Abstract：
:This study hypothesized that different types of anaesthesia management would result in similar postoperative sleep quality. In this prospective single-blind investigation, 219 patients undergoing elective thoracic surgery were randomized into three arms: general anaesthesia, as the control group (group C); general anaesthesia combined with thoracic epidural anaesthesia (TEA) (group E); and general anaesthesia combined with infusion of 1 μg/kg dexmedetomidine (group D). Plasma samples were obtained to measure the amine and inflammatory cytokine concentrations. All patients underwent assessment with the bispectral index (BIS) for sleep quality and the visual analogue scale (VAS) for pain. The primary outcomes were inflammatory cytokine [interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α)] secretion and postoperative sleep quality on the first and second postoperative nights. The secondary outcomes were amine (adrenaline and noradrenaline) secretion during the surgical period and haemodynamic stability. The postoperative BIS area under the curve was significantly lower in group E (75.7%) than in group C (87.3%) or group D (86.5%). Patients in group E had the highest BIS of sleep efficiency index (29.2%, P < 0.05) and the lowest VAS scores (3.5, P < 0.05). Group E had lower IL-6 levels than the other two groups 24 h after surgery (P < 0.05). Patients given TEA may show reduced sleep disturbances on the first night after surgery, perhaps due to better pain management and inhibition of IL-6 release.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Tan WF,Guo B,Ma H,Li XQ,Fang B,Lv HWdoi
10.1111/1440-1681.12530subject
Has Abstractpub_date
2016-03-01 00:00:00pages
304-11issue
3eissn
0305-1870issn
1440-1681journal_volume
43pub_type
杂志文章,随机对照试验abstract：:1. The effects of clomiphene (CLM) on cardiac outward K+ current components from rat isolated ventricular myocytes were investigated using the whole-cell patch-clamp technique. Clomiphene (10 micromol/L) significantly inhibited both peak (Ipeak) and end-pulse (Ilate) outward currents (elicited by a 500 msec voltage st...
journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.2004.03956.x
更新日期：2004-01-01 00:00:00
abstract：:1. Oxygen (O2) transfer from the blood to tissues is a function of the red blood cell (RBC) O2 saturation (SO2), the plasma O2 content being negligible. Under conditions of increased tissue O2 demand, the SO2 of arterial blood does not change appreciably (97%); however, the SO2 of mixed venous blood, equal to that of ...
journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1681.2000.03383.x
更新日期：2000-12-01 00:00:00
abstract：:Hypertension developed within 5 weeks in uninephrectomized rats administered deoxycorticosterone acetate (DOCA, 30 mg/kg, s.c., weekly) and given isotonic saline to drink. Chronic dietary administration of tryptophan (50 g/kg food) reduced intake of saline solution and prevented the elevation of systolic blood pressur...
journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1986.tb02380.x
更新日期：1986-11-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.2011.05536.x
更新日期：2011-08-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type：
doi：10.1046/j.1440-1681.2001.03542.x
更新日期：2001-11-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/1440-1681.12213
更新日期：2014-04-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1998.tb02144.x
更新日期：1998-01-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1981.tb00154.x
更新日期：1981-05-01 00:00:00
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doi：10.1111/1440-1681.13248
更新日期：2020-05-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1996.tb01186.x
更新日期：1996-09-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1986.tb00337.x
更新日期：1986-03-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1994.tb02561.x
更新日期：1994-08-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
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更新日期：2010-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1440-1681.1994.tb02494.x
更新日期：1994-03-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.2006.04482.x
更新日期：2006-11-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1986.tb00946.x
更新日期：1986-08-01 00:00:00
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pub_type： 杂志文章
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章,评审
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更新日期：1996-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-05-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
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更新日期：2006-07-01 00:00:00
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doi：10.1111/j.1440-1681.1992.tb00459.x
更新日期：1992-05-01 00:00:00
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更新日期：2007-12-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
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更新日期：1999-04-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1978.tb00708.x
更新日期：1978-09-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1994.tb02557.x
更新日期：1994-07-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
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更新日期：2009-04-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.2004.04090.x
更新日期：2004-11-01 00:00:00
