Identification and evaluation of 2 circulating microRNAs for non-small cell lung cancer diagnosis.

Abstract:

:The circulating miRNAs are dysregulated in non-small cell lung cancer (NSCLC) and have great promise for clinical diagnosis. The aim of this study was to screen and evaluate the reliability and diagnostic efficiency of candidate serum miRNAs for NSCLC diagnosis. We found that miR-21 and let-7a were significantly dysregulated in NSCLC patients (P < .001). When applied for NSCLC diagnosis, combined application of miR-21 and let-7a had a sensitivity of 0.790, specificity of 0.750, which is significantly higher than application alone of miR-21(sensitivity 0.647; specificity 0.641), let-7a (sensitivity 0.653; specificity 0.718) or computed tomography-guided core-needle biopsy (CTCB) (sensitivity 0.725; specificity 0.609) (P < .01). In conclusion, our study indicates that combined application of circulating miR-21 and let-7a has advantages over traditional CTCB technique.

authors

Wang X,Jia Z,Shi H,Pan C

doi

10.1111/1440-1681.12977

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1083-1086

issue

10

eissn

0305-1870

issn

1440-1681

journal_volume

45

pub_type

信件
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    abstract::1. Using a nested case-control study of 661 non-institutionalized elderly (> or = 60 years) residents of Dubbo, New South Wales, Australia, the aim of this study is to determine whether the A1166C polymorphism of the angiotensin II type I (AT1) receptor gene is associated with hypertension in the elderly. 2. Individua...

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    authors: Kennaway DJ

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    authors: Seim I,Amorim L,Walpole C,Carter S,Chopin LK,Herington AC

    更新日期:2010-01-01 00:00:00

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    abstract::1. It is known that the alpha(4)-subunit is likely to occur in the brain predominantly in alpha(4)beta(3)delta receptors at extrasynaptic sites. Recent studies have revealed that the alpha(1)-, alpha(4)-, gamma(2)- and delta-subunits may colocalize extrasynaptically in dentate granule cells of the hippocampus. In the ...

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