Helicobacter pylori infection may undergo spontaneous eradication in children: a 2-year follow-up study.

Abstract:

BACKGROUND:Helicobacter pylori infection is generally acquired early in life. However, it is still unknown whether a spontaneous eradication can occur. The purpose of this study was to evaluate whether H. pylori infection can undergo spontaneous eradication in children. METHODS:Three hundred and four Italian children (age range, 4.5 to 18.5 years) were tested for H. pylori by means of 13C-urea breath test. Infected children were followed up every 6 months for as long as 2 years. Parents were instructed to record consumption of antibiotics. At each visit, children underwent a repeat 13C-urea breath test. RESULTS:Eighty-five out of 304 (27.9%) children were H. pylori infected. Forty-eight out of 85 infected children (56.4%) participated in the follow-up study. After 2 years, 8 (16.6%) infected children had negative results on 13C-urea breath tests; 2 of them were given antibiotics for concomitant infections. One child was negative at 6 months but became positive again at the next 6-month 13C-urea breath test. Forty children remained persistently positive; of them, 10 were treated with a short course of antibiotics. CONCLUSIONS:Our findings support the hypothesis that, at least during childhood, H. pylori infection may be a fluctuating disease with spontaneous eradication and possible recurrence.

authors

Perri F,Pastore M,Clemente R,Festa V,Quitadamo M,Niro G,Conoscitore P,Rutgeerts P,Andriulli A

doi

10.1097/00005176-199808000-00010

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

181-3

issue

2

eissn

0277-2116

issn

1536-4801

journal_volume

27

pub_type

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