The influence of coumarin on tissue levels of radio-labelled plasma protein and povidone (polyvinylpyrrolidine) in normal and thermally injured rats.

Abstract:

:1. The administration of coumarin resulted in a two-fold increase in the entry of 51Cr-labelled rat plasma protein into otherwise normal tissues. 2. Prior treatment of rats with coumarin allowed about 50% more radio-labelled protein to enter the tissues immediately after thermal injury than occurred with thermal injury in untreated rats. 3. In coumarin-treated rats, 30 min or more after thermal injury, tissue levels of 125I-labelled povidone (polyvinylpyrrolidine) were significantly elevated or showed no change compared with tissue levels in rats which received only thermal injury. 4. Conversely, tissue levels or radio-labelled protein in coumarin-treated rats, 30 min or more after thermal injury were significantly reduced to between 20 and 30% of those in untreated, thermally injured rats. 5. These results were attributed to enhanced proteolysis of the radio-labelled protein caused by coumarin. Other results have shown that normal protein is similarly affected. 6. The products of proteolysis may then rapidly leave the tissues, freeing the osmotically-held fluids and reducing the oedema.

authors

Piller NB

doi

10.1111/j.1440-1681.1976.tb00633.x

keywords:

subject

Has Abstract

pub_date

1976-11-01 00:00:00

pages

523-30

issue

6

eissn

0305-1870

issn

1440-1681

journal_volume

3

pub_type

杂志文章
  • Noradrenaline release from the rat heart during anoxia: effects of changes in extracellular sodium concentration and inhibition of sodium uptake mechanisms.

    abstract::1. Anoxic perfusion of the isolated rat heart releases noradrenaline in the absence of sympathetic nerve fibre stimulation. 2. Anoxic noradrenaline release is enhanced by reducing the extracellular Na+ concentration, consistent with the proposal that such release occurs by carrier-mediated efflux. 3. Release is also e...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1991.tb01375.x

    authors: Dart AM,Riemersma RA

    更新日期:1991-01-01 00:00:00

  • Concentration of guanidines in normal human plasma.

    abstract::1. The concentration of methylguanidine and guanidinosuccinic acid has been measured in normal human plasma and discrepancies between various published methods for measuring methylguanidine have been resolved. Previous methods have been modified to allow these guanidines, together with guanidinoacetic acid and creatin...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1978.tb00654.x

    authors: Lazdins I,Dawborn JK

    更新日期:1978-01-01 00:00:00

  • Excess weight in children and adolescents is associated with altered subendocardial blood supply among girls but not boys.

    abstract::Subendocardial viability ratio (SEVR) is a reliable index of myocardial supply-workload balance. This study sought to investigate whether overweight/obese children and adolescents have altered SEVR and to identify which are the associated factors. This cross-sectional study involved 789 individuals. Central haemodynam...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 信件

    doi:10.1111/1440-1681.12922

    authors: Zaniqueli D,Alvim RO,Baldo MP,Luiz SG,Cunha RS,Mill JG

    更新日期:2018-05-01 00:00:00

  • Protective effects of L-carnitine on myoglobinuric acute renal failure in rats.

    abstract::1. Muscle injury (rhabdomyolysis) is one of the causes of acute renal failure (ARF). Iron, free radicals and nitric oxide (NO) play a critical role in the pathogenesis of glycerol-induced myoglobinuric ARF. L-Carnitine is an anti-oxidant and prevents the accumulation of end-products of lipid peroxidation. Therefore, t...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2006.04336.x

    authors: Aydogdu N,Atmaca G,Yalcin O,Taskiran R,Tastekin E,Kaymak K

    更新日期:2006-01-01 00:00:00

  • Oestrogen receptors and cardiovascular disease.

    abstract::1. Animal and human studies indicate that female sex hormones are protective against the development of coronary atherosclerosis. 2. Experiments on vascular smooth muscle cells suggest a direct effect of oestrogen on vascular tissue. Although oestrogen receptors (ER) in vascular tissues and an association between ER s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.1996.tb02775.x

    authors: Baysal K,Losordo DW

    更新日期:1996-06-01 00:00:00

  • Propofol block of cardiac sodium currents in rat isolated myocardial cells is increased at depolarized resting potentials.

    abstract::1. The effect of propofol on cardiac whole-cell sodium currents and single sodium channels in rat isolated ventricular myocytes was examined using patch-clamp techniques. 2. Propofol caused a block of the whole-cell sodium current, the potency of block depending on the holding potential. When cells were held at -90 mV...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1998.tb02360.x

    authors: Saint DA,Tang Y

    更新日期:1998-05-01 00:00:00

  • Cardiac-specific overexpression of catalase prolongs lifespan and attenuates ageing-induced cardiomyocyte contractile dysfunction and protein damage.

    abstract::1. Oxidative stress plays a role in senescence-associated organ deterioration. This is supported by the beneficial effects of anti-oxidants against ageing-related organ damage, although their role in cardiac ageing has not been elucidated. 2. The aim of the present study was to examine the impact of cardiac-specific o...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04540.x

    authors: Wu S,Li Q,Du M,Li SY,Ren J

    更新日期:2007-01-01 00:00:00

  • Validation of a portable indirect calorimeter (Metavine® ) for measuring energy expenditure in an elderly population.

    abstract::1. The aim of the present study was to evaluate the usefulness and reliability of a portable indirect calorimeter (Metavine; Vine, Tokyo, Japan). 2. We measured energy expenditure (EE) of elderly people (n = 191) at nursing homes using both Metavine and an authorized indirect calorimeter (Deltatrac Metabolic Monitor; ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.29.s4.6.x

    authors: Kato M,Tajika M,Miwa Y,Moriwaki H

    更新日期:2002-10-01 00:00:00

  • L-arginine and aminoguanidine reduce colonic damage of acetic acid-induced colitis in rats: potential modulation of nuclear factor-κB/p65.

    abstract::The transcription factor, nuclear factor-κB (NF-κB) is a key inducer of inducible nitric oxide synthase (iNOS) gene expression. The aim of the present study was to investigate the potential protective effect of l-arginine (Arg; nitric oxide precursor) and aminoguanidine (inducible nitric oxide synthase inhibitor) agai...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12287

    authors: Farghaly HS,Thabit RH

    更新日期:2014-10-01 00:00:00

  • Auranofin increases apoptosis and ischaemia-reperfusion injury in the rat isolated heart.

    abstract::Auranofin, an antirheumatic gold compound, is an inhibitor of selenocysteine enzymes, such as thioredoxin reductase and glutathione peroxidase. These enzymes play an important role in protecting cardiac tissue from oxidative stress generated during ischaemia-reperfusion. Auranofin (100 mg/kg) was administered to rats ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2004.03993.x

    authors: Venardos K,Harrison G,Headrick J,Perkins A

    更新日期:2004-05-01 00:00:00

  • Role of cAMP in the effects of K+ on the steroidogenesis of zona glomerulosa cells.

    abstract::1. Investigations of the role of cAMP in the stimulation of the steroidogenesis of zona glomerulosa (ZG) cells by increased extracellular K+ concentration are reviewed. 2. Possible reasons for discrepancies in the results of different investigators on whether K+ increases the cAMP content or output of ZG tissue or dis...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1681.1999.03173.x

    authors: Tait JF,Tait SA

    更新日期:1999-12-01 00:00:00

  • Effects of endothelin-1 on arterial pressure: a comparison of intravenous and intra-arterial administration in conscious rabbits.

    abstract::1. Intravenous endothelin-1 releases endothelium-derived relaxing factor (EDRF) and prostacyclin from the lungs, and substantial pulmonary clearance is claimed. Since these vaso-active substances could alter the haemodynamic effects of endothelin-1, the effects of boluses of endothelin-1 injected intravenously and int...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1994.tb02521.x

    authors: Roberts-Thomson P,McRitchie RJ,Cain MD,Chalmers JP

    更新日期:1994-04-01 00:00:00

  • Autonomic nervous system in acute kidney injury.

    abstract::Acute kidney injury (AKI) is a rapid loss of kidney function resulting in accumulation of end metabolic products and associated abnormalities in fluid, electrolyte and acid-base homeostasis. The pathophysiology of AKI is complex and multifactorial involving numerous vascular, tubular and inflammatory pathways. Neurohu...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/1440-1681.12694

    authors: Hering D,Winklewski PJ

    更新日期:2017-02-01 00:00:00

  • PPARD rs2016520 polymorphism affects repaglinide response in Chinese Han patients with type 2 diabetes mellitus.

    abstract::Repaglinide is a short-acting insulin secretagogue, which often results in considerable interindividual variability in therapeutic efficacy when widely used in a clinical setting. Among various reasons under discussion is genetic polymorphism, especially the genes related to insulin secretion and resistance. Recent st...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/1440-1681.12314

    authors: Song JF,Wang T,Zhu J,Zhou XY,Lu Q,Guo H,Zhang F,Wang Y,Li W,Wang DD,Cui YW,Lv DM,Yin XX

    更新日期:2015-01-01 00:00:00

  • 17Beta-oestradiol enhances nitric oxide synthase activity in endothelium-denuded rat aorta.

    abstract::1. It has been suggested that oestrogen-produced vasodilatation is due to induction of endothelial nitric oxide synthase (NOS), but there are many reports of direct effects on vascular smooth muscle. In the present study, these processes were investigated in rat aorta isolated from ovariectomized rats. 2. Short-term t...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1998.tb02188.x

    authors: Binko J,Murphy TV,Majewski H

    更新日期:1998-02-01 00:00:00

  • The initial fall in arterial pressure evoked by endotoxin is mediated by the ventrolateral periaqueductal gray.

    abstract::This study tested the hypothesis that the initial fall in arterial pressure evoked by lipopolysaccharide (LPS) is mediated by the ventrolateral column of the midbrain periaqueductal gray region (vlPAG). To test this hypothesis, the local anaesthetic lidocaine (2%; 0.1 μL, 0.2 μL or 1.0 μL), the delta opioid receptor a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12573

    authors: Millington WR,Yilmaz MS,Feleder C

    更新日期:2016-06-01 00:00:00

  • Influence of variation in dietary sodium intake on biochemical indices of sympathetic activity in normal man.

    abstract::The effects of variation in dietary sodium intake on biochemical indices of sympathetic activity were investigated in normal subjects. Sodium restriction for 7 days (mean urinary sodium excretion 21 mmol/day, s.e.m. = 4) increased supine plasma noradrenaline concentration significantly (1.78 nmol/l, s.e.m. = 0.23) com...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1984.tb00253.x

    authors: Watson RD,Esler MD,Leonard P,Korner PI

    更新日期:1984-03-01 00:00:00

  • Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects?

    abstract::1. Hypertension plays a critical role in the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD), but it has also been postulated that antihypertensive drugs that block the renin-angiotensin system (RAS) show class-specific renoprotective actions beyond their blood pressure (BP)-lowering effe...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2010.05453.x

    authors: Kujal P,Chábová VČ,Vernerová Z,Walkowska A,Kompanowska-Jezierska E,Sadowski J,Vaňourková Z,Husková Z,Opočenský M,Skaroupková P,Schejbalová S,Kramer HJ,Rakušan D,Malý J,Netuka I,Vaněčková I,Kopkan L,Cervenka L

    更新日期:2010-12-01 00:00:00

  • Hypertension mechanisms causing stroke.

    abstract::1. Although it is well established that hypertension is the main risk factor for stroke, the complexity of cerebrovascular problems related to hypertension is not generally appreciated. 2. Hypertension can cause stroke through many mechanisms. A high intraluminal pressure will lead to extensive alteration in endotheli...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1681.1999.03081.x

    authors: Johansson BB

    更新日期:1999-07-01 00:00:00

  • Enhanced tissue polyamine content in the spontaneously hypertensive rat.

    abstract::1. Endogenous polyamines play a key role in mediating cellular growth and differentiation. Hypertension is associated with structural modifications of the circulatory system, a process that may be facilitated by polyamines. In this study, we examined whether there are elevated polyamine concentrations in the cardiovas...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1996.tb02750.x

    authors: Ibrahim J,Hughes AD,Schachter M,Sever PS

    更新日期:1996-05-01 00:00:00

  • Streptokinase alters myocardial creatine kinase depletion after ischaemia and reperfusion in rabbits.

    abstract::The efficacy of streptokinase as an intracoronary thrombolytic agent is well-recognized. The effect of streptokinase, distinct from its thrombolytic action, on ischaemic myocardium distal to an area of coronary artery occlusion when reperfusion occurs has not been well-defined. In order to do this, myocardial creatine...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1986.tb02392.x

    authors: Mickelson JK,Carlson CJ,Margaretten W,Rapaport E

    更新日期:1986-09-01 00:00:00

  • Effects of combination therapy with perindopril and losartan on left ventricular remodelling in patients with myocardial infarction.

    abstract::1. Inhibiting the renin-angiotensin-aldosterone system prevents left ventricular (LV) remodelling after myocardial infarction (MI). 2. The present study was designed to assess the effects of a combination of perindopril and losartan on LV remodelling, cardiac function and serum procollagen type III amino terminal pept...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2009.05143.x

    authors: Li L,Liu RY,Zhao XY,Zhang JY,Jia M,Lu PQ

    更新日期:2009-07-01 00:00:00

  • Renin gene expression in various tissues determined by single-step polymerase chain reaction.

    abstract::1. Renin mRNA is present in the kidney and, in lower concentrations, in many extrarenal tissues and serves as an index of renin gene activity, as well as potential renin or prorenin synthesis in cell populations within those tissues. Unfortunately the quantity can be very low. 2. A new, highly sensitive technique is d...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1991.tb01463.x

    authors: Lou YK,Smith DL,Robinson BG,Morris BJ

    更新日期:1991-05-01 00:00:00

  • Sample size requirements for clinical trials of isolated systolic hypertension.

    abstract::1. This study investigated components of blood pressure variability in elderly subjects with isolated systolic hypertension (ISH) using both ambulatory blood pressure monitoring (ABPM) and casual clinic blood pressure measurement. These were then used to determine sample size requirements for clinical trials of differ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1992.tb00455.x

    authors: Silagy CA,McNeil JJ,McGrath BP

    更新日期:1992-05-01 00:00:00

  • Renal tubulointerstitial hypoxia: cause and consequence of kidney dysfunction.

    abstract::1. Intrarenal oxygen availability is the balance between supply, mainly dependent on renal blood flow, and demand, determined by the basal metabolic demand and the energy-requiring tubular electrolyte transport. Renal blood flow is maintained within close limits in order to sustain stable glomerular filtration, so inc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2011.05532.x

    authors: Palm F,Nordquist L

    更新日期:2011-07-01 00:00:00

  • Protecting murine hearts from ischaemia-reperfusion using selective inhibitors of adenosine metabolism.

    abstract::1. By selectively modifying adenosine metabolism via adenosine deaminase or adenosine kinase inhibitors, it may be possible to enhance the receptor-mediated protective actions of adenosine in a site- and event-specific fashion. 2. We characterized cardioprotective actions of the adenosine deaminase inhibitor erythro-2...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2005.04168.x

    authors: Willems L,Headrick JP

    更新日期:2005-03-01 00:00:00

  • Effects of neuromuscular presynaptic muscarinic M1 receptor blockade on rocuronium-induced neuromuscular blockade in immobilized tibialis anterior muscles.

    abstract::This in vivo study tested the hypothesis that the modulation of acetylcholine (ACh) release by the M1 muscarinic receptor (mAChR) in the neuromuscular junction of disused muscles may affect the tensions of the muscles during the neuromuscular monitoring of a rocuronium-induced neuromuscular block and compared the resu...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13012

    authors: Kim YB,Yang HS,Kim HJ,Choi HR,In J,Yoon SY,Ro YJ

    更新日期:2018-12-01 00:00:00

  • Elevation of blood pressure in hypertensive rats after lesioning serotonin nerves in the dorsomedial medulla oblongata.

    abstract::The possibility that serotonin (5HT) nerve endings in the dorsomedial medulla oblongata participate in the control of blood pressure was investigated in stroke-prone hypertensive rats and in normotensive rats. 5HT nerves were destroyed by injecting 5,7-dihydroxytryptamine bilaterally into the solitary tract nucleus. I...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1983.tb00196.x

    authors: Howe PR,Rogers PF,King RA,Smith RM

    更新日期:1983-05-01 00:00:00

  • Shift in the baroreflex-renal noradrenaline spillover curve during the development of congestive heart failure in the rabbit.

    abstract::1. Changes in renal sympathetic nerve activity (RSNA) were investigated during the development of congestive heart failure (CHF) in rabbits with doxorubicin-induced cardiomyopathy. 2. Controls (saline treated, n = 5) and doxorubicin-treated rabbits (1 mg/kg administered intravenously twice weekly, n = 5) were studied ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1990.tb01325.x

    authors: McGrath BP,Sano N,Way D

    更新日期:1990-04-01 00:00:00

  • Activation of imidazoline-I3 receptors ameliorates pancreatic damage.

    abstract::Agmatine, an endogenous ligand of imidazoline receptors, is reported to exhibit anti-hyperglycaemic and many other effects. It has been established that the imidazoline I3 receptor is involved in insulin secretion. The current study characterizes the role of the imidazoline I3 receptor in the protection of pancreatic ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12441

    authors: Li Y,Cheng KC,Asakawa A,Amitani H,Takimoto Y,Runtuwene J,Inui A

    更新日期:2015-09-01 00:00:00