Effect of ethamsylate on carrageenan-induced rat paw oedema: a comparison with indomethacin.

Abstract:

:1. Ethamsylate (diethylammonium 2,5-dihydroxybenzene sulfonate, Dicynene), a systemic haemostatic agent with an unknown mechanism of action, was tested for anti-inflammatory activity using the carrageenan-induced rat paw oedema test. 2. Ethamsylate was shown to be an effective anti-inflammatory agent with a time course and amplitude of effect similar to that of indomethacin, although the potency was only about 4% of that for indomethacin. 3. When ethamsylate and indomethacin were co-administered they did not show additive effects, suggesting that they do not share a common mode of action. It is proposed that ethamsylate, like indomethacin, may inhibit prostaglandin synthesis. Ulceration produced by indomethacin, it is suggested that it may prove to be a useful addition to, or replacement for, indomethacin in the treatment of inflammatory disorders.

authors

Gard PR,Trigger DJ

doi

10.1111/j.1440-1681.1990.tb01285.x

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

821-7

issue

12

eissn

0305-1870

issn

1440-1681

journal_volume

17

pub_type

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