Changes in postoperative night bispectral index of patients undergoing thoracic surgery with different types of anaesthesia management: a randomized controlled trial.

Abstract:

:This study hypothesized that different types of anaesthesia management would result in similar postoperative sleep quality. In this prospective single-blind investigation, 219 patients undergoing elective thoracic surgery were randomized into three arms: general anaesthesia, as the control group (group C); general anaesthesia combined with thoracic epidural anaesthesia (TEA) (group E); and general anaesthesia combined with infusion of 1 μg/kg dexmedetomidine (group D). Plasma samples were obtained to measure the amine and inflammatory cytokine concentrations. All patients underwent assessment with the bispectral index (BIS) for sleep quality and the visual analogue scale (VAS) for pain. The primary outcomes were inflammatory cytokine [interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α)] secretion and postoperative sleep quality on the first and second postoperative nights. The secondary outcomes were amine (adrenaline and noradrenaline) secretion during the surgical period and haemodynamic stability. The postoperative BIS area under the curve was significantly lower in group E (75.7%) than in group C (87.3%) or group D (86.5%). Patients in group E had the highest BIS of sleep efficiency index (29.2%, P < 0.05) and the lowest VAS scores (3.5, P < 0.05). Group E had lower IL-6 levels than the other two groups 24 h after surgery (P < 0.05). Patients given TEA may show reduced sleep disturbances on the first night after surgery, perhaps due to better pain management and inhibition of IL-6 release.

authors

Tan WF,Guo B,Ma H,Li XQ,Fang B,Lv HW

doi

10.1111/1440-1681.12530

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

304-11

issue

3

eissn

0305-1870

issn

1440-1681

journal_volume

43

pub_type

杂志文章,随机对照试验
  • Therapeutic effect of green tea extract on advanced glycation and cross-linking of collagen in the aorta of streptozotocin diabetic rats.

    abstract::1. The therapeutic effect of green tea extract (GTE) on the aortic collagen content and its characteristics were investigated in streptozotocin diabetic rats. 2. Diabetes was induced in rats by a single intra peritoneal injection of streptozotocin (60 mg/kg bodyweight). Six weeks after diabetes induction, GTE was admi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2006.04374.x

    authors: Babu PV,Sabitha KE,Shyamaladevi CS

    更新日期:2006-04-01 00:00:00

  • Sensitivity changes in guinea-pig atria and ileum following subacute administration of dyflos.

    abstract::1. Subacute administration of dyflos to guinea-pigs (1.2 mg/kg, s.c., daily for 10 days) led to the development of subsensitivity to carbachol in the ileum but not in the electrically stimulated left atrium. 2. Atria from dyflos-pretreated animals became supersensitive to acetylcholine but the ileum became subsensitiv...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1977.tb02683.x

    authors: Mitchelson F,O'Shea RA

    更新日期:1977-11-01 00:00:00

  • A randomized, controlled, phase II clinical trial of β-D-mannuronic acid (M2000) in pre-surgical breast cancer patients at early stage (T1-T2).

    abstract::Following the potent efficacy of β-D-Mannuronic acid in a breast cancer murine model, we evaluated the efficacy of this novel non-steroidal anti-inflammatory drug in breast cancer patients in the present clinical trial. The study was an 8-week randomized, controlled, phase II clinical trial (IRCT: 2017012213739N7 (in ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/1440-1681.13086

    authors: Kashefi S,Omranipour R,Mahmoodzadeh H,Ahmadi H,Alikhassi A,Hosseini M,Cuzzocrea S,Rehm BHA,Matsuo H,Mirshafiey A

    更新日期:2019-06-01 00:00:00

  • Cardiac effects of salbutamol-induced hypokalaemia in the conscious dog.

    abstract::1. Infusion of salbutamol (3.0 microgram/min after a bolus injection of 100 microgram) produced hypokalaemia in conscious dogs. 2. Measurement of arterial and coronary sinus potassium differences revealed no significant potassium loss from the heart with established hypokalaemia. 3. Shortly after the initial salbutamo...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1978.tb00717.x

    authors: Wahlqvist ML,Shanahan EA,Dennis PM,Pullan PT,Wilmshurst EG

    更新日期:1978-11-01 00:00:00

  • Urinary NO3- excretion as an indicator of nitric oxide formation in vivo during oral administration of L-arginine or L-name in rats.

    abstract::1. Endothelium-derived nitric oxide (NO), a major modulator of vascular tone, is synthesized from the terminal guanidino nitrogen of L-arginine. This reaction is inhibited by analogues of L-arginine, such as N-nitro-L-arginine methyl ester (L-NAME). Many of the biological effects of NO are mediated by the second messe...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:

    authors: Boger RH,Bode-Boger SM,Gerecke U,Gutzki FM,Tsikas D,Frolich JC

    更新日期:1996-01-01 00:00:00

  • Acute but not chronic angiotensin-converting enzyme inhibition induces enzyme synthesis in the glomerulus of the spontaneously hypertensive rat.

    abstract::1. Treatment with angiotensin-converting enzyme (ACE) inhibitors slows the rate of progression of nephropathy in the spontaneously hypertensive rat (SHR) with streptozotocin-induced diabetes. Paradoxically, however, chronic ACE inhibitor therapy has been reported to be associated with induction of ACE in the plasma. W...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1997.tb01226.x

    authors: Hodge G,Makarious MM,Charlesworth JA,Duggan KA

    更新日期:1997-06-01 00:00:00

  • Effects of an orally active vasopressin V1 receptor antagonist.

    abstract::1. This paper reports on the in vitro and in vivo characteristics of a non-peptide vasopressin V1 receptor antagonist 1-(1-[4-(3-acetylaminopropoxy)benzoyl]-4-piperidyl)-3,4-dihydro-2( 1H)- quinolinone (OPC-21268). 2. OPC-21268 caused a concentration-dependent displacement of the selective V1 receptor antagonist radio...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1993.tb01713.x

    authors: Burrell LM,Phillips PA,Stephenson J,Risvanis J,Hutchins AM,Johnston CI

    更新日期:1993-05-01 00:00:00

  • Interstitial Foxp3-positive T cells may predict renal survival in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.

    abstract::1. Regulatory T cells (T(reg)) and cytotoxic T cells (CTL) are involved in various immune diseases. However, the prognostic impact of T(reg) and CTL in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) is not well known. Therefore, in the present study, we e...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2010.05412.x

    authors: Yoshimura J,Fukami K,Koike K,Nagano M,Matsumoto T,Iwatani R,Kusumoto T,Hazama T,Ueda S,Adachi H,Hirai Y,Takasu K,Ohshima K,Yamagishi S,Okuda S

    更新日期:2010-09-01 00:00:00

  • Multiple oscillators, dynamic synchronization and sympathetic control.

    abstract::1. Intermittent bursts of activity are a robust feature of the discharges of sympathetic nerves. There are at least two major mechanisms producing such discharges: (i) phasic inputs influencing sympathetic circuits; and (ii) oscillators embedded within sympathetic networks. The functional significance of patterned and...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1681.2001.03414.x

    authors: Gilbey MP

    更新日期:2001-01-01 00:00:00

  • Facilitation of noradrenergic transmission by locally generated angiotensin II in guinea-pig isolated atria and in the perfused caudal artery of the rat.

    abstract::In guinea-pig isolated atria, angiotensin I and angiotensin II produced concentration dependent increases in the rate of spontaneous beating and in the release of noradrenaline produced by field stimulation of sympathetic nerves. In rat isolated caudal artery preparations, both angiotensin I and angiotensin II had dir...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1984.tb00290.x

    authors: Ziogas J,Story DF,Rand MJ

    更新日期:1984-07-01 00:00:00

  • Adenosine A1 receptor activation reduces opening of mitochondrial permeability transition pores in hypoxic cardiomyocytes.

    abstract::1. Adenosine A(1) receptors (A(1)R) play an important role in cardioprotection against hypoxic damage and the opening of mitochondrial permeability transition pores (MPTP) is central to the regulation of cell apoptosis and necrosis. However, it is still unclear whether A(1)R open MPTP in hypoxic cardiomyocytes. 2. The...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2009.05300.x

    authors: Xiang F,Huang YS,Zhang DX,Chu ZG,Zhang JP,Zhang Q

    更新日期:2010-03-01 00:00:00

  • Regulation of microvascular flow and metabolism: An overview.

    abstract::Skeletal muscle is an important site for insulin to regulate blood glucose levels. It is estimated that skeletal muscle is responsible for ~80% of insulin-mediated glucose disposal in the post-prandial period. The classical action of insulin to increase muscle glucose uptake involves insulin binding to insulin recepto...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/1440-1681.12688

    authors: Keske MA,Dwyer RM,Russell RD,Blackwood SJ,Brown AA,Hu D,Premilovac D,Richards SM,Rattigan S

    更新日期:2017-01-01 00:00:00

  • Renal function in adult rats subjected to prenatal dexamethasone.

    abstract::1. Prenatal dexamethasone leads to low birth weight and compromises organogenesis, but its effects on nephrogenesis in male and female rats have not yet been investigated extensively. Reduced renal mass may be responsible for hypertension and renal haemodynamic and morphological adjustments to maintain the glomerular ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2003.03787.x

    authors: Martins JP,Monteiro JC,Paixão AD

    更新日期:2003-01-01 00:00:00

  • Strategies of treating cancer by cytokine regulation of chromosome end remodelling.

    abstract::1. Telomeres (ends of chromosomes) undergo constant remodelling during cell development, proliferation and differentiation, as well as in neoplastic cell immortalization and transformation. How the cellular microenvironment influences telomere remodelling (lengthening or shortening) remains largely unknown. 2. Recentl...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2009.05251.x

    authors: Liu JP,Nicholls C,Chen SM,Li H,Tao ZZ

    更新日期:2010-01-01 00:00:00

  • Beta-adrenoceptor-mediated inhibition of mediator release from human peripheral blood-derived mast cells.

    abstract::1. Mast cells cultured from human peripheral blood have been used as a cell model for functional studies of human mast cells, particularly human lung mast cells. However, the beta-adrenoceptor subtype expressed by these cultured cells has not been identified. The aim of the present study was to characterize pharmacolo...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2006.04435.x

    authors: Wang XS,Lau HY

    更新日期:2006-08-01 00:00:00

  • Effect of furazolidone and nitrofurazone on brain gamma-amino butyric acid and glutamate concentrations in chickens.

    abstract::1. The concentrations of gamma-amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, the birds lost about 9% of their bodyweight when on the small ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1989.tb01572.x

    authors: Ali BH

    更新日期:1989-05-01 00:00:00

  • Renal tubulointerstitial hypoxia: cause and consequence of kidney dysfunction.

    abstract::1. Intrarenal oxygen availability is the balance between supply, mainly dependent on renal blood flow, and demand, determined by the basal metabolic demand and the energy-requiring tubular electrolyte transport. Renal blood flow is maintained within close limits in order to sustain stable glomerular filtration, so inc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2011.05532.x

    authors: Palm F,Nordquist L

    更新日期:2011-07-01 00:00:00

  • Silencing of astrocyte elevated gene-1 inhibits proliferation and migration of melanoma cells and induces apoptosis.

    abstract::Melanoma is an aggressive skin malignancy with a high mortality. Astrocyte elevated gene-1 (AEG-1), a downstream target of Ras and c-Myc, has been implicated in the development of multiple tumours, but its role in melanoma remains unclear. In the present study, the role of AEG-1 in melanoma was explored through AEG-1 ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12767

    authors: Zhang Y,Peng G,Wang Y,Cui L,Wu W,Wang L,Liu C,Han X

    更新日期:2017-07-01 00:00:00

  • Apoptotic death in an in vitro model of neuronal oxidative stress.

    abstract::1. Oxidative stress is believed to be an important mediator of neuronal cell death but the precise mechanism by which this occurs is unknown. 2. We have developed an in vitro model of neuronal oxidative stress to study the pathways by which free radicals kill neurones. 3. We have shown that oxidative stress, cystine d...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.1995.tb02006.x

    authors: Ratan RR,Baraban JM

    更新日期:1995-04-01 00:00:00

  • HIV infection confers distinct mechanisms in severe drug eruption: Endogenous virus activation with aberrant Th2/Th1 and CD8+ T cells function.

    abstract::Severe drug eruption (SDE), a common skin disease, becomes dangerous when it occurs in patients with human immunodeficiency virus (HIV). However, the molecular mechanisms are poorly understood. Forty patients including HIV+ SDE+ (n = 15), HIV- SDE+ (n = 15) and HIV+ SDE- (n = 10) subjects were enrolled in our study. A...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13266

    authors: Tang JT,Li YY,Zhang Y,Liu J,Guan W,Wang RR,He LP,Zhang JB,Kuang YQ

    更新日期:2020-06-01 00:00:00

  • NAMPT -3186C/T polymorphism affects repaglinide response in Chinese patients with Type 2 diabetes mellitus.

    abstract::1. In the present study, we investigated the associations of nicotinamide phosphoribosyltransferase (NAMPT)-3186 C/T and -948G/T polymorphisms with the risk of Type 2 diabetes mellitus (T2DM) and their impact on the efficacy of repaglinide in Chinese Han T2DM patients. 2. In all, 170 patients with T2DM and 129 healthy...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2011.05548.x

    authors: Sheng FF,Dai XP,Qu J,Lei GH,Lu HB,Wu J,Xu XJ,Pei Q,Dong M,Liu YZ,Zhou HH,Liu ZQ

    更新日期:2011-08-01 00:00:00

  • Calmodulin-antagonist drugs and porcine malignant hyperpyrexia.

    abstract::1. Landrace swine were identified as malignant hyperpyrexia susceptible (MHS) or control by the contracture responses of gracilis muscle fibre bundles to 3% halothane, 2 mmol/l caffeine and 80 mmol/l KCl. The effects of calmodulin-antagonist drugs on the contractile behaviour of control and MHS preparations were inves...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1988.tb01103.x

    authors: Collins SP,White MD,Denborough MA

    更新日期:1988-06-01 00:00:00

  • Efferent mechanisms responsible for the bradycardia produced by lesions coinciding with the A1 group of central catecholamine neurons in the conscious rabbit.

    abstract::The effector mechanisms responsible for the bradycardia evoked by bilateral lesions of the brainstem coinciding with the A1 catecholamine cells were analyzed in four groups of rabbits. Sham or lesion operations were carried out in animals with intact cardiac effectors, with cardiac sympathetic block induced by propran...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1984.tb00251.x

    authors: Denoroy L,West MJ,Chalmers J

    更新日期:1984-03-01 00:00:00

  • Effect of phosphorylation on L-type calcium current in ventricular myocytes dialysed with proteolytic enzymes.

    abstract::1. L-Type Ca2+ channels play important roles in cardiac excitation and conduction. The present study used the whole-cell patch-clamp technique to investigate properties of Ca2+ channels in guinea-pig isolated ventricular myocytes. The effects of internal application of the proteolytic enzymes trypsin and carboxypeptid...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.1999.02999.x

    authors: Dooley PC,Hancox JC,Chapman RA

    更新日期:1999-02-01 00:00:00

  • Fixed dose of long-acting erythropoietic stimulating agents at higher frequency improves appetite, reduces inflammation and corrects anaemia in patients on haemodialysis.

    abstract::Anaemia is an important issue in patients undergoing haemodialysis. We aimed to identify a better dosing schedule of a fixed monthly dose of continuous erythropoietin receptor activator (CERA) in patients with chronic kidney disease (CKD) on haemodialysis. The CERA dosing schedule included 100 μg once monthly for 2 mo...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/1440-1681.12618

    authors: Liu WS,Chu DC,Chan HL,Li SY,Liu CK,Yang CY,Chen YW,Lee PC,Lai YT,Lin CC

    更新日期:2016-10-01 00:00:00

  • C1q/TNF-related protein 6 (CTRP6) attenuates renal ischaemia-reperfusion injury through the activation of PI3K/Akt signalling pathway.

    abstract::C1q/TNF-related protein 6 (CTRP6) is a member of the CTRP family that has been reported to exhibit a nephroprotective effect. However, the role of CTRP6 in renal ischaemia/reperfusion (I/R) injury (IRI) remains unclear. In the present study, we aimed to explore the protective effect of CTRP6 in renal IRI and the poten...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13274

    authors: Xiang H,Xue W,Li Y,Zheng J,Ding C,Dou M,Wu X

    更新日期:2020-06-01 00:00:00

  • Spermidine prevents high glucose-induced senescence in HT-22 cells by upregulation of CB1 receptor.

    abstract::Hyperglycaemia-induced neurotoxicity involved in the pathogenesis of diabetic encephalopathy and neuronal senescence is one of the worst effects of hyperglyceamic neurotoxicity. Cannabinoid receptor type 1 (CB1) has neuroprotective function in a series of neuropathy. Spermidine (Spd) has anti-aging function in many ti...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12955

    authors: Zhu WW,Xiao F,Tang YY,Zou W,Li X,Zhang P,Wang AP,Tang XQ

    更新日期:2018-08-01 00:00:00

  • Cholinergic prejunctional inhibition of nitrergic neurotransmission in the guinea-pig isolated basilar artery.

    abstract::1. The effects of endogenous and exogenous acetylcholine (ACh) on nitrergic relaxations elicited by electrical field stimulation (EFS) were studied in guinea-pig endothelium-denuded basilar artery preparations precontracted with 1 mumol/L prostaglandin F2 alpha and a possible role of K+ channels in mediating the effec...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:

    authors: Jiang F,Li CG,Rand MJ

    更新日期:1999-04-01 00:00:00

  • New diagnostic tests for Cushing's syndrome: uses of naloxone, vasopressin and alprazolam.

    abstract::1. We set out to investigate whether the administration of naloxone alone, naloxone plus vasopressin (AVP) or naloxone plus alprazolam to patients with Cushing's syndrome would result in a blunted dynamic response of the pituitary-adrenal axis compared with normal volunteers. Cushing's syndrome is often difficult to d...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1440-1681.1996.tb02785.x

    authors: Jackson RV,Hockings GI,Torpy DJ,Grice JE,Crosbie GV,Walters MM,Strakosch CR

    更新日期:1996-06-01 00:00:00

  • Extraction of neurotensin by the liver.

    abstract::1. Neurotensin is released from the intestine into the portal circulation and to exert a systemic effect it must traverse the liver intact. 2. The role of the liver in neurotensin clearance was examined using the isolated perfused rat liver preparation. Two concentrations of neurotensin were used to determine the extr...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1987.tb01870.x

    authors: Brook CW,Shulkes A,Sewell RB,Smallwood RA

    更新日期:1987-10-01 00:00:00