Endothelin and post-ganglionic sympathetic neurons.

abstract：:Ventilation to one lobe of lung was reduced in anaesthetized open-chest cats and dogs to simulate the ventilation/perfusion (V/Q) mismatching of chronic lung disease. Blood flow to this lobe fell less than ventilation; thus lobar V/Q diminished. In seven cats almitrine (0.5 mg/kg + 10 micrograms/kg per min, i.v.) caus...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wach RA,Gill GW,Suggett AJ,Bee D,Barer G

更新日期：1986-06-01 00:00:00

abstract：:Based on 28 reported patients, constant features of the syndrome of hypertension and hyperkalaemia are hyperkalaemia, hyperchloraemia, normal renal glomerular function and, in all adult patients, hypertension. Inconstant features include short stature, intellectual impairment and muscle weakness. Levels of renin and a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gordon RD

更新日期：1986-04-01 00:00:00

abstract：:1. The effect of enalapril on handling of an Na load and on body Na during 96 h of zero Na intake was measured in hypertensive rats (GH and SHR) and their normotensive controls (N and WKY) by a whole body counting method. 2. Enalapril treatment led to a greater fall in body Na in the first 24 h after the Na load (as e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ledingham JM,Simpson FO

更新日期：1992-05-01 00:00:00

abstract：:1. Pressor responsiveness to angiotensin II (AII) and phenylephrine (PHE) was measured before and after 5 days of ACTH (1 mg i.m. daily) in six normal men maintained on low sodium diet (15 mmol daily). 2. ACTH caused a significant increase in systolic blood pressure of 9 mmHg. 3. There was no change in pressor respons...

journal_title：Clinical and experimental pharmacology & physiology

authors： Connell JM,Fisher BM,Davidson G,Fraser R,Whitworth JA

更新日期：1987-03-01 00:00:00

abstract：:1. Over the past 50 years considerable evidence has been reported suggesting that endogenous opioids participate in the control of renal function. 2. Exogenous administration of opioids produces profound changes in the renal excretion of water and sodium. 3. Opioids produce changes in urine output and urine sodium exc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kapusta DR

更新日期：1995-12-01 00:00:00

abstract：:1. The present study was designed to examine the cardiovascular effects of intravenously administered pcDNA3.1AM, a recombinant non-virus vector carrying a rat adrenomedullin (AM) gene translation fragment, in rats with chronic cardiac dysfunction induced by ligation of the left descending coronary artery. 2. Haemodyn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang XF,Shao Y,Chen SW,Tian DZ,Huang GY,Huang Y,Yao T,Lu LM

更新日期：2007-09-01 00:00:00

abstract：:1. Treatment with angiotensin converting enzyme (ACE) inhibitors ameliorates human and experimental diabetic nephropathy, possibly as a result of changes in angiotensin II (AngII) and/or bradykinin concentrations. However, ACE is an indiscriminate enzyme, which hydrolyses numerous vasoactive peptides at two catalytic ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Duggan KA,Hodge G,Makarious MM,Charlesworth JA

更新日期：1996-06-01 00:00:00

abstract：:1. When six female seropositive rheumatoid patients were given placebo therapy for 48 h, their plasma kininogen level, 9.2 +/- 0.7 microgram bradykinin equivalents (bk eq) per ml, was found to be 59% greater than that of a group of eight healthy female volunteers (5.8 +/- 0.5 microgram/ml). 2. When the rheumatoid pati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sharma JN,Zeitlin IJ,Brooks PM,Buchanan WW,Dick WC

更新日期：1980-07-01 00:00:00

abstract：:1. Deposition of β-amyloid (Aβ) peptide is a defining pathological hallmark of Alzheimer's disease (AD) and is involved in memory impairment. Evidence suggests that activation of an extracellular signal-regulated kinase (ERK) pathway is related to Aβ accumulation. Thus, the aim of the present study was to investigate ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jin P,Choi DY,Hong JT

更新日期：2012-10-01 00:00:00

abstract：:The effect of indomethacin suppositories on both acute urinary colic and urinary calculus, resistant or refractory to conventional therapy with analgesics and spasmolytics was investigated. Fifty-five patients with acute urinary colic refractory to treatment with repeated injections of antispasmodics and analgesics ha...

journal_title：Clinical and experimental pharmacology & physiology

authors： Al-Waili NS

更新日期：1986-03-01 00:00:00

abstract：:Hyperglycaemia-induced neurotoxicity involved in the pathogenesis of diabetic encephalopathy and neuronal senescence is one of the worst effects of hyperglyceamic neurotoxicity. Cannabinoid receptor type 1 (CB1) has neuroprotective function in a series of neuropathy. Spermidine (Spd) has anti-aging function in many ti...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhu WW,Xiao F,Tang YY,Zou W,Li X,Zhang P,Wang AP,Tang XQ

更新日期：2018-08-01 00:00:00

abstract：:1. The serotonin transporter (SERT) is strongly implicated in the pathogenesis of pulmonary arterial hypertension (PAH) in patients and animal models. Inhibitors of SERT have been reported to attenuate or reverse experimental PAH, which makes them potential therapeutic options for the treatment of PAH in humans. Howev...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhu SP,Mao ZF,Huang J,Wang JY

更新日期：2009-08-01 00:00:00

abstract：:Propofol (2,6-diisopropylphenol) is an anaesthetic agent with anti-oxidant properties. The aim of the present study was to determine whether propofol can protect pulmonary epithelial (A549) cells against lipopolysaccharide (LPS)-induced cell death and, if so, the mechanisms involved. The effects of LPS alone and in co...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gu X,Lu Y,Chen J,He H,Li P,Yang T,Li L,Liu G,Chen Y,Zhang L

更新日期：2012-05-01 00:00:00

abstract：:1. Effects of FR139317, an endothelin ETA receptor antagonist, on renal haemodynamic and excretory responses to acute nitric oxide (NO) blockade were examined using anaesthetized rats. 2. Intrarenal arterial infusion of NG-nitro-L-arginine (NOARG), the NO synthase inhibitor, at a rate of 40 micrograms/kg per min, prod...

journal_title：Clinical and experimental pharmacology & physiology

authors： Matsumura Y,Kuro T,Hashimoto N,Taira S

更新日期：1998-06-01 00:00:00

abstract：:1. A method is described which allows the determination of liquid junction potentials between biological fluid samples of less than 1 nL with a reproducibility of 10%. This was achieved by use of a micro-method and the use of 3% agarose added to the electrolyte in the measuring electrodes. 2. Validation was performed ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sugo E,Györy AZ

更新日期：1989-07-01 00:00:00

abstract：:The effects of variation in dietary sodium intake on biochemical indices of sympathetic activity were investigated in normal subjects. Sodium restriction for 7 days (mean urinary sodium excretion 21 mmol/day, s.e.m. = 4) increased supine plasma noradrenaline concentration significantly (1.78 nmol/l, s.e.m. = 0.23) com...

journal_title：Clinical and experimental pharmacology & physiology

authors： Watson RD,Esler MD,Leonard P,Korner PI

更新日期：1984-03-01 00:00:00

abstract：:1. The reproducibility of blood volume measurements, using [51Cr]-labelled red blood cells (RBC) was tested in three lambs, 79-89 days of age, and the accuracy was tested in eight lambs, 83 +/- 0.4 days of age, in which blood volume was measured simultaneously by [51Cr]-RBC and [125I]-gamma globulin plus haematocrit (...

journal_title：Clinical and experimental pharmacology & physiology

authors： Moritz KM,Potocnik SJ,Tangalakis K,Wintour EM

更新日期：1994-07-01 00:00:00

abstract：:An efficient animal model is fundamental for studies on the underlying mechanisms of constrictive pericarditis (CP). A novel CP rat model was established by pericardial injection composing of lipopolysaccharides (LPS) and talcum powder without thoracotomy. Pathological changes were confirmed by histological staining. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Qiao W,Xiao YJ,Wang X,Sun LJ,Chen YX,Ren WD

更新日期：2020-12-21 00:00:00

abstract：:Diets rich in saturated fats and cholesterol contribute to the incidence of hyperlipidaemia. An altered lipid profile is a major factor responsible for the development of CVD. Male Wistar rats were fed with a high-fat diet (HFD) (suspension (w/v) of 0.5% cholesterol, 3% coconut oil and 0.25% cholic acid for 30 days) t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kumar R,Akhtar F,Rizvi SI

更新日期：2020-04-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has been considered as a multi-factorial metabolic syndrome. MicroRNA-375 (MiR-375) was significantly up-regulated in serum of NAFLD patients and the role of miR-375 was addressed as a putative biomarker of NAFLD progression. However, the specific function of miR-375 in the pr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lei L,Zhou C,Yang X,Li L

更新日期：2018-08-01 00:00:00

abstract：:1. Administration of 2-thiophenecarboxylic acid to rats maintained on a low calcium diet resulted in a significant depression in the serum levels of total and ionized calcium and inorganic phosphate. 2. The serum magnesium levels were not altered by the drug. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Raman A,Chong YK

更新日期：1975-03-01 00:00:00

abstract：:There is a strong genetic predisposition towards abdominal aortic aneurysm (AAA), but it is unknown whether persons without AAA but with first-degree relatives who are AAA patients have a generalized dilating diathesis, defect arterial wall mechanics, or increased cardiovascular risk. The aim of the study was to inves...

journal_title：Clinical and experimental pharmacology & physiology

authors： De Basso R,Sandgren T,Ahlgren ÅR,Länne T

更新日期：2015-06-01 00:00:00

abstract：:1. Epidermal growth factor is a potent mitogen that causes natriuresis, diuresis and inhibition of arginine vasopressin-induced water reabsorption. 2. The aim of this study was to determine any interaction between epidermal growth factor and the V1 (vascular) and/or V2 (antidiuretic) arginine vasopressin receptor subt...

journal_title：Clinical and experimental pharmacology & physiology

authors： Grant SL,Phillips PA,Gow CB

更新日期：1994-03-01 00:00:00

abstract：:1. Recent reports have described the role of osteocalcin in glucose metabolism and glycaemic variability has been proven to be associated with an increased risk of diabetes complications. However, the relationship between osteocalcin and glycaemic variability remains unclear. The aim of the present study was to examin...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bao YQ,Zhou M,Zhou J,Lu W,Gao YC,Pan XP,Tang JL,Lu HJ,Jia WP

更新日期：2011-01-01 00:00:00

abstract：:1. The therapeutic effect of green tea extract (GTE) on the aortic collagen content and its characteristics were investigated in streptozotocin diabetic rats. 2. Diabetes was induced in rats by a single intra peritoneal injection of streptozotocin (60 mg/kg bodyweight). Six weeks after diabetes induction, GTE was admi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Babu PV,Sabitha KE,Shyamaladevi CS

更新日期：2006-04-01 00:00:00

abstract：:1. The hepatic reticulo-endothelial cell population is generally assumed to increase in size, along with the liver, during ageing in rats. However, this has not been rigorously established. 2. Using electron microscopy and stereological techniques, the present study has shown that the volume densities of hepatocytes a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Martin G,Sewell RB,Yeomans ND,Smallwood RA

更新日期：1992-07-01 00:00:00

abstract：:1. The present review describes the actions of sensory neuropeptides on the contractility of the rat and guinea-pig prostate gland and discusses the differences in sensitivity of the smooth muscle of the prostates taken from these species to these neuropeptides. 2. Nerve fibres immunoreactive for the tachykinins subst...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ventura S,Lau WA,Buljubasich S,Pennefather JN

更新日期：2000-11-01 00:00:00

abstract：:1. Carbachol (CCh)-induced desensitization to CCh was interrupted by a transient resensitization during its early stage, with concomitant changes at the muscarinic receptor/G-protein level in smooth muscle of guinea-pig taenia caeci. To assess whether such a peculiar desensitizing process may heterologously regulate s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hishinuma S,Matsumoto Y,Sato R,Saito M

更新日期：2007-01-01 00:00:00

abstract：:1. Oxidative stress plays a role in senescence-associated organ deterioration. This is supported by the beneficial effects of anti-oxidants against ageing-related organ damage, although their role in cardiac ageing has not been elucidated. 2. The aim of the present study was to examine the impact of cardiac-specific o...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wu S,Li Q,Du M,Li SY,Ren J

更新日期：2007-01-01 00:00:00

abstract：:1. Initial unsuccessful attempts to evaluate ventricular function in terms of the 'heart as a pump' led to focusing on the 'heart as a muscle' and to the concept of myocardial contractility. However, no clinically ideal index exists to assess the contractile state. The aim of the present study was to develop a mathema...

journal_title：Clinical and experimental pharmacology & physiology

authors： Curiel R,Perez-Gonzalez J,Torres E,Landaeta R,Cerrolaza M

更新日期：2005-10-01 00:00:00