Effects of brain lesions on the antinociceptive properties of morphine in rats.


:1. Electrolytic lesions were made in various brain regions of the rat, and the effects of these lesions on nociceptive threshold and the antinociceptive actions of morphine were tested using a shock titration technique. 2. Lesions in the medial thalamus, the periaqueductal grey area, or the caudate nucleus, had no effect on the nociceptive threshold; whereas, lesions in the posterior hypothalamus resulted in a small but statistically significant increase in this threshold. 3. Morphine administered intraperitoneally to rats having histologically verified lesions in the posterior hypothalamus, the caudate nucleus or the periaqueductal grey area resulted in a 15-30% increase in the nociceptive threshold. This increase was similar to that observed in unoperated control rats. On the other hand, injections of morphine into animals having greater than 50% of the medial thalamus destroyed produced a highly significant increase of 95% in the threshold. This potentiation of the antinociceptive action of morphine was not observed in rats having less than 50% destruction of the medial thalamus.


Yeung JC,Yaksh TL,Rudy TA





Has Abstract


1975-05-01 00:00:00












  • New diagnostic tests for Cushing's syndrome: uses of naloxone, vasopressin and alprazolam.

    abstract::1. We set out to investigate whether the administration of naloxone alone, naloxone plus vasopressin (AVP) or naloxone plus alprazolam to patients with Cushing's syndrome would result in a blunted dynamic response of the pituitary-adrenal axis compared with normal volunteers. Cushing's syndrome is often difficult to d...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章


    authors: Jackson RV,Hockings GI,Torpy DJ,Grice JE,Crosbie GV,Walters MM,Strakosch CR

    更新日期:1996-06-01 00:00:00

  • Poly(ADP-ribose)polymerase 1 inhibition protects against age-dependent endothelial dysfunction.

    abstract::Age-related endothelial dysfunction is closely associated with the local production of reactive oxygen species (ROS) within and in the vicinity of the vascular endothelium. Oxidant-induced DNA damage can activate the nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP-1), leading to endothelial dysfunction in various p...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Zhang GH,Chao M,Hui LH,Xu DL,Cai WL,Zheng J,Gao M,Zhang MX,Wang J,Lu QH

    更新日期:2015-12-01 00:00:00

  • A novel model of constrictive pericarditis associated with myocardial fibrosis in rats.

    abstract::An efficient animal model is fundamental for studies on the underlying mechanisms of constrictive pericarditis (CP). A novel CP rat model was established by pericardial injection composing of lipopolysaccharides (LPS) and talcum powder without thoracotomy. Pathological changes were confirmed by histological staining. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Qiao W,Xiao YJ,Wang X,Sun LJ,Chen YX,Ren WD

    更新日期:2020-12-21 00:00:00

  • Vasoconstrictor responses to polymorphonuclear leucocytes from atherosclerotic rabbits.

    abstract::1. The vascular contractile effects of polymorphonuclear leucocytes (PMN) isolated from control rabbits and from rabbits made atherosclerotic by 1% cholesterol feeding for 8 weeks were examined. 2. Rings of control rabbit thoracic aorta with or without endothelium were mounted at 2 g tension in 10 mL organ baths and w...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Sobey CG,Hart JL,Woodman OL

    更新日期:1994-02-01 00:00:00

  • Afferent control of vasopressin and renin release during haemorrhage in normal and autonomically blocked rabbits.

    abstract::1. The role of the arterial and cardiac baroreceptors on the arginine vasopressin (AVP) and plasma renin activity (PRA) responses to haemorrhage was studied in conscious rabbits. They were bled at a rate of approximately 3% of their blood volume (BV)/min, both when the autonomic nervous system (ANS) was intact and dur...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Courneya CA,Korner PI,Oliver JR,Woods RL

    更新日期:1992-11-01 00:00:00

  • Dihydrocyclosporin D in sheep: haemodynamic and renal effects.

    abstract::1. This study was designed to test the haemodynamic and renal effects in sheep of dihydrocyclosporin D (dCyD), an immunosuppressant agent derived from the fungus Tolypocladium inflatum Gams. 2. dCyD was infused for 5 days at 12 mg/kg per day. Mean arterial pressure (MAP) was elevated after 24 h, but thereafter returne...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Tresham JJ,Whitworth JA,de Lima JJ,McDougall JG,Scoggins BA

    更新日期:1988-05-01 00:00:00

  • Blood pressure responses to dietary sodium manipulation during normotensive human pregnancy.

    abstract::Short-term salt loading and salt restriction in a group of normal pregnant women produced no changes in lying, sitting or standing blood pressures or heart rates. Home blood pressures showed no trend to change over the periods of altered salt intake. Although plasma volume and plasma renin activity changed with altere...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: McEniery PJ,Hunyor SN,Cooper KA,Gallery ED,Gyory AZ,Boyce ES

    更新日期:1985-05-01 00:00:00

  • Modelling the neural control of intrarenal blood flow.

    abstract::1. The aim of the present study was to produce a mathematical model that describes the way dynamic changes in renal sympathetic nerve activity affect renal, cortical and medullary blood flow. 2. Cortical blood flow (CBF) and medullary blood flow (MBF) were measured using laser-Doppler flowmetry and (total) renal blood...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Navakatikyan MA,Leonard BL,Evans RG,Malpas SC

    更新日期:2000-08-01 00:00:00

  • Renal microvascular effects of P2 receptor stimulation.

    abstract::1. The field of extracellular nucleotides and purinoceptors has undergone a resurgence of interest and enthusiasm in the past decade. More and more investigators are probing the physiological and pathophysiological roles of P2 receptors in virtually every organ system, including the kidney. 2. With this renewed intere...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Inscho EW

    更新日期:2001-04-01 00:00:00

  • Autacoid interactions in the regulation of blood flow in the human placenta.

    abstract::1. Interactions between autacoids may play important roles in the regulation of blood flow in the foetal placenta. In order to investigate this aspect of placental haemodynamics, human normal-term placentae were perfused in vitro and the responses of the foetal vessels to various combinations of vasoactive agents were...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Gude NM,King RG,Brennecke SP

    更新日期:1998-09-01 00:00:00

  • Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.

    abstract::Autophagy promotes cell survival or induces apoptosis in cancer cells. While SIRT1 and AMPK induce autophagy in both normal and cancer cells, Akt and mTOR can inhibit it. Calycosin, a methoxyisoflavone, protects against several types of solid tumours including colorectal cancer. However, the mechanisms behind the anti...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: El-Kott AF,Al-Kahtani MA,Shati AA

    更新日期:2019-10-01 00:00:00

  • Facilitation of noradrenergic transmission by locally generated angiotensin II in guinea-pig isolated atria and in the perfused caudal artery of the rat.

    abstract::In guinea-pig isolated atria, angiotensin I and angiotensin II produced concentration dependent increases in the rate of spontaneous beating and in the release of noradrenaline produced by field stimulation of sympathetic nerves. In rat isolated caudal artery preparations, both angiotensin I and angiotensin II had dir...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ziogas J,Story DF,Rand MJ

    更新日期:1984-07-01 00:00:00

  • Does the baroreceptor-heart rate reflex indicate the capacity of the arterial baroreceptors to control blood pressure?

    abstract::1. We have examined the question asked in the title by studying: the carotid baroreceptor reflex in man with a variable-pressure neck chamber; the carotid baroreceptor reflex in conscious rabbits with a variable-pressure capsule around the carotid bifurcation; and the barorecptor-heart rate reflex. 2. At rest, the ass...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ludbrook J,Mancia G,Zanchetti A

    更新日期:1980-09-01 00:00:00

  • Anti-angiogenesis effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive properties under experimental model.

    abstract::Angiogenesis is a process through which new capillaries are formed from pre-existing ones, which contributes significantly to the pathogenesis of numerous diseases, such as cancer and chronic inflammatory disorders. The β-D-mannuronic acid (M2000) is a novel non-steroidal anti-inflammatory drug (NSAID) with immunosupp...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Rastegari-Pouyani M,Mostafaie A,Mansouri K,Mortazavi-Jahromi SS,Mohammadi-Motlagh HR,Mirshafiey A

    更新日期:2018-04-01 00:00:00

  • Enhanced antitumour activity of doxorubicin and simvastatin combination loaded nanoemulsion treatment against a Swiss albino mouse model of Ehrlich ascites carcinoma.

    abstract::Doxorubicin (DOX) is the most commonly used anticancer drug; however, it has limited use because prolonged administration may result in severe cardiotoxicity. Simvastatin (SIM), generally prescribed for hypercholesterolaemia, has also shown salubrious results in the monotherapy or combinational drug therapy of differe...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Alkreathy HM,Alkhatib MH,Al Musaddi SA,Balamash KSA,Osman NN,Ahmad A

    更新日期:2019-05-01 00:00:00

  • Reduced adenosine 3',5'-cyclic monophosphate levels in patients with reversible obstructive airways disease.

    abstract::1. Patients were grouped into categories of 'no airways disease', 'obstructive airways disease without response to bronchodilator' and 'obstructive airways disease with bronchodilator responsiveness'. 2. Cyclic nucleotides were assayed in specimens of lung tissue that were excised during surgery. 3. Reduced levels of ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Krzanowski JJ,Polson JB,Goldman AL,Ebel TA,Szentivanyi A

    更新日期:1979-01-01 00:00:00

  • Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia-inducible factors HIF1α and HIF2α.

    abstract::Chemotherapy resistance is a major contributor to poor treatment responses and tumour relapse, the development of which has been strongly linked to the action of cancer stem cells (CSCs). Mounting evidence suggests that CSCs are reliant on low oxygen conditions and hypoxia-inducible factors 1α and 2α (HIF1α and HIF2α)...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Schöning JP,Monteiro M,Gu W

    更新日期:2017-02-01 00:00:00

  • Existence of beta(3)-adrenoceptors in rat heart: functional implications.

    abstract::1. beta(3)-Adrenoceptors (AR) have been reported to be present in numerous species, where they mediate multiple responses. 2. The aim of the present study was to determine whether beta(3)-AR are present in intact rat heart and the functional implications of beta(3)-AR stimulation. The response to the cardiac beta(3)-A...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Barbier J,Mouas C,Rannou-Bekono F,Carré F

    更新日期:2007-08-01 00:00:00

  • Genetic factors regulate the rise in blood pressure in F2 generation crossed between stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats.

    abstract::1. There was no significant difference between the systolic blood pressure (SBP) of offspring derived from SHRSP mother and WKY father and the SBP of offspring derived from WKY mother and SHRSP father at the developing stage (5-13 weeks of age). 2. The degree of genetic determinations of SBP in stroke-prone spontaneou...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ikeda K,Nara Y,Nabica T,Fujimoto A,Endo J,Ishino H,Yamori Y

    更新日期:1991-09-01 00:00:00

  • LncRNA XIST promotes chemoresistance of breast cancer cells to doxorubicin by sponging miR-200c-3p to upregulate ANLN.

    abstract::The resistance of breast cancer cells to drugs is a major obstacle to effective cancer chemotherapy. Here, we study the function mechanisms of long non-coding RNA XIST in chemoresistance of breast cancer to doxorubicin. We examined the 50% inhibitive concentration of doxorubicin to MDA-MB-231 and MDA-MB-231/ADM cells,...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Zhang M,Wang F,Xiang Z,Huang T,Zhou WB

    更新日期:2020-08-01 00:00:00

  • On making multiple comparisons in clinical and experimental pharmacology and physiology.

    abstract::1. It is a central thesis of this review that in clinical and experimental pharmacology and physiology the goal of statistical analysis should be to minimize the risk of making any false-positive inferences from the results of an experiment (experimentwise Type I error). 2. It is common in clinical and experimental ph...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 社论,评审


    authors: Ludbrook J

    更新日期:1991-06-01 00:00:00

  • Auranofin increases apoptosis and ischaemia-reperfusion injury in the rat isolated heart.

    abstract::Auranofin, an antirheumatic gold compound, is an inhibitor of selenocysteine enzymes, such as thioredoxin reductase and glutathione peroxidase. These enzymes play an important role in protecting cardiac tissue from oxidative stress generated during ischaemia-reperfusion. Auranofin (100 mg/kg) was administered to rats ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Venardos K,Harrison G,Headrick J,Perkins A

    更新日期:2004-05-01 00:00:00

  • Ageing and blood pressure regulation: dose-response relationships for angiotensin, blood pressure, atrial natriuretic peptide and aldosterone in normal subjects of varying ages.

    abstract::1. Infusion of increasing doses of angiotensin II (AII) in normal subjects sequentially increased blood pressure, aldosterone and atrial natriuretic peptide (ANP) levels. 2. The slope of ANP response to AII was positively correlated with basal ANP and with the slope of blood pressure response to AII (pressor slope) bu...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Finn WL,Tunny TJ,Klemm SA,Ryan SJ,Gordon RD

    更新日期:1993-05-01 00:00:00

  • The effects of indomethacin in treated hypertensive patients.

    abstract::1. Twelve treated hypertensive patients (ages 58-71 years) who had also been treated for joint disease participated in a randomized double-blind crossover placebo-controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6-week period. 2. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wing LM,Bune AJ,Chalmers JP,Graham JR,West MJ

    更新日期:1981-09-01 00:00:00

  • In vitro anti-oxidant and DNA protective effects of the novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin.

    abstract::1. Free radical-induced lipid peroxidation and changes in protein and nucleic acid structures can result in various human ailments, including ageing, neurodegenerative disorders and cancer. High body fat or dietary fat further enhances the free radical-mediated pathogenesis of various diseases. 2. In the present study...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ajith TA,Riji T,Anu V

    更新日期:2008-05-01 00:00:00

  • Rodent motor and neuropsychological behaviour measured in home cages using the integrated modular platform SmartCage™.

    abstract::1. To facilitate investigation of diverse rodent behaviours in rodents' home cages, we have developed an integrated modular platform, the SmartCage(™) system (AfaSci, Inc. Burlingame, CA, USA), which enables automated neurobehavioural phenotypic analysis and in vivo drug screening in a relatively higher-throughput and...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Khroyan TV,Zhang J,Yang L,Zou B,Xie J,Pascual C,Malik A,Xie J,Zaveri NT,Vazquez J,Polgar W,Toll L,Fang J,Xie X

    更新日期:2012-07-01 00:00:00

  • Central choline suppresses plasma renin response to graded haemorrhage in rats.

    abstract::Central administration of choline increases blood pressure in normotensive and hypotensive states by increasing plasma concentrations of vasopressin and catecholamines. We hypothesized that choline could also modulate the renin-angiotensin pathway, the third main pressor system in the body. Plasma renin activity (PRA)...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Isbil-Buyukcoskun N,Ilcol YO,Cansev M,Hamurtekin E,Ozluk K,Ulus IH

    更新日期:2008-09-01 00:00:00

  • Molecular regulation of skeletal muscle mass.

    abstract::1. The maintenance of skeletal muscle mass is determined by a fine balance between protein synthesis and protein degradation. Skeletal mass is increased when there is a net gain in protein synthesis, which can occur following progressive exercise training. In contrast, skeletal muscle mass is lost when degradation occ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Russell AP

    更新日期:2010-03-01 00:00:00

  • Defective intracellular Ca2+ homeostasis contributes to myocyte dysfunction during ventricular remodelling induced by chronic volume overload in rats.

    abstract::1. Previous studies have demonstrated progressive ventricular hypertrophy, dilatation and contractile depression in response to chronic volume overload. Whether this decompensation was related to intrinsic myocyte dysfunction was not clear. The present study evaluated ventricular myocyte function at critical times dur...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ding YF,Brower GL,Zhong Q,Murray D,Holland M,Janicki JS,Zhong J

    更新日期:2008-07-01 00:00:00

  • Role of non-selective adenosine receptor blockade and phosphodiesterase inhibition in cisplatin-induced nephrogonadal toxicity in rats.

    abstract::1. It is well documented that cisplatin (CDDP) treatment increases the expression of adenosine A(1) receptors in both kidney and testes. However, the effect of adenosine at these receptors is controversial. Adenosine A(1) receptors have been documented to be involved in either cytoprotection or aggravation of nephroto...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Saad SY,Najjar TA,Alashari M

    更新日期:2004-12-01 00:00:00