Antihypertensive effects of DL-tetrahydropalmatine: an active principle isolated from Corydalis.

Abstract:

:1. The effects of DL-tetrahydropalmatine (DL-THP) on cardio-vascular function and hypothalamic release of monoamines were assessed in rats under urethane anaesthesia. 2. Intravenous administration of DL-THP (1-10 mg/kg) produced hypotension, bradycardia, a decrease in hypothalamic serotonin and noradrenaline release and an increase in hypothalamic dopamine release in rats. 3. Intrahypothalamic administration of DOI (a serotonergic 5-HT2 receptor antagonist) or apomorphine (a dopamine D2-receptor agonist) produced the opposite effects and reversed DL-THP-induced hypotension and bradycardia. 4. The data suggest that DL-THP acts through the 5-HT2 and/or D2-receptor antagonism in the hypothalamus to induce hypotension and bradycardia in rats.

authors

Lin MT,Chueh FY,Hsieh MT,Chen CF

doi

10.1111/j.1440-1681.1996.tb01769.x

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

738-42

issue

8

eissn

0305-1870

issn

1440-1681

journal_volume

23

pub_type

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