The effect of ivermectin on some haematological indices in rabbits: influence of vitamin K treatment.

abstract：:1. The endogenous production of and/or the bioavailability of nitric oxide (NO) is decreased in pulmonary hypertensive diseases. L-arginine (L-arg) is the substrate for NO synthase (NOS). L-arg is transported into cells via the cationic amino acid transporters (CAT), of which there are two isoforms in endothelial cell...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui H,Chen B,Chicoine LG,Nelin LD

更新日期：2011-12-01 00:00:00

abstract：:1. This paper reports on the in vitro and in vivo characteristics of a non-peptide vasopressin V1 receptor antagonist 1-(1-[4-(3-acetylaminopropoxy)benzoyl]-4-piperidyl)-3,4-dihydro-2( 1H)- quinolinone (OPC-21268). 2. OPC-21268 caused a concentration-dependent displacement of the selective V1 receptor antagonist radio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Burrell LM,Phillips PA,Stephenson J,Risvanis J,Hutchins AM,Johnston CI

更新日期：1993-05-01 00:00:00

abstract：:Bone is a remarkable living tissue that provides a framework for animal body support and motion. However, under excessive loads and deformations, bone is prone is to damage through fracture. Furthermore, once the bone is weakened by osteoporosis, bone fracture can occur even after only minimal trauma. Various techniqu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang L,Richardson M,Mendis P

更新日期：2012-08-01 00:00:00

abstract：:1. Chromium picolinate (CrPic) has been recommended as an alternative therapeutic regimen for Type 2 diabetes mellitus (T2DM). However, the molecular mechanism underlying the action of CrPic is poorly understood. 2. Using normal and insulin-resistant 3T3-L1 adipocytes, we examined the effects of CrPic on the gene tran...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang YQ,Dong Y,Yao MH

更新日期：2009-08-01 00:00:00

abstract：:1. Oxidative stress (OS) is a biological entity indicated as being responsible for several pathologies, including diabetes. Diabetes can also be associated with human cirrhosis. Portal hypertension (PH), a major syndrome in cirrhosis, produces hyperdynamic splanchnic circulation and hyperaemia. The present study was d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Evelson P,Llesuy S,Filinger E,Rodriguez RR,Lemberg A,Scorticati C,Susemihl M,Villareal I,Polo JM,Peredo H,Perazzo JC

更新日期：2004-03-01 00:00:00

abstract：:1. Atherosclerosis begins with the deposition of cholesterol in arterial tissue that is thought to be derived from circulating lipoproteins. There is considerable evidence implicating low density lipoprotein (LDL) as a primary source of plaque cholesterol and, consequently, there are many articles that deal with vario...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mamo JC,Yu KC,Elsegood CL,Smith D,Vine D,Gennat HC,Voevodin M,Proctor SD

更新日期：1997-03-01 00:00:00

abstract：:1. CYP2C19 is a polymorphism of cytochrome P450, which is responsible for the metabolism of many drugs. The genetic polymorphism shows interethnic variation and it has been demonstrated that the frequency of poor metabolizers (PM) and the distribution of alleles of CYP2C19 vary among Chinese ethnic nationalities. The ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang JH,Li PQ,Fu QY,Li QX,Cai WW

更新日期：2007-05-01 00:00:00

abstract：:1. Four, six and eight hours after gavage of rats with alpha-mercapto-beta-(2-furan)acrylic acid (MFA) (25 mg/kg) serum zinc concentration was increased ten-fold over control levels and a mean molar ratio of 1 albumin:0-4 zinc:0-8 MFA was found for seventeen sera. 2. At pH 7-5 a maximum of 1 mole of MFA could be bound...

journal_title：Clinical and experimental pharmacology & physiology

authors： Giroux E,Prakash NJ,Schechter PJ

更新日期：1977-01-01 00:00:00

abstract：:1. Reactive oxygen species (ROS) are a diverse family of molecules that are produced throughout the vascular wall. Many ROS, such as the superoxide anion (*O2-) and hydrogen peroxide (H2O2), are now known to act as cellular signalling molecules within blood vessels. In particular, these molecules can exert powerful ef...

journal_title：Clinical and experimental pharmacology & physiology

authors： Paravicini TM,Sobey CG

更新日期：2003-11-01 00:00:00

abstract：:1. In the present study we have examined the effects of angiotensin I converting enzyme (ACE) inhibition and nitric oxide (NO) synthesis inhibition on bradykinin (BK) depressor responses in pregnancy in both Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). 2. Ramipril (10 mg/kg, i.v.) significantly reduce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chu ZM,Beilin LJ

更新日期：1995-06-01 00:00:00

abstract：:1. Low-voltage electrical stimulation (LVES) in skeletal muscle at a level far below the threshold of muscle contraction has been reported to promote local angiogenesis. However, the mechanism underlying the promotion of local angiogenesis by LVES has not been fully elucidated. In the present study, we evaluated wheth...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nagasaka M,Kohzuki M,Fujii T,Kanno S,Kawamura T,Onodera H,Itoyama Y,Ichie M,Sato Y

更新日期：2006-07-01 00:00:00

abstract：:1. Effects of a newly developed phosphodiesterase (PDE) III inhibitor, E-1020, on intracellular calcium transients were compared with those of isoproterenol (ISO) in isolated single myocytes from failing hearts secondary to pulmonary hypertension induced by monocrotaline injection. Myocytes were isolated by enzyme dig...

journal_title：Clinical and experimental pharmacology & physiology

authors： Honda M,Kuramochi T,Ishinaga Y,Kuzuo H,Tanaka K,Morioka S,Enomoto K,Takabatake T

更新日期：1994-12-01 00:00:00

abstract：:1. The study examines whether intracerebroventricular (ICV) infusion of atrial natriuretic peptide (human ANP,1-28) influences renal electrolyte and water excretion, vasopressin release, renal and femoral blood flows in conscious ewes. The blood flow was measured by chronically implanted ultrasonic flow probes. 2. ICV...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gunnarsson U

更新日期：1994-03-01 00:00:00

abstract：:1. The effects of cold saline (25 mL) injected over the fetal skin on fetal heart rate (HR) and HR variability (HRV), measured as the coefficient of variation (CV) in pulse interval (PI) and by power spectral analysis (PSA), were measured in 10 chronically catheterized fetal sheep aged 140-144 days. To determine the e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yu ZY,Lumbers ER

更新日期：2000-08-01 00:00:00

abstract：:1. Pyruvate has been shown to enhance the contractile performance of cardiac muscle when provided as an alternative substrate to glucose. The aims of the present study were to determine whether the inotropic effects of pyruvate are due to increased mobilization of intracellular Ca2+ ([Ca2+]i) and to compare the effect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mellors LJ,Kotsanas G,Wendt IR

更新日期：1999-11-01 00:00:00

abstract：:1. NBPA is a derivative of 3-n-butylpathalide isolated from Apium granolens Linn. 2. At concentrations ranging from 6 x 10(-6) to 10(-6) mol/L, NBPA inhibited the L-type calcium current in guinea-pig myocardial cells and cultured human neuroblastoma cells. 3. At 10(-6) mol/L, NBPA markedly inhibited calcium-dependent ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang J,Peng X,Wei G,Su D

更新日期：1999-10-01 00:00:00

abstract：:1. Blood pressure (BP) and heart rate (HR) increase 6 and 24 h after sinoaortic baroreceptor denervation (SAD), whereas plasma renin activity (PRA) and renal renin mRNA levels remain unchanged. We postulated that a simultaneous rise in BP could offset the expected activation of renin associated with an increased renal...

journal_title：Clinical and experimental pharmacology & physiology

authors： Krieger MH,Moreira ED,Oliveira EM,Oliveira VL,Krieger EM,Krieger JE

更新日期：2006-05-01 00:00:00

abstract：:1. To assess the effect of dietary phytosterol on stroke and the lifespan of salt-loaded stroke-prone spontaneously hypertensive rats (SHRSP), we investigated the effects of the addition of phytosterol to soybean oil (phytosterol content: 0.3%) on stroke onset, lifespan following onset of stroke and overall lifespan c...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ogawa H,Yamamoto K,Kamisako T,Meguro T

更新日期：2003-12-01 00:00:00

abstract：:1. The turnover rate of inositol(1,4,5)trisphosphate (Ins(1,4,5)P3) in noradrenaline-stimulated adult rat left atria was calculated from changes in specific activity and was found to equal 110 ct/min per mg tissue. In contrast, the isomers of inositol mono- and bisphosphates accumulated at a rate of 508 ct/min per mg....

journal_title：Clinical and experimental pharmacology & physiology

authors： Anderson KE,Myers D,Woodcock EA

更新日期：1993-05-01 00:00:00

abstract：:1. Irinotecan (also known as CPT-11) is a water soluble, semi-synthetic analogue of 20(S)camptothecin (CPT) with promising activity against a range of tumour types. 2. As with all other active analogues of CPT, irinotecan causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rivory LP

更新日期：1996-10-01 00:00:00

abstract：:In the context of the ongoing debate on the mechanism of blood pressure (BP) regulation and pathophysiology of arterial hypertension ("renocentric" vs "neural" concepts), attention is focused on the putative regulatory role of changes in renal medullary blood flow (MBF). Experimental evidence is analysed with regard t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sadowski J,Bądzyńska B

更新日期：2020-08-01 00:00:00

abstract：:1. The present study sought to explain the mechanism leading to reduced availability of propranolol when given after a priming dose in the single-pass perfused rat liver. 2. Extracellular sucrose space (as a measure of sinusoidal relaxation) in perfused rat liver before and after propranolol or propranolol and N(G)-ni...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu X,Zou Y,Khlentzos AM,Yang Y,Nikolovski J,Weiss M,Roberts MS

更新日期：2010-10-01 00:00:00

abstract：:1. In the present study, the effects of the administration of adenosine on absence seizures were investigated in the Wistar Albino Glaxo/Rijswijk (WAG/Rij) strain of rats, which are an adequate model for human absence epilepsy. 2. After baseline electroencephalogram (EEG) recording, adenosine was injected intraperiton...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ilbay G,Sahin D,Karson A,Ates N

更新日期：2001-08-01 00:00:00

abstract：:1. The effects of taurine on the development of atherosclerotic lesions were investigated in apolipoprotein (apo) E-deficient mice, an animal model with severe hypercholesterolaemia and extensive atherosclerosis. These mice were fed a normal laboratory chow containing 2% taurine for 12 weeks. 2. Serum total cholestero...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kondo Y,Toda Y,Kitajima H,Oda H,Nagate T,Kameo K,Murakami S

更新日期：2001-10-01 00:00:00

abstract：:1. Mechanisms underlying the generation and propagation of gastrointestinal slow wave depolarizations have long been controversial. The present review aims to collate present knowledge on this subject with specific reference to slow waves in gastric smooth muscle. 2. At present, there is strong agreement that intersti...

journal_title：Clinical and experimental pharmacology & physiology

authors： van Helden DF,Laver DR,Holdsworth J,Imtiaz MS

更新日期：2010-04-01 00:00:00

abstract：:1. In a controlled, randomized double-blind trial, 15 patients with essential hypertension were treated with enalapril 5-20 mg/day, or doxazosin 1-8 mg/day, during a 7 week dose titration phase. This was followed by 7 weeks of combined treatment with doxazosin and enalapril. 2. Blood was taken after a 2 week placebo r...

journal_title：Clinical and experimental pharmacology & physiology

authors： Stokes GS,Monaghan JC,Marwood JF,Okoro EO,Johnston H

更新日期：1992-05-01 00:00:00

abstract：:1. For the past decade, using radioligand binding, contractility and immunohistochemical techniques, we have been characterizing vascular smooth muscle (VSM) adrenoceptors in four functionally different canine blood vessels, namely the dog aorta (DAO), dog mesenteric artery (DMA), dog mesenteric vein (DMV) and dog sap...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kwan DC

更新日期：1999-10-01 00:00:00

abstract：:1. In the mammalian central nervous system, GABA is the main inhibitory neurotransmitter. GABA is a highly flexible molecule and, thus, can exist in many low-energy conformations. Conformationally restricted analogues of GABA have been used to help identify three major GABA receptors, termed GABAA, GABAB and GABAC rec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chebib M,Johnston GA

更新日期：1999-11-01 00:00:00

abstract：:1. The development of microneurography, in which an insulated tungsten microelectrode is inserted into an accessible peripheral or cranial nerve in awake human subjects, has allowed detailed analyses of the signalling capacities of single mechanoreceptive afferents from the skin, muscles and joints. For example, we kn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Macefield VG

更新日期：2005-01-01 00:00:00

abstract：:1. Alpha-terpineol is a monoterpene found in the essential oils of several aromatic plant species. In the present study, we investigated the mechanisms underlying the cardiovascular changes induced by alpha-terpineol in rats. 2. In normotensive rats, administration of alpha-terpineol (1, 5, 10, 20 and 30 mg/kg, i.v.) ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ribeiro TP,Porto DL,Menezes CP,Antunes AA,Silva DF,De Sousa DP,Nakao LS,Braga VA,Medeiros IA

更新日期：2010-08-01 00:00:00