Combined bronchodilator protection against histamine-induced bronchoconstriction in man.

Abstract:

:Sixteen stable asthmatics had the protective effects of inhaled fenoterol (200 micrograms) and inhaled ipratropium bromide (60 micrograms) against standardized histamine inhalation tests at 1 h examined in a randomized double blind fashion. There was no significant difference in the baseline forced expired volume in 1 s (FEV1) for the two study days (P greater than 0.05). There was an increase in FEV1 at 1 h on the fenoterol and ipratropium day compared with the fenoterol day (0.26 versus 0.17 l; P less than 0.05). The geometric mean provocative concentration of histamine to cause a 20% fall in FEV1 (PC20) was 6.31 mg/ml after fenoterol and 8.51 mg/ml after fenoterol and ipratropium (P = 0.038). There was no significant relationship between bronchodilator effect of the bronchodilators and the increase in PC20 from pre-study values, r = 0.307 (P = 0.25) for fenoterol alone and r = 0.195 (P = 0.47) for fenoterol and ipratropium. The relationship between pre-study histamine responsiveness and the increase in PC20 caused by the bronchodilators just failed to reach statistical significance, r = -0.441 (P = 0.09) for fenoterol alone and r = -0.47 (P = 0.06) for fenoterol and ipratropium. The study has shown a greater right shift of histamine responsiveness for combined inhaled fenoterol and ipratropium compared with inhaled fenoterol alone in this group of asthmatics.

authors

Ruffin RE,Meki M,Alpers JH

doi

10.1111/j.1440-1681.1987.tb00961.x

subject

Has Abstract

pub_date

1987-02-01 00:00:00

pages

87-94

issue

2

eissn

0305-1870

issn

1440-1681

journal_volume

14

pub_type

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