Abstract:
:Recently, animal studies have demonstrated the efficacy of endothelial progenitor cell (EPC) therapy for diabetic wound healing. Based on these preclinical studies, we performed a prospective clinical trial phase I/IIa study of autologous G-CSF-mobilized peripheral blood (PB) CD34(+) cell transplantation for nonhealing diabetic foot patients. Diabetic patients with nonhealing foot ulcers were treated with 2 × 10(7) cells of G-CSF-mobilized PB CD34(+) cells as EPC-enriched population. Safety and efficacy (wound closure and vascular perfusion) were evaluated 12 weeks posttherapy and further followed for complete wound closure and recurrence. A total of five patients were enrolled. Although minor amputation and recurrence were seen in three out of five patients, no death, other serious adverse events, or major amputation was seen following transplantation. Complete wound closure was observed at an average of 18 weeks with increased vascular perfusion in all patients. The outcomes of this prospective clinical study indicate the safety and feasibility of CD34(+) cell therapy in patients with diabetic nonhealing wounds.
journal_name
Cell Transplantjournal_title
Cell transplantationauthors
Tanaka R,Masuda H,Kato S,Imagawa K,Kanabuchi K,Nakashioya C,Yoshiba F,Fukui T,Ito R,Kobori M,Wada M,Asahara T,Miyasaka Mdoi
10.3727/096368912X658007subject
Has Abstractpub_date
2014-02-01 00:00:00pages
167-79issue
2eissn
0963-6897issn
1555-3892pii
ct0852tanakajournal_volume
23pub_type
杂志文章abstract::Bone marrow-derived cells have different plastic properties, especially regarding cell fusion, which increases with time and is prompted by tissue injury. Several recessive mutations, including Purkinje Cell Degeneration, affect the number of Purkinje cells in homozygosis; heterozygous young animals have an apparently...
journal_title:Cell transplantation
pub_type: 杂志文章
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journal_title:Cell transplantation
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journal_title:Cell transplantation
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journal_title:Cell transplantation
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journal_title:Cell transplantation
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journal_title:Cell transplantation
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journal_title:Cell transplantation
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journal_title:Cell transplantation
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journal_title:Cell transplantation
pub_type: 杂志文章
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journal_title:Cell transplantation
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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