Human circular RNA hsa_circRNA_101705 (circTXNDC11) regulates renal cancer progression by regulating MAPK/ERK pathway.

abstract：:Resistance development against multiple drugs is a common feature among many pathogens--including bacteria such as Pseudomonas aeruginosa, viruses, and parasites--and also among cancers. The reasons are two-fold. Most commonly-used rationally-designed small molecule drugs or monoclonal antibodies, as well as antibioti...

journal_title：Bioengineered

authors： Avner BS,Fialho AM,Chakrabarty AM

更新日期：2012-09-01 00:00:00

abstract：:The influenza virus is a respiratory pathogen with a negative-sense, segmented RNA genome. Construction of recombinant influenza viruses in the laboratory was reported starting in the 1980s. Within a short period of time, pioneer researchers had devised methods that made it possible to construct influenza viral vector...

journal_title：Bioengineered

authors： Li J,Arévalo MT,Zeng M

更新日期：2013-01-01 00:00:00

abstract：:Harmful algal blooms caused by phytoplankton can occur in all aquatic environments. Some of the algae present in these blooms are capable of producing extremely potent toxins. Due to climate change and eutrophication, harmful algal blooms are increasing on a global scale. One kind of toxin producing algae are those th...

journal_title：Bioengineered

authors： Rubiolo JA,López-Alonso H,Alfonso A,Vega FV,Vieytes MR,Botana LM

更新日期：2013-03-01 00:00:00

abstract：:Malolactic enzymes (MLE) are known to directly convert L-malic acid into L-lactic acid with a catalytical requirement of nicotinamide adenine dinucleotide (NAD (+) ) and Mn ( 2+) ; however, the reaction mechanism is still unclear. To study a MLE, the structural gene from Oenococcus oeni strain DSM 20255 was heterologo...

journal_title：Bioengineered

authors： Schümann C,Michlmayr H,Del Hierro AM,Kulbe KD,Jiranek V,Eder R,Nguyen TH

更新日期：2013-05-01 00:00:00

abstract：:Most members of the genus Bifidobacterium are commensals of the human gastrointestinal tract and some strains were shown to exert beneficial effects on their host. Based on these effects and due to their status as GRAS (generally recognized as safe) microorganisms, specific strains of bifidobacteria are marketed as pr...

journal_title：Bioengineered

authors： Brancaccio VF,Zhurina DS,Riedel CU

更新日期：2013-07-01 00:00:00

abstract：:During the production of recombinant protein products, such as monoclonal antibodies, manufacturers must demonstrate clearance of host cell impurities and contaminants to appropriate levels prior to use in the clinic. These include host cell DNA and RNA, product related contaminants such as aggregates, and importantly...

journal_title：Bioengineered

authors： Hogwood CE,Bracewell DG,Smales CM

更新日期：2013-09-01 00:00:00

abstract：:Pullulanases are endo-acting enzymes capable of hydrolyzing α-1, 6-glycosidic linkages in starch, pullulan, amylopectin, and related oligosaccharides, while amylopullulanases are bifunctional enzymes with an active site capable of cleaving both α-1, 4 and α-1, 6 linkages in starch, amylose and other oligosaccharides, ...

journal_title：Bioengineered

authors： Nisha M,Satyanarayana T

更新日期：2013-11-01 00:00:00

abstract：:Saccharomyces boulardii (S. boulardii) is a probiotic yeast related to Saccharomyces cerevisiae (S. cerevisiae) but with distinct genetic, taxonomic and metabolic properties. S. cerevisiae has been used extensively in biotechnological applications. Currently, many strains are available, and multiple genetic tools have...

journal_title：Bioengineered

authors： Douradinha B,Reis VC,Rogers MB,Torres FA,Evans JD,Marques ET Jr

更新日期：2014-01-01 00:00:00

abstract：:Saccharomyces cerevisiae shows high growth activity under low pH conditions and can be used for producing acidic chemicals such as organic acids as well as fuel ethanol. However, ethanol can also be a problematic by-product in the production of chemicals except for ethanol. We have reported that a stable low-ethanol p...

journal_title：Bioengineered

authors： Hirasawa T,Ida Y,Furuasawa C,Shimizu H

更新日期：2014-03-01 00:00:00

abstract：:There is increasing urgency in the battle against drug-resistant bacterial pathogens, and this public health crisis has created a desperate need for novel antimicrobial agents. Recombinant human lysozyme represents one interesting candidate for treating pulmonary infections, but the wild type enzyme is subject to elec...

journal_title：Bioengineered

authors： Griswold KE,Bement JL,Teneback CC,Scanlon TC,Wargo MJ,Leclair LW

更新日期：2014-03-01 00:00:00

abstract：:We recently evaluated the relationship between abiotic environmental stresses and lutein biosynthesis in the green microalga Dunaliella salina and suggested a rational design of stress-driven adaptive evolution experiments for carotenoids production in microalgae. Here, we summarize our recent findings regarding the b...

journal_title：Bioengineered

authors： Wichuk K,Brynjólfsson S,Fu W

更新日期：2014-05-01 00:00:00

abstract：:Multidrug and toxic compound extrusion (MATE) proteins help maintain cellular homeostasis by secreting metabolic wastes. Flavins may occur as cellular waste products, with their production and secretion providing potential benefit for industrial applications related to biofuel cells. Here we find that MATE protein Yee...

journal_title：Bioengineered

authors： McAnulty MJ,Wood TK

更新日期：2014-01-01 00:00:00

abstract：:Some rare inositol stereoisomers are known to exert specific health-promoting effects, including scyllo-inositol (SI), which is a promising therapeutic agent for Alzheimer disease. We recently reported a Bacillus subtilis cell factory that performed the efficient production of SI from the cheapest and most abundant is...

journal_title：Bioengineered

authors： Tanaka K,Takanaka S,Yoshida K

更新日期：2014-09-01 00:00:00

abstract：:Bioconversion of hemicellulosic hydrolysate into ethanol plays a pivotal role in the overall success of biorefineries. For the efficient fermentative conversion of hemicellulosic hydrolysates into ethanol, the use of immobilized cells system could provide the enhanced ethanol productivities with significant time savin...

journal_title：Bioengineered

authors： Milessi TS,Antunes FA,Chandel AK,da Silva SS

更新日期：2015-01-01 00:00:00

abstract：:The purine degradation pathway in humans ends with uric acid, which has low water solubility. When the production of uric acid is increased either by elevated purine intake or by impaired kidney function, uric acid will accumulate in the blood (hyperuricemia). This increases the risk of gout, a disease described in hu...

journal_title：Bioengineered

authors： Jankowska DA,Trautwein-Schult A,Cordes A,Bode R,Baronian K,Kunze G

更新日期：2015-01-01 00:00:00

abstract：:In this paper, early mouldy grain rapid prediction method using probabilistic neural network (PNN) and electronic nose (e-nose) was studied. E-nose responses to rice, red bean, and oat samples with different qualities were measured and recorded. E-nose data was analyzed using principal component analysis (PCA), back p...

journal_title：Bioengineered

authors： Ying X,Liu W,Hui G,Fu J

更新日期：2015-01-01 00:00:00

abstract：:Azurin and Laz (lipidated azurin) are 2 bacterial proteins with anticancer, anti-viral and anti-parasitic activities. Azurin, isolated from the bacterium Pseudomonas aeruginosa, termed Paz, demonstrates anticancer activity against a range of cancers but not against brain tumors. In contrast, Laz is produced by members...

journal_title：Bioengineered

authors： Hashimoto W,Ochiai A,Hong CS,Murata K,Chakrabarty AM

更新日期：2015-01-01 00:00:00

abstract：:The naturally and widely occurring sulfonium compound, S-adenosylmethionine (AdoMet), one of nature's most versatile molecules, is biosynthesized from methionine and ATP by AdoMet synthetase or methionine adenosyltransferase (MAT) in a 2-step reaction in which the energy-rich sulfonium compound is formed by dephosphor...

journal_title：Bioengineered

authors： Porcelli M,Ilisso CP,Mosca L,Cacciapuoti G

更新日期：2015-01-01 00:00:00

abstract：:A method for designing the operating parameters (surface light intensity, operating temperature and agitation rate) was proposed for microalgal protein production. Furthermore, quadratic model was established and validated (R(2) > 0.90) with experimental data. It was recorded that temperature and agitation rate were s...

journal_title：Bioengineered

authors： Imamoglu E

更新日期：2015-01-01 00:00:00

abstract：:Mannitol is contained in brown macroalgae up to 33% (w/w, dry weight), and thus is a promising carbon source for white biotechnology. However, Saccharomyces cerevisiae, a key cell factory, is generally regarded to be unable to assimilate mannitol for growth. We have recently succeeded in producing S. cerevisiae that c...

journal_title：Bioengineered

authors： Yoshida S,Tanaka H,Hirayama M,Murata K,Kawai S

更新日期：2015-01-01 00:00:00

abstract：:Ganoderma lucidum is a well-known traditional medicinal mushroom that produces ganoderic acids with numerous interesting bioactivities. Genetic engineering is an efficient approach to improve ganoderic acid biosynthesis. However, reliable genetic transformation methods and appropriate genetic manipulation strategies r...

journal_title：Bioengineered

authors： Xu JW,Zhong JJ

更新日期：2015-01-01 00:00:00

abstract：:The synthesis of renewable bioproducts using photosynthetic microorganisms holds great promise. Sustainable industrial applications, however, are still scarce and the true limits of phototrophic production remain unknown. One of the limitations of further progress is our insufficient understanding of the quantitative ...

journal_title：Bioengineered

authors： Zavřel T,Červený J,Knoop H,Steuer R

更新日期：2016-11-01 00:00:00

abstract：:The present investigation is mainly concerned with the rapid development of extracellular xylanase assay conditions by using Taguchi methodology. The extracellular xylanase was produced from Aspergillus niger (KP874102.1), a new strain isolated from a soil sample of the Baramura forest, Tripura West, India. Four physi...

journal_title：Bioengineered

authors： Prasad Uday US,Bandyopadhyay TK,Bhunia B

更新日期：2016-11-01 00:00:00

abstract：:1,3-propanediol (1,3-PD) is an important compound from which many others can be synthesized. 2,3-butanediol (BDO) is the key by-product in the biosynthesis of 1,3-PD from glycerol, but it impedes its downstream purification. In Klebsiella, the budA, budB and budC genes encode enzymes that are responsible for the synth...

journal_title：Bioengineered

authors： Lu X,Ji G,Zong H,Zhuge B

更新日期：2016-11-01 00:00:00

abstract：:ABSTACT Recombinant human Growth Hormone (rhGH) is an important protein for human growth and is in high demand in clinics. Hence, it is necessary to develop an efficient fermentation process to produce highly pure rhGH. In this study, rhGH was expressed in Escherichia coli under alkaline phosphatase (phoA) promoter. T...

journal_title：Bioengineered

authors： Song H,Jiang J,Wang X,Zhang J

更新日期：2017-03-04 00:00:00

abstract：:The brain is one of the most vulnerable organs inside the human body. Head accidents often appear in daily life and are easy to cause different level of brain damage inside the skull. Once the brain suffered intense locomotive impact, external injuries, falls, or other accidents, it will result in different degrees of...

journal_title：Bioengineered

authors： Tseng JG,Huang BW,Ou YW,Yen KT,Wu YT

更新日期：2016-07-03 00:00:00

abstract：:Cellulase mainly consisting of exo-glucanase, endo-glucanase and β-glucosidase, was considered as the most important biocatalyst for bioconversion of ethanol and other biofuels, feedstuffs and pharmaceuticals. Hydrolysis product inhibition, especially of glucose inhibition, is one of the critical difficulty awaiting t...

journal_title：Bioengineered

authors： Wang X,Wu Y,Zhou Y

更新日期：2017-03-04 00:00:00

abstract：:Pan-cancer analysis can identify cell- and tissue-specific genomic loci and regions with underlying biological functions. Here we present an online curated DNA Methylation Annotation Knowledgebase, DMAK, which includes the pan-cancer analysis results for differentially-methylated loci and regions by the Reduced Repres...

journal_title：Bioengineered

authors： Tang B

更新日期：2017-03-04 00:00:00

abstract：:Cardiovascular disorders are on the rise worldwide due to alcohol abuse, obesity, hypertension, raised blood lipids, diabetes and age-related risks. The use of classical antiplatelet and anticoagulant therapies combined with surgical intervention helped to clear blood clots during the inceptive years. However, the dis...

journal_title：Bioengineered

authors： Adivitiya,Khasa YP

更新日期：2017-07-04 00:00:00

abstract：:ABSTACT With the rapid development of bionic science, especially the progress that has been made in the fields of biomaterials and biomimetics, there is now great interest in the surface and internal mechanical properties of biological materials at the micro- and nanoscale. The study of micro- and nanoscale biomateria...

journal_title：Bioengineered

authors： Zhang Z,Jia H,Sun J,Tong J

更新日期：2016-09-02 00:00:00