Angiosarcoma of the uterus: report of 2 new cases with deviant clinicopathologic features and review of the literature.

Abstract:

:A few cases of uterine angiosarcoma have been detailed in the literature: 2 new cases are herein described featuring some unusual clinical or phenotypic differences compared with previously published cases, such as occurrence in premenopausal age or a poorly differentiated histology. The patients were 35 and 81 years old, and both presented with extrauterine spread and evidence of distant metastases. Grossly, they were fleshy, hemorrhagic, and necrotic. Microscopically, they were made up of poorly differentiated, epithelioid, or spindle cells. In one case, the neoplastic growth deceitfully recalled a poorly differentiated leiomyosarcoma showing focal rudimentary endothelial differentiation. The other index case was characterized by a more pronounced vascular pattern, the neoplasm was composed of spindle cells arranged in loose channels. A diffuse immunopositivity for CD31, CD34, and factor VIII-related antigen was detected. Tumor cells were negative for other tested antigens including keratins, desmin, actins, and H-caldesmon. One patient died shortly during the follow-up, whereas the other is alive with evidence of disseminated disease. Occurrence in childbearing age or a deviant histologic pattern, as documented in this report, may be added to the clinicopathologic spectrum of uterine angiosarcoma.

journal_name

Ann Diagn Pathol

authors

Cardinale L,Mirra M,Galli C,Goldblum JR,Pizzolitto S,Falconieri G

doi

10.1016/j.anndiagpath.2007.08.001

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

217-21

issue

3

eissn

1092-9134

issn

1532-8198

pii

S1092-9134(07)00123-2

journal_volume

12

pub_type

杂志文章
  • Malignant glandular lesions and glandular differentiation in invasive/noninvasive urothelial carcinoma of the urinary bladder.

    abstract::Although the lumen of the urinary bladder is covered with only urothelial epithelium, malign glandular lesions (eg, nonurachal adenocarcinoma) and benign lesions (eg, cystitis cystica and cystitis glandularis) can also rarely occur in this site due to its characteristic embryologic development. Glandular differentiati...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2011.06.003

    authors: Behzatoğlu K

    更新日期:2011-12-01 00:00:00

  • Melanocytic "ball-in-mitts" and "microalveolar structures" and their role in the development of cellular blue nevi.

    abstract::To test the hypothesis of whether cellular blue nevi (CBN) may originate from "ordinary" compound and dermal nevi, a total of 275 melanocytic nevi including 59 CBN, 34 ordinary blue nevi, 87 combined nevi (including 43 so-called clonal nevi), 35 deep penetrating nevi, and 60 ordinary compound and dermal nevi (30 of ea...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.03.001

    authors: Kazakov DV,Michal M

    更新日期:2007-06-01 00:00:00

  • Cytologic and molecular correlates of SARS-CoV-2 infection of the nasopharynx.

    abstract::Infection by SARS-CoV-2 commonly begins in the nasopharynx, and the cytologic and molecular correlates are not characterized. Fifty-eight cytologic preps (20 oral and 38 from the nasopharynx) were obtained from ten patients and analyzed in a blinded fashion for SARS-CoV-2 spike and envelope protein by immunohistochemi...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2020.151565

    authors: Nuovo GJ,Magro C,Mikhail A

    更新日期:2020-10-01 00:00:00

  • Anaplastic large cell lymphoma: another entity in the differential diagnosis of small round blue cell tumors.

    abstract::We saw in consultation a biopsy specimen from a 6-year old girl with anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL). The tumor arose in soft tissue of the neck, and diagnostic tissue was obtained by core needle biopsy. Histologically, the neoplasm was cellular without pattern. Immunohi...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.anndiagpath.2009.09.002

    authors: Gustafson S,Medeiros LJ,Kalhor N,Bueso-Ramos CE

    更新日期:2009-12-01 00:00:00

  • Primary cutaneous histiocytic sarcoma: A report of five cases with primary cutaneous involvement and review of the literature.

    abstract:INTRODUCTION:Histiocytic sarcoma is an extremely rare hematologic malignancy of histiocytic origin. Five cases of primary cutaneous histiocytic sarcoma are presented. MATERIALS AND METHODS:Cases of primary cutaneous histiocytic sarcoma were identified using a natural language search from the dermatopathology data base...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.anndiagpath.2017.10.004

    authors: Magro CM,Kazi N,Sisinger AE

    更新日期:2018-02-01 00:00:00

  • Osteopontin: a marker for invasive oral squamous cell carcinoma but not for potentially malignant epithelial dysplasias.

    abstract::This study aimed to evaluate and correlate osteopontin (OPN) expression in oral squamous cell carcinoma (OSCC) and potentially malignant disorders including oral leukoplakia and oral submucous fibrosis (OSMF). Expression of OPN was investigated in 140 samples including OSCC, oral leukoplakia, and OSMF with or without ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2013.03.005

    authors: Routray S,Kheur SM,Kheur M

    更新日期:2013-10-01 00:00:00

  • Aggressive B-cell lymphomas: frequency, immunophenotype, and genetics in a reference laboratory population.

    abstract::Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma worldwide. The current World Health Organization classification includes several subtypes based on a combination of clinical, immunohistochemical, and genetic differences. Other aggressive variants of B-cell lymphomas, including Burkitt lymphoma...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2016.07.008

    authors: Naeini YB,Wu A,O'Malley DP

    更新日期:2016-12-01 00:00:00

  • Composite B-cell and T-cell lymphoma arising 24 years after nodular lymphocyte predominant Hodgkin's disease.

    abstract::Twenty-four years after apparently successful treatment for nodular lymphocyte predominant Hodgkin's disease (nLPHD), a 41-year old male developed "B" symptoms and extensive adenopathy. A right axillary lymph node biopsy showed two distinct regions including (1) histiocyte-rich B-cell lymphoma and (2) diffuse small T-...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1016/s1092-9134(99)80006-9

    authors: Hancock JC,Wells A,Halling KC,Tilashalski K,Conner MG,Johns C,Listinsky CM

    更新日期:1999-02-01 00:00:00

  • Primary extramedullary plasmacytoma of the esophagus.

    abstract::An uncommon manifestation of plasma cell neoplasia occurs outside the bone marrow and is designated "extramedullary plasmacytoma." These are usually encountered in mucosal sites of the head and neck region. The gastrointestinal tract may be secondarily involved in multiple myeloma or be the site of primary extramedull...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/s1092-9134(03)00017-0

    authors: Chetty R,Bramdev A,Reddy AD

    更新日期:2003-06-01 00:00:00

  • Adenocarcinoma arising in an ectopic mediastinal pancreas.

    abstract::Pancreatic ectopia in the mediastinum is rare, and there are no reports that it has ever given rise to malignancy. Here we report a case of adenocarcinoma arising in ectopic pancreatic tissue in the mediastinum of a 66-year-old woman. The tumor arose in a partially cystic and partially solid ectopic pancreas containin...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.anndiagpath.2011.04.005

    authors: St Romain P,Muehlebach G,Damjanov I,Fan F

    更新日期:2012-12-01 00:00:00

  • Invasive ductal carcinoma of the breast with a microglandular adenosis pattern.

    abstract::Invasive breast carcinomas of special type are composed of up to 35% of all cases, such as tubular carcinoma, mucinous carcinoma, invasive cribriform carcinoma, lobular carcinoma, metaplastic carcinoma, medullary carcinoma, and other rare variants. They are recognized by their specific growth and morphologic patterns,...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2003.11.009

    authors: Shen SS,Sahin AA

    更新日期:2004-02-01 00:00:00

  • Lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation.

    abstract::Cases of cerebral neuroblastoma or supratentorial primitive neuroectodermal tumor with malignant gliomatous components are relatively uncommon. Less frequent is the combination of these 2 elements with a mesenchymal component. This is a case report of a lipomatous supratentorial primitive neuroectodermal tumor with gl...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.04.009

    authors: Prayson RA

    更新日期:2009-02-01 00:00:00

  • Upregulation of inhibitory signaling receptor programmed death marker-1 (PD-1) in disease evolution from cutaneous lymphoid dyscrasias to mycosis fungoides and Sezary's syndrome.

    abstract:BACKGROUND:Negative immunoregulatory checkpoints impede effective immune responses to tumor and reduce the action of anticancer agents. One such example is programmed death marker-1 (PD-1), an inhibitory signaling receptor expressed on activated and regulatory T-cells. PD-1 expression was reported in a few reports, but...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2017.02.003

    authors: Nguyen GH,Olson LC,Magro CM

    更新日期:2017-06-01 00:00:00

  • Lymphoglandular bodies in malignant tumors: with special reference to histologic specimens.

    abstract::Lymphoglandular bodies (LGBs) have been described as cytoplasmic fragments of lymphocytes and a specific feature of organized lymphoid tissue. The recognition of LGBs is useful in distinguishing malignant lymphomas from carcinomas and sarcomas in cytology specimens, especially in Giemsa-stained tissues. So far, there ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.10.001

    authors: Murakami T,Kayano H,Itoh T,Shimizu Y,Ban S,Ogawa F,Sannohe S,Kondo S,Shimizu M

    更新日期:2008-08-01 00:00:00

  • Anorectal melanoma in childhood and adolescence.

    abstract::The mucosal surfaces represent the third most common site of origin for melanoma, after the skin and ocular uveal tract. However, anorectal mucosal melanoma is a rare neoplasm, usually occurring in the sixth and seventh decades of life. It may often be confused clinically with other pathologic entities, such as prolap...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2009.07.003

    authors: Ellis ZM,Jassim AD,Wick MR

    更新日期:2010-04-01 00:00:00

  • Gastrointestinal stromal tumor of the ampulla of Vater with osteoclastic giant cells, osteoid-like matrix deposition, and aneurysmal bone cyst-like features.

    abstract::Gastrointestinal stromal tumors are a heterogeneous group with a wide spectrum of histologic features. We describe the first case of 61-year-old woman who presented gastrointestinal stromal tumors of the ampulla of Vater with osteoclast-like giant cells surrounding osteoid-like material and aneurismal bone cyst-like a...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2012.08.003

    authors: Candanedo-Gonzalez F,Camacho-Rebollar L,Uscanga CC,Utrilla AR,Bucio ME,Rodriguez SS,Hernandez LM

    更新日期:2013-08-01 00:00:00

  • Expression of vitamin D receptor in clear cell papillary renal cell carcinoma.

    abstract::Clear cell papillary renal cell carcinoma (ccpRCC) is a recently recognized subtype of renal cell carcinoma. In this study, we investigated the clinicopathological and immunohistochemical features in a group of 26 cases of ccpRCC, with a special emphasis on the expression of vitamin D receptor (VDR). The mean age of p...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2018.06.007

    authors: Wang Y,Ding Y,Qin C,Gu M,Wang Z,Han C,Liu X,Li H,Hua H

    更新日期:2018-10-01 00:00:00

  • Ki-1 anaplastic large-cell lymphoma occurring at the site of ileocolonic anastomosis in a patient treated surgically for colonic adenocarcinoma: case report and review of the literature.

    abstract::Systemic anaplastic large-cell lymphoma is an uncommon type of non-Hodgkin lymphoma characterized by strong expression of the Ki-1 (CD30) antigen. Gastrointestinal involvement typically is less common than in other types of non-Hodgkin's lymphoma. We report a case of CD30-positive anaplastic large-cell lymphoma occurr...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1053/adpa.2001.25408

    authors: Cooperberg MR,Fiedler PN

    更新日期:2001-06-01 00:00:00

  • Cystic pancreatic schwannoma in a 46-year-old man.

    abstract::Pancreatic schwannomas are a rare benign mesenchymal neoplasm of the pancreas. They are thought to arise from the epineurium of either autonomic sympathetic or parasympathetic fibers, which course through the pancreas with the vagus nerve. Large pancreatic schwannomas often undergo cystic change, which causes them to ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2006.12.017

    authors: Tafe LJ,Suriawinata AA

    更新日期:2008-08-01 00:00:00

  • Five rare cases of Ewing sarcoma, including with epithelial differentiation, involving the female genital tract, displaying EWSR1 rearrangement: Diagnostic challenge and treatment implications.

    abstract::We present clinicopathological and molecular cytogenetic features of five rare cases of Ewing sarcomas, occurring in the female genital tract. A 40 year-old lady presented with a 5.4 cm-sized vaginal mass of 3 months duration, which was histopathologically diagnosed as ES. She defaulted chemotherapy and 8 months later...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2019.05.003

    authors: Rekhi B,Agrawal R,Shetty O,Deodhar KK,Menon S,Ghosh J,Kerkar R,Maheshwari A

    更新日期:2019-08-01 00:00:00

  • Association of urothelial carcinoma of the renal pelvis with papillary and medullary thyroid carcinomas. A new sporadic neoplastic syndrome?

    abstract::We describe 2 adult women (72 and 54 years), 1 with a low-grade noninvasive papillary urothelial carcinoma of the renal pelvis, who 14 years later developed a papillary carcinoma in 1 thyroid lobe and a medullary carcinoma in the contralateral lobe. Both neoplasms were similar in size and appeared symmetrical. Despite...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2014.08.003

    authors: Albores-Saavedra J,Dorantes-Heredia R,Chablé-Montero F,Córdova-Ramón JC,Henson DE

    更新日期:2014-10-01 00:00:00

  • Significance of isolated vasculitis in the gynecological tract: what clinicians do with the pathologic diagnosis of vasculitis?

    abstract::Vasculitides includes a heterogeneous group of disorders with the common histologic findings of vascular wall inflammation. Systemic or localized disease (eg, renal vasculitis) has serious consequences. The incidence of isolated gynecologic vasculitis diagnosed on pathology specimens and its significance is little kno...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2014.03.008

    authors: Roma AA,Amador-Ortiz C,Liapis H

    更新日期:2014-08-01 00:00:00

  • The complementary role of insulin-like growth factor II mRNA-binding protein 3 (IMP3) in diagnosis of Hodgkin's lymphoma.

    abstract:BACKGROUND:Hodgkin's Lymphoma (HL) is a peculiar subtype of lymphoid malignancies. The etiology of HL is still unknown. Insulin-like growth factor II mRNA-binding Protein 3 (IMP3) is a member of IMP family. In HL, IMP3 is expressed in the cytoplasmic compartment of the tumor cells (in both HRS cells & LP cells) against...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2019.06.006

    authors: Masoud R,Ibrahiem A,Tantawy D,Eldosoky I

    更新日期:2019-10-01 00:00:00

  • Loss of ELF3 immunoexpression is useful for detecting oral squamous cell carcinoma but not for distinguishing between grades of epithelial dysplasia.

    abstract::Early diagnosis and targeted therapy are crucial to mitigating the morbidity and mortality of oral squamous cell carcinoma. Among the potentially malignant oral disorders, epithelial dysplasia has known association with malignant transformation, but defensible gradation of dysplasia severity presents unmet challenges....

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2013.03.003

    authors: AbdulMajeed AA,Dalley AJ,Farah CS

    更新日期:2013-08-01 00:00:00

  • The surgical and cytopathology of viral infections: utility of immunohistochemistry, in situ hybridization, and in situ polymerase chain reaction amplification.

    abstract::The diagnosis of viral infections is an important part of the daily work of a surgical and cytopathologist. Some viral infections, such as human papillomavirus infection of the lower genital tract, are seen commonly, whereas others, such as fatal enteroviral infection, cannot be diagnosed on routine histological exami...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.anndiagpath.2006.02.003

    authors: Nuovo GJ

    更新日期:2006-04-01 00:00:00

  • Correlation of folate receptor alpha expression with clinicopathological parameters and outcome in triple negative breast cancer.

    abstract::Folate receptor alpha (FRα) is a membrane-bound protein with a high affinity for folate, which is necessary for the biosynthesis of amino acids and nucleotide bases. It has been shown to be a potential prognostic and therapeutic target, primarily in lung and ovarian cancer, as well as in breast cancer. The aim of this...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2020.151596

    authors: Zagorac I,Lončar B,Dmitrović B,Kralik K,Kovačević A

    更新日期:2020-10-01 00:00:00

  • Pseudosarcoma in Paget's disease of bone.

    abstract::The appearance of a sarcoma of bone is a well-recognized complication of Paget's disease. The most common type of such a sarcoma is osteosarcoma. Much less common are soft tissue lesions adjoining the pagetic bone that clinically and radiologically simulate sarcoma but histologically represent exaggerated periosteal b...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/s1092-9134(99)80037-9

    authors: Lamovec J,Rener M,Spiler M

    更新日期:1999-04-01 00:00:00

  • TP53 mutations are common in mantle cell lymphoma, including the indolent leukemic non-nodal variant.

    abstract:INTRODUCTION:Mantle cell lymphoma (MCL) is an aggressive B-cell neoplasm, but clinically indolent subtypes are also recognized. Data on the utility of mutation profiling in the context of routine workup and its role in risk-stratification of MCL patients are limited. In this study, we describe the mutational landscape ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2019.05.004

    authors: Sakhdari A,Ok CY,Patel KP,Kanagal-Shamanna R,Yin CC,Zuo Z,Hu S,Routbort MJ,Luthra R,Medeiros LJ,Khoury JD,Loghavi S

    更新日期:2019-08-01 00:00:00

  • Aggressive meningiomas involving the parotid gland.

    abstract::Parotid masses remain challenging secondary to the great diversity of primary tumors that may arise in the salivary glands and propensity for regional and even distant metastases to occur in this region. Meningioma must also be considered in the differential diagnosis of parotid masses, whether from direct extension, ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2011.08.006

    authors: Joggerst KH,Langford LA,Williams MD

    更新日期:2012-04-01 00:00:00

  • Correlation of anal cytology with follow-up histology and Human Papillomavirus genotyping: A 10-year experience from an academic medical center.

    abstract:BACKGROUND:Anal cytology (AC) is accepted as a practical screening modality for anal cancer. However, studies suggest that AC and anal biopsy dysplasia correlation is less robust than in cervicovaginal specimens. The current study goals were to look at our institutional experience in a subset of ACs and correlate with ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2020.151670

    authors: Hopp AM,Pant M,Sniedze S,Parsons LN,Hunt B,Giorgadze T

    更新日期:2020-11-20 00:00:00