当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY期刊下所有文献 > Carotid body potentiation induced by intermittent hypoxia: implications for cardiorespiratory changes induced by sleep apnoea.

Carotid body potentiation induced by intermittent hypoxia: implications for cardiorespiratory changes induced by sleep apnoea.

Abstract：

:1. The most usual form of chronic hypoxia in humans is the intermittent hypoxia resulting from obstructive sleep apnoea (OSA). The OSA syndrome is a highly prevalent sleep breathing disorder that is considered an independent risk factor for hypertension and cardiovascular diseases. Endothelial dysfunction, oxidative stress, inflammation and sympathetic activation have been proposed as potential mechanisms involved in the onset of the hypertension. However, evidence for a unique pathogenic mechanism has been difficult to establish in OSA patients because of concomitant comorbidities. Thus, animal models have been developed to study the pathological consequences of exposure to chronic intermittent hypoxia (CIH). 2. Because OSA patients and animals exposed to CIH show augmented ventilatory, sympathetic and cardiovascular responses to acute hypoxia, it has been proposed that enhanced carotid body responsiveness to hypoxia is involved in the autonomic changes induced by OSA and in the development of the hypertension. Recently, this proposal has received further support from recordings of carotid body chemosensory neural discharges in situ and in vitro showing that exposure of animals to CIH increases basal carotid body chemosensory discharges and enhances the chemosensory response to hypoxia. 3. In the present brief review, we discuss the evidence supporting an important role for the carotid body in the progression of cardiorespiratory changes induced by OSA and the contribution of oxidative stress, endothelin-1 and pro-inflammatory molecules in the potentiation of the carotid body chemosensory function induced by CIH.

journal_name

Clin Exp Pharmacol Physiol

journal_title

Clinical and experimental pharmacology & physiology

authors

Iturriaga R,Moya EA,Del Rio R

doi

10.1111/j.1440-1681.2009.05213.x

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1197-204

issue

12

eissn

0305-1870

issn

1440-1681

pii

CEP5213

journal_volume

36

pub_type

杂志文章,评审

相关文献

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY文献大全
  • αB-Crystallin R120G variant causes cardiac arrhythmias and alterations in the expression of Ca(2+) -handling proteins and endoplasmic reticulum stress in mice.

    abstract：:Mutations of αB-crystallin (CryαB), a small heat shock protein abundantly expressed in cardiac and skeletal muscles, are known to cause desmin-related myopathies. The CryαB R120G allele has been linked to a familial desminopathy and, in transgenic mice, causes a sudden death at about 28 weeks of age. To investigate th...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/1440-1681.12253

    authors： Jiao Q,Sanbe A,Zhang X,Liu JP,Minamisawa S

    更新日期：2014-08-01 00:00:00

  • Multiple inferences using confidence intervals.

    abstract：:1. In a recent review article, the problem of making false-positive inferences as a result of making multiple comparisons between groups of experimental units or between experimental outcomes was addressed. 2. It was concluded that the most universally applicable solution was to use the Ryan-Holm step-down Bonferroni ...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1681.2000.03223.x

    authors： Ludbrook J

    更新日期：2000-03-01 00:00:00

  • Effects of combination therapy with perindopril and losartan on left ventricular remodelling in patients with myocardial infarction.

    abstract：:1. Inhibiting the renin-angiotensin-aldosterone system prevents left ventricular (LV) remodelling after myocardial infarction (MI). 2. The present study was designed to assess the effects of a combination of perindopril and losartan on LV remodelling, cardiac function and serum procollagen type III amino terminal pept...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2009.05143.x

    authors： Li L,Liu RY,Zhao XY,Zhang JY,Jia M,Lu PQ

    更新日期：2009-07-01 00:00:00

  • Molecular regulation of skeletal muscle mass.

    abstract：:1. The maintenance of skeletal muscle mass is determined by a fine balance between protein synthesis and protein degradation. Skeletal mass is increased when there is a net gain in protein synthesis, which can occur following progressive exercise training. In contrast, skeletal muscle mass is lost when degradation occ...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1440-1681.2009.05265.x

    authors： Russell AP

    更新日期：2010-03-01 00:00:00

  • Urinary NO3- excretion as an indicator of nitric oxide formation in vivo during oral administration of L-arginine or L-name in rats.

    abstract：:1. Endothelium-derived nitric oxide (NO), a major modulator of vascular tone, is synthesized from the terminal guanidino nitrogen of L-arginine. This reaction is inhibited by analogues of L-arginine, such as N-nitro-L-arginine methyl ester (L-NAME). Many of the biological effects of NO are mediated by the second messe...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：

    authors： Boger RH,Bode-Boger SM,Gerecke U,Gutzki FM,Tsikas D,Frolich JC

    更新日期：1996-01-01 00:00:00

  • Generation and propagation of gastric slow waves.

    abstract：:1. Mechanisms underlying the generation and propagation of gastrointestinal slow wave depolarizations have long been controversial. The present review aims to collate present knowledge on this subject with specific reference to slow waves in gastric smooth muscle. 2. At present, there is strong agreement that intersti...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1440-1681.2009.05331.x

    authors： van Helden DF,Laver DR,Holdsworth J,Imtiaz MS

    更新日期：2010-04-01 00:00:00

  • The opposite effects of nitric oxide donor, S-nitrosoglutathione, on myocardial ischaemia/reperfusion injury in diabetic and non-diabetic mice.

    abstract：:Nitric oxide is a potent anti-apoptotic and cardioprotective molecule in healthy animals. However, recent study demonstrates that overexpression of eNOS exacerbates the liver injury in diabetic animals. whether diabetes may also alter NO's biologic activity in ischaemic/reperfused heart remains unknown. The present ex...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/1440-1681.12781

    authors： Liu Y,Xia C,Wang R,Zhang J,Yin T,Ma Y,Tao L

    更新日期：2017-08-01 00:00:00

  • Agonist function of the recombinant alpha 4 beta 3 delta GABAA receptor is dependent on the human and rat variants of the alpha 4-subunit.

    abstract：:1. It is known that the alpha(4)-subunit is likely to occur in the brain predominantly in alpha(4)beta(3)delta receptors at extrasynaptic sites. Recent studies have revealed that the alpha(1)-, alpha(4)-, gamma(2)- and delta-subunits may colocalize extrasynaptically in dentate granule cells of the hippocampus. In the ...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2010.05374.x

    authors： Wang MD,Rahman M,Johansson IM,Bäckström T

    更新日期：2010-07-01 00:00:00

  • Antihypertensive effects of DL-tetrahydropalmatine: an active principle isolated from Corydalis.

    abstract：:1. The effects of DL-tetrahydropalmatine (DL-THP) on cardio-vascular function and hypothalamic release of monoamines were assessed in rats under urethane anaesthesia. 2. Intravenous administration of DL-THP (1-10 mg/kg) produced hypotension, bradycardia, a decrease in hypothalamic serotonin and noradrenaline release a...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1996.tb01769.x

    authors： Lin MT,Chueh FY,Hsieh MT,Chen CF

    更新日期：1996-08-01 00:00:00

  • Signalling pathways activated by endothelin stimulation of renal cells.

    abstract：:1. Endothelin mediates its effects in a variety of renal cells via a multiplicity of intracellular signalling pathways. 2. Stimulation of phosphatidylinositol-specific phospholipase C (PI-PLC), resulting in the activation of inositol trisphosphate and diacylglycerol, can be detected even at picomolar concentrations of...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1440-1681.1996.tb02833.x

    authors： Nord EP

    更新日期：1996-04-01 00:00:00

  • Endothelin and post-ganglionic sympathetic neurons.

    abstract：:1. The present report documents evidence suggesting that endothelin (ET) is a mediator and modulator of post-ganglionic sympathetic neuronal development. 2. Endothelin is produced by post-ganglionic neurons and by cells adjacent to these neurons. 3. Post-ganglionic sympathetic neurons express functional receptors for ...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1681.1999.03179.x

    authors： Damon DH

    更新日期：1999-12-01 00:00:00

  • Mechanical stretch induces endothelial nitric oxide synthase gene expression in neonatal rat cardiomyocytes.

    abstract：:1. Mechanical stretch leads to cardiac hypertrophy and may ultimately cause heart failure. However, the effect of mechanical stretch on gene induction in cardiomyocytes remains to be determined. 2. In the present study, we compared transcript profiles of mechanically stretched neonatal rat cardiomyocytes with those of...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2008.05100.x

    authors： Cheng TH,Chen JJ,Shih NL,Lin JW,Liu JC,Chen YL,Chen CH,Chen JJ

    更新日期：2009-05-01 00:00:00

  • Lithium attenuates d-amphetamine-induced hyperlocomotor activity in mice via inhibition of interaction between cyclooxygenase-2 and indoleamine-2,3-dioxygenase.

    abstract：:In the present study, we investigated whether mood stabilizer lithium (Li) protects against d-amphetamine (AMP)-induced mania-like behaviours via modulating the novel proinflammatory potential. Repeated treatment with AMP resulted in significant increases in proinflammatory cyclooxygenase-2 (COX-2) and indolemaine-2,3...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/1440-1681.13243

    authors： Phan DH,Shin EJ,Jeong JH,Tran HQ,Sharma N,Nguyen BT,Jung TW,Nah SY,Saito K,Nabeshima T,Kim HC

    更新日期：2020-05-01 00:00:00

  • Effect of nisoldipine on stress-induced myocardial damage in the conscious pig.

    abstract：:1. The effect of the calcium channel blocker nisoldipine on the myocardial content of lipid peroxidation products (malondialdehyde (MDA), conjugated double bonds (CDB), fluorescent end-products (RF) and mitochondrial adenine nucleotides) was investigated in conscious pigs (n = 14) subjected to 24 h of immobilization s...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1990.tb01258.x

    authors： Herbaczyńska-Cedro K,Lewicki Z,Barcikowski B,Famulski K,Gordon-Majszak W,Kłoś J,Wutzen J,Ceremuzyński L

    更新日期：1990-01-01 00:00:00

  • Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia-inducible factors HIF1α and HIF2α.

    abstract：:Chemotherapy resistance is a major contributor to poor treatment responses and tumour relapse, the development of which has been strongly linked to the action of cancer stem cells (CSCs). Mounting evidence suggests that CSCs are reliant on low oxygen conditions and hypoxia-inducible factors 1α and 2α (HIF1α and HIF2α)...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章,评审

    doi：10.1111/1440-1681.12693

    authors： Schöning JP,Monteiro M,Gu W

    更新日期：2017-02-01 00:00:00

  • Inhibitory effect of emodin on bleomycin-induced pulmonary fibrosis in mice.

    abstract：:1. Currently, there is no satisfactory treatment for pulmonary fibrosis. Emodin, a component in Chinese herbs, has been shown to have an antifibrotic effect on pancreatic fibrosis and liver fibrosis. In the present study, we tested the hypothesis that emodin may attenuate the development of pulmonary fibrosis. 2. Mice...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2008.05048.x

    authors： Chen XH,Sun RS,Hu JM,Mo ZY,Yang ZF,Jin GY,Guan WD,Zhong NS

    更新日期：2009-02-01 00:00:00

  • Haemodynamic interactions between alpha- and beta-adrenoceptor antagonists in conscious or anaesthetized rats.

    abstract：:1. The alpha-adrenoceptor antagonist, phentolamine, was administered intravenously, to conscious or anaesthetized rats, before or after the beta-adrenoceptor antagonist, propanolol. 2. The bradycardia which followed the combined administration of propranolol and phentolamine exceeded that induced by propranolol alone,...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1980.tb00067.x

    authors： Oates HF,Stoker LM

    更新日期：1980-03-01 00:00:00

  • Nitric oxide induced sinusoidal relaxation after a propranolol priming dose in the perfused rat liver reduces propranolol availability on subsequent dosing.

    abstract：:1. The present study sought to explain the mechanism leading to reduced availability of propranolol when given after a priming dose in the single-pass perfused rat liver. 2. Extracellular sucrose space (as a measure of sinusoidal relaxation) in perfused rat liver before and after propranolol or propranolol and N(G)-ni...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2010.05434.x

    authors： Liu X,Zou Y,Khlentzos AM,Yang Y,Nikolovski J,Weiss M,Roberts MS

    更新日期：2010-10-01 00:00:00

  • The effect of althesin, ketamine or pentothal on renal function in saline loaded rats.

    abstract：:Rats were prepared with chronic cannulae in the carotid artery, jugular vein and urinary bladder; they were then kept 2 days to allow recovery from surgery. A steady-state continuous saline diuresis was established, then various anaesthetic agents were injected and changes in the urine flow, sodium and potassium excre...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1985.tb02311.x

    authors： Chen CF,Chapman BJ,Munday KA

    更新日期：1985-03-01 00:00:00

  • Neutrophil platelet-activating factor production and acetyltransferase activity in clinical acute myocardial infarction.

    abstract：:1. Neutrophil function was studied in 10 males presenting with acute myocardial infarction (MI) within 6 h of onset and in 10 normal males. Neutrophil production of platelet-activating factor (PAF), determined by bioassay, that of leukotriene B4 by HPLC, and the activity of an enzyme involved in the synthesis of PAF, ...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1995.tb01963.x

    authors： Strahan ME,Graham RM,Eccleston DS,Sturm MJ,Taylor RR

    更新日期：1995-02-01 00:00:00

  • Increased blood pressure and changes in membrane lipids associated with chronic ethanol treatment of rats.

    abstract：:1. Changes in membrane fluidity have been proposed to contribute to the pathogenesis of ethanol-induced hypertension possibly through changes in membrane lipid patterns, but reports are inconsistent. 2. In a controlled trial we documented ethanol-induced changes in blood pressure and composition of membrane lipids in ...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1995.tb02083.x

    authors： Puddey IB,Burke V,Croft K,Beilin LJ

    更新日期：1995-09-01 00:00:00

  • Cellular actions of opioids and other analgesics: implications for synergism in pain relief.

    abstract：:1. mu-Opioid receptor agonists mediate their central analgesic effects by actions on neurons within brain regions such as the mid-brain periaqueductal grey (PAG). Within the PAG, mu-opioid receptor-mediated analgesia results from inhibition of GABAergic influences on output projection neurons. We have established that...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1681.2000.03291.x

    authors： Christie MJ,Connor M,Vaughan CW,Ingram SL,Bagley EE

    更新日期：2000-07-01 00:00:00

  • The effect of hypertensive episodes and cardiac hypertrophy on the canine cardiac baroreflex.

    abstract：:1. Left ventricular (LV) hypertrophy has been implicated in the reduction of baroreflex sensitivity present in hypertension. The aim of the current study was to investigate the mean arterial pressure-heart rate reflex (MAP-HR) in a model which induced left ventricular hypertrophy but no sustained blood pressure elevat...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1994.tb02433.x

    authors： Kingwell BA,Krause L,Julius S

    更新日期：1994-01-01 00:00:00

  • Effects of dietary fibre on dimethylhydrazine-induced changes in prostanoid concentrations in rat colonic mucosa.

    abstract：:1. This study was designed to elucidate the effects of guar gum, a dietary fibre, on changes in prostanoid contents induced by 1,2-dimethylhydrazine, a carcinogenic agent, in rat colonic mucosa. 2. Prostanoid contents were determined using high performance liquid chromatography; five prostanoids, namely 6-keto-prostag...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1995.tb01928.x

    authors： Kanamori S,Sugiyama S,Goto H,Hayakawa T,Shimomura Y,Ozawa T

    更新日期：1995-10-01 00:00:00

  • Sequential activation of the reactive oxygen species/angiotensinogen/renin-angiotensin system axis in renal injury of type 2 diabetic rats.

    abstract：:1. The present study was performed to test the hypothesis that the reactive oxygen species (ROS)-angiotensinogen (AGT)-renin angiotensin system (RAS) axis is sequentially activated in the development of diabetic nephropathy in Zucker diabetic fatty (ZDF) obese rats. 2. Genetic pairs of male ZDF obese and control ZDF l...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.2008.04938.x

    authors： Miyata K,Ohashi N,Suzaki Y,Katsurada A,Kobori H

    更新日期：2008-08-01 00:00:00

  • Oxytocin in the regulation of social behaviours in medial amygdala-lesioned mice via the inhibition of the extracellular signal-regulated kinase signalling pathway.

    abstract：:The neuropeptide oxytocin (OXT) has been implicated in the pathophysiology of behavioural deficits among patients with autism spectrum disorder (ASD). However, the molecular mechanisms underlying its role in ASD remain unclear. In the present study, a murine model with ASD-like phenotypes was induced by intra-medial a...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/1440-1681.12378

    authors： Wang Y,Zhao S,Wu Z,Feng Y,Zhao C,Zhang C

    更新日期：2015-05-01 00:00:00

  • Excess weight in children and adolescents is associated with altered subendocardial blood supply among girls but not boys.

    abstract：:Subendocardial viability ratio (SEVR) is a reliable index of myocardial supply-workload balance. This study sought to investigate whether overweight/obese children and adolescents have altered SEVR and to identify which are the associated factors. This cross-sectional study involved 789 individuals. Central haemodynam...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 信件

    doi：10.1111/1440-1681.12922

    authors： Zaniqueli D,Alvim RO,Baldo MP,Luiz SG,Cunha RS,Mill JG

    更新日期：2018-05-01 00:00:00

  • Hesperidin attenuates altered redox homeostasis in an experimental hyperlipidaemic model of rat.

    abstract：:Diets rich in saturated fats and cholesterol contribute to the incidence of hyperlipidaemia. An altered lipid profile is a major factor responsible for the development of CVD. Male Wistar rats were fed with a high-fat diet (HFD) (suspension (w/v) of 0.5% cholesterol, 3% coconut oil and 0.25% cholic acid for 30 days) t...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/1440-1681.13221

    authors： Kumar R,Akhtar F,Rizvi SI

    更新日期：2020-04-01 00:00:00

  • Effects of opioid (tramadol) treatment on testicular functions in adult male rats: The role of nitric oxide and oxidative stress.

    abstract：:Nowadays, tramadol hydrochloride is frequently used as a pain reliever, and for the treatment of premature ejaculation. Decreased semen quality was noted in chronic tramadol users. The present study aimed to elucidate the effects of tramadol on the testicular functions of adult male rats. A total of 40 albino adult ma...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/1440-1681.12213

    authors： Ahmed MA,Kurkar A

    更新日期：2014-04-01 00:00:00

  • Effects of brain lesions on the antinociceptive properties of morphine in rats.

    abstract：:1. Electrolytic lesions were made in various brain regions of the rat, and the effects of these lesions on nociceptive threshold and the antinociceptive actions of morphine were tested using a shock titration technique. 2. Lesions in the medial thalamus, the periaqueductal grey area, or the caudate nucleus, had no eff...

    journal_title：Clinical and experimental pharmacology & physiology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1681.1975.tb03031.x

    authors： Yeung JC,Yaksh TL,Rudy TA

    更新日期：1975-05-01 00:00:00