Increased blood pressure and changes in membrane lipids associated with chronic ethanol treatment of rats.

abstract：:1. Angiotensin (Ang) II causes growth-related effects on vascular smooth muscle cells in vitro and in vivo. 2. Chronic infusions of AngII systemically, at doses that are initially subpressor, result in slowly progressive increases in arterial pressure ('slow-pressor' hypertension). It has been suggested that the hyper...

journal_title：Clinical and experimental pharmacology & physiology

authors： Edgley A,Kett M,Anderson W

更新日期：2001-12-01 00:00:00

abstract：:Atherosclerosis is a complex chronic inflammatory disease that remains one of the leading causes of death and disability worldwide. A previous study reported that glaucocalyxin A (GLA), a natural ent-Kaurane diterpenoid triptolide, exhibits anti-atherosclerotic activity. However, the underlying molecular mechanism has...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhu S,Zhang J,Lv Y

更新日期：2020-05-01 00:00:00

abstract：:Hantaviruses are enveloped negative (-) single-stranded RNA viruses belongs to Hantaviridae family, hosted by small rodents and entering into the human body through inhalation, causing haemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) also known as hantavirus cardiopulmonary syndrom...

journal_title：Clinical and experimental pharmacology & physiology

authors： Munir N,Jahangeer M,Hussain S,Mahmood Z,Ashiq M,Ehsan F,Akram M,Ali Shah SM,Riaz M,Sana A

更新日期：2020-09-07 00:00:00

abstract：:The efficacy of streptokinase as an intracoronary thrombolytic agent is well-recognized. The effect of streptokinase, distinct from its thrombolytic action, on ischaemic myocardium distal to an area of coronary artery occlusion when reperfusion occurs has not been well-defined. In order to do this, myocardial creatine...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mickelson JK,Carlson CJ,Margaretten W,Rapaport E

更新日期：1986-09-01 00:00:00

abstract：:In the context of the ongoing debate on the mechanism of blood pressure (BP) regulation and pathophysiology of arterial hypertension ("renocentric" vs "neural" concepts), attention is focused on the putative regulatory role of changes in renal medullary blood flow (MBF). Experimental evidence is analysed with regard t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sadowski J,Bądzyńska B

更新日期：2020-08-01 00:00:00

abstract：:1. Angiotensin (Ang) II plays a major role in vascular remodelling. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in the tissue remodelling processes. The aim of the present study was to investigate whether AngII modulates TIMP-2 expression in rat aortic smooth muscle cells in vivo....

journal_title：Clinical and experimental pharmacology & physiology

authors： Castoldi G,di Gioia CR,Travaglini C,Busca G,Redaelli S,Bombardi C,Stella A

更新日期：2007-03-01 00:00:00

abstract：:1. Pyruvate has been shown to enhance the contractile performance of cardiac muscle when provided as an alternative substrate to glucose. The aims of the present study were to determine whether the inotropic effects of pyruvate are due to increased mobilization of intracellular Ca2+ ([Ca2+]i) and to compare the effect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mellors LJ,Kotsanas G,Wendt IR

更新日期：1999-11-01 00:00:00

abstract：:The purpose of the present study was to identify the differential proteins that synchronously change in urine and glomeruli and could be used to monitor glomerular lesions of IgA nephropathy (IgAN). The proteomes of urine and glomeruli from four IgAN patients who were graded III/IV according to the grading system of L...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ning X,Yin Z,Li Z,Xu J,Wang L,Shen W,Lu Y,Cai G,Zhang X,Chen X

更新日期：2017-05-01 00:00:00

abstract：:1. It has previously been shown that perfusion with high O2-affinity-erythrocytes decreases venous PO2 (PVO2) and decreases O2 uptake (VO2) in contracting muscle at the same O2 delivery (arterial O2 concentration x flow). A linear VO2-PVO2 relationship has been obtained with a VO2-axis intercept, suggesting that, duri...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kohzuki H,Misawa H,Kishi T,Ohga Y,Sakata S,Takaki M

更新日期：1999-08-01 00:00:00

abstract：:Posture changes may differ between types of hypertensive disease. The aim is to evaluate the orthostatic response of impedance cardiography (ICG) measurements in uncomplicated and hypertensive pregnancies. Measurements were performed in supine and standing position in 202 women: 41 uncomplicated pregnancies (UP), 59 g...

journal_title：Clinical and experimental pharmacology & physiology

authors： Staelens AS,Vonck S,Mesens T,Tomsin K,Molenberghs G,Gyselaers W

更新日期：2015-10-01 00:00:00

abstract：:Malignant tumours are a major cause of mortality in humans. Currently used therapeutic regimens have not improved survival rates of patients suffering from malignant tumours much because of their limited efficacy and side-effects. A therapeutic approach that uses Newcastle disease virus (NDV) represents an attractive ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhao L,Liu H

更新日期：2012-08-01 00:00:00

abstract：:Acute kidney injury (AKI) is a rapid loss of kidney function resulting in accumulation of end metabolic products and associated abnormalities in fluid, electrolyte and acid-base homeostasis. The pathophysiology of AKI is complex and multifactorial involving numerous vascular, tubular and inflammatory pathways. Neurohu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hering D,Winklewski PJ

更新日期：2017-02-01 00:00:00

abstract：:Nowadays, tramadol hydrochloride is frequently used as a pain reliever, and for the treatment of premature ejaculation. Decreased semen quality was noted in chronic tramadol users. The present study aimed to elucidate the effects of tramadol on the testicular functions of adult male rats. A total of 40 albino adult ma...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ahmed MA,Kurkar A

更新日期：2014-04-01 00:00:00

abstract：:1. The Type 2C protein phosphatases (PP2C) represent a highly conserved gene family in the mammalian genome. Recent studies have revealed that PP2C isoforms possess unique patterns of tissue and subcellular distribution associated with diverse functionalities. 2. The functional importance of PP2C isoforms has been sho...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lu G,Wang Y

更新日期：2008-02-01 00:00:00

abstract：:1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over trial was performed using 60 and 90 mg/kg doses of APAP in healthy patients undergoing third molar dental extraction. P...

journal_title：Clinical and experimental pharmacology & physiology

authors： Reith D,Medlicott NJ,Kumara De Silva R,Yang L,Hickling J,Zacharias M

更新日期：2009-01-01 00:00:00

abstract：:Serotonin causes a dose related (0.1-20 micrograms/kg i.v.) increase in mean arterial blood pressure (MAP) and heart rate in conscious sheep. Ketanserin (0.1 mg/kg per h i.v.) causes a decrease in blood pressure, and an increase in heart rate. In the presence of ketanserin, serotonin induced increases in MAP are atten...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nelson MA,Coghlan JP,Denton DA,Mills EH,Spence CD,Whitworth JA,Scoggins BA

更新日期：1984-11-01 00:00:00

abstract：:1. One hour exposure to hyperoxia has been shown previously to limit a subsequent ischaemia-reperfusion injury in spontaneously breathing rats. We tested the cardioprotective effect of a shorter period of hyperoxia during mechanical ventilation and the possible contribution of reactive oxygen species (ROS) and mitocho...

journal_title：Clinical and experimental pharmacology & physiology

authors： Colantuono G,Tiravanti EA,Di Venosa N,Cazzato A,Rastaldo R,Cagiano R,D'Agostino D,Federici A,Fiore T

更新日期：2008-01-01 00:00:00

abstract：:Preeclampsia is a complication affecting pregnant women worldwide, which leads to maternal and fetal morbidity and mortality. In this study, we evaluated the efficacy of ferulic acid (FA) on an Nω -nitro-L-arginine methyl ester hydrochloride (L-NAME) induced rat model of preeclampsia. L-NAME was administered to pregna...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gong W,Wan J,Yuan Q,Man Q,Zhang X

更新日期：2017-10-01 00:00:00

abstract：:1. The present study sought to explain the mechanism leading to reduced availability of propranolol when given after a priming dose in the single-pass perfused rat liver. 2. Extracellular sucrose space (as a measure of sinusoidal relaxation) in perfused rat liver before and after propranolol or propranolol and N(G)-ni...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu X,Zou Y,Khlentzos AM,Yang Y,Nikolovski J,Weiss M,Roberts MS

更新日期：2010-10-01 00:00:00

abstract：:1. Mast cells cultured from human peripheral blood have been used as a cell model for functional studies of human mast cells, particularly human lung mast cells. However, the beta-adrenoceptor subtype expressed by these cultured cells has not been identified. The aim of the present study was to characterize pharmacolo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang XS,Lau HY

更新日期：2006-08-01 00:00:00

abstract：:1. Sulfur dioxide (SO(2) ) has recently been found to have various biological effects on the cardiovascular system. The present study was designed to explore the effects of SO(2) derivatives on the L-type calcium current (I (Ca, L) ) in isolated rat ventricular cardiomyocytes. 2. A Langendorf system was used to dissoc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang RY,Du JB,Sun Y,Chen S,Tsai HJ,Yuan L,Li L,Tang CS,Jin HF

更新日期：2011-07-01 00:00:00

abstract：:1. Ethamsylate (diethylammonium 2,5-dihydroxybenzene sulfonate, Dicynene), a systemic haemostatic agent with an unknown mechanism of action, was tested for anti-inflammatory activity using the carrageenan-induced rat paw oedema test. 2. Ethamsylate was shown to be an effective anti-inflammatory agent with a time cours...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gard PR,Trigger DJ

更新日期：1990-12-01 00:00:00

abstract：:Cardiotoxin (CTX) III, a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. In the present study, we investigated the mechanisms underlying the anticancer activity of CTX III in human leukaemia (HL-60 cells). Cardiotoxin III activated the en...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chien CM,Yang SH,Chang LS,Lin SR

更新日期：2008-09-01 00:00:00

abstract：:1. The effect of the calcium channel blocker nisoldipine on the myocardial content of lipid peroxidation products (malondialdehyde (MDA), conjugated double bonds (CDB), fluorescent end-products (RF) and mitochondrial adenine nucleotides) was investigated in conscious pigs (n = 14) subjected to 24 h of immobilization s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Herbaczyńska-Cedro K,Lewicki Z,Barcikowski B,Famulski K,Gordon-Majszak W,Kłoś J,Wutzen J,Ceremuzyński L

更新日期：1990-01-01 00:00:00

abstract：:1. The effects of DL-tetrahydropalmatine (DL-THP) on cardio-vascular function and hypothalamic release of monoamines were assessed in rats under urethane anaesthesia. 2. Intravenous administration of DL-THP (1-10 mg/kg) produced hypotension, bradycardia, a decrease in hypothalamic serotonin and noradrenaline release a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lin MT,Chueh FY,Hsieh MT,Chen CF

更新日期：1996-08-01 00:00:00

abstract：:1. The effects of the Class I anti-arrhythmic drugs quinidine, procainamide, lidocaine, phenytoin and tocainide on mitochondrial lactate dehydrogenase activity were compared in guinea-pig heart preparations. 2. All the tested drugs inhibited the enzyme activity in a concentration-dependent fashion, exhibiting varying ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dzimiri N,Almotrefi AA

更新日期：1993-04-01 00:00:00

abstract：:1. Infusion of increasing doses of angiotensin II (AII) in normal subjects sequentially increased blood pressure, aldosterone and atrial natriuretic peptide (ANP) levels. 2. The slope of ANP response to AII was positively correlated with basal ANP and with the slope of blood pressure response to AII (pressor slope) bu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Finn WL,Tunny TJ,Klemm SA,Ryan SJ,Gordon RD

更新日期：1993-05-01 00:00:00

abstract：:Following the potent efficacy of β-D-Mannuronic acid in a breast cancer murine model, we evaluated the efficacy of this novel non-steroidal anti-inflammatory drug in breast cancer patients in the present clinical trial. The study was an 8-week randomized, controlled, phase II clinical trial (IRCT: 2017012213739N7 (in ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kashefi S,Omranipour R,Mahmoodzadeh H,Ahmadi H,Alikhassi A,Hosseini M,Cuzzocrea S,Rehm BHA,Matsuo H,Mirshafiey A

更新日期：2019-06-01 00:00:00

abstract：:1. In infants, promethazine has been implicated in the pathogenesis of sleep apnoea, apparent life threatening events (ALTE) and the Sudden Infant Death syndrome (SIDS). The aim of the present study was to investigate, in a neonatal animal, the effects of a commonly used promethazine-containing medication on airway pr...

journal_title：Clinical and experimental pharmacology & physiology

authors： McKelvey GM,Post EJ,Wood AK,Jeffery HE

更新日期：2001-07-01 00:00:00

abstract：:Cyclo-oxygenase (COX) is an enzyme that participates in the wound healing process. Aspirin, a non-steroidal anti-inflammatory drug, simultaneously inhibits the aromatase activity of COX-1 and COX-2 isoforms, which is needed for prostaglandin synthesis. The aim of the present study was to determine whether aspirin, and...

journal_title：Clinical and experimental pharmacology & physiology

authors： dos Santos JS,Monte-Alto-Costa A

更新日期：2013-02-01 00:00:00