Is Fleming's lysozyme an analgesic agent? Experiments on mice.


:1. Antinociceptive activity of hen egg white lysozyme (Fleming's lysozyme) was determined against abdominal contractions provoked by irritants injected intraperitoneally into mice. Carrageenan (2 mg) (CA) injected with arachidonic acid (15 micrograms) (AA) or prostaglandins PGE1 or PGF2 alpha (0.04 ng), brewer's yeast (10 mg), caolin (10 mg), mepartricin (80 U) and phenylquinone (50 micrograms) were used as irritants. 2. Lysozyme was active at 400-800 mg/kg i.v. against CA + AA, CA + PG, brewer's yeast and caolin nociceptive stimulation. The compound was more effective against CA + AA than against CA + PG. Acetylsalicylic acid at 50-100-200 mg/kg p.o. was equally active against CA + AA and CA + PG. 3. Lysozyme was inactive in the tail pinch and hot plate tests that mainly detect central analgesics. 4. The results are discussed in relation to the claim advanced years ago that lysozyme is an effective analgesic agent in humans. The compound was found active against herpes zoster or cancer pain but did not find use despite the favourable reports presented. 5. The experimental results obtained on laboratory animals do not contradict the conclusions drawn after the clinical use of the compound.


Bianchi C




Has Abstract


1983-01-01 00:00:00












  • Effects of torasemide on renal haemodynamics and function in anaesthetized dogs.

    abstract::1. We examined the effects of torasemide (0.3 and 1 mg/kg i.v.) on renal haemodynamics and function employing renal clearance and stop-flow techniques in anaesthetized dogs and compared these with furosemide (1 and 3 mg/kg i.v.). 2. Torasemide and furosemide did not influence renal haemodynamics, in the renal clearanc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Uchida T,Hayashi K,Suzuki Y,Matsumura Y

    更新日期:1991-07-01 00:00:00

  • Carotid body potentiation induced by intermittent hypoxia: implications for cardiorespiratory changes induced by sleep apnoea.

    abstract::1. The most usual form of chronic hypoxia in humans is the intermittent hypoxia resulting from obstructive sleep apnoea (OSA). The OSA syndrome is a highly prevalent sleep breathing disorder that is considered an independent risk factor for hypertension and cardiovascular diseases. Endothelial dysfunction, oxidative s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Iturriaga R,Moya EA,Del Rio R

    更新日期:2009-12-01 00:00:00

  • Activation of imidazoline-I3 receptors ameliorates pancreatic damage.

    abstract::Agmatine, an endogenous ligand of imidazoline receptors, is reported to exhibit anti-hyperglycaemic and many other effects. It has been established that the imidazoline I3 receptor is involved in insulin secretion. The current study characterizes the role of the imidazoline I3 receptor in the protection of pancreatic ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Li Y,Cheng KC,Asakawa A,Amitani H,Takimoto Y,Runtuwene J,Inui A

    更新日期:2015-09-01 00:00:00

  • A locus on the long arm of chromosome 1 as a possible cause of essential hypertension.

    abstract::1. None of the genes responsible for essential hypertension has been identified. Recent work in genetically hypertensive rats has shown linkage of blood pressure with alleles of the renin gene. Since the renin gene is a member of a conserved synteny group that in humans spans chromosome 1q21.3-32.3 and includes the ge...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Griffiths LR,Zee RY,Ying LH,Morris BJ

    更新日期:1991-05-01 00:00:00

  • Systemic and regional haemodynamic responses to isoprenaline in conscious renal hypertensive rabbits.

    abstract::1. Using the electromagnetic flow probe and the radioactive microsphere technique, systemic and regional haemodynamic variables were measured in conscious normotensive and hypertensive rabbits. The rabbits were made hypertensive by unilateral nephrectomy combined with cellophane-wrapping of the remaining kidney and sy...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: van Boom M,Saxena PR

    更新日期:1981-05-01 00:00:00

  • Role of brain prostanoids in glucagon-like peptide-1-induced central activation of sympatho-adrenomedullary outflow in rats.

    abstract::1. The aim of the present study was to characterize the source of plasma catecholamines induced by centrally administered glucagon-like peptide-1 (GLP-1), with regard to brain prostanoids, in urethane-anaesthetized rats. 2. Glucagon-like peptide-1 and other compounds were administered intracerebroventricularly (i.c.v....

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Arai J,Okada S,Yamaguchi-Shima N,Shimizu T,Sasaki T,Yorimitsu M,Wakiguchi H,Yokotani K

    更新日期:2008-08-01 00:00:00

  • Effect of ethamsylate on carrageenan-induced rat paw oedema: a comparison with indomethacin.

    abstract::1. Ethamsylate (diethylammonium 2,5-dihydroxybenzene sulfonate, Dicynene), a systemic haemostatic agent with an unknown mechanism of action, was tested for anti-inflammatory activity using the carrageenan-induced rat paw oedema test. 2. Ethamsylate was shown to be an effective anti-inflammatory agent with a time cours...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Gard PR,Trigger DJ

    更新日期:1990-12-01 00:00:00

  • The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age.

    abstract::1. In order to investigate further whether the increased sensitivity to inhibition by nifedipine of the responses to noradrenaline of aortae from spontaneously hypertensive stroke-prone (SHRSP) rats is related to the development of the hypertension, we have compared the sensitivity to noradrenaline, potassium chloride...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Jiang GC,Iwanov V,Moulds RF

    更新日期:1995-01-01 00:00:00

  • Relationship between the dose-response effects of diazepam and clobazam on electroencephalographic parameters and on kindled amygdaloid seizure activity in rats.

    abstract::1. The possibility that the anticonvulsant activity of the benzodiazepines, diazepam and clobazam, is related to changes in EEG parameters, particularly beta activity, was investigated in amygdaloid kindled rats. 2. The effects of diazepam (1, 2, 4, 8 and 16 mumols/kg), administered intraperitoneally (i.p.), clobazam ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Harris QL,Lewis SJ,Young NA,Vajda FJ,Jarrott B

    更新日期:1988-10-01 00:00:00

  • Agonist function of the recombinant alpha 4 beta 3 delta GABAA receptor is dependent on the human and rat variants of the alpha 4-subunit.

    abstract::1. It is known that the alpha(4)-subunit is likely to occur in the brain predominantly in alpha(4)beta(3)delta receptors at extrasynaptic sites. Recent studies have revealed that the alpha(1)-, alpha(4)-, gamma(2)- and delta-subunits may colocalize extrasynaptically in dentate granule cells of the hippocampus. In the ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wang MD,Rahman M,Johansson IM,Bäckström T

    更新日期:2010-07-01 00:00:00

  • In-vivo modification of angiotensin II pressor responsiveness in sheep by indomethacin.

    abstract::1. Sodium (Na) depletion, due to uncompensated loss of parotid saliva, reduces the pressor responsiveness to angiotensin II (AII) in intact conscious sheep. 2. Inhibition of prostaglandin synthesis by indomethacin restored AII pressor responsiveness in Na-deplete sheep. 3. Indomethacin infusion also increased the pres...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Beilby DS,Coghlan JP,Denton DA,Graham WF,Humphery TJ,Scoggins BA,Whitworth JA

    更新日期:1981-01-01 00:00:00

  • A novel model of constrictive pericarditis associated with myocardial fibrosis in rats.

    abstract::An efficient animal model is fundamental for studies on the underlying mechanisms of constrictive pericarditis (CP). A novel CP rat model was established by pericardial injection composing of lipopolysaccharides (LPS) and talcum powder without thoracotomy. Pathological changes were confirmed by histological staining. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Qiao W,Xiao YJ,Wang X,Sun LJ,Chen YX,Ren WD

    更新日期:2020-12-21 00:00:00

  • Pressor responsiveness in steroid-induced hypertension in man.

    abstract::Pressor responsiveness to angiotensin II (AII) and phenylephrine (PE) was examined before and after 5 days of ACTH (1 mg, i.m., daily) or hydrocortisone (200 mg, orally, daily) in six normotensive men. Pulse pressure was higher prior to PE than AII infusion, presumably due to feeding. Systolic blood pressure (SBP) was...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Whitworth JA,Connell JM,Lever AF,Fraser R

    更新日期:1986-04-01 00:00:00

  • The cardiovascular effects of intraventricular 5,6-dihydroxytryptamine in conscious hypertensive rats.

    abstract::1. Conscious experimental hypertensive rats injected intraventricularly with 5,6-dihydroxytryptamine (50 microgram) responded with a rapid and long-lasting (4 days) fall in blood pressure and this was accompanied by a bradycardia of similar duration. 2. The acute actions of 5,6-dihydroxytryptamine on the cardiovascula...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Finch L

    更新日期:1975-11-01 00:00:00

  • Activation of plasma prekallikrein and inactive renin by puff adder venom.

    abstract::The activation of inactive renin during incubation of human plasma with puff adder venom at pH 7.4 was found to be a complex process. Gel filtration on Sephacryl S-200 indicated that the venom contains a major peak of caseinolytic and renin-activating activity of low molecular weight. This enzyme was a metalloproteina...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Morris BJ,Lawrence CH,Catanzaro DF

    更新日期:1980-09-01 00:00:00

  • Reduced store-operated Ca2+ entry impairs mesenteric artery function in response to high external glucose in type 2 diabetic ZDF rats.

    abstract::Diabetes is a major risk factor for cardiovascular disease, affecting both endothelial and smooth muscle cells. Store-operated Ca2+ channels (SOCCs) have been implicated in many diabetic complications. Vascular dysfunction is common in patients with diabetes, but the role of SOCCs in diabetic vasculopathy is still unc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Schach C,Wester M,Leibl F,Redel A,Gruber M,Maier LS,Endemann D,Wagner S

    更新日期:2020-07-01 00:00:00

  • Neural pathways from the lamina terminalis influencing cardiovascular and body fluid homeostasis.

    abstract::1. The lamina terminalis, a region of the brain with a high concentration of angiotensin AT1 receptors, consists of three distinct nuclei, the median preoptic nucleus, the subfornical organ and organum vasculosum of the lamina terminalis (OVLT). These latter two regions lack a blood-brain and detect changes in plasma ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: McKinley MJ,Allen AM,May CN,McAllen RM,Oldfield BJ,Sly D,Mendelsohn FA

    更新日期:2001-12-01 00:00:00

  • The inhibition of nitric oxide-mediated relaxations in rat aorta and anococcygeus muscle by diphenylene iodonium.

    abstract::1. The effects of diphenylene iodonium (DPI), an inhibitor of reduced nicotinamide adenine dinucleotide phosphate-dependent oxidases (which generate superoxide anions), were studied on nitric oxide (NO)-mediated responses in isolated preparations of the rat aorta and anococcygeus muscle. 2. In aortic rings, the endoth...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Rand MJ,Li CG

    更新日期:1993-03-01 00:00:00

  • Endothelin stimulates inositol phosphate accumulation in rat right and left atria: a comparison with noradrenaline.

    abstract::1. The effect of endothelin on phosphatidylinositol turnover in rat atria was investigated by measuring the generation of inositol phosphates following [3H]-inositol labelling. 2. In the presence of 10 mmol/L LiCl, endothelin caused dose-dependent increases in the accumulation of inositol mono, bis and trisphosphates ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kuraja IJ,Woodcock EA

    更新日期:1990-04-01 00:00:00

  • Chronic exercise partially restores the transmural heterogeneity of action potential duration in left ventricular myocytes of spontaneous hypertensive rats.

    abstract::Hypertension leads to electrophysiological changes in the heart. Chronic exercise induced by a treadmill-running programme (TRP) is considered a potential non-pharmacological treatment for hypertension and may have implications in heart remodelling. However, it is not known whether the TRP is able to improve the elect...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Roman-Campos D,Carneiro-Júnior MA,Prímola-Gomes TN,Silva KA,Quintão-Júnior JF,Gondim AN,Duarte HL,Cruz JS,Natali AJ

    更新日期:2012-02-01 00:00:00

  • Dihydrocyclosporin D in sheep: haemodynamic and renal effects.

    abstract::1. This study was designed to test the haemodynamic and renal effects in sheep of dihydrocyclosporin D (dCyD), an immunosuppressant agent derived from the fungus Tolypocladium inflatum Gams. 2. dCyD was infused for 5 days at 12 mg/kg per day. Mean arterial pressure (MAP) was elevated after 24 h, but thereafter returne...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Tresham JJ,Whitworth JA,de Lima JJ,McDougall JG,Scoggins BA

    更新日期:1988-05-01 00:00:00

  • Comparative bioavailability of two cefadroxil products using serum and urine data in healthy human volunteers.

    abstract::1. The aim of the present study was to assess the bioequivalence of two cefadroxil products, namely Ultracef (a reference product) in the form of a 500 mg capsule (produced by Bristol-Myers Squibb Laboratories, Princeton, NJ, USA) and Roxil (a test product) in the form of a 500 mg capsule (produced by Tabuk Pharmaceut...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Otoom S,Hasan M,Najib N

    更新日期:2004-07-01 00:00:00

  • Ketanserin stabilizes blood pressure in conscious spontaneously hypertensive rats.

    abstract::1. It has been demonstrated that blood pressure variability (BPV) is increased in hypertension and related to organ damage. It will be important to lower BPV in the treatment of hypertension. The present study was designed to investigate the effect of ketanserin, a 5-HT2A receptor antagonist with a weak alpha1-adrenoc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Miao CY,Xie HH,Yu H,Chu ZX,Su DF

    更新日期:2003-03-01 00:00:00

  • Effects of atropine on the time and frequency domain estimates of blood pressure and heart rate variability in mice.

    abstract::1. Indices quantifying blood pressure (BP) and heart rate (HR) variability have been recently developed and may be used to assess the contribution of the autonomic nervous system to cardiovascular fluctuations. 2. Cardiovascular variables were measured in eight conscious mice equipped with a BP telemetric device. Each...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Laude D,Baudrie V,Elghozi JL

    更新日期:2008-04-01 00:00:00

  • Angiotensin II-nitric oxide interaction in glomerular arterioles.

    abstract::1. Resistance changes of the afferent and efferent arterioles determine blood flow and filtration rate in the kidney. The tone of both vessels results from the influence of nerves and humoral and paracrine factors, through a balance of constrictor and dilator systems. Angiotensin (Ang) II and nitric oxide (NO) are imp...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Patzak A,Lai E,Persson PB,Persson AE

    更新日期:2005-05-01 00:00:00

  • Effect of exercise on plasma adrenomedullin and natriuretic peptide levels in myocardial infarction.

    abstract::1. We investigated the effect of exercise on plasma adrenomedullin, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations and studied the relationship between these peptides and haemodynamic parameters in nine patients with old myocardial infarction (MI) and in eight normal subjects. 2. T...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Morimoto A,Nishikimi T,Takaki H,Okano Y,Matsuoka H,Takishita S,Kitamura K,Miyata A,Kangawa K,Matsuo H

    更新日期:1997-05-01 00:00:00

  • Vancomycin dosing, monitoring and toxicity: Critical review of the clinical practice.

    abstract::Vancomycin is an antibiotic used in the treatment of infections caused by multidrug-resistant Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus. In the last decades, vancomycin has been widely used in hospital environments due to the increasing incidence of sepsis and septic shock. Sepsis ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Zamoner W,Prado IRS,Balbi AL,Ponce D

    更新日期:2019-04-01 00:00:00

  • Antisense oligonucleotides: from design to therapeutic application.

    abstract::1. An antisense oligonucleotide (ASO) is a short strand of deoxyribonucleotide analogue that hybridizes with the complementary mRNA in a sequence-specific manner via Watson-Crick base pairing. Formation of the ASO-mRNA heteroduplex either triggers RNase H activity, leading to mRNA degradation, induces translational ar...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Chan JH,Lim S,Wong WS

    更新日期:2006-05-01 00:00:00

  • Effect of placental growth factor in models of experimental pre-eclampsia and trophoblast invasion.

    abstract::Placental growth factor (PlGF) is decreased in early gestation of pregnant women who subsequently develop pre-eclampsia. In this study, pre-emptive treatment with PlGF to prevent pre-eclampsia was evaluated in an in vivo rodent model of experimental pre-eclampsia (EPE) induced by TNF-α and in an in vitro model of huma...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Chau K,Bobek G,Xu B,Stait-Gardner T,Price W,Hennessy A,Makris A

    更新日期:2020-01-01 00:00:00

  • Plasmalemmal calcium in cardiac excitation-contraction coupling.

    abstract::1. Mammalian heart muscle is extremely sensitive to the external calcium concentration. It reacts to alterations of the external calcium concentration with an immediate adaptation of contractile force. 2. In mammalian heart there is a network of large transverse tubules throughout the cell. These structures are regula...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Lüllmann H,Peters T

    更新日期:1977-01-01 00:00:00