Abstract:
BACKGROUND:A study of occupational asthma among workers exposed to 4,4'-Diphenylmethane Diisocyanate (MDI). OBJECTIVE:To demonstrate if serum concentrations of MDI-specific IgG or IgE are sensitive biological markers of disease or of MDI exposure. METHODS:The study group consisted of nine MDI-exposed workers and nine nonexposed workers. Air sampling for MDI and polymethylene polyphenyl isocyanate, occupational and medical histories, respiratory physical exams, pre- and postshift spirometry, and self-administered peak expiratory flow rates were performed. Serum specific IgE and IgG antibodies to an MDI-human serum albumin (HSA) conjugate were assayed by the radioallergosorbent test and the enzyme-linked immunosorbent assay, respectively, and compared to nine nonexposed laboratory controls. RESULTS:No definitive cases of occupational asthma were documented. The mean level of MDI-specific IgG was significantly greater among exposed workers compared to nonexposed workers and laboratory controls (p = 0.04). Mean levels of TDI and HDI-specific IgG were also increased. CONCLUSION:This study demonstrates that serum concentrations of MDI-specific IgG appear to be a moderately sensitive biological marker of MDI exposure, but not an indicator of occupational asthma. Workers with IgG antibodies specific for one diisocyanate-HSA conjugate exhibit cross-reactivity to antigens prepared with other diisocyanates.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Lushniak BD,Reh CM,Bernstein DI,Gallagher JSdoi
10.1002/(sici)1097-0274(199805)33:5<471::aid-ajim6subject
Has Abstractpub_date
1998-05-01 00:00:00pages
471-7issue
5eissn
0271-3586issn
1097-0274pii
10.1002/(SICI)1097-0274(199805)33:5<471::AID-AJIM6journal_volume
33pub_type
杂志文章abstract::Several studies have indicated an increased risk for cancer of the urinary bladder among hairdressers. In a Danish linkage between census data and cancer register data both male and female hairdressers have an elevated risk for bladder cancer. The risk for lung cancer is close to unity, indicating that occupational fa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700170206
更新日期:1990-01-01 00:00:00
abstract::This paper describes the development of an evaluative outcome measure for patients with upper extremity musculoskeletal conditions. The goal is to produce a brief, self-administered measure of symptoms and functional status, with a focus on physical function, to be used by clinicians in daily practice and as a researc...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199606)29:6<602::AID-AJIM4
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Community Participatory Approach to Measuring Farmworker Pesticide Exposure, PACE3, used a longitudinal design to document pesticide biomarkers among farmworkers. This article presents an overview of PACE3 and provides a descriptive analysis of participant characteristics and one set of pesticide biomarkers,...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20703
更新日期:2009-07-01 00:00:00
abstract::This report presents a mortality study among the 17,344 members of the Construction Workers' Health Insurance Society of Mie Prefecture in Japan. The study period was between 1973 and 1993. During this period, 480 members died. Age-specific mortality rates of Mie Prefecture were used as comparison standards. Significa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199707)32:1<35::aid-ajim5>
更新日期:1997-07-01 00:00:00
abstract::The objectives of this study were to determine the exposure levels among workers who handle 2-ethoxyethylacetate (EGEEA) in the liquid crystal display (LCD) manufacturing industry and to study the menstrual patterns among the exposed workers compared to a referent group of workers. A total of 52 female exposed workers...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199702)31:2<148::aid-ajim3
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVES:To examine disparities between job control scores in Black and White subjects and attempt to discern whether self-rated low job control in Blacks may arise from structural segregation into different jobs, or represents individual responses to race-based discrimination in hiring or promotion. METHODS:Data fr...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22255
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:In the city of Petrópolis, Brazil, artisans carve souvenirs from a variety of silica-containing minerals. The finding of pulmonary massive fibrosis in one of the workers motivated an investigation of the prevalence of silicosis in this group. METHODS:Between January 2000 and June 2002, a cross-sectional stu...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10331
更新日期:2004-02-01 00:00:00
abstract::Workers in a potato processing plant were exposed at the particular workplace to large concentrations of airborne microorganisms and endotoxin. The presence of precipitins to microbial antigens was significantly correlated with the occurrence of the work-related respiratory and general symptoms that were found in 45.9...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700250111
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:There are few population-based studies addressing hypersensitivity pneumonitis (HP) in the United States. The National Institute for Occupational Safety and Health (NIOSH) has nationally comprehensive longitudinal mortality data that can contribute to a better understanding of the epidemiology of HP. METHOD...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20405
更新日期:2006-12-01 00:00:00
abstract::Certain refining processes were investigated to determine their influence on the dermal carcinogenic activity of petroleum-derived lubricating oil distillates. Specifically, the effects of solvent refining, hydroprocessing, a combination of both processes, and the blending of oils processed using each technique were e...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700050403
更新日期:1984-01-01 00:00:00
abstract::Cohort mortality and nested case-control studies were conducted involving 2,901 men employed 1 year or more between 1940 and 1986 at any of four California facilities of a major chemical company. Employees experienced fewer deaths from each of the major causes than were expected based on U.S., California, and local co...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700220107
更新日期:1992-01-01 00:00:00
abstract::Injury is the leading cause of death in adolescence, with the highest rates for 15- to 19-year-olds, an age span also marked, for many, by entry into the workforce. Occupational injuries affecting youth occur in the context of the larger problem of injury affecting children and adolescents. An understanding of the bro...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700240307
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:This study examines the hypothesis that acid mist or mixtures of acid mists and acid gases are associated with ulcerative lesions of the oral mucosa. METHODS:All 665 active male workers of a metal processing factory were the study population. Semi-quantitative measures of exposure were estimated from a job ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10343
更新日期:2004-03-01 00:00:00
abstract:INTRODUCTION:Silicosis is a fibrotic lung disease resulting from the inhalation of crystalline silica and can be classified as simple or complicated according to the International Labour Organization criteria. Furthermore, individuals exposed to crystalline silica also have a higher risk for the development of tubercul...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.23066
更新日期:2020-01-01 00:00:00
abstract::The evidence from animal studies indicates that organic extracts of diesel particulate are mutagenic and carcinogenic. Of four animal inhalation studies, two have been positive and two have been largely negative. The most recent data indicate that inhalation studies may be positive only with high doses of exhaust. Hum...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700100208
更新日期:1986-01-01 00:00:00
abstract::Organic acids and bases are among the most frequently used chemicals in the manufacturing industries. However, the toxicology of only a number of them has been fully characterized, and for fewer still have occupational exposure limits been established. This paper reviews the acute and chronic toxicity data of the orga...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.4700180610
更新日期:1990-01-01 00:00:00
abstract::In 1982, White et al published an assessment of quantitative leukemia risk associated with lifetime occupational exposure to benzene. At about the same time, IARC (1982) published estimates of quantitative cancer risk associated with industrial chemicals. Benzene was one of the two chemicals selected by IARC for its r...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.4700070507
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Case reports have identified hydrofluoric acid (HF) as causing fatal work injury, and HF has both local and systemic toxicity. Surveillance for HF-related mortality is problematic because of the lack of unique coding for this acid in hospital records and vital statistics. METHODS:We identified HF-related fa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.1090
更新日期:2001-08-01 00:00:00
abstract::Thirty-six car painters and 115 control persons participated in a follow-up investigation 6 years after the initial study, including measurement of lung function (dynamic spirometry and nitrogen washout test) and estimation of exposure to diisocyanates based on individual working routines, use of respiratory protectio...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700170302
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The need to expand the use of evaluation to learn how education programs contribute to workers' occupational safety and health is well documented. Similarly recognized is the need to expand workers' involvement as primary stakeholders in program evaluation. METHODS:Articles for this review were identified t...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/1097-0274(200011)38:5<584::aid-ajim11>3.0.
更新日期:2000-11-01 00:00:00
abstract::The objectives of this study were 1) to summarize in a clinically meaningful way information on occupational risk factors for carpal tunnel syndrome (CTS), and 2) to test a questionnaire on risk factors that could be used by physicians with their patients. For the two objectives, a systematic literature review was per...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0274(199803)33:3<224::aid-ajim3
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Occupational exposure to free silica is widespread in several economic sectors and is well known to cause silicosis. This study was designed to establish a database of enterprises and workers in industrial sectors involving silica exposure in Italy and to estimate the number of workers potentially at high ri...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20619
更新日期:2008-12-01 00:00:00
abstract::This study uses the National Mortality Followback Survey of 1986 to identify the top five Sentinel Health Events Occupational [SHE(O)s], the five leading causes of death, and to ascertain the primary occupations and industries associated with these. We found that, as expected, cardiovascular diseases were four of the ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700270205
更新日期:1995-02-01 00:00:00
abstract::Chemically induced epidermal carcinogenesis is usually divided into two stages: initiation, which involves the conversion of some epidermal cells into latent neoplastic cells; and promotion, which results in tumors. The hallmark of chemical promoters is epidermal hyperplasia. The hyperplasia caused by a strong promote...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700080412
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Death certificates contain a box labeled "Injury at Work" which is to be marked "Yes" for all fatal occupational injuries. The accuracy of this box in Michigan is not fully characterized. METHODS:The accuracy of the Injury at Work box on the Michigan death certificate was compared to deaths identified from ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.23100
更新日期:2020-06-01 00:00:00
abstract::This retrospective analysis reviews the clinical experience of a major urban referral hospital with diffuse malignant pleural mesothelioma during the 14-year period from 1973 through 1986. Seventy-five cases of definite or equivocal mesothelioma were identified. There were four cases of primary malignant peritoneal me...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700160405
更新日期:1989-01-01 00:00:00
abstract::Lifetime industrial and occupational histories of women with a medically-confirmed diagnosis of infertility (n = 281) were compared to a group of postpartum women (n = 216) for risks of infertility. Controlling for age of first pregnancy or self-report of infertility, date of outcome, cigarette use, and employment in ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199704)31:4<445::aid-ajim1
更新日期:1997-04-01 00:00:00
abstract::In order to determine the possible actual exposure to benzene in the shoe industry from industrially used solvents, glues, and paints containing benzene as a nondeclared constituent, phenol in urine and benzene in blood, as indices of internal exposure to benzene, were measured in workers (N = 33). Since toluene, in c...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700120507
更新日期:1987-01-01 00:00:00
abstract::In the past 10 years there has been growing awareness among occupational health professionals worldwide of the large burden of illness associated with musculoskeletal disorders of the neck and upper limbs. It has been suggested that these disorders are associated with highly repetitive work and are due, at least in pa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,meta分析
doi:10.1002/ajim.4700190111
更新日期:1991-01-01 00:00:00
abstract::Recent studies suggest that semiconductor workers have an increased incidence of work-related illness. Semiconductor manufacturing is a chemically intensive industry involving many potentially hazardous operations. As this industry moves into new geographic areas, health care professionals will be asked to evaluate me...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700110209
更新日期:1987-01-01 00:00:00