Small cell osteosarcoma with Ewing sarcoma breakpoint region 1 gene rearrangement detected by interphase fluorescence in situ hybridization.

Abstract:

:Because of its characteristic morphologic appearance, small cell osteosarcoma (SCO) can be confused with other small round cell malignancies of the bone, most importantly with Ewing sarcoma, making this distinction difficult. A specific tool used in separating SCO from Ewing sarcoma has been the detection of Ewing sarcoma breakpoint region 1 (EWSR1) gene rearrangements in Ewing sarcoma and their absence in SCO. However, there are rare case reports that have documented the existence of EWSR1 gene rearrangement in SCO. In this report, we describe another case of SCO with an EWSR1 gene rearrangement detected by interphase fluorescence in situ hybridization. Our finding adds support to the existing evidence that SCO is a tumor that can be characterized by EWSR1 gene arrangements. Therefore, we caution the pathology community not to rely solely on molecular studies in distinguishing SCO from Ewing sarcoma.

journal_name

Ann Diagn Pathol

authors

Dragoescu E,Jackson-Cook C,Domson G,Massey D,Foster WC

doi

10.1016/j.anndiagpath.2012.08.004

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

377-82

issue

4

eissn

1092-9134

issn

1532-8198

pii

S1092-9134(12)00101-3

journal_volume

17

pub_type

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