Effect of enalapril on body sodium and handling of a sodium chloride load in hypertensive and normotensive rats.


:1. The effect of enalapril on handling of an Na load and on body Na during 96 h of zero Na intake was measured in hypertensive rats (GH and SHR) and their normotensive controls (N and WKY) by a whole body counting method. 2. Enalapril treatment led to a greater fall in body Na in the first 24 h after the Na load (as expected from the known effect of ACE inhibition on aldosterone production) and thus to a slightly faster excretion of an amount equivalent to the load. 3. Enalapril-treated rats were unable to maintain body Na on a zero Na intake. This was also expected from the known effect on aldosterone production, though other mechanisms are not excluded. The effect was more marked in the SHR and WKY than in GH and N but there was no significant difference in this effect between the hypertensives and their respective control strains.


Ledingham JM,Simpson FO





Has Abstract


1992-05-01 00:00:00












  • Cerebrovascular and metabolic effects of bradykinin, ATP and hypercapnia in the goat.

    abstract::Cerebral blood flow (CBF) and cerebral O2 metabolism (CMRO2) changes were measured in these studies during treatment with three reputed cerebral vasodilators: bradykinin, adenosine triphosphate (ATP) and increased arterial PCO2. Intracerebrovascular bradykinin infusions increased CMRO2 and CBF to a similar degree. Int...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Hoffman WE,Miletich DJ,Volkman PH,Albrecht RF

    更新日期:1983-03-01 00:00:00

  • Ketamine inhibits aerobic glycolysis in colorectal cancer cells by blocking the NMDA receptor-CaMK II-c-Myc pathway.

    abstract::Aerobic glycolysis plays a crucial role in cancer progression. Ketamine is often used for cancer pain relief in clinical settings. Moreover, ketamine inhibits proliferation and induces apoptosis in many cancer cell types. However, the anti-tumour mechanism of ketamine is still poorly understood. In the present study, ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Hu J,Duan W,Liu Y

    更新日期:2020-05-01 00:00:00

  • Ketanserin stabilizes blood pressure in conscious spontaneously hypertensive rats.

    abstract::1. It has been demonstrated that blood pressure variability (BPV) is increased in hypertension and related to organ damage. It will be important to lower BPV in the treatment of hypertension. The present study was designed to investigate the effect of ketanserin, a 5-HT2A receptor antagonist with a weak alpha1-adrenoc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Miao CY,Xie HH,Yu H,Chu ZX,Su DF

    更新日期:2003-03-01 00:00:00

  • Chronic exercise partially restores the transmural heterogeneity of action potential duration in left ventricular myocytes of spontaneous hypertensive rats.

    abstract::Hypertension leads to electrophysiological changes in the heart. Chronic exercise induced by a treadmill-running programme (TRP) is considered a potential non-pharmacological treatment for hypertension and may have implications in heart remodelling. However, it is not known whether the TRP is able to improve the elect...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Roman-Campos D,Carneiro-Júnior MA,Prímola-Gomes TN,Silva KA,Quintão-Júnior JF,Gondim AN,Duarte HL,Cruz JS,Natali AJ

    更新日期:2012-02-01 00:00:00

  • Effects of adenosine administration on spike-wave discharge frequency in genetically epileptic rats.

    abstract::1. In the present study, the effects of the administration of adenosine on absence seizures were investigated in the Wistar Albino Glaxo/Rijswijk (WAG/Rij) strain of rats, which are an adequate model for human absence epilepsy. 2. After baseline electroencephalogram (EEG) recording, adenosine was injected intraperiton...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ilbay G,Sahin D,Karson A,Ates N

    更新日期:2001-08-01 00:00:00

  • Effect of stress on serotonin, norepinephrine, epinephrine and corticosterone contents in the soft-shelled turtle.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Mahapatra MS,Mahata SK,Maiti B

    更新日期:1991-10-01 00:00:00

  • Antisense oligonucleotides: from design to therapeutic application.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Chan JH,Lim S,Wong WS

    更新日期:2006-05-01 00:00:00

  • 7,8-dihydroxyflavone enhanced cholinergic contraction of rat gastric smooth muscle via augmenting muscarinic M3 receptor expression.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: He B,Qu Z,Tian Z,Zhao K,Wei L,Ma L

    更新日期:2018-11-01 00:00:00

  • The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Jiang GC,Iwanov V,Moulds RF

    更新日期:1995-01-01 00:00:00

  • Relationship between serum osteocalcin and glycaemic variability in Type 2 diabetes.

    abstract::1. Recent reports have described the role of osteocalcin in glucose metabolism and glycaemic variability has been proven to be associated with an increased risk of diabetes complications. However, the relationship between osteocalcin and glycaemic variability remains unclear. The aim of the present study was to examin...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章


    authors: Bao YQ,Zhou M,Zhou J,Lu W,Gao YC,Pan XP,Tang JL,Lu HJ,Jia WP

    更新日期:2011-01-01 00:00:00

  • Characterization of an extracellular epitope antibody to the neuronal K-Cl cotransporter, KCC2.

    abstract::1. Ion gradients across the cell membrane are important for proper cellular communication and homeostasis. With the exception of erythrocytes, chloride (Cl), one of the most important free anions in animal cells, is not distributed at thermodynamic equilibrium across the plasma membrane. The K-Cl cotransporter (COT), ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Gagnon KB,Fyffe RE,Adragna NC,Lauf PK

    更新日期:2007-07-01 00:00:00

  • In Vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative.

    abstract::Summary 1. The non-selective K(+) channel blocker 4-aminopyridine (4-AP) has shown clinical efficacy in the treatment of neurological disorders such as multiple sclerosis. The clinical usefulness of 4-AP is hampered by its ability to produce seizures. Nerispirdine, an analogue of 4-AP, is currently under clinical inve...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Smith C,Kongsamut S,Wang H,Ji J,Kang J,Rampe D

    更新日期:2009-11-01 00:00:00

  • In vivo estimation of changes in distal tubule flow and their role in dexamethasone-induced kaliuresis in control and potassium-adapted rats.

    abstract::The aim of this study was to determine whether the kaliuresis associated with glucocorticoids is due to a direct tubular action or is secondary to effects of glucocorticoids on distal tubule flow. A whole kidney technique was used to avoid the problem, inherent in microperfusion and micropuncture studies, of deciding ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Adam WR,Adams BA,Ellis AG

    更新日期:1987-01-01 00:00:00

  • Inhibition of cardiac baroreflex sensitivity after central dopaminergic stimulation.

    abstract::1. Stimulation of the mesolimbic dopamine system, by micro-injection of the substance P analogue [pGlu5,MePhe8,Sar9] substance P (DiMe-C7) into the ventral tegmental area induced a prolonged increase in blood pressure and circulating levels of vasopressin. 2. In the present study, this treatment produced a significant...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: van den Buuse M,Wilks DP,Cornish JL

    更新日期:1998-07-01 00:00:00

  • Autacoid interactions in the regulation of blood flow in the human placenta.

    abstract::1. Interactions between autacoids may play important roles in the regulation of blood flow in the foetal placenta. In order to investigate this aspect of placental haemodynamics, human normal-term placentae were perfused in vitro and the responses of the foetal vessels to various combinations of vasoactive agents were...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Gude NM,King RG,Brennecke SP

    更新日期:1998-09-01 00:00:00

  • Renomedullary interstitial cells: a target for endocrine and paracrine actions of vasoactive peptides in the renal medulla.

    abstract::1. The renal medulla plays an important role in regulating body sodium and fluid balance and blood pressure homeostasis through its unique structural relationships and interactions between renomedullary interstitial cells (RMIC), renal tubules and medullary vasculature. 2. Several endocrine and/or paracrine factors, i...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Zhuo JL

    更新日期:2000-07-01 00:00:00

  • High-salt diet and responses of the pressurized mesenteric artery of the dog to noradrenaline and acetylcholine.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Sofola O,Knill A,Myers D,Hainsworth R,Drinkhill M

    更新日期:2004-10-01 00:00:00

  • The opposite effects of nitric oxide donor, S-nitrosoglutathione, on myocardial ischaemia/reperfusion injury in diabetic and non-diabetic mice.

    abstract::Nitric oxide is a potent anti-apoptotic and cardioprotective molecule in healthy animals. However, recent study demonstrates that overexpression of eNOS exacerbates the liver injury in diabetic animals. whether diabetes may also alter NO's biologic activity in ischaemic/reperfused heart remains unknown. The present ex...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Liu Y,Xia C,Wang R,Zhang J,Yin T,Ma Y,Tao L

    更新日期:2017-08-01 00:00:00

  • Atrial natriuretic factor in chronic renal failure: studies in man and the rat.

    abstract::1. Plasma concentration and atrial content of atrial natriuretic factor (ANF) were measured in rats with chronic renal failure induced by subtotal nephrectomy. 2. Plasma ANF was higher, and atrial ANF content lower in rats with renal failure when compared with sham-operated controls. 3. Plasma renin activity (PRA) and...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Hodsman GP,Jackson B,Debrevi LM,Ogawa K,Johnston CI

    更新日期:1987-03-01 00:00:00

  • A rat model of ischaemic or dilated cardiomyopathy for investigating left ventricular repair surgery.

    abstract::1. The effects of left ventricular repair (LVR) surgery for ischaemic or dilated cardiomyopathy are not fully understood. The development of a proper animal model will help to resolve this issue. 2. The ischaemic cardiomyopathy (ICM) model used was as follows. Twenty-six rats developed ICM with a large akinetic left v...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nishina T,Miwa S,Yuasa S,Nishimura K,Komeda M

    更新日期:2002-08-01 00:00:00

  • Uric acid permeability coefficient in the rat papillary collecting duct.

    abstract::1. While it is believed that the mammalian distal nephron is not involved in uric acid transport, this has not been directly evaluated. Nevertheless, some studies are consistent with significant distal nephron transport. 2. As uric acid transport in man may be similar to the rat, undirectional uric acid permeability w...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ray C,Carney S,Morgan T

    更新日期:1997-09-01 00:00:00

  • Estradiol alters the chemosensitive cardiac afferent reflex in female rats by augmenting sympathoinhibition and attenuating sympathoexcitation.

    abstract::The chemosensitive cardiac vagal and sympathetic afferent reflexes are implicated in driving pathophysiological changes in sympathetic nerve activity (SNA) in cardiovascular disease states. This study investigated the impact of sex and ovarian hormones on the chemosensitive cardiac afferent reflex. Experiments were pe...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Pinkham MI,Barrett CJ

    更新日期:2015-06-01 00:00:00

  • Diabetic retinopathy: early functional changes.

    abstract::1. The present review reports some of the earliest physiological changes that occur in the diabetic retina prior to any clinical or anatomical changes in an animal model of diabetes. 2. Using chemically induced diabetes (by streptozotocin) in rats, retinal blood flow and vitreal and retinal oxygen tension were determi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Alder VA,Su EN,Yu DY,Cringle SJ,Yu PK

    更新日期:1997-09-01 00:00:00

  • Cardiac baroreflexes and hypertension.

    abstract::1. The role of cardiac reflexes in baroreflex control mechanisms and the changes that occur in chronic hypertension is reviewed. The rapid resetting properties of the arterial baroreceptors ensures its role in short-term rather than long-term control of blood pressure. 2. In hypertensive humans and animals, the barore...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Head GA

    更新日期:1994-10-01 00:00:00

  • Extraction of neurotensin by the liver.

    abstract::1. Neurotensin is released from the intestine into the portal circulation and to exert a systemic effect it must traverse the liver intact. 2. The role of the liver in neurotensin clearance was examined using the isolated perfused rat liver preparation. Two concentrations of neurotensin were used to determine the extr...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Brook CW,Shulkes A,Sewell RB,Smallwood RA

    更新日期:1987-10-01 00:00:00

  • Early origins of heart disease: low birth weight and the role of the insulin-like growth factor system in cardiac hypertrophy.

    abstract::Epidemiological studies indicate that poor growth before birth is associated with left ventricular hypertrophy and an increased risk of death from heart disease later in life. In fetal life, the insulin-like growth factor (IGF) system has been implicated in physiological growth of the heart, whereas in postnatal life ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Wang KC,Botting KJ,Padhee M,Zhang S,McMillen IC,Suter CM,Brooks DA,Morrison JL

    更新日期:2012-11-01 00:00:00

  • Newcastle disease virus: a promising agent for tumour immunotherapy.

    abstract::Malignant tumours are a major cause of mortality in humans. Currently used therapeutic regimens have not improved survival rates of patients suffering from malignant tumours much because of their limited efficacy and side-effects. A therapeutic approach that uses Newcastle disease virus (NDV) represents an attractive ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Zhao L,Liu H

    更新日期:2012-08-01 00:00:00

  • Acute but not chronic angiotensin-converting enzyme inhibition induces enzyme synthesis in the glomerulus of the spontaneously hypertensive rat.

    abstract::1. Treatment with angiotensin-converting enzyme (ACE) inhibitors slows the rate of progression of nephropathy in the spontaneously hypertensive rat (SHR) with streptozotocin-induced diabetes. Paradoxically, however, chronic ACE inhibitor therapy has been reported to be associated with induction of ACE in the plasma. W...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Hodge G,Makarious MM,Charlesworth JA,Duggan KA

    更新日期:1997-06-01 00:00:00

  • Effects of optic tract stimulation on baroreflex vagal bradycardia in rats.

    abstract::1. Arterial baroreflexes are suppressed in stressful conditions. Intense visual stimuli can cause a threatening sensation and produce defensive reactions. 2. The present study was designed to determine whether and how electrical stimulation of the optic tract (OT) affects arterial baroreflexes, especially the heart ra...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Cheng ZB,Kobayashi M,Nosaka S

    更新日期:2001-09-01 00:00:00

  • Effect of phosphorylation on L-type calcium current in ventricular myocytes dialysed with proteolytic enzymes.

    abstract::1. L-Type Ca2+ channels play important roles in cardiac excitation and conduction. The present study used the whole-cell patch-clamp technique to investigate properties of Ca2+ channels in guinea-pig isolated ventricular myocytes. The effects of internal application of the proteolytic enzymes trypsin and carboxypeptid...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Dooley PC,Hancox JC,Chapman RA

    更新日期:1999-02-01 00:00:00