Abstract：
:A striking property of many prokaryotes is their enormous metabolic flexibility with respect not only to catabolic and anabolic substrates but also with respect to the continuously changing availability of nutrients. The phenotypic responses to low-nutrient growth conditions involve structural changes in the cellular make-up, changes in the specific capacity of the enzyme system(s) involved in uptake and/or assimilation of the limiting nutrient and changes in the affinity of these enzymes. Here the responses of some members of the Enterobacteriaceae to potassium-, ammonium- and energy source-limited conditions will be reviewed. The focus will be on the energetic consequences of these adaptations as reflected by the growth yield value for the energy source (Y energy source). It will be illustrated that Y energy source values can be dramatically lowered as a result of incomplete oxidation of the energy source (overflow metabolism), bypassing potential sites of energy conservation (uncoupling) or catabolic cycles that have no other apparent effect than the hydrolysis of ATP (futile cycles). Thus, it is concluded that adaptation to low nutrient conditions aims at maintaining high metabolic fluxes at low nutrient concentrations at the cost of a loss in the energetic efficiency of the overall metabolism.
journal_name
J Biotechnoljournal_title
Journal of biotechnologyauthors
Teixeira de Mattos MJ,Neijssel OMdoi
10.1016/s0168-1656(97)00174-0subject
Has Abstractpub_date
1997-12-17 00:00:00pages
117-26issue
1-2eissn
0168-1656issn
1873-4863pii
S0168-1656(97)00174-0journal_volume
59pub_type
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