Piretanide and urinary excretion of ions in rat. Effect of indomethacin.

abstract：:1. Using the electromagnetic flow probe and the radioactive microsphere technique, systemic and regional haemodynamic variables were measured in conscious normotensive and hypertensive rabbits. The rabbits were made hypertensive by unilateral nephrectomy combined with cellophane-wrapping of the remaining kidney and sy...

journal_title：Clinical and experimental pharmacology & physiology

authors： van Boom M,Saxena PR

更新日期：1981-05-01 00:00:00

abstract：:1. A method is described which allows the determination of liquid junction potentials between biological fluid samples of less than 1 nL with a reproducibility of 10%. This was achieved by use of a micro-method and the use of 3% agarose added to the electrolyte in the measuring electrodes. 2. Validation was performed ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sugo E,Györy AZ

更新日期：1989-07-01 00:00:00

abstract：:1. The aim of the present study was to examine the effect of bacterial lipopolysaccharide (LPS) on the disposition of an organic anion transporting polypeptide and P-glycoprotein substrate in the rat isolated perfused liver. 2. Male Sprague-Dawley rats were divided into four groups. Three of the groups received 1, 2.5...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tong Y,Zhang R,Ngo SN,Davey AK

更新日期：2006-08-01 00:00:00

abstract：:1. The development of microneurography, in which an insulated tungsten microelectrode is inserted into an accessible peripheral or cranial nerve in awake human subjects, has allowed detailed analyses of the signalling capacities of single mechanoreceptive afferents from the skin, muscles and joints. For example, we kn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Macefield VG

更新日期：2005-01-01 00:00:00

abstract：:1. The contractile effects of tea polyphenols (TP) and its four principle catechins, namely (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC) and (-)-epigallocatechin-3-gallate (EGCG), on rat aorta contractility were investigated using the isometric tension recording technique. 2. At co...

journal_title：Clinical and experimental pharmacology & physiology

authors： Shen JZ,Zheng XF,Wei EQ,Kwan CY

更新日期：2003-01-01 00:00:00

abstract：:Alcohol-induced hypertension is well recognized with clear evidence for a direct pressor effect of chronic alcohol consumption provided by a number of intervention studies in humans. In experimental animals, the effect of alcohol on blood pressure is less consistent; however, in Sprague-Dawley rats, alcohol feeding co...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cowpland C,Su GM,Murray M,Puddey IB,Croft KD

更新日期：2006-03-01 00:00:00

abstract：:1. Acute myocardial infarction (AMI) is strongly associated with atherosclerosis, and is responsible for significant morbidity and mortality worldwide. The pathogenic mechanisms that underlie atherosclerosis and AMI are undefined at present. The calcium-sensing receptor (CaSR) is a member of the superfamily of G-prote...

journal_title：Clinical and experimental pharmacology & physiology

authors： Guo J,Li HZ,Zhang WH,Wang LC,Wang LN,Zhang L,Li GW,Li HX,Yang BF,Wu L,Wang R,Xu CQ

更新日期：2010-03-01 00:00:00

abstract：:1. The administration of aldosterone to adrenalectomized rats produces an increase in K+ and decrease in Na+ excretion in the urine. The relationship of the post-aldosterone to the pre-aldosterone urinary sodium and potassium excretion is termed the renal response to aldosterone. 2. The administration of L-dopa enhanc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Adam WR

更新日期：1979-01-01 00:00:00

abstract：:1. The aim of the present study was to assess the bioequivalence of two cefadroxil products, namely Ultracef (a reference product) in the form of a 500 mg capsule (produced by Bristol-Myers Squibb Laboratories, Princeton, NJ, USA) and Roxil (a test product) in the form of a 500 mg capsule (produced by Tabuk Pharmaceut...

journal_title：Clinical and experimental pharmacology & physiology

authors： Otoom S,Hasan M,Najib N

更新日期：2004-07-01 00:00:00

abstract：:Bone is a remarkable living tissue that provides a framework for animal body support and motion. However, under excessive loads and deformations, bone is prone is to damage through fracture. Furthermore, once the bone is weakened by osteoporosis, bone fracture can occur even after only minimal trauma. Various techniqu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang L,Richardson M,Mendis P

更新日期：2012-08-01 00:00:00

abstract：:1. The influence of the passive force on the contraction and endothelium-dependent relaxation in aortae of normotensive Wistar Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP) were compared. 2. Force changes of endothelium-intact and -removed preparations were measured isometrically by a force...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sekiguchi F,Adachi T,Matsubara H,Matsuda K,Kita K,Shimamura K,Sunano S

更新日期：1996-06-01 00:00:00

abstract：:According to Guyton's model, impaired renal sodium excretion plays a key role in the increased salt sensitivity of blood pressure (BP). Several factors contribute to impaired renal sodium excretion, including the sympathetic nervous system, the renin-angiotensin system and aldosterone. Accumulating evidence suggests t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kawarazaki W,Fujita T

更新日期：2013-12-01 00:00:00

abstract：:1. Medullary blood flow (MBF) is important in the long-term control of arterial pressure. However, it is unclear which vascular elements regulate MBF. 2. Exogenous endothelin (ET)-1 decreases cortical more than medullary blood flow. We hypothesized that ET-1 would therefore constrict afferent (AA) and efferent arterio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Denton KM,Shweta A,Finkelstein L,Flower RL,Evans RG

更新日期：2004-08-01 00:00:00

abstract：:1. The effects of reserpine pretreatment on neurotransmission in the guinea-pig vas deferens have been re-examined with a view to study the role of noradrenaline (NA) in mediating postjunctional electrical responses and, in particular, excitatory junction potentials (EJP). 2. Reserpine (5 mg/kg, i.p.) caused almost to...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cunnane TC,Manchanda R

更新日期：1989-06-01 00:00:00

abstract：:1. During the destruction of articular cartilage, fibrinolytic enzymes and matrix metalloproteinases (MMP) may contribute to the related pathology. The activities, antigens and messenger RNA (mRNA) levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in articular cartilage...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kikuchi H,Shimada W,Nonaka T,Ueshima S,Tanaka S

更新日期：1996-10-01 00:00:00

abstract：:The chemosensitive cardiac vagal and sympathetic afferent reflexes are implicated in driving pathophysiological changes in sympathetic nerve activity (SNA) in cardiovascular disease states. This study investigated the impact of sex and ovarian hormones on the chemosensitive cardiac afferent reflex. Experiments were pe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pinkham MI,Barrett CJ

更新日期：2015-06-01 00:00:00

abstract：:1. The present study examined whether or not cilostazol reduces the myocardial infarct size, and investigated its mechanism in a rabbit model of myocardial infarction. 2. Japanese white rabbits underwent 30 min of coronary occlusion, followed by 48 h of reperfusion. Cilostazol (1 and 5 mg/kg) or vehicle was given intr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bai Y,Muqier,Murakami H,Iwasa M,Sumi S,Yamada Y,Ushikoshi H,Aoyama T,Nishigaki K,Takemura G,Uno B,Minatoguchi S

更新日期：2011-10-01 00:00:00

abstract：:1. Angiotensin (Ang) II plays a major role in vascular remodelling. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in the tissue remodelling processes. The aim of the present study was to investigate whether AngII modulates TIMP-2 expression in rat aortic smooth muscle cells in vivo....

journal_title：Clinical and experimental pharmacology & physiology

authors： Castoldi G,di Gioia CR,Travaglini C,Busca G,Redaelli S,Bombardi C,Stella A

更新日期：2007-03-01 00:00:00

abstract：:1. Rabbits were treated with the antiparasitic drug ivermectin at subcutaneous doses of 0.2, 1 and 2.5 mg/kg and blood collected weekly for 4 weeks thereafter for measuring some blood parameters. At a dose of 0.2 or 1 mg/kg the drug had no significant effect on any of the parameters measured. At a dose of 2.5 mg/kg, t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ali BH

更新日期：1990-10-01 00:00:00

abstract：:1. The endothelin (ET) system and NADPH oxidase play important roles in the regulation of cardiovascular function, as well as in the pathogenesis of hypertension and other cardiovascular diseases. 2. Endothelins activate NADPH oxidases and thereby increase superoxide production, resulting in oxidative stress and cardi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dammanahalli KJ,Sun Z

更新日期：2008-01-01 00:00:00

abstract：:Repaglinide is a short-acting insulin secretagogue, which often results in considerable interindividual variability in therapeutic efficacy when widely used in a clinical setting. Among various reasons under discussion is genetic polymorphism, especially the genes related to insulin secretion and resistance. Recent st...

journal_title：Clinical and experimental pharmacology & physiology

authors： Song JF,Wang T,Zhu J,Zhou XY,Lu Q,Guo H,Zhang F,Wang Y,Li W,Wang DD,Cui YW,Lv DM,Yin XX

更新日期：2015-01-01 00:00:00

abstract：:1. Conscious experimental hypertensive rats injected intraventricularly with 5,6-dihydroxytryptamine (50 microgram) responded with a rapid and long-lasting (4 days) fall in blood pressure and this was accompanied by a bradycardia of similar duration. 2. The acute actions of 5,6-dihydroxytryptamine on the cardiovascula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Finch L

更新日期：1975-11-01 00:00:00

abstract：:1. In the mammalian central nervous system, GABA is the main inhibitory neurotransmitter. GABA is a highly flexible molecule and, thus, can exist in many low-energy conformations. Conformationally restricted analogues of GABA have been used to help identify three major GABA receptors, termed GABAA, GABAB and GABAC rec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chebib M,Johnston GA

更新日期：1999-11-01 00:00:00

abstract：:The intrarenal renin-angiotensin system (RAS) plays a critical role in the pathogenesis and progression of hypertension and kidney disease. In angiotensin (Ang) II-dependent hypertension, collecting duct renin synthesis and secretion are stimulated despite suppression of juxtaglomerular (JG) renin. This effect is medi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gonzalez AA,Prieto MC

更新日期：2015-01-01 00:00:00

abstract：:1. In a number of species, high concentrations of angiotensin II (AngII) receptors have been found in the rostral ventrolateral medulla (RVLM) in the hindbrain, which is an important region involved in the modulation of sympathetic vasomotor tone. The present review describes studies in which the contribution of angio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Head GA

更新日期：1996-09-01 00:00:00

abstract：:1. The choice of initial pharmacological therapy is one area where the different hypertension management guidelines vary in recommending either the use of diuretics and beta-blockers as preferred drugs or choosing from any of the five major classes of antihypertensives. 2. Improvement in cardiovascular morbidity and m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tomlinson B

更新日期：1997-12-01 00:00:00

abstract：:Pathogenic inflammation mediated by overactive type 1 helper T cell (Th1) responses could exacerbate and perpetuate Crohn's disease. Programmed death (PD)-1 and its ligand PD-L1 pathway could be upregulated to suppress inflammation. We wondered why this pathway is ineffective at suppressing pathogenic Th1 inflammation...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ma F,Zhao M,Song Z,Wang Z

更新日期：2019-09-01 00:00:00

abstract：:In guinea-pig isolated atria, angiotensin I and angiotensin II produced concentration dependent increases in the rate of spontaneous beating and in the release of noradrenaline produced by field stimulation of sympathetic nerves. In rat isolated caudal artery preparations, both angiotensin I and angiotensin II had dir...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ziogas J,Story DF,Rand MJ

更新日期：1984-07-01 00:00:00

abstract：:1. Calcified arteriosclerotic lesions have been recognized early in life as abnormalities in coronary arteries. 2. We examined coronary arterial plaques as an undecalcified tissue and revealed widespread mineralization within the plaque. Non-collagenous proteins that regulate calcification, such as osteopontin, have b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fitzpatrick LA

更新日期：1996-03-01 00:00:00

abstract：:1. Inhibiting the renin-angiotensin-aldosterone system prevents left ventricular (LV) remodelling after myocardial infarction (MI). 2. The present study was designed to assess the effects of a combination of perindopril and losartan on LV remodelling, cardiac function and serum procollagen type III amino terminal pept...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li L,Liu RY,Zhao XY,Zhang JY,Jia M,Lu PQ

更新日期：2009-07-01 00:00:00