Renal microvascular effects of P2 receptor stimulation.

abstract：:1. The common pathological alteration in virtually every progressive chronic kidney disease (CKD) is renal fibrosis. 2. This review focuses on some growth factors, which are particularly well-established in contributing to fibrosis, such as the profibrotic, transforming growth factor-β, and connective tissue growth fa...

journal_title：Clinical and experimental pharmacology & physiology

authors： Boor P,Floege J

更新日期：2011-07-01 00:00:00

abstract：:1. In the rectum and distal nephron, sodium reabsorption is mediated by the amiloride-sensitive epithelial sodium channel (ENaC). The ENaC-mediated sodium transport is electrogenic and creates an amiloride-sensitive transepithelial potential difference (PD). 2. We have evaluated the salt- and angiotensin (Ang)II-depen...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang Q,Horisberger JD,Maillard M,Brunner HR,Rossier BC,Burnier M

更新日期：2000-01-01 00:00:00

abstract：:1. Interactions between autacoids may play important roles in the regulation of blood flow in the foetal placenta. In order to investigate this aspect of placental haemodynamics, human normal-term placentae were perfused in vitro and the responses of the foetal vessels to various combinations of vasoactive agents were...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gude NM,King RG,Brennecke SP

更新日期：1998-09-01 00:00:00

abstract：:1. The ulcerogenesis of gastric haemorrhagic damage during sepsis is unclear. The present study first proposes that gastric haemorrhagic ulcer is modulated by mucosal glutathione, histamine and oxyradicals in lipopolysaccharide (LPS)-induced sepsis in rats. The protective effects of several drugs on the ulcerogenic pa...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hung CR

更新日期：2000-04-01 00:00:00

abstract：:Cardiac output and rhythm depend on the release and the take-up of calcium from the sarcoplasmic reticulum (SR). Excessive diastolic calcium leak from the SR due to dysfunctional calcium release channels (RyR2) contributes to the formation of delayed after-depolarizations, which underlie the fatal arrhythmias that occ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Walweel K,Oo YW,Laver DR

更新日期：2017-01-01 00:00:00

abstract：:1. The aim of the present study was to determine the relationship between plasma levels of nitrite/nitrite (NO(x)) and brachial flow-mediated dilation (FMD) in healthy young men and women. 2. Brachial artery FMD was assessed non-invasively using high-resolution ultrasound in 36 young men and women (21 +/- 3 years; 18 ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Casey DP,Beck DT,Braith RW

更新日期：2007-12-01 00:00:00

abstract：:1. The effect of cicletanine, a novel antihypertensive agent with natriuretic activity, on blood pressure and progression of renal failure of 5/6 nephrectomized spontaneously hypertensive rats with salt loading was examined. 2. All nephrectomized rats were randomly assigned to one of four groups and their diet was cha...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nakamoto H,Suzuki H,Ohishi A,Katsumata H,Sakaguchi H,Saruta T

更新日期：1999-03-01 00:00:00

abstract：:Pathogenic inflammation mediated by overactive type 1 helper T cell (Th1) responses could exacerbate and perpetuate Crohn's disease. Programmed death (PD)-1 and its ligand PD-L1 pathway could be upregulated to suppress inflammation. We wondered why this pathway is ineffective at suppressing pathogenic Th1 inflammation...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ma F,Zhao M,Song Z,Wang Z

更新日期：2019-09-01 00:00:00

abstract：:1. The present study sought to explain the mechanism leading to reduced availability of propranolol when given after a priming dose in the single-pass perfused rat liver. 2. Extracellular sucrose space (as a measure of sinusoidal relaxation) in perfused rat liver before and after propranolol or propranolol and N(G)-ni...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu X,Zou Y,Khlentzos AM,Yang Y,Nikolovski J,Weiss M,Roberts MS

更新日期：2010-10-01 00:00:00

abstract：:1. Over the past 50 years considerable evidence has been reported suggesting that endogenous opioids participate in the control of renal function. 2. Exogenous administration of opioids produces profound changes in the renal excretion of water and sodium. 3. Opioids produce changes in urine output and urine sodium exc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kapusta DR

更新日期：1995-12-01 00:00:00

abstract：:The neuropeptide oxytocin (OXT) has been implicated in the pathophysiology of behavioural deficits among patients with autism spectrum disorder (ASD). However, the molecular mechanisms underlying its role in ASD remain unclear. In the present study, a murine model with ASD-like phenotypes was induced by intra-medial a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang Y,Zhao S,Wu Z,Feng Y,Zhao C,Zhang C

更新日期：2015-05-01 00:00:00

abstract：:1. Using a nested case-control study of 661 non-institutionalized elderly (> or = 60 years) residents of Dubbo, New South Wales, Australia, the aim of this study is to determine whether the A1166C polymorphism of the angiotensin II type I (AT1) receptor gene is associated with hypertension in the elderly. 2. Individua...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liyou N,Davis D,James K,Simons L,Friedlander Y,Simons J,McCallum J,Johnson A

更新日期：1999-07-01 00:00:00

abstract：:This study explored the effects and mechanisms of dopamine D1 receptors (DR1) activation on the apoptosis of osteosarcoma cells (OS732).The DR1 agonist SKF-38393 decreased the viability of OS732 cells and increased their rate of apoptosis, whereas the DR1 antagonist SCH-23390 abolished the effects of SKF-38393. In OS7...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gao J,Gao F

更新日期：2017-11-01 00:00:00

abstract：:1. Alpha-terpineol is a monoterpene found in the essential oils of several aromatic plant species. In the present study, we investigated the mechanisms underlying the cardiovascular changes induced by alpha-terpineol in rats. 2. In normotensive rats, administration of alpha-terpineol (1, 5, 10, 20 and 30 mg/kg, i.v.) ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ribeiro TP,Porto DL,Menezes CP,Antunes AA,Silva DF,De Sousa DP,Nakao LS,Braga VA,Medeiros IA

更新日期：2010-08-01 00:00:00

abstract：:1. Rabbits were treated with the antiparasitic drug ivermectin at subcutaneous doses of 0.2, 1 and 2.5 mg/kg and blood collected weekly for 4 weeks thereafter for measuring some blood parameters. At a dose of 0.2 or 1 mg/kg the drug had no significant effect on any of the parameters measured. At a dose of 2.5 mg/kg, t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ali BH

更新日期：1990-10-01 00:00:00

abstract：:1. Piretanide is a new loop diuretic resembling furosemide. The effects of this diuretic on various parameters of renal function and on the excretion of the major ions were studied on anaesthetized, hydrated rats. 2. Piretanide induced a marked diuresis and increased sodium, potassium, chloride and calcium excretion. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nguyen-Simonnet H,Gauthier C,Pellet M

更新日期：1981-07-01 00:00:00

abstract：:1. The most usual form of chronic hypoxia in humans is the intermittent hypoxia resulting from obstructive sleep apnoea (OSA). The OSA syndrome is a highly prevalent sleep breathing disorder that is considered an independent risk factor for hypertension and cardiovascular diseases. Endothelial dysfunction, oxidative s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iturriaga R,Moya EA,Del Rio R

更新日期：2009-12-01 00:00:00

abstract：:1. The antitumour effect of orally administered cordycepin, a component isolated from water extracts of Cordyceps sinensis, was examined in mice inoculated with B16 melanoma (B16-BL6) cells. 2. B16-BL6 (1 x 10(6)) cells were inoculated subcutaneously into the right footpad of mice. At 2 weeks after the cell inoculatio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yoshikawa N,Nakamura K,Yamaguchi Y,Kagota S,Shinozuka K,Kunitomo M

更新日期：2004-12-01 00:00:00

abstract：:1. The present study aimed to determine the feasibility of conducting a 5 year cardiovascular outcome trial of the treatment of 6000 elderly hypertensive patients in Australian general practices. 2. General practitioners (GPs) were invited to participate by mail and personal follow-up. Patient records were reviewed to...

journal_title：Clinical and experimental pharmacology & physiology

authors： Reid CM,Nelson M,Beckinsale P,Ryan P,Wing LM,Beilin LJ,Brown MA,Jennings GL,Johnston CI,Marley J,McNeil JJ,Morgan TO,Shaw J,Steven ID,West MJ

更新日期：1997-05-01 00:00:00

abstract：:This study hypothesized that different types of anaesthesia management would result in similar postoperative sleep quality. In this prospective single-blind investigation, 219 patients undergoing elective thoracic surgery were randomized into three arms: general anaesthesia, as the control group (group C); general ana...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tan WF,Guo B,Ma H,Li XQ,Fang B,Lv HW

更新日期：2016-03-01 00:00:00

abstract：:1. The differential identification of the angiotensin AT1A and AT1B receptor subtypes is impaired by the existing>96% homology of both receptors. In the present study, we characterized two polyclonal rabbit peptide antibodies, namely alpha-AT1A and alpha-AT1B, that recognize the C-terminal region of mouse AT1A and AT1...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hoffmann A,Cool DR

更新日期：2005-11-01 00:00:00

abstract：:1. CYP2C19 is a polymorphism of cytochrome P450, which is responsible for the metabolism of many drugs. The genetic polymorphism shows interethnic variation and it has been demonstrated that the frequency of poor metabolizers (PM) and the distribution of alleles of CYP2C19 vary among Chinese ethnic nationalities. The ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang JH,Li PQ,Fu QY,Li QX,Cai WW

更新日期：2007-05-01 00:00:00

abstract：:1. Insulin-liposomes of four different lipid combinations were given intragastrically to normal rats on twenty occasions and to diabetic rats on 164 occasions. 2. Normal rats showed no hypoglycaemic response to either sonicated or unsonicated liposomes. 3. Diabetic rats failed to respond to sonicated liposomes but six...

journal_title：Clinical and experimental pharmacology & physiology

authors： Shenfield GM,Hill JC

更新日期：1982-07-01 00:00:00

abstract：:1. The present study was designed to determine the effects of ginkgolide A, ginkgolide B and quercetin on CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes. 2. Hepatocytes were pretreated with ginkgolide A, ginkgolide B and quercetin (at 1, 3, 10 and 30 micromol/L) for 48 h and then...

journal_title：Clinical and experimental pharmacology & physiology

authors： He N,Cai HB,Xie HG,Collins X,Edeki TI,Strom SC

更新日期：2007-07-01 00:00:00

abstract：:1. Hepatic sulphobromophthalein (BSP) transport was studied in guinea-pigs pretreated intraperitoneally with 0.7 ml of diethyl maleate to depress hepatic glutathione levels. 2. Diethyl maleate depressed the hepatic transport of infused conjugated BSP from hepatocytes into bile without influencing hepatic uptake. 3. Un...

journal_title：Clinical and experimental pharmacology & physiology

authors： Whelan G

更新日期：1980-11-01 00:00:00

abstract：:1. Infusion of salbutamol (3.0 microgram/min after a bolus injection of 100 microgram) produced hypokalaemia in conscious dogs. 2. Measurement of arterial and coronary sinus potassium differences revealed no significant potassium loss from the heart with established hypokalaemia. 3. Shortly after the initial salbutamo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wahlqvist ML,Shanahan EA,Dennis PM,Pullan PT,Wilmshurst EG

更新日期：1978-11-01 00:00:00

abstract：:1. Ethamsylate (diethylammonium 2,5-dihydroxybenzene sulfonate, Dicynene), a systemic haemostatic agent with an unknown mechanism of action, was tested for anti-inflammatory activity using the carrageenan-induced rat paw oedema test. 2. Ethamsylate was shown to be an effective anti-inflammatory agent with a time cours...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gard PR,Trigger DJ

更新日期：1990-12-01 00:00:00

abstract：:1. During the destruction of articular cartilage, fibrinolytic enzymes and matrix metalloproteinases (MMP) may contribute to the related pathology. The activities, antigens and messenger RNA (mRNA) levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in articular cartilage...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kikuchi H,Shimada W,Nonaka T,Ueshima S,Tanaka S

更新日期：1996-10-01 00:00:00

abstract：:1. To investigate whether the difference in the SA gene expression in the kidneys is causally related to the pathogenesis of hypertension, we reassessed the expression of the SA gene in the kidneys of the spontaneously hypertensive rat (SHR), its stroke-prone substrain (SHRSP) and Wistar-Kyoto (WKY) rat from different...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ishinaga Y,Nabika T,Shimada T,Hiraoka J,Nara Y,Yamori Y

更新日期：1997-01-01 00:00:00

abstract：:1. Sulfur dioxide (SO(2) ) has recently been found to have various biological effects on the cardiovascular system. The present study was designed to explore the effects of SO(2) derivatives on the L-type calcium current (I (Ca, L) ) in isolated rat ventricular cardiomyocytes. 2. A Langendorf system was used to dissoc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang RY,Du JB,Sun Y,Chen S,Tsai HJ,Yuan L,Li L,Tang CS,Jin HF

更新日期：2011-07-01 00:00:00