Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2.

Abstract:

:1. Protease-activated receptor 2 (PAR2), present in capsaicin-sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection. 2. We studied the possible cross-talk between PAR2 and vanilloid receptor 1 (VR1). The VR1 antagonist capsazepine partially inhibited the PAR2-mediated increase in gastric mucus secretion. 3. Thus, activation of VR1 is responsible, at least in part, for the neurally mediated mucosal cytoprotection following activation of PAR2.

authors

Kawabata A,Kinoshita M,Kuroda R,Kakehi K

doi

10.1046/j.1440-1681.2002.03641.x

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

360-1

issue

4

eissn

0305-1870

issn

1440-1681

journal_volume

29

pub_type

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