Effects of brain lesions on the antinociceptive properties of morphine in rats.

abstract：:1. The chronotropic and inotropic effects of the anti-anginal agent SG-75 (2-nicotinamidoethyl nitrate) and 1-verapamil were investigated in isolated blood-perfused canine atrial preparations. The compounds were administered via the cannulated sinus node artery. 2. SG-75 induced a selective negative inotropic as oppos...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chiba S,Furukawa Y,Kobayashi M

更新日期：1980-03-01 00:00:00

abstract：:1. Ion gradients across the cell membrane are important for proper cellular communication and homeostasis. With the exception of erythrocytes, chloride (Cl), one of the most important free anions in animal cells, is not distributed at thermodynamic equilibrium across the plasma membrane. The K-Cl cotransporter (COT), ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gagnon KB,Fyffe RE,Adragna NC,Lauf PK

更新日期：2007-07-01 00:00:00

abstract：:1. Although it is well established that hypertension is the main risk factor for stroke, the complexity of cerebrovascular problems related to hypertension is not generally appreciated. 2. Hypertension can cause stroke through many mechanisms. A high intraluminal pressure will lead to extensive alteration in endotheli...

journal_title：Clinical and experimental pharmacology & physiology

authors： Johansson BB

更新日期：1999-07-01 00:00:00

abstract：:1. Activities of acetylcholinesterase (AChE), neuropathy target esterase (NTE), and carboxylesterase (CbxE) were compared in neuroblastoma cells of human origin (SH-SY5Y) and murine origin (NB41A3). 2. Mouse neuroblastoma cells had lower specific activities of NTE and CbxE than did human neuroblastoma cells; specific ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ehrich M,Veronesi B

更新日期：1995-05-01 00:00:00

abstract：:Nitric oxide is a potent anti-apoptotic and cardioprotective molecule in healthy animals. However, recent study demonstrates that overexpression of eNOS exacerbates the liver injury in diabetic animals. whether diabetes may also alter NO's biologic activity in ischaemic/reperfused heart remains unknown. The present ex...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu Y,Xia C,Wang R,Zhang J,Yin T,Ma Y,Tao L

更新日期：2017-08-01 00:00:00

abstract：:1. Stretch-induced muscle injury results in the damage that causes reduced force and increased membrane permeability. This muscle damage is caused, in part, by ionic entry through stretch-activated channels and blocking these channels with Gd3+ or streptomycin reduces the force deficit associated with damage. 2. Dystr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yeung EW,Allen DG

更新日期：2004-08-01 00:00:00

abstract：:1. mu-Opioid receptor agonists mediate their central analgesic effects by actions on neurons within brain regions such as the mid-brain periaqueductal grey (PAG). Within the PAG, mu-opioid receptor-mediated analgesia results from inhibition of GABAergic influences on output projection neurons. We have established that...

journal_title：Clinical and experimental pharmacology & physiology

authors： Christie MJ,Connor M,Vaughan CW,Ingram SL,Bagley EE

更新日期：2000-07-01 00:00:00

abstract：:1. We tested the effects of intravenous infusions of angiotensin II (AngII; 300 ng/kg per min) and the vasopressin V1 receptor agonist [Phe2,Ile3,Orn8]-vasopressin (30 ng/kg per min) on regional kidney perfusion in an extracorporeal circuit model in anaesthetized rabbits in which renal artery pressure (RAP) can be set...

journal_title：Clinical and experimental pharmacology & physiology

authors： Evans RG,Correia AG,Weekes SR,Madden AC

更新日期：2000-12-01 00:00:00

abstract：:1. Infections and related sepsis are two of the most prevalent issues in the care of critically ill patients, with mortality as high as 70%. Appropriate antibiotic selection, as well as adequate dosing, is important to improve the clinical outcome for these patients. 2. β-Lactams are the most common antibiotic class u...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sinnollareddy MG,Roberts MS,Lipman J,Roberts JA

更新日期：2012-06-01 00:00:00

abstract：:1. Although several epidemiological studies have not observed significant independent relationships between physical activity or fitness and blood pressure, others have concluded that blood pressure is lower in individuals who are more fit or active. However, longitudinal intervention studies are more appropriate for ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fagard RH

更新日期：2006-09-01 00:00:00

abstract：:1. In the [(13)C]-octanoic acid breath test, the time versus pulmonary [(13)CO(2)] excretion rate curve is analysed using mathematical curve-fitting techniques to calculate gastric emptying parameters. Thus, the goodness-of-fit highly influences the accuracy of the breath test. However, a double-peaked [(13)CO(2)] exc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sanaka M,Yamamoto T,Tsutsumi H,Abe K,Kuyama Y

更新日期：2005-07-01 00:00:00

abstract：:1. Adrenaline can enhance the stimulation-induced release of transmitter noradrenaline in sympathetically innervated tissues by activating prejunctional beta-adrenoceptors. 2. Adrenaline incorporated into sympathetic transmitter stores by neuronal uptake can be subsequently released as a co-transmitter and can then ac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Majewski H,Tung LH,Rand MJ

更新日期：1981-09-01 00:00:00

abstract：:1. Calcium regulation has been reported to be associated with the development of diabetic nephropathy. Thus, changes in Ca2+ uptake induced by ATP, an important regulator of Ca2+ uptake, in the diabetic condition and related signal pathways were examined in primary cultures of rabbit renal proximal tubule cells (PTC)....

journal_title：Clinical and experimental pharmacology & physiology

authors： Han HJ,Park SH,Lee YJ,Lee JC,Lee JH

更新日期：2003-09-01 00:00:00

abstract：:Acute kidney injury (AKI) occurs in 5% of hospitalized patients and in 50% of sepsis patients with acute renal dysfunction. However, there have been no safe and effective therapeutic strategies. The hypoxia condition is closely related to renal injury and function under AKI. As hypoxia-inducible factor 1α (HIF-1α) is ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang H,Liu N,Li R,Tian J,Hu W,Zhang J

更新日期：2018-10-01 00:00:00

abstract：:This study hypothesized that different types of anaesthesia management would result in similar postoperative sleep quality. In this prospective single-blind investigation, 219 patients undergoing elective thoracic surgery were randomized into three arms: general anaesthesia, as the control group (group C); general ana...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tan WF,Guo B,Ma H,Li XQ,Fang B,Lv HW

更新日期：2016-03-01 00:00:00

abstract：:The P2X7 receptor is a ligand-gated purinergic receptor activated by extracellular ATP. The receptor is highly expressed in immune cells and in the brain, and, upon activation, the P2X7 receptor allows a cation flux, leading to the distinct activation of intracellular signalling pathways as the secretion of pro-inflam...

journal_title：Clinical and experimental pharmacology & physiology

authors： Guerra Martinez C

更新日期：2019-06-01 00:00:00

abstract：:1. Mechanisms involved in the plasma extravasation observed following thermal injury of rat dorsal skin were investigated. 2. Heat applied to the dorsal skin of anaesthetized rats by a temperature-controlled skin heater (1 cm diameter) for 5 min induced temperature-dependent plasma protein extravasation at 48-48.5 deg...

journal_title：Clinical and experimental pharmacology & physiology

authors： Waller J,Siney L,Hoult JR,Brain SD

更新日期：1997-11-01 00:00:00

abstract：:1. Quantitative autoradiography and homogenate radioligand binding of [125I]-Bolton Hunter substance P ([125I]-BHSP) were used to compare brain NK1 receptors in young (2 months) and aged (18-20 months) rats. 2. The autoradiographic distribution and density of [125I]-BHSP binding sites was similar in all cortical regio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Geraghty DP,Maguire CM

更新日期：2002-12-01 00:00:00

abstract：:Pressor responsiveness to angiotensin II (AII) and phenylephrine (PE) was examined before and after 5 days of ACTH (1 mg, i.m., daily) or hydrocortisone (200 mg, orally, daily) in six normotensive men. Pulse pressure was higher prior to PE than AII infusion, presumably due to feeding. Systolic blood pressure (SBP) was...

journal_title：Clinical and experimental pharmacology & physiology

authors： Whitworth JA,Connell JM,Lever AF,Fraser R

更新日期：1986-04-01 00:00:00

abstract：:1. It has been suggested that oestrogen-produced vasodilatation is due to induction of endothelial nitric oxide synthase (NOS), but there are many reports of direct effects on vascular smooth muscle. In the present study, these processes were investigated in rat aorta isolated from ovariectomized rats. 2. Short-term t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Binko J,Murphy TV,Majewski H

更新日期：1998-02-01 00:00:00

abstract：:1. The present study compared the binding and functional characteristics of tachykinin NK2 receptors in human detrusor muscle with those in human colon circular muscle. 2. In radioligand binding studies, similar KD values were observed for tachykinin NK2 receptor radioligands [125I]-neurokinin (NK) A, [125I]-[Lys5,Tyr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Warner FJ,Miller RC,Burcher E

更新日期：2003-09-01 00:00:00

abstract：:1. Anoxic perfusion of the isolated rat heart releases noradrenaline in the absence of sympathetic nerve fibre stimulation. 2. Anoxic noradrenaline release is enhanced by reducing the extracellular Na+ concentration, consistent with the proposal that such release occurs by carrier-mediated efflux. 3. Release is also e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dart AM,Riemersma RA

更新日期：1991-01-01 00:00:00

abstract：:1. Following local vasoconstriction-inducing stimuli, such as the cold pressor test (CPT), significant changes occur in haemodynamics, with a rise in arterial blood pressure and heart rate (HR) due to the activation of the sympathetic nervous system. Among the compensatory mechanisms to local ischaemia, the endogenous...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pasini FL,Capecchi PL,Colafati M,Randisi P,Puccetti L,Di Perri T

更新日期：1999-10-01 00:00:00

abstract：:1. The effects of bromocriptine and indomethacin on prolactin-induced pseudopregnancy were studied in pituitary grafted rats. 2.Administration of bromocriptine (a prolactin suppressant drug) at a total dose of 3 mg/kg body weight, given in 3 divided doses on day 5 of pseudopregnancy, effectively terminated it within 3...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tan GJ

更新日期：1980-05-01 00:00:00

abstract：:1. Visfatin (also known as nicotinamide phosphoribosyltransferase or Nampt) is a novel adipokine associated with metabolic abnormalities in obesity and diabetes. The aim of the present study was to determine whether visfatin levels in the circulation and visfatin expression in fat tissues are altered in Lyon hypertens...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang P,Bai C,Xu QY,Xu TY,Su DF,Sassard J,Miao CY

更新日期：2010-09-01 00:00:00

abstract：:1. The serotonin transporter (SERT) is strongly implicated in the pathogenesis of pulmonary arterial hypertension (PAH) in patients and animal models. Inhibitors of SERT have been reported to attenuate or reverse experimental PAH, which makes them potential therapeutic options for the treatment of PAH in humans. Howev...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhu SP,Mao ZF,Huang J,Wang JY

更新日期：2009-08-01 00:00:00

abstract：:1. Renomedullary interstitial cells (RMIC), abundant throughout the medulla of the kidney, have been demonstrated to have binding sites for many vasoactive peptides, including atrial natriuretic peptide, endothelin, angiotensin II and bradykinin (BK). These observations would support the hypothesis that interactions b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dean R,Maric C,Aldred GP,Casley D,Zhuo J,Harris P,Alcorn D,Mendelsohn FA

更新日期：1999-01-01 00:00:00

abstract：:1. Nitric oxide (NO), or peroxynitrite, is known to inhibit haemoproteins, including cytochrome P450 mono-oxygenases. The present study explores the functional correlates of the inhibition by NO of renal epoxygenase on the vascular responses to arachidonic acid (AA) in the perfused kidney. 2. Control kidneys produce m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Oyekan A

更新日期：2002-11-01 00:00:00

abstract：:Tiron functions as an effective antioxidant alleviating the intracellular reactive oxygen species (ROS) or the acute toxic metal overload. Previous studies have shown that cardiac myocyte apoptosis can be effectively inhibited by tiron administration in streptozotocin (STZ)-induced diabetic rats, primary neonatal rat ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiang P,Zhang D,Qiu H,Yi X,Zhang Y,Cao Y,Zhao B,Xia Z,Wang C

更新日期：2017-07-01 00:00:00

abstract：:1. The aim of the present study was to investigate the effects of hypoxia on energy metabolism and contraction of rat urinary bladder smooth muscle, thereby gaining insight into the capacity of this smooth muscle to maintain contractile function when rendered hypoxic. 2. Isometric force, oxygen consumption, lactate pr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wendt IR,Paul RJ

更新日期：2003-08-01 00:00:00