abstract::It remains unclear whether limitations in activities of daily living (ADL) increase the risk of stroke in older Chinese adults. This longitudinal study used data from the Chinese Longitudinal Healthy Longevity Survey to investigate the effects of limitations in ADL on the incidence of stroke in older adults. Between 2...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.320994
更新日期:2022-03-01 00:00:00
abstract::Despite the recognized significance of reversible protein lipidation (S-acylation) for T cell receptor signal transduction, the enzymatic control of this post-translational modification in T cells remains poorly understood. Here, we demonstrate that DHHC21 (also known as ZDHHC21), a member of the DHHC family of mammal...
journal_title:Journal of cell sciencepub_type: 杂志文章
doi:10.1242/jcs.258186
更新日期:2022-03-01 00:00:00
abstract::Hypoxic preconditioning can protect against cerebral ischemia/reperfusion injury. However, the underlying mechanisms that mediate this effect are not completely clear. In this study, mice were pretreated with continuous, intermittent hypoxic preconditioning; 1 hour later, cerebral ischemia/reperfusion models were gene...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.314317
更新日期:2022-02-01 00:00:00
abstract::[This corrects the article DOI: 10.4103/1673-5374.276359]. ...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.314115
更新日期:2022-02-01 00:00:00
abstract::[This corrects the article DOI: 10.3969/j.issn.1673-5374.2013.30.006]. ...
journal_title:Neural regeneration researchpub_type: 杂志文章,撤回出版物
doi:10.4103/1673-5374.317993
更新日期:2022-02-01 00:00:00
abstract::Human memory is prone to error and distortion. Schacter (1999, 2001) proposed that memory's misdeeds can be classified into seven categories or "sins". This article discusses the impact of media and technology on four memory sins, transience (forgetting over time), absent-mindedness (lapses in attention that produce f...
journal_title:Memory, mind & mediapub_type: 杂志文章
doi:10.1017/mem.2021.3
更新日期:2022-01-01 00:00:00
abstract::The three-dimensional (3D) organization of the genome is shaped by interactions with multiple structures within the nucleus, affecting gene expression outcomes. Technological breakthroughs in recent years have generated vast data reflecting various aspects of nuclear genome architecture in space and time. Integrating ...
journal_title:Methods in molecular biology (Clifton, N.J.)pub_type: 杂志文章
doi:10.1007/978-1-0716-1390-0_18
更新日期:2022-01-01 00:00:00
abstract::Breast cancer has five major immune types; luminal A, luminal B, HER2, Basal-like, and normal-like. Cells produce a family of protein called heat shock proteins (Hsps) in response to exposure to thermal and other proteotoxic stresses play essential roles in cancer metabolism and this large family shows a diverse set o...
journal_title:Methods in molecular biology (Clifton, N.J.)pub_type: 杂志文章
doi:10.1007/978-1-0716-1170-8_15
更新日期:2022-01-01 00:00:00
abstract::Microbial communities are key components of all ecosystems, but characterization of their complete genomic structure remains challenging. Typical analysis tends to elude the complexity of the mixes in terms of species, strains, as well as extrachromosomal DNA molecules. Recently, approaches have been developed that bi...
journal_title:Methods in molecular biology (Clifton, N.J.)pub_type: 杂志文章
doi:10.1007/978-1-0716-1390-0_8
更新日期:2022-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of noncoding RNAs of 17-22 nucleotides in length with a critical function in posttranscriptional gene regulation. These master regulators are themselves subject to regulation both transcriptionally and posttranscriptionally. Recently, miRNA function has been shown to be modulated by exog...
journal_title:Methods in molecular biology (Clifton, N.J.)pub_type: 杂志文章
doi:10.1007/978-1-0716-1170-8_5
更新日期:2022-01-01 00:00:00
abstract::Standard tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detect the presence of viral RNA using real-time reverse transcription (rRT)-PCR. Recently, convenient, rapid, and relatively inexpensive SARS-CoV-2 antigen (Ag) detection methods have been developed. The STANDARD Q COVID-19 Ag test (SD Bi...
journal_title:Annals of laboratory medicinepub_type: 杂志文章
doi:10.3343/alm.2022.42.1.100
更新日期:2022-01-01 00:00:00
abstract::Immunoassays are powerful qualitative and quantitative analytical techniques. Since the first description of an immunoassay method in 1959, advances have been made in assay designs and analytical characteristics, opening the door for their widespread implementation in clinical laboratories. Clinical endocrinology is c...
journal_title:Annals of laboratory medicinepub_type: 杂志文章,评审
doi:10.3343/alm.2022.42.1.3
更新日期:2022-01-01 00:00:00
abstract::Spinal cord injury (SCI) is associated with high production and excessive accumulation of pathological 4-hydroxy-trans-2-nonenal (4-HNE), a reactive aldehyde, formed by SCI-induced metabolic dysregulation of membrane lipids. Reactive aldehyde load causes redox alteration, neuroinflammation, neurodegeneration, pain-lik...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.314312
更新日期:2022-01-01 00:00:00
abstract::Glaucoma, a progressive age-related optic neuropathy characterized by the death of retinal ganglion cells, is the most common neurodegenerative cause of irreversible blindness worldwide. The therapeutic management of glaucoma, which is limited to lowering intraocular pressure, is still a challenge since visual loss pr...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.314308
更新日期:2022-01-01 00:00:00
abstract::This study evaluated the performance of 6 commercially available hard hat designs-differentiated by shell design, number of suspension points, and suspension tightening system-in regard to their ability to attenuate accelerations during vertical impacts to the head. Tests were conducted with impactor materials of stee...
journal_title:Journal of applied biomechanicspub_type: 杂志文章
doi:10.1123/jab.2020-0182
更新日期:2021-12-29 00:00:00
abstract:BACKGROUND:Phase 3 clinical studies showed non-inferiority of long-acting intramuscular cabotegravir and rilpivirine dosed every 4 weeks to oral antiretroviral therapy. Important phase 2 results of every 8 weeks dosing, and supportive modelling, underpin further evaluation of every 8 weeks dosing in this trial, which h...
journal_title:Lancet (London, England)pub_type: 杂志文章
doi:10.1016/S0140-6736(20)32666-0
更新日期:2021-12-19 00:00:00
abstract:BACKGROUND:Older adults (aged ≥70 years) are at increased risk of severe disease and death if they develop COVID-19 and are therefore a priority for immunisation should an efficacious vaccine be developed. Immunogenicity of vaccines is often worse in older adults as a result of immunosenescence. We have reported the im...
journal_title:Lancet (London, England)pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/S0140-6736(20)32466-1
更新日期:2021-12-19 00:00:00
abstract:OBJECTIVES:To explore the potential of SARS-CoV-2 spread during air travel and the risk of in-flight transmission. METHODS:We enrolled all passengers and crew suspected of being infected with SARS-CoV-2, who bounded for Beijing on international flights. We specified the characteristics of all confirmed cases of COVID-...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1973084
更新日期:2021-12-01 00:00:00
abstract::In this paper, we introduce three within-host and one within-vector models of Zika virus. The within-host models are the target cell limited model, the target cell limited model with natural killer (NK) cells class, and a within-host-within-fetus model of a pregnant individual. The within-vector model includes the Zik...
journal_title:Journal of biological dynamicspub_type: 杂志文章
doi:10.1080/17513758.2021.1970261
更新日期:2021-12-01 00:00:00
abstract::An earlier described three-component variant of the Castagnoli-Cushman reaction employing homophthalic anhydrides, carbonyl compound and ammonium acetate was applied towards the preparation of 1-oxo-3,4-dihydroisoquinoline-4-carboxamides with variable substituent in position 3. These compounds displayed inhibitory act...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1969386
更新日期:2021-12-01 00:00:00
abstract:...
journal_title:Animal science journal = Nihon chikusan Gakkaihopub_type: 杂志文章
doi:10.1111/asj.13611
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Online video learning has been gaining substantial attention in medical education. The purpose of the study was to evaluate medical students' online video-viewing patterns as well as to identify features associated with their class style preferences in precision medicine courses. METHODS:A mixed methods res...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1967441
更新日期:2021-12-01 00:00:00
abstract::There has been renewed interest in the use of low titer group O whole blood (LTOWB) for the resuscitation of civilian casualties. LTOWB offers several advantages over conventional components such as providing balanced resuscitation in one bag that contains less additive/preservative solution than an equivalent volume ...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1967257
更新日期:2021-12-01 00:00:00
abstract:PURPOSE:This study aimed to describe extended collaboration in situations when an ambulance was called, as experienced by older patients, a significant other, and ambulance- and primary healthcare (PHC) centre personnel. METHODS:The study used a phenomenological reflective lifeworld research (RLR) approach. Participan...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1970095
更新日期:2021-12-01 00:00:00
abstract::The primary aim of this study was to determine if self-reported occupational noise exposure was associated with Raynaud's phenomenon. In northern Sweden, a nested case-control study was performed on subjects reporting Raynaud's phenomenon (N=461), and controls (N=763) matched by age, sex and geographical location. The...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1969745
更新日期:2021-12-01 00:00:00
abstract::Immune cell infiltration (ICI) plays a pivotal role in the development of diabetic nephropathy (DN). Evidence suggests that immune-related genes play an important role in the initiation of inflammation and the recruitment of immune cells. However, the underlying mechanisms and immune-related biomarkers in DN have not ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1960766
更新日期:2021-12-01 00:00:00
abstract::Some adipocytes are produced from bone marrow hematopoietic stem cells. In vitro studies previously indicated that these bone marrow-derived adipocytes (BMDAs) were generated from adipose tissue macrophage (ATM) that lose their hematopoietic markers and acquire mesenchymal markers prior to terminal adipogenic differen...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2021.1957290
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:To the best of our knowledge, the association of inflammatory parameters with hepatic hydatid disease (HD) has not been investigated in a single study. We aimed to evaluate the potential value of inflammatory indices in this disorder. METHODS:The retrospective study including 114 patients was performed from...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1966084
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:The effect of kaempferol, a regulator of oestrogen receptors, on atherosclerosis (AS) and the underlying mechanism is elusive. OBJECTIVE:To explore the effect and mechanism of kaempferol on AS. METHODS AND MATERIALS:In vivo, C57BL/6 and apolipoprotein E (APOE)-/- mice were randomly categorized into six groups...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1961823
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the effects of PPM1K rs1440581 and rs7678928 single nucleotide polymorphisms (SNPs) on the serum branched-chain amino acids (BCAAs) levels and cardiovascular disease (CVD) risk. METHODS:Anthropometric and biochemical examinations were performed at baseline and the end of 4 yea...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1965204
更新日期:2021-12-01 00:00:00
abstract:...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1963035
更新日期:2021-12-01 00:00:00
abstract::Tracking enzyme, substrate, and surfactant interactions to reach maximum reducing sugar production during enzymatic hydrolysis of plant biomass may provide a better understanding of factors that limit the lignocellulosic material degradation in native rice straw. In this study, enzymes (Cellic Ctec2 cellulase and Cell...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1961662
更新日期:2021-12-01 00:00:00
abstract::Investigators increasingly need high quality face photographs that they can use in service of their scholarly pursuits-whether serving as experimental stimuli or to benchmark face recognition algorithms. Up to now, an index of known face databases, their features, and how to access them has not been available. This ab...
journal_title:Methods in Psychology (Online)pub_type: 杂志文章
doi:10.1016/j.metip.2021.100063
更新日期:2021-12-01 00:00:00
abstract::Surra, one of the most important animal diseases with economic consequences in Asia and South America, is caused by Trypanosoma evansi. However, the mechanism of immune evasion by T. evansi has not been extensively studied. In the present study, T. evansi extracellular vesicles (TeEVs) were characterized and the role ...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1959495
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:The quantification of diabetes-related quality of life (DR-QoL) is an essential step in making Type 2 Diabetes (T2DM) self-management arrangements. The European General Practitioners Research Network (EGPRN) initiated the EUROBSTACLE study to develop a broadly conceptualised DR-QoL instrument for diverse cul...
journal_title:The European journal of general practicepub_type: 杂志文章
doi:10.1080/13814788.2021.1954615
更新日期:2021-12-01 00:00:00
abstract::Novel quinazolinones conjugated with indole acetamide (4a-c), ibuprofen (7a-e), or thioacetohydrazide (13a,b, and 14a-d) were designed to increase COX-2 selectivity. The three synthesised series exhibited superior COX-2 selectivity compared with the previously reported quinazolinones and their NSAID analogue and had e...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1956912
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:Nitric oxide (NO) plays a vital role in neurological development. As an easily accessible and non-invasive fluid, saliva hasn't been evaluated for nitrite among children with autism spectrum disorder (ASD). This study aims to quantify saliva nitrite and explore its relation with serum NO. METHODS:Saliva sam...
journal_title:Redox report : communications in free radical researchpub_type: 杂志文章
doi:10.1080/13510002.2021.1959133
更新日期:2021-12-01 00:00:00
abstract::We investigated the effects of wood kraft pulp (KP) feeding on feed digestibility and rumen fermentation of Japanese Black (JB) steer in the middle fattening stage. The feeding experiment was carried out a replicated 3 × 3 Latin square design using six JB steers (16.2 ± 0.8 months of age). Steers were fed rice straw a...
journal_title:Animal science journal = Nihon chikusan Gakkaihopub_type: 杂志文章
doi:10.1111/asj.13589
更新日期:2021-12-01 00:00:00
abstract::Control of blood retinol levels in cattle during fattening is important in the production of marbled beef. However, it is difficult to easily measure the blood retinol concentration in the field. In this study, we attempted to develop an analysis method that does not require blood cell separation and uses a compact fl...
journal_title:Animal science journal = Nihon chikusan Gakkaihopub_type: 杂志文章
doi:10.1111/asj.13606
更新日期:2021-12-01 00:00:00
abstract::Circular RNAs (circRNAs) play essential roles in the progression of human tumors, including renal cell carcinoma (RCC). The present study aimed to explore the functions and potential mechanisms of human circular RNA hsa_circRNA_101705 (circTXNDC11) in RCC. Quantitative real-time polymerase chain reaction (qRT-PCR) was...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1955579
更新日期:2021-12-01 00:00:00