Dopamine D1 receptors induce apoptosis of osteosarcoma cells via changes of MAPK pathway.

Abstract:

:This study explored the effects and mechanisms of dopamine D1 receptors (DR1) activation on the apoptosis of osteosarcoma cells (OS732).The DR1 agonist SKF-38393 decreased the viability of OS732 cells and increased their rate of apoptosis, whereas the DR1 antagonist SCH-23390 abolished the effects of SKF-38393. In OS732 cells, overexpression of DR1 increased the rate of apoptosis, caspase-9 and -3 expression, and the release of cytochrome c (Cyt c), reduced Bcl-2 expression, inhibited extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation, and induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and c-Jun N-terminal kinase (JNK). These results suggest that activation of DR1 induces osteosarcoma cell apoptosis via changes to the MAPK pathway.

authors

Gao J,Gao F

doi

10.1111/1440-1681.12814

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1166-1168

issue

11

eissn

0305-1870

issn

1440-1681

journal_volume

44

pub_type

信件
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    abstract::1. Salt intake is not only known to play an important role in determining blood pressure (BP) but has been shown to have other deleterious effects independent of BP. 2. Epidemiological and animal studies have provided evidence that salt intake may have an adverse effect on stroke mortality independent of BP. 3. Signif...

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  • Maintenance of pseudopregnancy by prolactin in indomethacin treated rats.

    abstract::1. The effects of bromocriptine and indomethacin on prolactin-induced pseudopregnancy were studied in pituitary grafted rats. 2.Administration of bromocriptine (a prolactin suppressant drug) at a total dose of 3 mg/kg body weight, given in 3 divided doses on day 5 of pseudopregnancy, effectively terminated it within 3...

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    journal_title:Clinical and experimental pharmacology & physiology

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/1440-1681.12694

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  • Decreased oxidative stress in prehepatic portal hypertensive rat livers following the induction of diabetes.

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  • In vitro autoradiographic endothelin-1 binding sites and sarafotoxin S6B binding sites in rat tissues.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

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  • Increased cardiovascular risk without generalized arterial dilating diathesis in persons who do not have abdominal aortic aneurysm but who are first-degree relatives of abdominal aortic aneurysm patients.

    abstract::There is a strong genetic predisposition towards abdominal aortic aneurysm (AAA), but it is unknown whether persons without AAA but with first-degree relatives who are AAA patients have a generalized dilating diathesis, defect arterial wall mechanics, or increased cardiovascular risk. The aim of the study was to inves...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

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  • Regional brain activation in humans during respiratory and blood pressure challenges.

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  • Effects of mild aerobic physical exercise on membrane fluidity of erythrocytes in essential hypertension.

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    doi:10.1046/j.1440-1681.2003.03860.x

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    authors: Ozkececi ZT,Gonul Y,Karavelioglu A,Bozkurt MF,Kacar E,Bal A,Ozsoy M,Turamanlar O,Celep B

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  • Lipidomics reveals the dynamics of lipid profile altered by omega-3 polyunsaturated fatty acid supplementation in healthy people.

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    authors: Allen K,Chuter KM,Fithon K,Marshall L,Hauton D

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    更新日期:2006-09-01 00:00:00

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    doi:10.1046/j.1440-1681.29.s4.6.x

    authors: Kato M,Tajika M,Miwa Y,Moriwaki H

    更新日期:2002-10-01 00:00:00

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    authors: Cuevas-Romero E,Sánchez-Cardiel A,Zamora-Gallegos AM,Cruz-Lumbreras R,Corona-Quintanilla DL,Castelán F,Martínez-Gómez M

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

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    更新日期:2010-11-01 00:00:00

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    更新日期:1999-01-01 00:00:00

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    journal_title:Clinical and experimental pharmacology & physiology

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    authors: Chen CF,Chen LW,Chien CT,Wu MS,Tsai TJ

    更新日期:1996-09-01 00:00:00