Abstract：
:Twenty-four years after apparently successful treatment for nodular lymphocyte predominant Hodgkin's disease (nLPHD), a 41-year old male developed "B" symptoms and extensive adenopathy. A right axillary lymph node biopsy showed two distinct regions including (1) histiocyte-rich B-cell lymphoma and (2) diffuse small T-cell lymphoma. A clonal rearrangement of the gene for the T-cell receptor beta chain confirmed the presence of a T-cell neoplasm, and this was further confirmed by selective polymerase chain reaction (PCR) on this morphologic zone. PCR on the morphologic B-cell lymphoma confirmed the presence of an immunoglobulin gene rearrangement. These two regions were separated by a less-defined zone containing a mixture of small CD57 positive T lymphocytes, small B lymphocytes, and rare lymphocytic and histiocytic (L&H) cells, highly suggestive of recurrent LPHD. The development of composite B-cell and T-cell lymphoma in this patient raises the speculation that nLPHD may be a neoplasm of lymphoid cells, which can differentiate in both B- and T-cell directions, with the "L&H" cells constituting their B-cell progeny.
journal_name
Ann Diagn Patholjournal_title
Annals of diagnostic pathologyauthors
Hancock JC,Wells A,Halling KC,Tilashalski K,Conner MG,Johns C,Listinsky CMdoi
10.1016/s1092-9134(99)80006-9subject
Has Abstractpub_date
1999-02-01 00:00:00pages
23-34issue
1eissn
1092-9134issn
1532-8198pii
S1092-9134(99)80006-9journal_volume
3pub_type
杂志文章,评审abstract：:Encephalitis caused by Balamuthia amebic species is an increasingly recognized chronic granulomatous infectious process that may affect both immunocompetent and immunocompromised individuals. The course of the disease is insidious but fatal in most cases, mainly because of delayed diagnosis, difficulty in isolation an...
journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2003.11.009
更新日期：2004-02-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/s1092-9134(98)80032-4
更新日期：1998-02-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2007.06.003
更新日期：2008-06-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2005.12.005
更新日期：2007-02-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2007.08.001
更新日期：2008-06-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1016/j.anndiagpath.2016.04.009
更新日期：2016-10-01 00:00:00
abstract：:The mucosal surfaces represent the third most common site of origin for melanoma, after the skin and ocular uveal tract. However, anorectal mucosal melanoma is a rare neoplasm, usually occurring in the sixth and seventh decades of life. It may often be confused clinically with other pathologic entities, such as prolap...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2009.07.003
更新日期：2010-04-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1016/j.anndiagpath.2007.04.001
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
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更新日期：2000-02-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2007.06.009
更新日期：2009-04-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2007.10.001
更新日期：2008-08-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2005.07.007
更新日期：2006-02-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/s1092-9134(97)80003-2
更新日期：1997-10-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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更新日期：2011-10-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2013.06.004
更新日期：2013-12-01 00:00:00
abstract：:Chondrosarcoma (CS) is a distinctly uncommon tumor in young patients and tends to be located in the extremities. Cartilaginous tumors in young patients are benign tumors. We report a case of a childhood CS in a 6-year-old boy who presented with right-sided proptosis. Radiological examination revealed a large destructi...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2005.09.004
更新日期：2006-06-01 00:00:00
