Abstract:
:The effect of indomethacin suppositories on both acute urinary colic and urinary calculus, resistant or refractory to conventional therapy with analgesics and spasmolytics was investigated. Fifty-five patients with acute urinary colic refractory to treatment with repeated injections of antispasmodics and analgesics had dramatic or complete pain relief after receiving indomethacin suppositories (100 mg) (P less than 0.01). Fifteen of the 55 patients passed urinary stones within 30 days of treatment with indomethacin. Three out of 30 other patients with renal or ureteric stones were treated with indomethacin suppositories (100 mg) twice daily. Twenty-one of the 30 patients passed their stones within 30 days of treatment. It is concluded that indomethacin suppositories can relieve acute urinary colic resistant to treatment with analgesic/antispasmodic drugs, and facilitate expulsion of urinary calculi. The mechanism of action of indomethacin is discussed in terms of its analgesic and anti-inflammatory effects and its prostaglandin synthesis inhibition.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Al-Waili NSdoi
10.1111/j.1440-1681.1986.tb00337.xsubject
Has Abstractpub_date
1986-03-01 00:00:00pages
195-9issue
3eissn
0305-1870issn
1440-1681journal_volume
13pub_type
杂志文章abstract::Afferent splanchnic nerve stimulation with different frequencies in Wistar Kyoto rats caused depressor and pressor responses depending on the frequency employed. Similar visceral afferent activation in spontaneously hypertensive rats caused depressor responses at all frequencies of stimulation. It is suggested that th...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1985.tb00300.x
更新日期:1985-01-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1681.2009.05269.x
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.2003.03939.x
更新日期:2003-12-01 00:00:00
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pub_type: 信件
doi:10.1111/1440-1681.12977
更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1982.tb00840.x
更新日期:1982-11-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1992.tb00489.x
更新日期:1992-06-01 00:00:00
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pub_type: 杂志文章
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doi:10.1111/j.1440-1681.1990.tb01320.x
更新日期:1990-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1995.tb01963.x
更新日期:1995-02-01 00:00:00
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更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1111/1440-1681.12177
更新日期:2013-12-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1986.tb02392.x
更新日期:1986-09-01 00:00:00
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更新日期:2007-08-01 00:00:00
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更新日期:1980-09-01 00:00:00
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更新日期:2004-12-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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更新日期:1992-08-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,评审
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更新日期:1977-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.2005.04155.x
更新日期:2005-01-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
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更新日期:1988-06-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1681.1996.tb02775.x
更新日期:1996-06-01 00:00:00