Identification and evaluation of 2 circulating microRNAs for non-small cell lung cancer diagnosis.

Abstract:

:The circulating miRNAs are dysregulated in non-small cell lung cancer (NSCLC) and have great promise for clinical diagnosis. The aim of this study was to screen and evaluate the reliability and diagnostic efficiency of candidate serum miRNAs for NSCLC diagnosis. We found that miR-21 and let-7a were significantly dysregulated in NSCLC patients (P < .001). When applied for NSCLC diagnosis, combined application of miR-21 and let-7a had a sensitivity of 0.790, specificity of 0.750, which is significantly higher than application alone of miR-21(sensitivity 0.647; specificity 0.641), let-7a (sensitivity 0.653; specificity 0.718) or computed tomography-guided core-needle biopsy (CTCB) (sensitivity 0.725; specificity 0.609) (P < .01). In conclusion, our study indicates that combined application of circulating miR-21 and let-7a has advantages over traditional CTCB technique.

authors

Wang X,Jia Z,Shi H,Pan C

doi

10.1111/1440-1681.12977

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1083-1086

issue

10

eissn

0305-1870

issn

1440-1681

journal_volume

45

pub_type

信件
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    doi:10.1111/j.1440-1681.1995.tb02335.x

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  • Indomethacin abolishes core temperature, but not cardiovascular or renal, responses to lipopolysaccharide in conscious lambs.

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    journal_title:Clinical and experimental pharmacology & physiology

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    authors: Smith FG,Fewell JE,Qi W

    更新日期:2011-08-01 00:00:00

  • Accelerated dosing frequency of a pulmonary formulation of tissue plasminogen activator is well-tolerated in mice.

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    doi:10.1111/j.1440-1681.2008.05011.x

    authors: Stringer KA,Tobias M,Dunn JS,Campos J,Van Rheen Z,Mosharraf M,Nayar R

    更新日期:2008-12-01 00:00:00

  • Activation of plasma prekallikrein and inactive renin by puff adder venom.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2011.05640.x

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    更新日期:2012-01-01 00:00:00

  • Moderate-to-high normal levels of thyrotropin is a risk factor for urinary incontinence and an unsuitable quality of life in women over 65 years.

    abstract::The present study aimed to investigate the relationship between normal serum concentrations of thyrotropin (TSH) and urinary incontinence (IU), urinary infections, and quality of life in old women. Euthyroid post-menopausal women without sarcopenia, estrogen replacement, emotional illness, and/or cancer were enrolled ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12788

    authors: Cuevas-Romero E,Sánchez-Cardiel A,Zamora-Gallegos AM,Cruz-Lumbreras R,Corona-Quintanilla DL,Castelán F,Martínez-Gómez M

    更新日期:2017-12-01 00:00:00

  • 7,8-dihydroxyflavone enhanced cholinergic contraction of rat gastric smooth muscle via augmenting muscarinic M3 receptor expression.

    abstract::Although 7,8-dihydroxyflavone (7,8-DHF), a synthetic agonist specific for tyrosine kinase receptor B (TrkB), has been reported to promote intestinal dynamics, its effect on gastric dynamics has not been studied as yet. In this study, we explored how 7,8-DHF affected the carbachol (CCh)-induced contraction of rat gastr...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12999

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    更新日期:2018-11-01 00:00:00

  • Effects of taurine and homocysteine on calcium homeostasis and hydrogen peroxide and superoxide anions in rat myocardial mitochondria.

    abstract::1. Taurine and homocysteine are metabolites of methionine. Hyperhomocysteinaemia is one of the risk factors for cardiovascular disease. Although taurine may be a cardiovascular cytoprotective substance, we hypothesized that it may antagonize the effects of homocysteine on myocardial mitochondrial function. 2. We studi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2004.03983.x

    authors: Chang L,Zhao J,Xu J,Jiang W,Tang CS,Qi YF

    更新日期:2004-04-01 00:00:00

  • C1q/TNF-related protein 6 (CTRP6) attenuates renal ischaemia-reperfusion injury through the activation of PI3K/Akt signalling pathway.

    abstract::C1q/TNF-related protein 6 (CTRP6) is a member of the CTRP family that has been reported to exhibit a nephroprotective effect. However, the role of CTRP6 in renal ischaemia/reperfusion (I/R) injury (IRI) remains unclear. In the present study, we aimed to explore the protective effect of CTRP6 in renal IRI and the poten...

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    authors: Xiang H,Xue W,Li Y,Zheng J,Ding C,Dou M,Wu X

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  • Rutaecarpine attenuates osteoclastogenesis by impairing macrophage colony stimulating factor and receptor activator of nuclear factor κ-B ligand-stimulated signalling pathways.

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    pub_type: 信件

    doi:10.1111/1440-1681.12941

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  • Effects of neuromuscular presynaptic muscarinic M1 receptor blockade on rocuronium-induced neuromuscular blockade in immobilized tibialis anterior muscles.

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  • Stimulation of phosphatidylinositol turnover in adult rat left atria does not involve release of inositol(1,4,5)trisphosphate.

    abstract::1. The turnover rate of inositol(1,4,5)trisphosphate (Ins(1,4,5)P3) in noradrenaline-stimulated adult rat left atria was calculated from changes in specific activity and was found to equal 110 ct/min per mg tissue. In contrast, the isomers of inositol mono- and bisphosphates accumulated at a rate of 508 ct/min per mg....

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    doi:10.1111/j.1440-1681.1993.tb01698.x

    authors: Anderson KE,Myers D,Woodcock EA

    更新日期:1993-05-01 00:00:00

  • Capillary permeability in normal and hypertensive human pregnancy.

    abstract::Capillary permeability (CP) is elevated in late normal pregnancy, when compared to postpartum values. In women with pregnancy associated hypertension (PAH), pregnancy CP levels are not different from postpartum and are less than in normal pregnancy. These changes in capillary permeability are not explained by alterati...

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    更新日期:1983-05-01 00:00:00

  • Hypertension mechanisms causing stroke.

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    authors: Morris BJ,Catanzaro DF,Hardman J,Mesterovic N,Tellam J,Hort Y,Bennetts BH,Shine J

    更新日期:1984-07-01 00:00:00

  • Effects of endothelin-1 on arterial pressure: a comparison of intravenous and intra-arterial administration in conscious rabbits.

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    doi:10.1111/j.1440-1681.1979.tb00033.x

    authors: Kunes J,Jelínek J

    更新日期:1979-09-01 00:00:00

  • Afferent control of vasopressin and renin release during haemorrhage in normal and autonomically blocked rabbits.

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  • Nitric oxide modulates μ-opioid receptor function in vitro.

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  • Feasibility of conducting cardiovascular outcome research in Australian general practice: results from the ANBP2 pilot study. Australian National Blood Pressure Study.

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1997-05-01 00:00:00

  • The effect of spontaneous diabetes mellitus on fatty acid oxidation, beta-hydroxybutyrate dehydrogenase activity and respiratory coupling of hepatic mitochondria in the guinea-pig (Cavia porcellus).

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    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1978.tb00674.x

    authors: Nevalainen TO,White WJ,Lang CM,Munger BL

    更新日期:1978-05-01 00:00:00

  • Effect of Anoectochilus formosanus on fibrosis and regeneration of the liver in rats.

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    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2004.04062.x

    authors: Shih CC,Wu YW,Hsieh CC,Lin WC

    更新日期:2004-09-01 00:00:00

  • Vancomycin dosing, monitoring and toxicity: Critical review of the clinical practice.

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    pub_type: 杂志文章,评审

    doi:10.1111/1440-1681.13066

    authors: Zamoner W,Prado IRS,Balbi AL,Ponce D

    更新日期:2019-04-01 00:00:00

  • Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2.

    abstract::1. Protease-activated receptor 2 (PAR2), present in capsaicin-sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection. 2. We studied the possible cross-talk between PAR2 and vanilloid receptor 1 (VR1). The VR1 antagonist capsazepine partially inhibited the PAR2-mediated increase in gastri...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2002.03641.x

    authors: Kawabata A,Kinoshita M,Kuroda R,Kakehi K

    更新日期:2002-04-01 00:00:00

  • Mechanical stretch induces endothelial nitric oxide synthase gene expression in neonatal rat cardiomyocytes.

    abstract::1. Mechanical stretch leads to cardiac hypertrophy and may ultimately cause heart failure. However, the effect of mechanical stretch on gene induction in cardiomyocytes remains to be determined. 2. In the present study, we compared transcript profiles of mechanically stretched neonatal rat cardiomyocytes with those of...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2008.05100.x

    authors: Cheng TH,Chen JJ,Shih NL,Lin JW,Liu JC,Chen YL,Chen CH,Chen JJ

    更新日期:2009-05-01 00:00:00

  • Effects of rilmenidine on proximal tubular fluid absorption in rats.

    abstract::The antihypertensive agent rilmenidine has threefold higher affinity for I(1) imidazoline receptors compared with alpha(2)-adrenoceptors and acts on the central nervous system by reducing sympathetic activity and in the kidney by inhibiting Na(+)/H(+) exchange activity. In the present study, we examined: (i) the effec...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2004.04008.x

    authors: Jovanovska V,Eitle E,Harris PJ

    更新日期:2004-05-01 00:00:00