Cholinergic prejunctional inhibition of nitrergic neurotransmission in the guinea-pig isolated basilar artery.

abstract：:1. Stroke is the second most common cause of death and a major cause of disability worldwide. Despite increasing knowledge of the cellular and molecular mechanisms that occur in stroke, there are still large gaps in our understanding that are impeding therapeutic progress. In addition, there are no drugs yet that can ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sun XL,Hu G

更新日期：2010-02-01 00:00:00

abstract：:The prostaglandin synthesis inhibitor diclofenac sodium has been compared with a placebo in the treatment of primary nocturnal enuresis in a double-blind crossover trial. Twenty patients were entered: 14 female, six male; age range 6-17 years. The results showed that diclofenac sodium was significantly more effective ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Al-Waili NS

更新日期：1986-02-01 00:00:00

abstract：:1. The effects of ouabain and acetazolamide on the secretion of pancreatic juice stimulated by secretin in anaesthetized dogs were investigated. 2. Intra-arterial injection of ouabain (1-10 micrograms) and acetazolamide (1-10 mg) caused dose-dependent decreases in the volume of pancreatic juice. When both drugs were a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iwatsuki K,Horiuchi A,Yonekura Y,Chiba S

更新日期：1989-03-01 00:00:00

abstract：:1. Animal and human studies indicate that female sex hormones are protective against the development of coronary atherosclerosis. 2. Experiments on vascular smooth muscle cells suggest a direct effect of oestrogen on vascular tissue. Although oestrogen receptors (ER) in vascular tissues and an association between ER s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Baysal K,Losordo DW

更新日期：1996-06-01 00:00:00

abstract：:1. The effects of clomiphene (CLM) on cardiac outward K+ current components from rat isolated ventricular myocytes were investigated using the whole-cell patch-clamp technique. Clomiphene (10 micromol/L) significantly inhibited both peak (Ipeak) and end-pulse (Ilate) outward currents (elicited by a 500 msec voltage st...

journal_title：Clinical and experimental pharmacology & physiology

authors： Borg JJ,Hancox JC,Hogg DS,James AF,Kozlowski RZ

更新日期：2004-01-01 00:00:00

abstract：:1. The effect of the calcium channel blocker nisoldipine on the myocardial content of lipid peroxidation products (malondialdehyde (MDA), conjugated double bonds (CDB), fluorescent end-products (RF) and mitochondrial adenine nucleotides) was investigated in conscious pigs (n = 14) subjected to 24 h of immobilization s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Herbaczyńska-Cedro K,Lewicki Z,Barcikowski B,Famulski K,Gordon-Majszak W,Kłoś J,Wutzen J,Ceremuzyński L

更新日期：1990-01-01 00:00:00

abstract：:1. The effects of ethacrynic acid were studied on relaxations elicited by nitric oxide (NO), the NO-donors sodium nitroprusside (SNP) and glyceryl trinitrate (GTN), nitrergic nerve stimulation and the NO-independent agent papaverine in isolated preparations of rat anococcygeus muscles. 2. Ethacrynic acid (100 mumol/L)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li CG,Brosch SF,Rand MJ

更新日期：1994-04-01 00:00:00

abstract：:1. Pre- and postjunctional effects of endothelin (1-10 nmol/L) have been studied in the rabbit isolated ear artery and in rat isolated atria. 2. Endothelin produced concentration-dependent increases in arterial perfusion pressure, and had positive chronotropic and inotropic effects in rat atria. 3. Vasoconstrictor res...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wong-Dusting HK,Reid JJ,Rand MJ

更新日期：1989-04-01 00:00:00

abstract：:1. By selectively modifying adenosine metabolism via adenosine deaminase or adenosine kinase inhibitors, it may be possible to enhance the receptor-mediated protective actions of adenosine in a site- and event-specific fashion. 2. We characterized cardioprotective actions of the adenosine deaminase inhibitor erythro-2...

journal_title：Clinical and experimental pharmacology & physiology

authors： Willems L,Headrick JP

更新日期：2005-03-01 00:00:00

abstract：:1. Atherosclerosis begins with the deposition of cholesterol in arterial tissue that is thought to be derived from circulating lipoproteins. There is considerable evidence implicating low density lipoprotein (LDL) as a primary source of plaque cholesterol and, consequently, there are many articles that deal with vario...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mamo JC,Yu KC,Elsegood CL,Smith D,Vine D,Gennat HC,Voevodin M,Proctor SD

更新日期：1997-03-01 00:00:00

abstract：:1. We examined the effects of torasemide (0.3 and 1 mg/kg i.v.) on renal haemodynamics and function employing renal clearance and stop-flow techniques in anaesthetized dogs and compared these with furosemide (1 and 3 mg/kg i.v.). 2. Torasemide and furosemide did not influence renal haemodynamics, in the renal clearanc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Uchida T,Hayashi K,Suzuki Y,Matsumura Y

更新日期：1991-07-01 00:00:00

abstract：:The circulating miRNAs are dysregulated in non-small cell lung cancer (NSCLC) and have great promise for clinical diagnosis. The aim of this study was to screen and evaluate the reliability and diagnostic efficiency of candidate serum miRNAs for NSCLC diagnosis. We found that miR-21 and let-7a were significantly dysre...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang X,Jia Z,Shi H,Pan C

更新日期：2018-10-01 00:00:00

abstract：:1. The hepatic reticulo-endothelial cell population is generally assumed to increase in size, along with the liver, during ageing in rats. However, this has not been rigorously established. 2. Using electron microscopy and stereological techniques, the present study has shown that the volume densities of hepatocytes a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Martin G,Sewell RB,Yeomans ND,Smallwood RA

更新日期：1992-07-01 00:00:00

abstract：:1. The study examines whether intracerebroventricular (ICV) infusion of atrial natriuretic peptide (human ANP,1-28) influences renal electrolyte and water excretion, vasopressin release, renal and femoral blood flows in conscious ewes. The blood flow was measured by chronically implanted ultrasonic flow probes. 2. ICV...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gunnarsson U

更新日期：1994-03-01 00:00:00

abstract：:Urinary levels of glycosaminoglycans (GAG) and hydroxyproline from normal and fluoride treated rabbits were estimated. The hydroxylysine content of serum and urine of rabbits after excessive ingestion of fluoride was also investigated. There was a progressive decrease in GAG content, reduction in hydroxylysine, wherea...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jha M,Koacher J,Susheela AK

更新日期：1983-09-01 00:00:00

abstract：:1. Obstruction of the upper airway could be an initiating factor in the Sudden Infant Death Syndrome (SIDS). Responses to upper airway obstruction include augmentation of respiratory efforts, active dilation of the upper airway and electrocortical arousal. Vulnerable individuals may fail to mount these responses effec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Harding R,Jakubowska AE,McCrabb GJ

更新日期：1995-08-01 00:00:00

abstract：:1. Trophoblast invasion during embryo implantation in some aspects resembles tumour cell invasion but, unlike tumour cells, trophoblast cells are able to differentiate and establish a placenta. Because direct cell-cell communication is believed to be involved in growth control and differentiation, we have investigated...

journal_title：Clinical and experimental pharmacology & physiology

authors： Winterhager E,Reuss B,Hellmann P,Spray DC,Gruemmer R

更新日期：1996-12-01 00:00:00

abstract：:Atherosclerosis is a complex chronic inflammatory disease that remains one of the leading causes of death and disability worldwide. A previous study reported that glaucocalyxin A (GLA), a natural ent-Kaurane diterpenoid triptolide, exhibits anti-atherosclerotic activity. However, the underlying molecular mechanism has...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhu S,Zhang J,Lv Y

更新日期：2020-05-01 00:00:00

abstract：:1. Ethionine administered acutely to the adult female rat markedly elevates and then lowers plasma iron concentration over several days. Liver iron undergoes a reverse cycle. 2. Ethionine does not cause changes in the blood parameters, including total plasma iron-binding capacity and plasma iron clearance. Erythrocyte...

journal_title：Clinical and experimental pharmacology & physiology

authors： Loh TT,Archdeacon JW

更新日期：1975-11-01 00:00:00

abstract：:1. In the mammalian central nervous system, GABA is the main inhibitory neurotransmitter. GABA is a highly flexible molecule and, thus, can exist in many low-energy conformations. Conformationally restricted analogues of GABA have been used to help identify three major GABA receptors, termed GABAA, GABAB and GABAC rec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chebib M,Johnston GA

更新日期：1999-11-01 00:00:00

abstract：:Spinal cord injury (SCI) is a major disability requiring more effective treatment than is currently available. MicroRNAs have been shown to effectively regulate gene expression at the translational level. The aim of the present study was to explore the potential role of miR-30-5p and possible mechanism in SCI. We foun...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fu X,Shen Y,Wang W,Li X

更新日期：2018-01-01 00:00:00

abstract：:1. The haemodynamic and metabolic effects of oral intake of approximately 30 mg/kg per day N-nitro-L-arginine (NOLA) were examined in sham and adrenocorticotrophin (ACTH, 0.5 mg/kg per day) treated conscious Sprague-Dawley rats (n = 33). 2. NOLA administration produced an increase in systolic blood pressure of 24 +/- ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li M,Dusting GJ,Whitworth JA

更新日期：1992-10-01 00:00:00

abstract：:1. There has been considerable recent interest in the possibility that increased intake of dietary anti-oxidants may protect against cardiovascular disease. This is partly due to the knowledge that oxidative events in vivo may play a role in the pathogenesis of atherosclerosis. 2. While dietary anti-oxidants, such as ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morton LW,Abu-Amsha Caccetta R,Puddey IB,Croft KD

更新日期：2000-03-01 00:00:00

abstract：:1. The clinical observation that hypertension is more common in males and postmenopausal women than in premenopausal women suggests vascular protective effects of female sex hormones, including hormone-mediated inhibition of vascular tone. The purpose of the present study was to investigate whether the Ca2+ mobilizati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Crews JK,Khalil RA

更新日期：1999-09-01 00:00:00

abstract：:1. Physical movement is accompanied by coordinated changes in respiratory and cardiovascular activity proportional to the metabolic demands of the locomotor task. Cardiorespiratory changes include increases in ventilation, blood pressure and heart rate, as well as altered regional sympathetic nerve activity and blood ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kramer JM,Beatty JA,Plowey ED,Waldrop TG

更新日期：2002-01-01 00:00:00

abstract：:1. The spinal sympathetic outflow (C7-T2) of pithed male Wistar rats was electrically stimulated (30-50 V, 0.5 ms, 0.1-1.0 Hz) and heart rate and arterial blood pressure were recorded. D-Tubocurarine (1 mg/kg) and atropine (1 mg/kg) were administered intravenously (i.v.) to reduce voluntary and parasympathetic nerve a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rechtman MP,King RG,Boura AL

更新日期：1988-12-01 00:00:00

abstract：:1. Total fluid and saline intakes were greater in spontaneously hypertensive rats (SHR) than in normotensive rats (NTR). 2. Total fluid and saline intake were significantly elevated in prehypertensive SHR, 5 weeks old, compared with age-matched NTR, and the intakes fell with age in both strains but remained considerab...

journal_title：Clinical and experimental pharmacology & physiology

authors： May CN,Parsons BJ

更新日期：1983-01-01 00:00:00

abstract：:1. The present study examined the effects of an aqueous extract of Anoectochilus formosanus (AFE) on both hepatic fibrosis and regeneration in rats. 2. Fibrosis was induced by intraperitoneal injection of dimethylnitrosamine (DMN) for 3 consecutive days per week for 4 weeks. 3. In DMN-treated rats, liver cirrhosis-ass...

journal_title：Clinical and experimental pharmacology & physiology

authors： Shih CC,Wu YW,Hsieh CC,Lin WC

更新日期：2004-09-01 00:00:00

abstract：:1. We studied the association between the level of the left ventricular ejection fraction and the severity of coronary atherosclerosis. 2. The study population consisted of 850 consecutive patients who underwent coronary angiography for suspected or known coronary atherosclerosis. Anthropometric measurements including...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jia EZ,Xu ZX,Yang ZJ,Zhu TB,Wang LS,Cao KJ,Ma WZ

更新日期：2011-02-01 00:00:00

abstract：:1. The role of cardiac reflexes in baroreflex control mechanisms and the changes that occur in chronic hypertension is reviewed. The rapid resetting properties of the arterial baroreceptors ensures its role in short-term rather than long-term control of blood pressure. 2. In hypertensive humans and animals, the barore...

journal_title：Clinical and experimental pharmacology & physiology

authors： Head GA

更新日期：1994-10-01 00:00:00