming of human MSCs could be administered to predicti...

journal_title：Stem cell research & therapy

authors： Liu FD,Tam K,Pishesha N,Poon Z,Van Vliet KJ

更新日期：2018-10-24 00:00:00

abstract：OBJECTIVE:Autologous bone marrow stem cell (ABMSC) transplantation has been considered a promising option for hepatitis B virus-related cirrhosis (HBV-C). Although an analysis of the published literature has been performed, the exact effects and safety have yet to be systematically investigated. METHODS:We conducted a...

journal_title：Stem cell research & therapy

authors： Sun A,Gao W,Xiao T

更新日期：2020-03-05 00:00:00

abstract：BACKGROUND:The dog represents an excellent large animal model for translational cell-based studies. Importantly, the properties of canine multipotent stromal cells (cMSCs) and the ideal tissue source for specific translational studies have yet to be established. The aim of this study was to characterize cMSCs derived f...

journal_title：Stem cell research & therapy

authors： Bearden RN,Huggins SS,Cummings KJ,Smith R,Gregory CA,Saunders WB

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory ...

journal_title：Stem cell research & therapy

authors： Li Y,Xu J,Shi W,Chen C,Shao Y,Zhu L,Lu W,Han X

更新日期：2016-10-28 00:00:00

abstract：:Because of their multi/pluripotency and immunosuppressive properties, mesenchymal stem/stromal cells (MSCs) are important tools for treating immune disorders and for tissue repair. The increasing use of MSCs, their definition as advanced-therapy medicinal products in European regulations, and the US Food and Drug Admi...

journal_title：Stem cell research & therapy

authors： Sensebé L,Gadelorge M,Fleury-Cappellesso S

更新日期：2013-06-07 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) were shown to harbor therapeutic potential in models of respiratory diseases, such as bronchopulmonary dysplasia (BPD), the most common sequel of preterm birth. In these studies, cells or animals were challenged with hyperoxia or other injury-inducing agents. However, little is ...

journal_title：Stem cell research & therapy

authors： Obendorf J,Fabian C,Thome UH,Laube M

更新日期：2020-12-09 00:00:00

abstract：OBJECTIVES:Mesenchymal stem cells (MSCs) have been intensively investigated as to their therapeutic potentials. However, the full chemical-defined medium supporting the isolation and expansion of human MSCs has not been developed yet. MATERIALS AND METHODS:Here, we developed the full chemical-defined medium, NBVbe med...

journal_title：Stem cell research & therapy

authors： Xu J,Lian W,Chen J,Li W,Li L,Huang Z

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:Application of genetically modified hematopoietic stem cells is increasingly mooted as a clinically relevant approach to protein replacement therapy, immune tolerance induction or conditions where both outcomes may be helpful. Hematopoietic stem and progenitor cell (HSPC)-mediated gene therapy often requires...

journal_title：Stem cell research & therapy

authors： Bhatt KH,Rudraraju R,Brooks JF,Jung JW,Galea R,Wells JW,Steptoe RJ

更新日期：2017-03-09 00:00:00

abstract：:The original article [1] contained errors in the presentation of Figure 7. ...

journal_title：Stem cell research & therapy

authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Critical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly diminishing oxygen and nutrient supply. CLI patients usually undergo amputation of fingers, feet, or ex...

journal_title：Stem cell research & therapy

authors： Beltran-Camacho L,Jimenez-Palomares M,Rojas-Torres M,Sanchez-Gomar I,Rosal-Vela A,Eslava-Alcon S,Perez-Segura MC,Serrano A,Antequera-González B,Alonso-Piñero JA,González-Rovira A,Extremera-García MJ,Rodriguez-Piñero M,Moreno-Lu

更新日期：2020-03-06 00:00:00

abstract：INTRODUCTION:Osteopontin (OPN) is a phosphoglycoprotein with important roles in tissue homeostasis, wound healing, immune regulation, and stress responses. It is expressed constitutively in the brain and upregulated during neuroinflammatory responses; for example, after focal cerebral ischemia. To date, its effects on ...

journal_title：Stem cell research & therapy

authors： Rabenstein M,Hucklenbroich J,Willuweit A,Ladwig A,Fink GR,Schroeter M,Langen KJ,Rueger MA

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:For adipose-derived stromal cells (ASCs) to be safe for use in the clinical setting, they need to be prepared using good manufacturing practices (GMPs). Fetal bovine serum (FBS), used to expand ASCs in vitro in some human clinical trials, runs the risk of xenoimmunization and zoonotic disease transmission. T...

journal_title：Stem cell research & therapy

authors： Dessels C,Ambele MA,Pepper MS

更新日期：2019-08-14 00:00:00

abstract：BACKGROUND:Senescent cells are undesirable in cell therapy products due to reduced therapeutic activity and risk of aberrant cellular effects, and methods for assessing senescence are needed. Early-passage mesenchymal stromal cells (MSCs) are known to be small and spindle-shaped but become enlarged upon cell aging. Ind...

journal_title：Stem cell research & therapy

authors： Oja S,Komulainen P,Penttilä A,Nystedt J,Korhonen M

更新日期：2018-01-10 00:00:00

abstract：AIM:Myocardial infarction (MI) is a severe disease with increased mortality and disability rates, posing heavy economic burden for society. Exosomes were uncovered to mediate intercellular communication after MI. This study aims to explore the effect and mechanism of lncRNA KLF3-AS1 in exosomes secreted by human mesenc...

journal_title：Stem cell research & therapy

authors： Mao Q,Liang XL,Zhang CL,Pang YH,Lu YX

更新日期：2019-12-17 00:00:00

abstract：INTRODUCTION:Stem cells have been evaluated as a potential therapeutic approach for several neurological disorders of the central and peripheral nervous system as well as for traumatic brain and spinal cord injury. Currently, the lack of a reliable and safe method to accurately and non-invasively locate the site of imp...

journal_title：Stem cell research & therapy

authors： Micci MA,Boone DR,Parsley MA,Wei J,Patrikeev I,Motamedi M,Hellmich HL

更新日期：2015-07-21 00:00:00

abstract：INTRODUCTION:Fetal bovine serum (FBS) is an animal product used as a medium supplement. The animal origin of FBS is a concern if cultured stem cells are to be utilized for human cell therapy. Therefore, a substitute for FBS is desirable. In this study, an industrial, xeno-free, pharmaceutical-grade supplement for cell ...

journal_title：Stem cell research & therapy

authors： Díez JM,Bauman E,Gajardo R,Jorquera JI

更新日期：2015-03-13 00:00:00

abstract：:Cognitive deficit has been identified in one third of patients affected by Duchenne Muscular Dystrophy, primarily attributed to loss of the short Dp71 dystrophin, the major brain dystrophin isoform. In this study, we investigated for the first time the Dp71 and Dp71-associated proteins cellular localization and expres...

journal_title：Stem cell research & therapy

authors： Ruggieri S,Viggiano L,Annese T,Rubolino C,Gerbino A,De Zio R,Corsi P,Tamma R,Ribatti D,Errede M,Operto F,Margari L,Resta N,Di Tommaso S,Rosati J,Trojano M,Nico B

更新日期：2019-01-15 00:00:00

abstract：BACKGROUND:Apelin plays a key beneficial role in energy metabolism by increasing glucose uptake and insulin sensitivity; however, apelin has a short half-life because it is rapidly cleared from the circulation limiting its therapeutic benefit. The aim of this study is to create a new approach to treat type 2 diabetes b...

journal_title：Stem cell research & therapy

authors： Gao LR,Zhang NK,Zhang Y,Chen Y,Wang L,Zhu Y,Tang HH

更新日期：2018-12-07 00:00:00

abstract：INTRODUCTION:A feature which makes stem cells promising candidates for cell therapy is their ability to migrate effectively into damaged or diseased tissues. Recent reports demonstrated the increased motility of human mesenchymal stem cells (hMSC) grown under hypoxic conditions compared to normoxic cells. However, the ...

journal_title：Stem cell research & therapy

authors： Vertelov G,Kharazi L,Muralidhar MG,Sanati G,Tankovich T,Kharazi A

更新日期：2013-01-07 00:00:00

abstract：INTRODUCTION:Stem cell-based therapies are currently widely explored as a tool to treat neuroimmune diseases. Multipotent adult progenitor cells (MAPC) have been suggested to have strong immunomodulatory and neuroprotective properties in several experimental models. In this study, we investigate whether MAPC are of the...

journal_title：Stem cell research & therapy

authors： Ravanidis S,Bogie JF,Donders R,Craeye D,Mays RW,Deans R,Gijbels K,Bronckaers A,Stinissen P,Pinxteren J,Hellings N

更新日期：2015-09-16 00:00:00

abstract：BACKGROUND:Within the last years, the interest in physical exercise as non-invasive stimulus influencing circulating hematopoietic stem and progenitor cell (CPC) concentrations has constantly grown. Cell estimates are often derived by determining the subgroup of CPC as percent lymphocytes (LYM) or mononuclear cells (MN...

journal_title：Stem cell research & therapy

authors： Kröpfl JM,Schmid M,Di Marzio Y,Schreiber K,Spengler CM

更新日期：2019-10-17 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) are an attractive cell source for cell therapy in cartilage. Although their therapeutic potential is clear, the requirements and conditions for effective induction of chondrogenesis in MSCs and for the production of a stable cartilaginous tissue by these cells are far from ...

journal_title：Stem cell research & therapy

authors： Boeuf S,Richter W

更新日期：2010-10-13 00:00:00

abstract：BACKGROUND:Currently, the overall therapeutic efficiency of mesenchymal stem cells (MSCs) transplantation for the treatment of cardiovascular disease is not satisfactory. The low viability and angiogenic capacity of the implanted cells in the local infarct tissues restrict their further application. Evidence shows that...

journal_title：Stem cell research & therapy

authors： Hou J,Wang L,Wu Q,Zheng G,Long H,Wu H,Zhou C,Guo T,Zhong T,Wang L,Chen X,Wang T

更新日期：2018-04-19 00:00:00

abstract：:Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a membrane-enclosed intercellular delivery system with the potential to improve the therapeutic efficacy of the treatment of a variety of disorders. As the i...

journal_title：Stem cell research & therapy

authors： Hegyesi H,Sándor N,Sáfrány G,Lovas V,Kovács Á,Takács A,Kőhidai L,Turiák L,Kittel Á,Pálóczi K,Bertók L,Buzás EI

更新日期：2019-10-29 00:00:00