Signalling pathways activated by endothelin stimulation of renal cells.


:1. Endothelin mediates its effects in a variety of renal cells via a multiplicity of intracellular signalling pathways. 2. Stimulation of phosphatidylinositol-specific phospholipase C (PI-PLC), resulting in the activation of inositol trisphosphate and diacylglycerol, can be detected even at picomolar concentrations of peptide. 3. Endothelin activation of cPLA2 is sensitive to ambient [Ca2+]i, is not contingent upon protein kinase C activation and is independent of PI-PLC stimulation, being coupled to the endothelin receptor in a yet to be determined manner. 4. Activation by endothelin of phosphatidylcholine-specific phospholipase D is under the dual regulation of protein kinase C and [Ca2+]i, with protein kinase C being the major regulator and [Ca2+]i playing a secondary, modulatory role. 5. Phosphatidylcholine-specific phospholipase C (PC-PLC) is stimulated by endothelin and accounts for the prolonged activation of diacylglycerol by this peptide. PC-PLC activity is critically dependent upon [Ca2+]i, whereas protein kinase C plays no role in modulating the activity of this enzyme. 6. Endothelin enhances the phosphorylation of protein tyrosine kinases, with evidence that phosphorylation of pp60 Src may be an important early event.


Nord EP




Has Abstract


1996-04-01 00:00:00












  • Ketamine inhibits aerobic glycolysis in colorectal cancer cells by blocking the NMDA receptor-CaMK II-c-Myc pathway.

    abstract::Aerobic glycolysis plays a crucial role in cancer progression. Ketamine is often used for cancer pain relief in clinical settings. Moreover, ketamine inhibits proliferation and induces apoptosis in many cancer cell types. However, the anti-tumour mechanism of ketamine is still poorly understood. In the present study, ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Hu J,Duan W,Liu Y

    更新日期:2020-05-01 00:00:00

  • Comparison of vaccination of mice and rats with Haemophilus influenzae and Bordetella pertussis as models of atopy.

    abstract::1. Rats and mice were vaccinated with Haemophilus influenzae in different vaccination schedules whereafter blood eosinophils were counted. In rats a single vaccination resulted in a dose-dependent effect on the blood eosinophil count in a pattern comparable with that after Bordetella pertussis vaccination. In a long-t...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Terpstra GK,Raaijmakers JA,Kreukniet J

    更新日期:1979-03-01 00:00:00

  • Salt- and angiotensin II-dependent variations in amiloride-sensitive rectal potential difference in mice.

    abstract::1. In the rectum and distal nephron, sodium reabsorption is mediated by the amiloride-sensitive epithelial sodium channel (ENaC). The ENaC-mediated sodium transport is electrogenic and creates an amiloride-sensitive transepithelial potential difference (PD). 2. We have evaluated the salt- and angiotensin (Ang)II-depen...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wang Q,Horisberger JD,Maillard M,Brunner HR,Rossier BC,Burnier M

    更新日期:2000-01-01 00:00:00

  • Gender-related differences in the development of atherosclerosis: studies at the cellular level.

    abstract::1. Calcified arteriosclerotic lesions have been recognized early in life as abnormalities in coronary arteries. 2. We examined coronary arterial plaques as an undecalcified tissue and revealed widespread mineralization within the plaque. Non-collagenous proteins that regulate calcification, such as osteopontin, have b...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Fitzpatrick LA

    更新日期:1996-03-01 00:00:00

  • Onset and offset of structural arteriolar changes in DOCA/salt hypertension in the rat.

    abstract::1. Structural changes in resistance vessels were studied sequentially (a) by hindquarter perfusion and (b) by planimetry of renal arterioles less than or equal to 20 micrometers radius, for 10 weeks during development of DOCA (deoxycorticosterone acetate)/salt hypertension in uninephrectomized rats and 5 weeks after c...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Vial JH,Yong AC,Boyd GW

    更新日期:1982-05-01 00:00:00

  • Increased expression of calcium-sensing receptors induced by ox-LDL amplifies apoptosis of cardiomyocytes during simulated ischaemia-reperfusion.

    abstract::1. Acute myocardial infarction (AMI) is strongly associated with atherosclerosis, and is responsible for significant morbidity and mortality worldwide. The pathogenic mechanisms that underlie atherosclerosis and AMI are undefined at present. The calcium-sensing receptor (CaSR) is a member of the superfamily of G-prote...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Guo J,Li HZ,Zhang WH,Wang LC,Wang LN,Zhang L,Li GW,Li HX,Yang BF,Wu L,Wang R,Xu CQ

    更新日期:2010-03-01 00:00:00

  • Beneficial effect of T-1095, a selective inhibitor of renal Na+-glucose cotransporters, on metabolic index and insulin secretion in spontaneously diabetic GK rats.

    abstract::1. To investigate the pharmacological effects of T-1095, this novel derivative of phlorizin was administered to GK rats for 8 weeks. T-1095 treatment significantly lowered plasma glucose and glycosylated haemoglobin (HbA1c) levels, but did not significantly affect bodyweight. 2. T-1095 treatment did not affect 3.3 mmo...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nunoi K,Yasuda K,Adachi T,Okamoto Y,Shihara N,Uno M,Tamon A,Suzuki N,Oku A,Tsuda K

    更新日期:2002-05-01 00:00:00

  • Pathophysiology of renal tissue damage by iodinated contrast media.

    abstract::1. The present review focuses on the cytotoxic effects of iodinated contrast media (CM) that are shared by all types of CM. 2. Although the clinical nephrotoxicity of CM has been progressively improved, all currently available CM still possess a level of cytotoxicity, which is probably caused by iodine. 3. The toxicit...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Sendeski MM

    更新日期:2011-05-01 00:00:00

  • Propofol block of cardiac sodium currents in rat isolated myocardial cells is increased at depolarized resting potentials.

    abstract::1. The effect of propofol on cardiac whole-cell sodium currents and single sodium channels in rat isolated ventricular myocytes was examined using patch-clamp techniques. 2. Propofol caused a block of the whole-cell sodium current, the potency of block depending on the holding potential. When cells were held at -90 mV...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Saint DA,Tang Y

    更新日期:1998-05-01 00:00:00

  • Combined bronchodilator protection against histamine-induced bronchoconstriction in man.

    abstract::Sixteen stable asthmatics had the protective effects of inhaled fenoterol (200 micrograms) and inhaled ipratropium bromide (60 micrograms) against standardized histamine inhalation tests at 1 h examined in a randomized double blind fashion. There was no significant difference in the baseline forced expired volume in 1...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ruffin RE,Meki M,Alpers JH

    更新日期:1987-02-01 00:00:00

  • Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia-inducible factors HIF1α and HIF2α.

    abstract::Chemotherapy resistance is a major contributor to poor treatment responses and tumour relapse, the development of which has been strongly linked to the action of cancer stem cells (CSCs). Mounting evidence suggests that CSCs are reliant on low oxygen conditions and hypoxia-inducible factors 1α and 2α (HIF1α and HIF2α)...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Schöning JP,Monteiro M,Gu W

    更新日期:2017-02-01 00:00:00

  • Effect of low-voltage electrical stimulation on angiogenic growth factors in ischaemic rat skeletal muscle.

    abstract::1. Low-voltage electrical stimulation (LVES) in skeletal muscle at a level far below the threshold of muscle contraction has been reported to promote local angiogenesis. However, the mechanism underlying the promotion of local angiogenesis by LVES has not been fully elucidated. In the present study, we evaluated wheth...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nagasaka M,Kohzuki M,Fujii T,Kanno S,Kawamura T,Onodera H,Itoyama Y,Ichie M,Sato Y

    更新日期:2006-07-01 00:00:00

  • Reduced adenosine 3',5'-cyclic monophosphate levels in patients with reversible obstructive airways disease.

    abstract::1. Patients were grouped into categories of 'no airways disease', 'obstructive airways disease without response to bronchodilator' and 'obstructive airways disease with bronchodilator responsiveness'. 2. Cyclic nucleotides were assayed in specimens of lung tissue that were excised during surgery. 3. Reduced levels of ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Krzanowski JJ,Polson JB,Goldman AL,Ebel TA,Szentivanyi A

    更新日期:1979-01-01 00:00:00

  • Urinary excretion of glycosaminoglycans, hydroxyproline and hydroxylysine in rabbits after excessive ingestion of fluoride.

    abstract::Urinary levels of glycosaminoglycans (GAG) and hydroxyproline from normal and fluoride treated rabbits were estimated. The hydroxylysine content of serum and urine of rabbits after excessive ingestion of fluoride was also investigated. There was a progressive decrease in GAG content, reduction in hydroxylysine, wherea...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Jha M,Koacher J,Susheela AK

    更新日期:1983-09-01 00:00:00

  • Controlled study of the effects of dietary protein on blood pressure in normotensive humans.

    abstract::1. The object of this study was to determine whether meat protein per se is responsible for the higher blood pressures (BP) in omnivores compared with vegetarians. 2. Assessments were made by a double blind randomized control trial in 64 normotensive volunteers recruited from Royal Perth Hospital staff. 3. All volunte...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Prescott SL,Jenner DA,Beilin LJ,Margetts BM,Vandongen R

    更新日期:1987-03-01 00:00:00

  • Resveratrol induces gastric cancer cell apoptosis via reactive oxygen species, but independent of sirtuin1.

    abstract::The currently available chemotherapeutic regimens against gastric cancer are not very effective, leading to high recurrence and poor survival. Resveratrol is a naturally occurring polyphenol with potent apoptosis-inducing activity. However, the mechanism underlying its actions remains unknown. In the present study, hu...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wang Z,Li W,Meng X,Jia B

    更新日期:2012-03-01 00:00:00

  • Dose-dependent effect of alcohol on insulin-like growth factor systems in male rats.

    abstract::1. Chronic alcohol treatment has been reported to be associated with liver and kidney damage. The insulin-like growth factor (IGF) is the major growth factor related to alcohol consumption. However, the effect of alcohol on the IGF system in the liver and kidney has not been fully elucidated. Thus, the present study w...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Park SH,Heo JS,Kang CW

    更新日期:2004-01-01 00:00:00

  • The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene.

    abstract::Cardiac output and rhythm depend on the release and the take-up of calcium from the sarcoplasmic reticulum (SR). Excessive diastolic calcium leak from the SR due to dysfunctional calcium release channels (RyR2) contributes to the formation of delayed after-depolarizations, which underlie the fatal arrhythmias that occ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Walweel K,Oo YW,Laver DR

    更新日期:2017-01-01 00:00:00

  • Regional brain activation in humans during respiratory and blood pressure challenges.

    abstract::1. The aim of the present study was to determine the brain sites mediating aspects of respiratory and cardiovascular control in adult humans using non-invasive functional magnetic resonance (fMRI) procedures, thereby avoiding the spatial and temporal sampling limitations associated with classic neural assessment techn...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章


    authors: Harper RM,Gozal D,Bandler R,Spriggs D,Lee J,Alger J

    更新日期:1998-06-01 00:00:00

  • 17Beta-oestradiol enhances nitric oxide synthase activity in endothelium-denuded rat aorta.

    abstract::1. It has been suggested that oestrogen-produced vasodilatation is due to induction of endothelial nitric oxide synthase (NOS), but there are many reports of direct effects on vascular smooth muscle. In the present study, these processes were investigated in rat aorta isolated from ovariectomized rats. 2. Short-term t...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Binko J,Murphy TV,Majewski H

    更新日期:1998-02-01 00:00:00

  • Structure of human renin and expression of the renin gene.

    abstract::The amino acid sequence of human renin was identified for the first time. This was determined from the nucleotide sequence of exons in the human renin gene identified in a genomic library by recombinant DNA techniques. Examination of amino acid residues involved in the enzymatic hydrolysis by human renin of the unique...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Morris BJ,Catanzaro DF,Hardman J,Mesterovic N,Tellam J,Hort Y,Bennetts BH,Shine J

    更新日期:1984-07-01 00:00:00

  • Exercise is good for your blood pressure: effects of endurance training and resistance training.

    abstract::1. Although several epidemiological studies have not observed significant independent relationships between physical activity or fitness and blood pressure, others have concluded that blood pressure is lower in individuals who are more fit or active. However, longitudinal intervention studies are more appropriate for ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,meta分析


    authors: Fagard RH

    更新日期:2006-09-01 00:00:00

  • High-salt diet and responses of the pressurized mesenteric artery of the dog to noradrenaline and acetylcholine.

    abstract::A high-salt diet in rats has been shown to result in enhanced vasoconstrictor and/or reduced vasodilator responses of isolated arteries to agonists. The present experiments were designed to investigate the effects of dietary salt on the responses of the pressurized mesenteric resistance artery of the dog to constricto...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Sofola O,Knill A,Myers D,Hainsworth R,Drinkhill M

    更新日期:2004-10-01 00:00:00

  • Mechanisms mediating propofol protection of pulmonary epithelial cells against lipopolysaccharide-induced cell death.

    abstract::Propofol (2,6-diisopropylphenol) is an anaesthetic agent with anti-oxidant properties. The aim of the present study was to determine whether propofol can protect pulmonary epithelial (A549) cells against lipopolysaccharide (LPS)-induced cell death and, if so, the mechanisms involved. The effects of LPS alone and in co...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Gu X,Lu Y,Chen J,He H,Li P,Yang T,Li L,Liu G,Chen Y,Zhang L

    更新日期:2012-05-01 00:00:00

  • Involvement of opioid system in antidepressant-like effect of the cannabinoid CB1 receptor inverse agonist AM-251 after physical stress in mice.

    abstract::Cannabinoid inverse agonists possess antidepressant-like properties, but the mechanism of this action is unknown. Numerous studies have reported the interaction between opioid and cannabinoid pathways. In this study, acute foot-shock stress was used in mice to investigate the involvement of the opioid pathway in the a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ostadhadi S,Haj-Mirzaian A,Nikoui V,Kordjazy N,Dehpour AR

    更新日期:2016-02-01 00:00:00

  • Paf antagonists block induction of nitric oxide synthase in cultured macrophages and vascular smooth muscle cells.

    abstract::1. Nitric oxide (NO) synthase inhibitors and Paf antagonists abrogate hypotension in septic shock. The latter may act by blocking intracellular transduction mechanisms in vascular smooth muscle cells and inflammatory cells. We examined the effect of Paf antagonists on expression of inducible NO synthase. 2. A murine m...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Arthur JF,Shahin S,Dusting GJ

    更新日期:1995-06-01 00:00:00

  • The effect of hypertensive episodes and cardiac hypertrophy on the canine cardiac baroreflex.

    abstract::1. Left ventricular (LV) hypertrophy has been implicated in the reduction of baroreflex sensitivity present in hypertension. The aim of the current study was to investigate the mean arterial pressure-heart rate reflex (MAP-HR) in a model which induced left ventricular hypertrophy but no sustained blood pressure elevat...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kingwell BA,Krause L,Julius S

    更新日期:1994-01-01 00:00:00

  • Early origins of heart disease: low birth weight and the role of the insulin-like growth factor system in cardiac hypertrophy.

    abstract::Epidemiological studies indicate that poor growth before birth is associated with left ventricular hypertrophy and an increased risk of death from heart disease later in life. In fetal life, the insulin-like growth factor (IGF) system has been implicated in physiological growth of the heart, whereas in postnatal life ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Wang KC,Botting KJ,Padhee M,Zhang S,McMillen IC,Suter CM,Brooks DA,Morrison JL

    更新日期:2012-11-01 00:00:00

  • Nerve growth factor mRNA content parallels altered sympathetic innervation in the spontaneously hypertensive rat.

    abstract::1. In order to explore the mechanisms responsible for the hypernoradrenergic innervation of the vasculature in the spontaneously hypertensive rat (SHR) the tissue content of nerve growth factor messenger ribonucleic acid (NGFmRNA) was examined. 2. The concentration of NGFmRNA was markedly elevated in mesenteric veins ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Falckh PH,Harkin LA,Head RJ

    更新日期:1992-08-01 00:00:00

  • Cardiovascular sensitivity changes to eicosanoids in rats with experimentally induced diabetes mellitus.

    abstract::This paper attempts to provide a short review of the evidence for: 1. Increased platelet production of thromboxane A2 and reduced vascular production of prostacyclin in the human and also animal models of diabetes. 2. Reduced depressor responsiveness to arachidonic acid of anaesthetized alloxan- and streptozotocin-ind...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Hodgson WC,Sikorski BW,King RG

    更新日期:1992-01-01 00:00:00