Importance of histamine, glutathione and oxyradicals in modulating gastric haemorrhagic ulcer in septic rats.


:1. The ulcerogenesis of gastric haemorrhagic damage during sepsis is unclear. The present study first proposes that gastric haemorrhagic ulcer is modulated by mucosal glutathione, histamine and oxyradicals in lipopolysaccharide (LPS)-induced sepsis in rats. The protective effects of several drugs on the ulcerogenic parameters also were evaluated. 2. Male specific pyrogen-free Wistar rats were deprived of food for 24 h. For the induction of sepsis, intravenous LPS (0, 1, 3 or 10 mg/kg in 1 mL sterilized normal saline) was challenged to rats 12 h after withdrawal of food. Rat stomachs were vagotomized, followed by irrigation for 3 h with normal saline or a physiological acid solution containing 100 mmol/L HCI and 54 mmol/L NaCl. 3. The aggravation of gastric ulcerogenic parameters, such as gastric acid back-diffusion, luminal haemoglobin content, mucosal lipid peroxide production, histamine concentration, as well as lowered concentrations of defensive substances, including mucosal glutathione, were dependent on the doses of LPS used for challenge. A high correlation was observed between mucosal histamine release and lipid peroxide production in LPS rats. 4. The ulcerogenic parameters obtained in LPS (3 mg/kg, i.v.) rats were potently attenuated by diamine oxidase, ketotifen and zinc sulphate. 5. Several oxyradical scavengers, including glutathione, dimethylsulphoxide and allopurinol, also were effective in inhibiting haemorrhagic ulcer. 6. In conclusion, gastric mucosal histamine release and oxyradical generation play pivotal roles in the formation of haemorrhagic ulcers in septic rats.


Hung CR





Has Abstract


2000-04-01 00:00:00












  • The effects of indomethacin in treated hypertensive patients.

    abstract::1. Twelve treated hypertensive patients (ages 58-71 years) who had also been treated for joint disease participated in a randomized double-blind crossover placebo-controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6-week period. 2. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wing LM,Bune AJ,Chalmers JP,Graham JR,West MJ

    更新日期:1981-09-01 00:00:00

  • Exercise is good for your blood pressure: effects of endurance training and resistance training.

    abstract::1. Although several epidemiological studies have not observed significant independent relationships between physical activity or fitness and blood pressure, others have concluded that blood pressure is lower in individuals who are more fit or active. However, longitudinal intervention studies are more appropriate for ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,meta分析


    authors: Fagard RH

    更新日期:2006-09-01 00:00:00

  • The action of aspirin on plasma kininogen and other plasma proteins in rheumatoid patients: relationship to disease activity.

    abstract::1. When six female seropositive rheumatoid patients were given placebo therapy for 48 h, their plasma kininogen level, 9.2 +/- 0.7 microgram bradykinin equivalents (bk eq) per ml, was found to be 59% greater than that of a group of eight healthy female volunteers (5.8 +/- 0.5 microgram/ml). 2. When the rheumatoid pati...

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    pub_type: 临床试验,杂志文章


    authors: Sharma JN,Zeitlin IJ,Brooks PM,Buchanan WW,Dick WC

    更新日期:1980-07-01 00:00:00

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    abstract::1. Several selective antagonists are available to differentiate between muscarinic receptors. 2. Further subdivision of M1 and M2 muscarinic receptors appears possible and is supported by studies with cloned receptors. 3. Reasons for differences between affinity constants determined in functional and binding studies a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Mitchelson F,Choo LK,Darroch S

    更新日期:1989-06-01 00:00:00

  • Existence of beta(3)-adrenoceptors in rat heart: functional implications.

    abstract::1. beta(3)-Adrenoceptors (AR) have been reported to be present in numerous species, where they mediate multiple responses. 2. The aim of the present study was to determine whether beta(3)-AR are present in intact rat heart and the functional implications of beta(3)-AR stimulation. The response to the cardiac beta(3)-A...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Barbier J,Mouas C,Rannou-Bekono F,Carré F

    更新日期:2007-08-01 00:00:00

  • Octreotide inhibits capsaicin-induced activation of C and Aδ afferent fibres in rat hairy skin in vivo.

    abstract::1. The present study investigated whether the somatostatin receptor (SSTR) agonist, octreotide, could inhibit the activation of dorsal skin afferent fibres induced by local injection of capsaicin in the rat. 2. Single unit activity from Aδ mechano-heat sensitive (AMH; n = 41) and C mechano-heat sensitive (CMH; n = 30)...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wang J,Cao DY,Guo Y,Ma SJ,Luo R,Pickar JG,Zhao Y

    更新日期:2011-08-01 00:00:00

  • Renal kallikrein in chronic hypoxic rats.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Chen CF,Chen LW,Chien CT,Wu MS,Tsai TJ

    更新日期:1996-09-01 00:00:00

  • L-type calcium channels and CRH-mediated ACTH and cortisol release in humans.

    abstract::1. The effect of pretreatment with nifedipine on naloxone-stimulated corticotrophin-releasing hormone (CRH)-induced adrenocorticotrophin (ACTH) release in humans was investigated. The mean peak plasma ACTH and cortisol levels and the mean peak change in cortisol levels from basal were significantly lower in the nifedi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Hockings GI,Grice JE,Walters MM,Jackson RV

    更新日期:1991-05-01 00:00:00

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Tofovic SP,Zacharia LC,Carcillo JA,Jackson EK

    更新日期:2000-10-01 00:00:00

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    abstract::1. The effects of ATP and some of its more stable analogues have been examined upon preparations of epididymal and prostatic halves of vasa deferentia and of cauda epididymides from rats that had undergone vasectomy by medial transection of the vas deferens. 2. After unilateral vasectomy, the potencies of ATP, beta, g...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ventura S,DeGaris RM,Stead CK,Pennefather JN

    更新日期:1990-08-01 00:00:00

  • Energy cost of contraction in rat urinary bladder smooth muscle during anoxia.

    abstract::1. The aim of the present study was to investigate the effects of hypoxia on energy metabolism and contraction of rat urinary bladder smooth muscle, thereby gaining insight into the capacity of this smooth muscle to maintain contractile function when rendered hypoxic. 2. Isometric force, oxygen consumption, lactate pr...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wendt IR,Paul RJ

    更新日期:2003-08-01 00:00:00

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    journal_title:Clinical and experimental pharmacology & physiology

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    authors: Song HP,Zhang L,Dang YM,Yan H,Chu ZG,Huang YS

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    abstract::1. Ambulatory monitoring provides a unique opportunity for studying the temporal relationships between lifestyle factors and blood pressure (BP). These include physical activity, mental activity, environmental stressors, substances ingested for pleasure such as smoking, alcohol and caffeine, and nutrition. 2. Changes ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Pickering TG,Schwartz JE,James GD

    更新日期:1995-03-01 00:00:00

  • Facilitation of noradrenergic transmission by locally generated angiotensin II in guinea-pig isolated atria and in the perfused caudal artery of the rat.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ziogas J,Story DF,Rand MJ

    更新日期:1984-07-01 00:00:00

  • Enhanced tissue polyamine content in the spontaneously hypertensive rat.

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    authors: Ibrahim J,Hughes AD,Schachter M,Sever PS

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ojiri Y,Noguchi K,Shiroma N,Matsuzaki T,Sakanashi M,Sakanashi M

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Messiha FS,Hughes MJ

    更新日期:1979-05-01 00:00:00

  • A controlled study of the effects of aerobic exercise on antihypertensive drug requirements of essential hypertensive patients in the general practice setting.

    abstract::1. To investigate the effect of an exercise training programme on antihypertensive drug requirements, 19 sedentary subjects (14 men and five women) with mild essential hypertension (systolic blood pressure greater than 140 mmHg but less than 180 mmHg), aged 29-55 years, were randomly assigned to 16 weeks of moderate i...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Allen DH,Puddey IB,Morton AR,Beilin LJ

    更新日期:1991-05-01 00:00:00

  • Lack of inotropic effect of nitric oxide on the rat myocardium.

    abstract::1. Nitric oxide (NO) is an important mediator of contractile function in the heart. However, isolated papillary muscle preparations appear to lack NO responsiveness in certain animal species. Although cat, guinea-pig and ferret models have been NO responsive, there have been mixed results in the rat papillary muscle. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Worthley MI,Horowitz JD,Zeitz CJ

    更新日期:2005-07-01 00:00:00

  • Characterization of the acute cardiovascular effects of intravenously administered insulin-like growth factor-I in conscious Sprague-Dawley rats.

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    pub_type: 杂志文章


    authors: Cao N,Lau S,Nguyen TT,White PJ

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  • Role of brain prostanoids in glucagon-like peptide-1-induced central activation of sympatho-adrenomedullary outflow in rats.

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    pub_type: 杂志文章


    authors: Arai J,Okada S,Yamaguchi-Shima N,Shimizu T,Sasaki T,Yorimitsu M,Wakiguchi H,Yokotani K

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Whitworth JA,Connell JM,Lever AF,Fraser R

    更新日期:1986-04-01 00:00:00

  • MicroRNAs in common diseases and potential therapeutic applications.

    abstract::1. Evidence gathered in recent years has revealed microRNAs (miRNAs) fine-tune gene expression and play an important role in various cellular processes, including cell growth, differentiation, proliferation and apoptosis. 2. The present review summarizes current knowledge of miRNA pathways in the pathogenesis of cance...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Tsai LM,Yu D

    更新日期:2010-01-01 00:00:00

  • Endoplasmic reticulum stress involved in heart and liver injury in iron-loaded rats.

    abstract::1. Iron overload contributes to the pathogenesis of various diseases and directly induces tissue injury. In the present study, we investigated the relationship between heart and liver injury induced by iron overload and cellular endoplasmic reticulum (ER) stress to explore the molecular mechanism of iron overload-indu...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Lou LX,Geng B,Chen Y,Yu F,Zhao J,Tang CS

    更新日期:2009-07-01 00:00:00

  • Renal prostaglandin efflux induced by vasopressin, dDAVP and arachidonic acid: contrasting profile and sites of release.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Miller MJ,Westlin WF,McNeill H,McGiff JC

    更新日期:1986-08-01 00:00:00

  • Cardiovascular actions of human endothelin in conscious sheep.

    abstract::1. Synthetic human endothelin was injected intravenously over the range 1.5-50 micrograms to examine its cardiovascular actions in conscious sheep. 2. Mean arterial pressure increased by 9-21 mmHg within 30-120 s over the range 5-50 micrograms endothelin. The increase in blood pressure was associated with increased ca...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Scoggins BA,Spence CD,Parkes DG,McDonald M,Wade JD,Coghlan JP

    更新日期:1989-04-01 00:00:00

  • Endothelin stimulates inositol phosphate accumulation in rat right and left atria: a comparison with noradrenaline.

    abstract::1. The effect of endothelin on phosphatidylinositol turnover in rat atria was investigated by measuring the generation of inositol phosphates following [3H]-inositol labelling. 2. In the presence of 10 mmol/L LiCl, endothelin caused dose-dependent increases in the accumulation of inositol mono, bis and trisphosphates ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kuraja IJ,Woodcock EA

    更新日期:1990-04-01 00:00:00

  • Validation of a portable indirect calorimeter (Metavine® ) for measuring energy expenditure in an elderly population.

    abstract::1. The aim of the present study was to evaluate the usefulness and reliability of a portable indirect calorimeter (Metavine; Vine, Tokyo, Japan). 2. We measured energy expenditure (EE) of elderly people (n = 191) at nursing homes using both Metavine and an authorized indirect calorimeter (Deltatrac Metabolic Monitor; ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kato M,Tajika M,Miwa Y,Moriwaki H

    更新日期:2002-10-01 00:00:00

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: McIlveen S,White S,Parsons G

    更新日期:1997-12-01 00:00:00

  • Lack of effect of age on the cardiovascular response to neuropeptide Y injection in the rat nucleus tractus solitarius.

    abstract::1. Neuropeptide Y (NPY) is colocalized with catecholamines in central regions involved in blood pressure regulation and exerts depressor responses in the nucleus tractus solitarius (NTS). Ageing is accompanied by a decline in baroreflex function and a reduction in NPY concentrations in some brain areas. The present st...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Morris MJ,Pavia JM

    更新日期:1997-02-01 00:00:00