Follow-up study of the revascularization process of purified rat islet beta-cell grafts.

abstract：:The present study was designed to evaluate the use of collagen gel loaded with human retinal pigment epithelium (ARPE19) in cellular transfer and to assess its viability within the gel. Collagen solution was prepared by dissolving calfskin in hydrochloric acid to make a final concentration of 2.0 mg/ml and this was mi...

journal_title：Cell transplantation

authors： Yeung CK,Chiang SW,Chan KP,Lam DS,Pang CP

更新日期：2004-01-01 00:00:00

abstract：:The present study was designed to evaluate the clinical outcome of cell-based therapy with cultured adipose derived stromal cells (ASCs) for the treatment of cutaneous manifestations in patients affected by systemic sclerosis (SSc). ASCs have an extraordinary developmental plasticity, including the ability to undergo ...

journal_title：Cell transplantation

authors： Scuderi N,Ceccarelli S,Onesti MG,Fioramonti P,Guidi C,Romano F,Frati L,Angeloni A,Marchese C

更新日期：2013-01-01 00:00:00

abstract：:Recent advances in tissue engineering technologies have highlighted the ability to create functional liver systems using isolated hepatocytes in vivo. Considering the serious shortage of donor livers that can be used for hepatocyte isolation, it has remained imperative to establish a hepatocyte propagation protocol t...

journal_title：Cell transplantation

authors： Ohashi K,Tatsumi K,Tateno C,Kataoka M,Utoh R,Yoshizato K,Okano T

更新日期：2012-01-01 00:00:00

abstract：:Mechanical thrombectomy (MT) is effective in managing patients with acute ischemic stroke (AIS) caused by large-vessel occlusions and allows for valuable histological analysis of thrombi. However, whether bridging therapy (pretreatment with intravenous thrombolysis before MT) provides additional benefits in patients w...

journal_title：Cell transplantation

authors： Gong L,Zheng X,Feng L,Zhang X,Dong Q,Zhou X,Wang H,Zhang X,Shu Z,Zhao Y,Liu X

更新日期：2019-06-01 00:00:00

abstract：:Osteoarthritis (OA) is degenerative disease, leading to pain and functional disability. It is reported that polydeoxyribonucleotide (PDRN) is a suitable therapy for OA. However, the therapeutic mechanisms of PDRN in OA are not fully understood. To investigate the effect of PDRN in an in vitro model of OA, interleukin ...

journal_title：Cell transplantation

authors： Baek A,Kim Y,Lee JW,Lee SC,Cho SR

更新日期：2018-11-01 00:00:00

abstract：:The main challenge of cell transplantation as a treatment of myopathies is the large amount of tissue to treat. Intravascular delivery of cells may be an ideal route if proven to be effective and safe. Given the importance of nonhuman primates for preclinical research in transplantation, we tested the intra-arterial i...

journal_title：Cell transplantation

authors： Skuk D,Tremblay JP

更新日期：2014-01-01 00:00:00

abstract：:Liver cell transplantation into host organs like the spleen may possibly provide a temporary relief after extensive liver resection or severe liver disease or may enable treatment of an enzyme deficiency. With time, however, dedifferentiation or malignant transformation of the ectopically transplanted cells may be pos...

journal_title：Cell transplantation

authors： Lupp A,Danz M,Müller D

更新日期：2003-01-01 00:00:00

abstract：:One of the goals of islet transplantation is to transplant viable islets without host immunosuppression. The present study was designed to determine whether pretreatment of islets with mitomycin-C (MMC) followed by culture enhances islet survival in a rat-to-mouse xenogeneic combination. WS(RT1k) rat islets pretreated...

journal_title：Cell transplantation

authors： Gunji T,Saito T,Sato Y,Matsuyama S,Ise K,Kimura T,Anazawa T,Gotoh M

更新日期：2008-01-01 00:00:00

abstract：:Regenerative medicine is a new field primarily based on the concept of transplanting exogenous or stimulating endogenous stem cells to generate biological substitutes and improve tissue functions. Recently, amnion-derived cells have been reported to have multipotent differentiation ability, and these cells have attrac...

journal_title：Cell transplantation

authors： Yu SJ,Soncini M,Kaneko Y,Hess DC,Parolini O,Borlongan CV

更新日期：2009-01-01 00:00:00

abstract：:Acute kidney injury (AKI) is a major clinical problem that still has no established treatment. We investigated the efficacy of cultured human peripheral blood mononuclear cells (PBMNCs) for AKI. Ischemia/reperfusion injury (IRI) was used to induce AKI in male nonobese diabetic (NOD/severe combined immunodeficiency) mi...

journal_title：Cell transplantation

authors： Ohtake T,Kobayashi S,Slavin S,Mochida Y,Ishioka K,Moriya H,Hidaka S,Matsuura R,Sumida M,Katagiri D,Noiri E,Okada K,Mizuno H,Tanaka R

更新日期：2018-03-01 00:00:00

abstract：:End-stage organ failure is a major cause of death worldwide that can occur in patients of all ages and transplantation is the current standard of care for chronic end-stage disease of many organs. Despite the success of organ transplantation, it is becoming clear that there will never be enough organs made available t...

journal_title：Cell transplantation

authors： Triolo F,Gridelli B

更新日期：2006-01-01 00:00:00

abstract：:We developed a reliable and quantitative method for measuring the dynamic process of unidirectional two-dimensional (2-D) tissue formation of endothelial cells (ECs) in vitro. The culturing of bovine ECs in an assembled culture chamber provided a square monolayered cell sheet with a linear margin when disassembled at ...

journal_title：Cell transplantation

authors： Niu S,Matsuda T

更新日期：1992-01-01 00:00:00

abstract：:Transplantation of human cells after isolation and culture has become an important alternative for treatment of acute or chronic skin wounds. To increase the efficacy and reduce cost for transplantation of skin cells, more efficient and accurate techniques for evaluation of cell proliferation are needed. Hemocytometer...

journal_title：Cell transplantation

authors： Boyce ST,Anderson BA,Rodriguez-Rilo HL

更新日期：2006-01-01 00:00:00

abstract：:Hepatocyte transplantation is a promising therapy for acute liver failure in humans. Recently, we succeeded in inducing various acute and chronic liver failures in nude mice. Engraftment of transplanted xenogeneic rat hepatocytes, visualized in the host liver by anti-MHC class I immunohistochemistry, revealed that liv...

journal_title：Cell transplantation

authors： Vidal I,Blanchard N,Alexandre E,Gandillet A,Chenard-Neu MP,Staedtler F,Schumacher M,Bachellier P,Jaeck D,Firat H,Heyd B,Richert L

更新日期：2008-01-01 00:00:00

abstract：:Islet isolation involves enzymatic digestion of the interstitial matrix and mechanical disruption of the tissue. It is possible that a fundamental change of islet biology resulting from the loss of critical factors required for islet function or survival will occur. Extracellular matrix (ECM) is one of the most import...

journal_title：Cell transplantation

authors： Nagata N,Gu Y,Hori H,Balamurugan AN,Touma M,Kawakami Y,Wang W,Baba TT,Satake A,Nozawa M,Tabata Y,Inoue K

更新日期：2001-01-01 00:00:00

abstract：:Testis-derived Sertoli cells have been used to create an immune "privileged" site outside of the testis to facilitate cell transplantation protocols for diabetes and neurodegenerative diseases. In addition to secreting immunoprotective factors, Sertoli cells also secrete growth and trophic factors that appear to enhan...

journal_title：Cell transplantation

authors： Cameron DF,Othberg AI,Borlongan CV,Rashed S,Anton A,Saporta S,Sanberg PR

更新日期：1997-03-01 00:00:00

abstract：:Functional demands on a bioartificial liver support (BAL) device are not limited to biosynthetic activities, but must also encompass metabolic removal of potentially toxic substances. For most BALs, however, the concept and design are exclusively directed to biosynthetic support. To add the ability to metabolize and r...

journal_title：Cell transplantation

authors： Takahashi M,Sakurai M,Enosawa S,Omasa T,Tsuruoka S,Matsumura T

更新日期：2006-01-01 00:00:00

abstract：:Autism spectrum disorders (ASDs) are heterogeneous complex neurodevelopmental pathologies defined by behavioral symptoms, but which have well-characterized genetic, immunological, and physiological comorbidities. Despite extensive research efforts, there are presently no agreed upon therapeutic approaches for either t...

journal_title：Cell transplantation

authors： Bradstreet JJ,Sych N,Antonucci N,Klunnik M,Ivankova O,Matyashchuk I,Demchuk M,Siniscalco D

更新日期：2014-01-01 00:00:00

abstract：:Antibodies to the ligand for CD40 (CD154) have been shown to exert profound effects on the development of cell-mediated immune responses in mice. The present study shows that an antibody to human CD154 (hCD40L) inhibits in vivo Tetanus toxoid (TT) specific secondary antibody responses in hu-PBL-scid mice, as well as t...

journal_title：Cell transplantation

authors： Foy TM,McIlraith M,Masters SR,Dunn JJ,Rossini AA,Shultz LD,Hesselton RA,Wagar EJ,Lipsky PE,Noelle RJ,Greiner DL

更新日期：1998-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) migrate to injury sites and aid in tissue repair. However, clinical success is poor and is partially due to limited HSC recruitment. We hypothesized that HSC pretreatment with H2O2 would enhance their recruitment to injured gut. As HSCs are rare cells, the number of primary cells obtain...

journal_title：Cell transplantation

authors： Kavanagh DP,Yemm AI,Alexander JS,Frampton J,Kalia N

更新日期：2013-01-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) mobilizes peripheral blood stem cells (PBSCs) derived from bone marrow. We hypothesized that intraspinal transplantation of PBSCs mobilized by G-CSF could promote functional recovery after spinal cord injury. Spinal cords of adult nonobese diabetes/severe immunodeficiency ...

journal_title：Cell transplantation

authors： Takahashi H,Koda M,Hashimoto M,Furuya T,Sakuma T,Kato K,Okawa A,Inada T,Kamiya K,Ota M,Maki S,Takahashi K,Yamazaki M,Mannoji C

更新日期：2016-01-01 00:00:00

abstract：:This invited concise review was written for the special issue of Cell Transplantation to celebrate the 25th anniversary of the American Society for Neural Therapy and Repair (ASNTR). I aimed to present a succinct summary of two interweaved lines of research work carried out by my team members and collaborators over th...

journal_title：Cell transplantation

authors： Teng YD

更新日期：2019-04-01 00:00:00

abstract：:Persistent fetal vasculature (PFV) is a potentially serious developmental anomaly in human eyes, which results from a failure of the primary vitreous and the hyaloid vascular systems to regress during development. Recent findings from our laboratory indicate that fibrovascular membranes harvested from subjects with P...

journal_title：Cell transplantation

authors： Chen G,Ma J,Shatos MA,Chen H,Cyr D,Lashkari K

更新日期：2012-01-01 00:00:00

abstract：:Circular RNAs (circRNAs) could sponge micro-RNAs (miRNAs) to regulate tumor progression of hepatocellular carcinoma (HCC). Hsa_circ_104566 contributes to papillary thyroid carcinoma progression. However, the tumorigenic mechanism of hsa_circ_104566 on HCC remains enigmatic. The role of hsa_circ_104566 on HCC was there...

journal_title：Cell transplantation

authors： Liu G,Guo W,Rao M,Qin J,Hu F,Li K

更新日期：2020-01-01 00:00:00

abstract：:Recently, animal studies have demonstrated the efficacy of endothelial progenitor cell (EPC) therapy for diabetic wound healing. Based on these preclinical studies, we performed a prospective clinical trial phase I/IIa study of autologous G-CSF-mobilized peripheral blood (PB) CD34(+) cell transplantation for nonhealin...

journal_title：Cell transplantation

authors： Tanaka R,Masuda H,Kato S,Imagawa K,Kanabuchi K,Nakashioya C,Yoshiba F,Fukui T,Ito R,Kobori M,Wada M,Asahara T,Miyasaka M

更新日期：2014-02-01 00:00:00

abstract：:During the isolation of human islets of Langerhans the digest has repeated direct contact with the ambient atmosphere. In order to fulfill GMP requirements in clinical applications, the entire cell preparation must be performed in clean room facilities. We hypothesized that the use of a closed system, which avoids the...

journal_title：Cell transplantation

authors： Klaffschenkel RA,Biesemeier A,Waidmann M,Northoff H,Steurer W,Königsrainer A,Lembert N

更新日期：2007-01-01 00:00:00

abstract：:Biological pacing has been proposed as a physiologic counterpart to electronic pacing, and the sinoatrial node (SAN) is the general standard for biological pacemakers. We tested the expression of SAN pacemaker cell activity when implanted autologously in the right ventricle (RV). We induced complete heart block and i...

journal_title：Cell transplantation

authors： Zhang H,Lau DH,Shlapakova IN,Zhao X,Danilo P,Robinson RB,Cohen IS,Qu D,Xu Z,Rosen MR

更新日期：2011-01-01 00:00:00

abstract：:The incidence of cell transplant-transmitted infection is unknown and can only be inferred from prospective studies--that have not yet been performed and reported. The possibility of donor-to-recipient disease transmission through cell transplant therapy can be considered by reviewing the risk associated with other tr...

journal_title：Cell transplantation

authors： Eastlund T

更新日期：1995-09-01 00:00:00

abstract：:After a unilateral striatal lesion, animals have generally been seen to have a bilateral impairment in paw reaching, with the contralateral paw being more affected. However, most studies to date have not used a pretraining paradigm to assess maximal capacity for paw reaching, to compare with any lesion-induced loss. T...

journal_title：Cell transplantation

authors： Fricker-Gates RA,Smith R,Muhith J,Dunnett SB

更新日期：2003-01-01 00:00:00

abstract：:Hepatocyte transplantation is an alternative therapy to orthotopic liver transplantation for the treatment of liver diseases. However, the supply of hepatocytes is limited given the shortage of organs available to isolate good-functioning quality cells. Neonatal livers may be a potential source alternative to adult li...

journal_title：Cell transplantation

authors： Tolosa L,Pareja-Ibars E,Donato MT,Cortés M,López S,Jiménez N,Mir J,Castell JV,Gómez-Lechón MJ

更新日期：2014-01-01 00:00:00