The effect of ivermectin on some haematological indices in rabbits: influence of vitamin K treatment.


:1. Rabbits were treated with the antiparasitic drug ivermectin at subcutaneous doses of 0.2, 1 and 2.5 mg/kg and blood collected weekly for 4 weeks thereafter for measuring some blood parameters. At a dose of 0.2 or 1 mg/kg the drug had no significant effect on any of the parameters measured. At a dose of 2.5 mg/kg, the drug reduced significantly the erythrocyte counts, haemoglobin concentration, haematocrit, mean corpuscular haemoglobin concentration and mean corpuscular haemoglobin on weeks 1, 2, 3 and 4. Platelet counts were not significantly affected. 2. In another trial, ivermectin was injected subcutaneously at a dose of 2.5 mg/kg, after pre-treatment with either saline or vitamin K (30 micrograms/kg for 30 days), and prothrombin time, bleeding time and platelet counts measured at weekly intervals for 4 weeks. Bleeding time and thrombin time were significantly increased 1 week after treatment, and remained higher than the control for 4 weeks.


Ali BH




Has Abstract


1990-10-01 00:00:00












  • Characterization of two polyclonal peptide antibodies that recognize the carboxy terminus of angiotensin II AT1A and AT1B receptors.

    abstract::1. The differential identification of the angiotensin AT1A and AT1B receptor subtypes is impaired by the existing>96% homology of both receptors. In the present study, we characterized two polyclonal rabbit peptide antibodies, namely alpha-AT1A and alpha-AT1B, that recognize the C-terminal region of mouse AT1A and AT1...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Hoffmann A,Cool DR

    更新日期:2005-11-01 00:00:00

  • Effects of an orally active vasopressin V1 receptor antagonist.

    abstract::1. This paper reports on the in vitro and in vivo characteristics of a non-peptide vasopressin V1 receptor antagonist 1-(1-[4-(3-acetylaminopropoxy)benzoyl]-4-piperidyl)-3,4-dihydro-2( 1H)- quinolinone (OPC-21268). 2. OPC-21268 caused a concentration-dependent displacement of the selective V1 receptor antagonist radio...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Burrell LM,Phillips PA,Stephenson J,Risvanis J,Hutchins AM,Johnston CI

    更新日期:1993-05-01 00:00:00

  • The opposite effects of nitric oxide donor, S-nitrosoglutathione, on myocardial ischaemia/reperfusion injury in diabetic and non-diabetic mice.

    abstract::Nitric oxide is a potent anti-apoptotic and cardioprotective molecule in healthy animals. However, recent study demonstrates that overexpression of eNOS exacerbates the liver injury in diabetic animals. whether diabetes may also alter NO's biologic activity in ischaemic/reperfused heart remains unknown. The present ex...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Liu Y,Xia C,Wang R,Zhang J,Yin T,Ma Y,Tao L

    更新日期:2017-08-01 00:00:00

  • Blood pressure regulation in baroreceptor-denervated rats.

    abstract::1. Arterial baroreceptor denervation produces acute hypertension, but chronically denervated animals have an average arterial pressure that is similar to that of baroreceptor intact animals. 2. Although cardiopulmonary baroreceptors and renal compensations have been suggested to mediate the restoration of a normal ave...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Sved AF,Schreihofer AM,Kost CK Jr

    更新日期:1997-01-01 00:00:00

  • NBPA: a cerebral ischaemic protective agent.

    abstract::1. NBPA is a derivative of 3-n-butylpathalide isolated from Apium granolens Linn. 2. At concentrations ranging from 6 x 10(-6) to 10(-6) mol/L, NBPA inhibited the L-type calcium current in guinea-pig myocardial cells and cultured human neuroblastoma cells. 3. At 10(-6) mol/L, NBPA markedly inhibited calcium-dependent ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Zhang J,Peng X,Wei G,Su D

    更新日期:1999-10-01 00:00:00

  • Type-specific orthostatic hemodynamic response of hypertensive diseases in pregnancy.

    abstract::Posture changes may differ between types of hypertensive disease. The aim is to evaluate the orthostatic response of impedance cardiography (ICG) measurements in uncomplicated and hypertensive pregnancies. Measurements were performed in supine and standing position in 202 women: 41 uncomplicated pregnancies (UP), 59 g...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Staelens AS,Vonck S,Mesens T,Tomsin K,Molenberghs G,Gyselaers W

    更新日期:2015-10-01 00:00:00

  • Dopamine D1 receptors induce apoptosis of osteosarcoma cells via changes of MAPK pathway.

    abstract::This study explored the effects and mechanisms of dopamine D1 receptors (DR1) activation on the apoptosis of osteosarcoma cells (OS732).The DR1 agonist SKF-38393 decreased the viability of OS732 cells and increased their rate of apoptosis, whereas the DR1 antagonist SCH-23390 abolished the effects of SKF-38393. In OS7...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 信件


    authors: Gao J,Gao F

    更新日期:2017-11-01 00:00:00

  • Functional interaction between DPI 201-106, a drug that mimics congenital long QT syndrome, and sevoflurane on the guinea-pig cardiac action potential.

    abstract::1. Sevoflurane produces QT prolongation on the electrocardiogram, predominantly via inhibition of the slow delayed rectifier K(+) current. DPI 201-106 is an experimental drug that produces QT prolongation by reducing Na(+) channel inactivation, thereby mimicking congenital long QT syndrome type 3 (LQT3). The present s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kang J,Chen XL,Reynolds WP,Rampe D

    更新日期:2007-12-01 00:00:00

  • Effects of rilmenidine on proximal tubular fluid absorption in rats.

    abstract::The antihypertensive agent rilmenidine has threefold higher affinity for I(1) imidazoline receptors compared with alpha(2)-adrenoceptors and acts on the central nervous system by reducing sympathetic activity and in the kidney by inhibiting Na(+)/H(+) exchange activity. In the present study, we examined: (i) the effec...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Jovanovska V,Eitle E,Harris PJ

    更新日期:2004-05-01 00:00:00

  • A locus on the long arm of chromosome 1 as a possible cause of essential hypertension.

    abstract::1. None of the genes responsible for essential hypertension has been identified. Recent work in genetically hypertensive rats has shown linkage of blood pressure with alleles of the renin gene. Since the renin gene is a member of a conserved synteny group that in humans spans chromosome 1q21.3-32.3 and includes the ge...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Griffiths LR,Zee RY,Ying LH,Morris BJ

    更新日期:1991-05-01 00:00:00

  • Blood pressure regulation via the epithelial sodium channel: from gene to kidney and beyond.

    abstract::The epithelial sodium channel (ENaC) has long been recognized as playing a vital role in blood pressure (BP) regulation due to its involvement in fluid balance. The genes encoding the three ENaC subunits are likewise important contributors to hypertension, both in rare monogenic diseases and in the general population....

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Büsst CJ

    更新日期:2013-08-01 00:00:00

  • Reperfusion injury in the human forearm is mild and not attenuated by short-term ischaemic preconditioning.

    abstract::1. Ischaemia-reperfusion (IR) injury is an important contributor to tissue damage and has been shown to be attenuated by preconditioning (PC) in some animal models. A recent report has suggested that the forearm can be used for the study of this phenomenon in humans. We aimed to reproduce and further characterize this...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章


    authors: Kilian JG,Nakhla S,Griffith K,Harmer J,Skilton M,Celermajer DS

    更新日期:2005-01-01 00:00:00

  • Cholinergic prejunctional inhibition of nitrergic neurotransmission in the guinea-pig isolated basilar artery.

    abstract::1. The effects of endogenous and exogenous acetylcholine (ACh) on nitrergic relaxations elicited by electrical field stimulation (EFS) were studied in guinea-pig endothelium-denuded basilar artery preparations precontracted with 1 mumol/L prostaglandin F2 alpha and a possible role of K+ channels in mediating the effec...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Jiang F,Li CG,Rand MJ

    更新日期:1999-04-01 00:00:00

  • Cathelicidin deficiency exacerbates cardiac dysfunction in lipopolysaccharide-induced endotoxaemic mice.

    abstract::The therapeutic potential of the antimicrobial peptide cathelicidin (Camp) administration in sepsis has been widely investigated. However, little is known about the pathophysiological roles of cathelicidin in septic cardiomyopathy. In a lipopolysaccharide (LPS)-induced endotoxaemic model, we found that the mRNA and pr...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Zhai T,Zhang J,Zhang Y,Wu Y

    更新日期:2020-04-01 00:00:00

  • The effect of althesin, ketamine or pentothal on renal function in saline loaded rats.

    abstract::Rats were prepared with chronic cannulae in the carotid artery, jugular vein and urinary bladder; they were then kept 2 days to allow recovery from surgery. A steady-state continuous saline diuresis was established, then various anaesthetic agents were injected and changes in the urine flow, sodium and potassium excre...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Chen CF,Chapman BJ,Munday KA

    更新日期:1985-03-01 00:00:00

  • Stimulation of oestrogen receptor-expressing endothelial cells with oestrogen reduces proliferation of cocultured vascular smooth muscle cells.

    abstract::1. Oestrogen reduces vascular smooth muscle cell proliferation in mouse vascular injury models. Data on the antiproliferative effect of oestrogen in cultured vascular smooth muscle cells (VSMC) are less conclusive than those obtained in whole animal studies. 2. In the present study, we investigated the hypothesis that...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Odenlund M,Ekblad E,Nilsson BO

    更新日期:2008-03-01 00:00:00

  • Muscarinic receptor differentiation.

    abstract::1. Several selective antagonists are available to differentiate between muscarinic receptors. 2. Further subdivision of M1 and M2 muscarinic receptors appears possible and is supported by studies with cloned receptors. 3. Reasons for differences between affinity constants determined in functional and binding studies a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Mitchelson F,Choo LK,Darroch S

    更新日期:1989-06-01 00:00:00

  • Toxic marine dinoflagellates in Singapore waters that cause seafood poisonings.

    abstract::1. The present paper reviews the toxic dinoflagellates found in Singapore waters that produce toxins that can accumulate through marine food chains to cause seafood poisonings. 2. Singapore waters contain dinoflagellate species linked to three types of seafood poisoning: paralytic shellfish poisoning, diarrhetic shell...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Holmes MJ,Teo SL

    更新日期:2002-09-01 00:00:00

  • Hypertension mechanisms causing stroke.

    abstract::1. Although it is well established that hypertension is the main risk factor for stroke, the complexity of cerebrovascular problems related to hypertension is not generally appreciated. 2. Hypertension can cause stroke through many mechanisms. A high intraluminal pressure will lead to extensive alteration in endotheli...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Johansson BB

    更新日期:1999-07-01 00:00:00

  • Role of cAMP in the effects of K+ on the steroidogenesis of zona glomerulosa cells.

    abstract::1. Investigations of the role of cAMP in the stimulation of the steroidogenesis of zona glomerulosa (ZG) cells by increased extracellular K+ concentration are reviewed. 2. Possible reasons for discrepancies in the results of different investigators on whether K+ increases the cAMP content or output of ZG tissue or dis...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Tait JF,Tait SA

    更新日期:1999-12-01 00:00:00

  • Progesterone antagonizes development but not maintenance of ACTH-induced hypertension in sheep.

    abstract::1. This study investigated the effect of progesterone, which, under certain circumstances, can antagonize both the mineralocorticoid and glucocorticoid activities of steroid hormones, on the development and maintenance of adrenocorticotrophic hormone (ACTH)-induced hypertension in conscious sheep. 2. Progesterone (500...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Spence CD,Reid AF,Coghlan JP,Mills EH,Whitworth JA,Scoggins BA

    更新日期:1989-08-01 00:00:00

  • Demonstration of hereditarily accelerated proliferation in astrocytes derived from spontaneously hypertensive rats.

    abstract::1. We examined the proliferative rates of cultured astrocytes isolated from stroke-prone spontaneously hypertensive rats (SHRSP) and stroke-resistant spontaneously hypertensive rats (SHRSR). Wistar-Kyoto rats (WKY) were used as a control for SHRSP and SHRSR. 2. In the presence of 10% fetal bovine serum (FBS), the doub...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Yamagata K,Nara Y,Tagami M,Yamori Y

    更新日期:1995-09-01 00:00:00

  • Increased Ca2+ sensitivity of myofibrillar tension in ischaemic vs dilated cardiomyopathy.

    abstract::1. There is evidence that different aetiologies of heart failure, especially ischaemic vs dilated cardiomyopathy (ICM and DCM, respectively), may influence the prognosis of patients with this disease. Patients with ICM have a worse prognosis than those with DCM; the mechanisms underlying this difference have not yet b...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Lee S,Lu R,Müller-Ehmsen J,Schwinger RH,Brixius K

    更新日期:2010-12-01 00:00:00

  • The association between serum albumin/prealbumin level and disease severity in non-CF bronchiectasis.

    abstract::Non-cystic fibrosis (non-CF) bronchiectasis is a chronic pulmonary disease that can lead to malnutrition. Serum prealbumin and albumin level are related to inflammatory and nutritional status. Thus, we aimed to confirm our hypothesis that low serum albumin and prealbumin level, as well as body mass index (BMI), is cor...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Li L,Li Z,Bi J,Li H,Wang S,Shao C,Song Y

    更新日期:2020-09-01 00:00:00

  • Rilmenidine acts as a partial agonist at prejunctional alpha 2-adrenoceptors in guinea-pig atria.

    abstract::1. The present study was carried out to determine whether rilmenidine, a recently introduced antihypertensive agent which acts on alpha 2-adrenoceptors, has partial agonist activity on prejunctional alpha 2-adrenoceptors in guinea-pig atria. 2. Isolated preparations of guinea-pig atria were incubated with [3H]-noradre...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Li CG,Rand MJ

    更新日期:1988-10-01 00:00:00

  • Quantitative tissue velocity imaging evaluation of ventricular function in obstructive sleep apnoea-hypopnoea syndrome in children.

    abstract::This study aimed to evaluate the changes in left and right ventricular functions of children with obstructive sleep apnoea-hypopnoea syndrome (OSAHS) and to determine the efficacy of surgical treatment for OSAHS in children. The subjects included 20 normal controls and 55 children of OSAHS with adenoid and/or tonsil h...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Mu H,Liu J,Gong K,Li D,Zhang J

    更新日期:2015-06-01 00:00:00

  • Inhibition of nuclear translocation of transcription factor nuclear factor-kappa B induces FAS- as well as tumour necrosis factor-alpha-mediated apoptosis through downregulation of a conserved family of inhibitor of apoptosis 1.

    abstract::1. In the present study, we examined whether the nuclear transcription factor (NF)-kappaB activity plays a role in the determination of sensitivity to tumour necrosis factor (TNF)-alpha or agonistic Fas antibody (Ab) in human vascular smooth muscle cells (hVSMC). 2. To inhibit agonist-induced NF-kappaB activation in h...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Imanishi T,Hano T,Takarada S,Nishio I

    更新日期:2003-03-01 00:00:00

  • Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscle.

    abstract::1. Inflammation, particularly the pro-inflammatory cytokine tumour necrosis factor (TNF), increases necrosis of skeletal muscle. Depletion of inflammatory cells, such as neutrophils, cromolyn blockade of mast cell degranulation or pharmacological blockade of TNF reduces necrosis of dystrophic myofibres in the mdx mous...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Grounds MD,Radley HG,Gebski BL,Bogoyevitch MA,Shavlakadze T

    更新日期:2008-07-01 00:00:00

  • Elevation of blood pressure in hypertensive rats after lesioning serotonin nerves in the dorsomedial medulla oblongata.

    abstract::The possibility that serotonin (5HT) nerve endings in the dorsomedial medulla oblongata participate in the control of blood pressure was investigated in stroke-prone hypertensive rats and in normotensive rats. 5HT nerves were destroyed by injecting 5,7-dihydroxytryptamine bilaterally into the solitary tract nucleus. I...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Howe PR,Rogers PF,King RA,Smith RM

    更新日期:1983-05-01 00:00:00

  • Disease-induced changes in alpha-adrenoceptor-mediated cardiac and vascular responses in rats.

    abstract::1. The physiological relevance of cardiac and vascular alpha-adrenoceptors may increase in disease states in which beta-adrenoceptors are altered. To test this, positive inotropic and vasoconstrictor responses to phenylephrine were measured in isolated tissues from rats with experimentally-induced hyperthyroidism, hyp...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Brown L,Amos G,Miller B

    更新日期:1994-09-01 00:00:00