Abstract:
:1. During the destruction of articular cartilage, fibrinolytic enzymes and matrix metalloproteinases (MMP) may contribute to the related pathology. The activities, antigens and messenger RNA (mRNA) levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in articular cartilage were measured in patients with no history of joint diseases (control), those with osteoarthritis (OA) classified into osteophyte-formed site (OS) and weight-bearing site (WS), and in patients with rheumatoid arthritis (RA). 2. The uPA content was higher in WS and RA compared to normal. The PAI-1 content was higher in OS and RA compared to normal. Weight-bearing site patients expressed a high uPA mRNA level but a low PAI-1 mRNA level. Osteophyte-formed site patients expressed a low uPA mRNA level but a high PAI-1 mRNA level. 3. The levels of the MMP and mRNA of tissue inhibitors of metalloproteinases (TIMP) were measured in WS, OS, and RA. In WS, the levels of MMP were high and levels of TIMP mRNA expression low. In OS, the levels of TIMP were high and levels of MMP mRNA were low. In RA, the levels of MMP and TIMP mRNA were high. 4. These findings suggest that regulation of fibrinolysis may play an important role in the matrix of articular cartilage with arthropathy.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Kikuchi H,Shimada W,Nonaka T,Ueshima S,Tanaka Sdoi
10.1111/j.1440-1681.1996.tb01138.xsubject
Has Abstractpub_date
1996-10-01 00:00:00pages
885-9issue
10-11eissn
0305-1870issn
1440-1681journal_volume
23pub_type
杂志文章abstract::1. Phytoncides are volatile substances released mainly from trees. We studied whether phytoncides can reduce stress responses in stroke-prone spontaneously hypertensive rats (SHRSP). 2. Under the restraint stress, SHRSP exposed to phytoncides showed lower blood pressure than those without the exposure (186.8 +/- 3.9 v...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.2004.04102.x
更新日期:2004-12-01 00:00:00
abstract::In the present study, we investigated the relationship between the docosahexaenoic acid (DHA)-induced protection of learning deficit of amyloid beta(1-40)-infused Alzheimer's disease (AD) model rats and changes in synaptosomal plasma membrane fluidity of the cerebral cortex. Synaptosomal membrane lateral and rotationa...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.2006.04467.x
更新日期:2006-10-01 00:00:00
abstract::Orthostatic stress triggers a response to maintain cerebral perfusion and prevent syncope. Given the hypotensive effects of inorganic nitrate this response to orthostasis may be altered by acute supplementation with inorganic nitrate and modified by ethnic origin. Caucasian and SE Asian (n = 30 for both), were recruit...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/1440-1681.13010
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1984.tb00251.x
更新日期:1984-03-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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doi:10.1111/1440-1681.13221
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
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更新日期:1983-09-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
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更新日期:1981-05-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1987.tb00382.x
更新日期:1987-03-01 00:00:00
abstract::Following the potent efficacy of β-D-Mannuronic acid in a breast cancer murine model, we evaluated the efficacy of this novel non-steroidal anti-inflammatory drug in breast cancer patients in the present clinical trial. The study was an 8-week randomized, controlled, phase II clinical trial (IRCT: 2017012213739N7 (in ...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,随机对照试验
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更新日期:2019-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/1440-1681.12788
更新日期:2017-12-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1975.tb03031.x
更新日期:1975-05-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1993.tb01684.x
更新日期:1993-05-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.2010.04282.x
更新日期:2005-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.2006.04519.x
更新日期:2006-12-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1987-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1984.tb00866.x
更新日期:1984-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1997-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2001-03-01 00:00:00
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更新日期:1998-01-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1987-03-01 00:00:00
abstract::1. Regulatory T cells (T(reg)) and cytotoxic T cells (CTL) are involved in various immune diseases. However, the prognostic impact of T(reg) and CTL in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) is not well known. Therefore, in the present study, we e...
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.2010.05412.x
更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.2008.05011.x
更新日期:2008-12-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1046/j.1440-1681.2002.03688.x
更新日期:2002-07-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/1440-1681.12252
更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1997-03-01 00:00:00
abstract::1. Erlotinib, a small-molecule epidermal growth factor receptor-tyrosine kinase (EGFR-TK) inhibitor, has been approved for the management of advanced non-small cell lung cancer. The aim of the present study was to investigate whether erlotinib exerts potent antitumour activities through the reactive oxygen species (RO...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.2008.05091.x
更新日期:2009-05-01 00:00:00
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doi:10.1111/j.1440-1681.2010.05416.x
更新日期:2010-09-01 00:00:00